FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8362, 443 aa 1>>>pF1KB8362 443 - 443 aa - 443 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.3676+/-0.000346; mu= -5.8340+/- 0.022 mean_var=246.5007+/-52.657, 0's: 0 Z-trim(123.1): 34 B-trim: 2389 in 1/55 Lambda= 0.081689 statistics sampled from 42273 (42307) to 42273 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.805), E-opt: 0.2 (0.496), width: 16 Scan time: 8.670 The best scores are: opt bits E(85289) NP_002042 (OMIM: 131320,146255) trans-acting T-cel ( 443) 3145 383.3 6.8e-106 NP_001002295 (OMIM: 131320,146255) trans-acting T- ( 444) 3133 381.9 1.8e-105 XP_005252500 (OMIM: 131320,146255) PREDICTED: tran ( 444) 3133 381.9 1.8e-105 XP_005252499 (OMIM: 131320,146255) PREDICTED: tran ( 444) 3133 381.9 1.8e-105 NP_001139133 (OMIM: 137295,614038,614172,614286) e ( 480) 1342 170.8 6.7e-42 NP_116027 (OMIM: 137295,614038,614172,614286) endo ( 480) 1342 170.8 6.7e-42 NP_002040 (OMIM: 190685,300367,300835,305371,31405 ( 413) 776 104.1 7.1e-22 XP_011542199 (OMIM: 190685,300367,300835,305371,31 ( 418) 756 101.8 3.7e-21 XP_011542200 (OMIM: 190685,300367,300835,305371,31 ( 335) 748 100.8 5.9e-21 XP_006723762 (OMIM: 611496) PREDICTED: transcripti ( 397) 747 100.7 7.4e-21 NP_536721 (OMIM: 611496) transcription factor GATA ( 397) 747 100.7 7.4e-21 NP_002043 (OMIM: 187500,600576,607941,614429,61443 ( 442) 727 98.3 4.1e-20 XP_006716311 (OMIM: 187500,600576,607941,614429,61 ( 443) 724 98.0 5.3e-20 XP_016868801 (OMIM: 187500,600576,607941,614429,61 ( 443) 724 98.0 5.3e-20 XP_005272442 (OMIM: 187500,600576,607941,614429,61 ( 443) 724 98.0 5.3e-20 NP_001295022 (OMIM: 187500,600576,607941,614429,61 ( 443) 724 98.0 5.3e-20 XP_011542119 (OMIM: 187500,600576,607941,614429,61 ( 443) 724 98.0 5.3e-20 XP_005272443 (OMIM: 187500,600576,607941,614429,61 ( 443) 724 98.0 5.3e-20 XP_011542120 (OMIM: 187500,600576,607941,614429,61 ( 443) 724 98.0 5.3e-20 NP_001295023 (OMIM: 187500,600576,607941,614429,61 ( 236) 715 96.8 6.5e-20 NP_005248 (OMIM: 187500,217095,600001,601656,61447 ( 595) 672 91.9 4.8e-18 NP_001139134 (OMIM: 137295,614038,614172,614286) e ( 466) 664 90.9 7.4e-18 NP_001317528 (OMIM: 190350,190351,604386) zinc fin (1281) 255 43.0 0.0057 XP_011515570 (OMIM: 190350,190351,604386) PREDICTE (1281) 255 43.0 0.0057 NP_001269831 (OMIM: 190350,190351,604386) zinc fin (1285) 255 43.0 0.0057 NP_001269832 (OMIM: 190350,190351,604386) zinc fin (1287) 255 43.0 0.0057 XP_011515569 (OMIM: 190350,190351,604386) PREDICTE (1287) 255 43.0 0.0057 XP_006716688 (OMIM: 190350,190351,604386) PREDICTE (1294) 255 43.0 0.0057 XP_011515568 (OMIM: 190350,190351,604386) PREDICTE (1294) 255 43.0 0.0057 NP_054831 (OMIM: 190350,190351,604386) zinc finger (1294) 255 43.0 0.0057 XP_011515566 (OMIM: 190350,190351,604386) PREDICTE (1294) 255 43.0 0.0057 XP_016869290 (OMIM: 190350,190351,604386) PREDICTE (1317) 255 43.0 0.0058 >>NP_002042 (OMIM: 131320,146255) trans-acting T-cell-sp (443 aa) initn: 3145 init1: 3145 opt: 3145 Z-score: 2022.1 bits: 383.3 E(85289): 6.8e-106 Smith-Waterman score: 3145; 99.8% identity (100.0% similar) in 443 aa overlap (1-443:1-443) 10 20 30 40 50 60 pF1KB8 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYELHNINRPLTMKKEG :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: NP_002 IKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 IQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPT 370 380 390 400 410 420 430 440 pF1KB8 PMHPPSSLSFGPHHPSSMVTAMG ::::::::::::::::::::::: NP_002 PMHPPSSLSFGPHHPSSMVTAMG 430 440 >>NP_001002295 (OMIM: 131320,146255) trans-acting T-cell (444 aa) initn: 2010 init1: 1849 opt: 3133 Z-score: 2014.4 bits: 381.9 E(85289): 1.8e-105 Smith-Waterman score: 3133; 99.5% identity (99.8% similar) in 444 aa overlap (1-443:1-444) 10 20 30 40 50 60 pF1KB8 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 GGSPTGFGCKSRPKARSST-GRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRP ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 GGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 LIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYELHNINRPLTMKKE ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_001 LIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 GIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTP 370 380 390 400 410 420 420 430 440 pF1KB8 TPMHPPSSLSFGPHHPSSMVTAMG :::::::::::::::::::::::: NP_001 TPMHPPSSLSFGPHHPSSMVTAMG 430 440 >>XP_005252500 (OMIM: 131320,146255) PREDICTED: trans-ac (444 aa) initn: 2010 init1: 1849 opt: 3133 Z-score: 2014.4 bits: 381.9 E(85289): 1.8e-105 Smith-Waterman score: 3133; 99.5% identity (99.8% similar) in 444 aa overlap (1-443:1-444) 10 20 30 40 50 60 pF1KB8 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 GGSPTGFGCKSRPKARSST-GRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRP ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: XP_005 GGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 LIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYELHNINRPLTMKKE ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_005 LIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 GIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTP 370 380 390 400 410 420 420 430 440 pF1KB8 TPMHPPSSLSFGPHHPSSMVTAMG :::::::::::::::::::::::: XP_005 TPMHPPSSLSFGPHHPSSMVTAMG 430 440 >>XP_005252499 (OMIM: 131320,146255) PREDICTED: trans-ac (444 aa) initn: 2010 init1: 1849 opt: 3133 Z-score: 2014.4 bits: 381.9 E(85289): 1.8e-105 Smith-Waterman score: 3133; 99.5% identity (99.8% similar) in 444 aa overlap (1-443:1-444) 10 20 30 40 50 60 pF1KB8 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 GGSPTGFGCKSRPKARSST-GRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRP ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: XP_005 GGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 LIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYELHNINRPLTMKKE ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_005 LIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 GIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTP 370 380 390 400 410 420 420 430 440 pF1KB8 TPMHPPSSLSFGPHHPSSMVTAMG :::::::::::::::::::::::: XP_005 TPMHPPSSLSFGPHHPSSMVTAMG 430 440 >>NP_001139133 (OMIM: 137295,614038,614172,614286) endot (480 aa) initn: 1477 init1: 814 opt: 1342 Z-score: 873.2 bits: 170.8 E(85289): 6.7e-42 Smith-Waterman score: 1918; 62.3% identity (77.7% similar) in 485 aa overlap (1-443:1-480) 10 20 30 40 50 pF1KB8 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFN-IDGQGNH :::. .::::..: :::::.::::.:::::.:.::. :: :.::::.:: .:.::: NP_001 MEVAPEQPRWMAH--PAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGN- 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VPPYYGNSVRATVQ-RYPPTHH---GSQVCRPPLLHG-SLPWLDGGKALGSH---HTASP :::.: ..: .. : :.: :.:.::: :::. .::::::::: : : .: NP_001 --PYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNP 60 70 80 90 100 110 120 130 140 150 pF1KB8 WNLSPFSKTSIHH---GSPG-PLSVYPPASSSSLSGG------------HASPHLFTFPP :..:::::: .: :.:: :::::: :...: .:. :.. ::: ::: NP_001 WTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPP 120 130 140 150 160 170 160 170 180 190 200 pF1KB8 TPPKDVSPDPSLS---TPGSA---GSA-RQDEKECLKYQVPLPDSMKLESSHSRGSMTAL ::::.:::::: . .:.:. ::: : ..:. .:::: : .:::.::. : NP_001 TPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLAT 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB8 GGASSSTHHPITTYPPYVP----EYSSGLFPPSSLLGGSPTGFGCKSRPKARS-STGREC :.. .::::: ::: ::: .:::::: :...::: ..: :.: :::: : :::: NP_001 MGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGREC 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB8 VNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTT ::::::.::::::::::::::::::::::::::::::::::::::::::::: ::::::: NP_001 VNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTT 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB8 TTTLWRRNANGDPVCNACGLYYELHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSLE ::::::::::::::::::::::.:::.:::::::::::::::::::.:::: :: . .: NP_001 TTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFE 360 370 380 390 400 410 390 400 410 420 430 pF1KB8 DFPK-----NSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSSM .. : .: :. :::. ::. ..:. :::::.:.: ::::.:: :::::: ::::: NP_001 ELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSM 420 430 440 450 460 470 440 pF1KB8 VTAMG ::::: NP_001 VTAMG 480 >>NP_116027 (OMIM: 137295,614038,614172,614286) endothel (480 aa) initn: 1477 init1: 814 opt: 1342 Z-score: 873.2 bits: 170.8 E(85289): 6.7e-42 Smith-Waterman score: 1918; 62.3% identity (77.7% similar) in 485 aa overlap (1-443:1-480) 10 20 30 40 50 pF1KB8 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFN-IDGQGNH :::. .::::..: :::::.::::.:::::.:.::. :: :.::::.:: .:.::: NP_116 MEVAPEQPRWMAH--PAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGN- 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VPPYYGNSVRATVQ-RYPPTHH---GSQVCRPPLLHG-SLPWLDGGKALGSH---HTASP :::.: ..: .. : :.: :.:.::: :::. .::::::::: : : .: NP_116 --PYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNP 60 70 80 90 100 110 120 130 140 150 pF1KB8 WNLSPFSKTSIHH---GSPG-PLSVYPPASSSSLSGG------------HASPHLFTFPP :..:::::: .: :.:: :::::: :...: .:. :.. ::: ::: NP_116 WTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPP 120 130 140 150 160 170 160 170 180 190 200 pF1KB8 TPPKDVSPDPSLS---TPGSA---GSA-RQDEKECLKYQVPLPDSMKLESSHSRGSMTAL ::::.:::::: . .:.:. ::: : ..:. .:::: : .:::.::. : NP_116 TPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLAT 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB8 GGASSSTHHPITTYPPYVP----EYSSGLFPPSSLLGGSPTGFGCKSRPKARS-STGREC :.. .::::: ::: ::: .:::::: :...::: ..: :.: :::: : :::: NP_116 MGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGREC 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB8 VNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTT ::::::.::::::::::::::::::::::::::::::::::::::::::::: ::::::: NP_116 VNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTT 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB8 TTTLWRRNANGDPVCNACGLYYELHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSLE ::::::::::::::::::::::.:::.:::::::::::::::::::.:::: :: . .: NP_116 TTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFE 360 370 380 390 400 410 390 400 410 420 430 pF1KB8 DFPK-----NSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSSM .. : .: :. :::. ::. ..:. :::::.:.: ::::.:: :::::: ::::: NP_116 ELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSM 420 430 440 450 460 470 440 pF1KB8 VTAMG ::::: NP_116 VTAMG 480 >>NP_002040 (OMIM: 190685,300367,300835,305371,314050) e (413 aa) initn: 766 init1: 714 opt: 776 Z-score: 513.7 bits: 104.1 E(85289): 7.1e-22 Smith-Waterman score: 782; 40.7% identity (60.9% similar) in 381 aa overlap (105-442:51-408) 80 90 100 110 120 130 pF1KB8 YPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYP : ::. :. . . .. :: ..::: NP_002 PALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSP-VFQVYP 30 40 50 60 70 140 150 160 170 180 pF1KB8 PASS-SSLSGGHASPHL-FTFPPT---PPKDVSPDPSLSTPGSA----GSARQDEKECLK . .. :: ::. ... : : . : : : : .. :.. . : :: NP_002 LLNCMEGIPGG--SPYAGWAYGKTGLYPASTVCPTREDSPPQAVEDLDGKGSTSFLETLK 80 90 100 110 120 130 190 200 210 220 230 240 pF1KB8 YQVPLPDSMKLESSHSRGSMTALGGA-SSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSP . :: . .:: : :: : ..: :..:: .: :. ::: NP_002 TERLSPD------------LLTLGPALPSSLPVPNSAYGG--PDFSSTFFSPT----GSP 140 150 160 170 250 260 270 280 290 pF1KB8 TGFGCKSRPKARSST------GRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNR . . : :: :.. .:::::::::.::::::: :::::::::::::::::::: NP_002 LNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNR 180 190 200 210 220 230 300 310 320 330 340 350 pF1KB8 PLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYELHNINRPLTMKK :::.::.:: ...::::.:.::::::::::::::.::::::::::::.::..::::::.: NP_002 PLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRK 240 250 260 270 280 290 360 370 380 390 pF1KB8 EGIQTRNRKMSSKSKKCKKVHDSL-----EDFPKNS--------------------SFNP .:::::::: :.:.: :: .:: . : .. ...: NP_002 DGIQTRNRKASGKGK--KKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGP 300 310 320 330 340 350 400 410 420 430 440 pF1KB8 AALSRHMSSLSHISPFSHSSHMLTTPTPM--HPPSSLSFGPHHPSSMVTAMG . .. ...:. . . ::.. : :. : .:. :: :.. .:.. NP_002 PGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS 360 370 380 390 400 410 >>XP_011542199 (OMIM: 190685,300367,300835,305371,314050 (418 aa) initn: 752 init1: 584 opt: 756 Z-score: 500.8 bits: 101.8 E(85289): 3.7e-21 Smith-Waterman score: 762; 40.2% identity (60.1% similar) in 386 aa overlap (105-442:51-413) 80 90 100 110 120 130 pF1KB8 YPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYP : ::. :. . . .. :: ..::: XP_011 PALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSP-VFQVYP 30 40 50 60 70 140 150 160 170 180 pF1KB8 PASS-SSLSGGHASPHL-FTFPPT---PPKDVSPDPSLSTPGSA----GSARQDEKECLK . .. :: ::. ... : : . : : : : .. :.. . : :: XP_011 LLNCMEGIPGG--SPYAGWAYGKTGLYPASTVCPTREDSPPQAVEDLDGKGSTSFLETLK 80 90 100 110 120 130 190 200 210 220 230 240 pF1KB8 YQVPLPDSMKLESSHSRGSMTALGGA-SSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSP . :: . .:: : :: : ..: :..:: .: :. ::: XP_011 TERLSPD------------LLTLGPALPSSLPVPNSAYGG--PDFSSTFFSPT----GSP 140 150 160 170 250 260 270 280 290 pF1KB8 TGFGCKSRPKARSST------GRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNR . . : :: :.. .:::::::::.::::::: :::::::::::::::::::: XP_011 LNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNR 180 190 200 210 220 230 300 310 320 330 340 350 pF1KB8 PLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYELHN-----INRP :::.::.:: ...::::.:.::::::::::::::.::::::::::::.::. .::: XP_011 PLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQPPFWQVNRP 240 250 260 270 280 290 360 370 380 pF1KB8 LTMKKEGIQTRNRKMSSKSKKCKKVHDSL-----EDFPKNS------------------- :::.:.:::::::: :.:.: :: .:: . : .. XP_011 LTMRKDGIQTRNRKASGKGK--KKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASG 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB8 -SFNPAALSRHMSSLSHISPFSHSSHMLTTPTPM--HPPSSLSFGPHHPSSMVTAMG ...: . .. ...:. . . ::.. : :. : .:. :: :.. .:.. XP_011 LTLGPPGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLS 360 370 380 390 400 410 XP_011 S >>XP_011542200 (OMIM: 190685,300367,300835,305371,314050 (335 aa) initn: 729 init1: 584 opt: 748 Z-score: 497.2 bits: 100.8 E(85289): 5.9e-21 Smith-Waterman score: 753; 45.8% identity (66.4% similar) in 286 aa overlap (196-442:53-330) 170 180 190 200 210 220 pF1KB8 SLSTPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMTALGGA-SSSTHHPITTYPP :.. . .. .:: : :: : ..: XP_011 ASTVCPTREDSPPQAVEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGG 30 40 50 60 70 80 230 240 250 260 270 pF1KB8 YVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSST------GRECVNCGATSTPLWRRDG :..:: .: :. ::: . . : :: :.. .:::::::::.::::::: XP_011 --PDFSSTFFSPT----GSPLNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDR 90 100 110 120 130 280 290 300 310 320 330 pF1KB8 TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVC :::::::::::::::::::::::.::.:: ...::::.:.::::::::::::::.::::: XP_011 TGHYLCNACGLYHKMNGQNRPLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVC 140 150 160 170 180 190 340 350 360 370 380 pF1KB8 NACGLYYELHN-----INRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSL-----EDFPKN :::::::.::. .::::::.:.:::::::: :.:.:: : .:: . : . XP_011 NACGLYYKLHQPPFWQVNRPLTMRKDGIQTRNRKASGKGKK--KRGSSLGGTGAAEGPAG 200 210 220 230 240 250 390 400 410 420 pF1KB8 S--------------------SFNPAALSRHMSSLSHISPFSHSSHMLTTPTPM--HPPS . ...: . .. ...:. . . ::.. : :. : . XP_011 GFMVVAGGSGSGNCGEVASGLTLGPPGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTG 260 270 280 290 300 310 430 440 pF1KB8 SLSFGPHHPSSMVTAMG :. :: :.. .:.. XP_011 SFPTGPMPPTTSTTVVAPLSS 320 330 >>XP_006723762 (OMIM: 611496) PREDICTED: transcription f (397 aa) initn: 889 init1: 651 opt: 747 Z-score: 495.5 bits: 100.7 E(85289): 7.4e-21 Smith-Waterman score: 747; 41.8% identity (61.8% similar) in 361 aa overlap (98-434:18-359) 70 80 90 100 110 120 pF1KB8 VRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSP------FSKTS :.:. : . ..:: . : .: : XP_006 MYQSLALAASPRQAAYADSGSFLHAPGAGSPMFVPPARVPSMLSYLS 10 20 30 40 130 140 150 160 170 pF1KB8 IHHGSPGP--LSVYP----PASSSSLSGGHASPHLFTFPPTP-PKDVSPDP---SLSTPG . :: : :.. : :...: . : .::: ::. : .. : : : :: XP_006 GCEPSPQPPELAARPGWAQTATADSSAFGPGSPH----PPAAHPPGATAFPFAHSPSGPG 50 60 70 80 90 100 180 190 200 210 220 230 pF1KB8 SAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSS :.::: .. :: : .. . .: :.: :. .: . : . ... XP_006 SGGSA--GGRDGSAYQGALLPREQFAAPLGRPV-----GTSYSATYPAYVSPDVAQSWTA 110 120 130 140 150 240 250 260 270 280 pF1KB8 GLFPPSSLLG--GSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGL : : : : : : : .. . . ::::::::: :::::::::::::::::::: XP_006 GPFDGSVLHGLPGRRPTF-VSDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGL 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB8 YHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYELHN :::::: ::::..:..:::..:::: :.::.::.:::::::..:.:::::::::..::. XP_006 YHKMNGVNRPLVRPQKRLSSSRRAGLCCTNCHTTNTTLWRRNSEGEPVCNACGLYMKLHG 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB8 INRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSS--LSHIS . :::.::::.::::.: : : :.. : .:.: .:.:.. :: :. . XP_006 VPRPLAMKKESIQTRKR----KPKTIAKARGS-SGSTRNASASPSAVASTDSSAATSKAK 280 290 300 310 320 330 410 420 430 440 pF1KB8 PFSHSSHMLTTPTPMHPPSSL----SFGPHHPSSMVTAMG : : .: . :. : : .: :..: : XP_006 P-SLASPVCPGPS-MAPQASGQEDDSLAPGHLEFKFEPEDFAFPSTAPSPQAGLRGALRQ 340 350 360 370 380 XP_006 EAWCALALA 390 443 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:09:40 2016 done: Fri Nov 4 12:09:41 2016 Total Scan time: 8.670 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]