Result of FASTA (omim) for
pF1KB8366
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8366, 178 aa
1>>>pF1KB8366 178 - 178 aa - 178 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5638+/-0.000312; mu= 11.6577+/- 0.019
mean_var=83.5086+/-15.834, 0's: 0 Z-trim(118.5): 99 B-trim: 374 in 2/51
Lambda= 0.140349
statistics sampled from 31346 (31459) to 31346 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.369), width: 16
Scan time: 5.870
The best scores are: opt bits E(85289)
NP_001720 (OMIM: 600345) probetacellulin isoform 1 ( 178) 1220 256.1 2.3e-68
XP_011530513 (OMIM: 600345) PREDICTED: probetacell ( 178) 1220 256.1 2.3e-68
NP_001303892 (OMIM: 600345) probetacellulin isofor ( 129) 653 141.1 6.4e-34
XP_016864057 (OMIM: 600345) PREDICTED: probetacell ( 119) 373 84.4 7e-17
NP_001093161 (OMIM: 190170) protransforming growth ( 159) 247 59.0 4.2e-09
NP_003227 (OMIM: 190170) protransforming growth fa ( 160) 247 59.0 4.2e-09
NP_001295088 (OMIM: 190170) protransforming growth ( 165) 247 59.0 4.3e-09
NP_001295087 (OMIM: 190170) protransforming growth ( 166) 247 59.0 4.3e-09
NP_003683 (OMIM: 603421) tomoregulin-1 precursor [ ( 380) 238 57.5 2.9e-08
XP_011509192 (OMIM: 605734) PREDICTED: tomoregulin ( 365) 228 55.4 1.2e-07
NP_057276 (OMIM: 605734) tomoregulin-2 isoform 1 p ( 374) 228 55.4 1.2e-07
XP_016859228 (OMIM: 605734) PREDICTED: tomoregulin ( 337) 217 53.2 5.1e-07
NP_001292063 (OMIM: 605734) tomoregulin-2 isoform ( 346) 217 53.2 5.2e-07
NP_001423 (OMIM: 602061) proepiregulin preproprote ( 169) 213 52.1 5.2e-07
NP_001936 (OMIM: 126150) proheparin-binding EGF-li ( 208) 179 45.3 7.2e-05
NP_001153468 (OMIM: 142445,603013) pro-neuregulin- ( 308) 166 42.8 0.00061
XP_016863341 (OMIM: 131530,611718) PREDICTED: pro- (1010) 172 44.4 0.00066
XP_016863340 (OMIM: 131530,611718) PREDICTED: pro- (1060) 172 44.4 0.00069
XP_016863339 (OMIM: 131530,611718) PREDICTED: pro- (1141) 172 44.4 0.00073
XP_016863338 (OMIM: 131530,611718) PREDICTED: pro- (1142) 172 44.4 0.00073
NP_001171602 (OMIM: 131530,611718) pro-epidermal g (1165) 172 44.4 0.00074
XP_011530009 (OMIM: 131530,611718) PREDICTED: pro- (1178) 172 44.4 0.00074
XP_016863337 (OMIM: 131530,611718) PREDICTED: pro- (1181) 172 44.4 0.00075
NP_001954 (OMIM: 131530,611718) pro-epidermal grow (1207) 172 44.5 0.00076
XP_016863335 (OMIM: 131530,611718) PREDICTED: pro- (1215) 172 44.5 0.00076
XP_005262853 (OMIM: 131530,611718) PREDICTED: pro- (1215) 172 44.5 0.00076
XP_016863334 (OMIM: 131530,611718) PREDICTED: pro- (1223) 172 44.5 0.00077
XP_016868859 (OMIM: 142445,603013) PREDICTED: pro- ( 486) 166 43.0 0.00087
NP_053584 (OMIM: 603818) pro-neuregulin-2, membran ( 844) 169 43.7 0.00087
NP_001171601 (OMIM: 131530,611718) pro-epidermal g (1166) 168 43.6 0.0013
XP_016863336 (OMIM: 131530,611718) PREDICTED: pro- (1182) 168 43.6 0.0013
NP_004874 (OMIM: 603818) pro-neuregulin-2, membran ( 850) 163 42.5 0.002
NP_039254 (OMIM: 142445,603013) pro-neuregulin-1, ( 462) 157 41.1 0.0029
XP_016868860 (OMIM: 142445,603013) PREDICTED: pro- ( 469) 157 41.1 0.003
NP_001309126 (OMIM: 142445,603013) pro-neuregulin- ( 483) 157 41.1 0.003
NP_039258 (OMIM: 142445,603013) pro-neuregulin-1, ( 640) 157 41.2 0.0038
XP_016868854 (OMIM: 142445,603013) PREDICTED: pro- ( 647) 157 41.2 0.0038
XP_005273543 (OMIM: 142445,603013) PREDICTED: pro- ( 695) 156 41.0 0.0047
NP_001153480 (OMIM: 142445,603013) pro-neuregulin- ( 420) 148 39.3 0.0097
>>NP_001720 (OMIM: 600345) probetacellulin isoform 1 pre (178 aa)
initn: 1220 init1: 1220 opt: 1220 Z-score: 1348.5 bits: 256.1 E(85289): 2.3e-68
Smith-Waterman score: 1220; 99.4% identity (100.0% similar) in 178 aa overlap (1-178:1-178)
10 20 30 40 50 60
pF1KB8 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL
70 80 90 100 110 120
130 140 150 160 170
pF1KB8 VICMIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA
130 140 150 160 170
>>XP_011530513 (OMIM: 600345) PREDICTED: probetacellulin (178 aa)
initn: 1220 init1: 1220 opt: 1220 Z-score: 1348.5 bits: 256.1 E(85289): 2.3e-68
Smith-Waterman score: 1220; 99.4% identity (100.0% similar) in 178 aa overlap (1-178:1-178)
10 20 30 40 50 60
pF1KB8 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL
70 80 90 100 110 120
130 140 150 160 170
pF1KB8 VICMIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA
130 140 150 160 170
>>NP_001303892 (OMIM: 600345) probetacellulin isoform 2 (129 aa)
initn: 740 init1: 653 opt: 653 Z-score: 730.0 bits: 141.1 E(85289): 6.4e-34
Smith-Waterman score: 766; 72.5% identity (72.5% similar) in 178 aa overlap (1-178:1-129)
10 20 30 40 50 60
pF1KB8 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL
::::::::::::::::::::::::::::::::::
NP_001 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCV--------------------------
70 80 90
130 140 150 160 170
pF1KB8 VICMIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA
:::::::::::::::::::::::::::::::::::
NP_001 -----------------------PLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA
100 110 120
>>XP_016864057 (OMIM: 600345) PREDICTED: probetacellulin (119 aa)
initn: 392 init1: 373 opt: 373 Z-score: 424.1 bits: 84.4 E(85289): 7e-17
Smith-Waterman score: 373; 87.3% identity (96.8% similar) in 63 aa overlap (1-63:1-63)
10 20 30 40 50 60
pF1KB8 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::.. ..
XP_016 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAGVISDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL
:..
XP_016 KKRKQNTDQLKKWGAVEKSLLYSLETSMNWEYDDLVQTAPFLAPSGSCNRARNTLSKSS
70 80 90 100 110
>>NP_001093161 (OMIM: 190170) protransforming growth fac (159 aa)
initn: 235 init1: 222 opt: 247 Z-score: 284.4 bits: 59.0 E(85289): 4.2e-09
Smith-Waterman score: 263; 35.8% identity (65.0% similar) in 137 aa overlap (17-147:8-127)
10 20 30 40 50
pF1KB8 MDRAARCSGASSLPLLLAL-ALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQ
::: :::.:. : . . ::: :: . :: :...
NP_001 MVPSAGQLALFALGIVLAACQALE-NST-SPLS------DPPVAAAVVS--
10 20 30 40
60 70 80 90 100 110
pF1KB8 SKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYL--RGDRG
::. :: .. ..:..: :::.: :. :.::: ::.:::::..::. . ...
NP_001 -----HFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKK
50 60 70 80 90
120 130 140 150 160 170
pF1KB8 QILVICMIAVMVVFIILVIGVCT---CCHPLRKRRKRKKKEEEMETLGKDITPINEDIEE
: .. ... .:.. .:.: .:. ::. .::
NP_001 QAITALVVVSIVALAVLII-TCVLIHCCQ-VRKHCEWCRALICRHEKPSALLKGRTACCH
100 110 120 130 140 150
pF1KB8 TNIA
NP_001 SETVV
>>NP_003227 (OMIM: 190170) protransforming growth factor (160 aa)
initn: 235 init1: 222 opt: 247 Z-score: 284.4 bits: 59.0 E(85289): 4.2e-09
Smith-Waterman score: 270; 36.5% identity (65.7% similar) in 137 aa overlap (17-147:8-128)
10 20 30 40 50
pF1KB8 MDRAARCSGASSLPLLLAL-ALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQ
::: :::.:. : . . ::: :: : .:: :...
NP_003 MVPSAGQLALFALGIVLAACQALE-NST-SP-----LSADPPVAAAVVS--
10 20 30 40
60 70 80 90 100 110
pF1KB8 SKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYL--RGDRG
::. :: .. ..:..: :::.: :. :.::: ::.:::::..::. . ...
NP_003 -----HFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKK
50 60 70 80 90
120 130 140 150 160 170
pF1KB8 QILVICMIAVMVVFIILVIGVCT---CCHPLRKRRKRKKKEEEMETLGKDITPINEDIEE
: .. ... .:.. .:.: .:. ::. .::
NP_003 QAITALVVVSIVALAVLII-TCVLIHCCQ-VRKHCEWCRALICRHEKPSALLKGRTACCH
100 110 120 130 140 150
pF1KB8 TNIA
NP_003 SETVV
160
>>NP_001295088 (OMIM: 190170) protransforming growth fac (165 aa)
initn: 235 init1: 222 opt: 247 Z-score: 284.2 bits: 59.0 E(85289): 4.3e-09
Smith-Waterman score: 255; 33.1% identity (62.8% similar) in 145 aa overlap (9-147:5-133)
10 20 30 40 50
pF1KB8 MDRAARCSGASSLPLLLAL-ALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQ
: ..: :. : ..: ..: : ::: :: . :: :...
NP_001 MFKIGRGALDLFSELLSFGGIVLAACQALENST-SPLS------DPPVAAAVVS--
10 20 30 40
60 70 80 90 100 110
pF1KB8 SKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYL--RGDRG
::. :: .. ..:..: :::.: :. :.::: ::.:::::..::. . ...
NP_001 -----HFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKK
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB8 QILVICMIAVMVVFIILVIGVCT---CCHPLRKRRKRKKKEEEMETLGKDITPINEDIEE
: .. ... .:.. .:.: .:. ::. .::
NP_001 QAITALVVVSIVALAVLII-TCVLIHCCQ-VRKHCEWCRALICRHEKPSALLKGRTACCH
110 120 130 140 150 160
pF1KB8 TNIA
NP_001 SETVV
>>NP_001295087 (OMIM: 190170) protransforming growth fac (166 aa)
initn: 235 init1: 222 opt: 247 Z-score: 284.2 bits: 59.0 E(85289): 4.3e-09
Smith-Waterman score: 262; 33.8% identity (63.4% similar) in 145 aa overlap (9-147:5-134)
10 20 30 40 50
pF1KB8 MDRAARCSGASSLPLLLAL-ALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQ
: ..: :. : ..: ..: : ::: :: : .:: :...
NP_001 MFKIGRGALDLFSELLSFGGIVLAACQALENST-SP-----LSADPPVAAAVVS--
10 20 30 40
60 70 80 90 100 110
pF1KB8 SKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYL--RGDRG
::. :: .. ..:..: :::.: :. :.::: ::.:::::..::. . ...
NP_001 -----HFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKK
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB8 QILVICMIAVMVVFIILVIGVCT---CCHPLRKRRKRKKKEEEMETLGKDITPINEDIEE
: .. ... .:.. .:.: .:. ::. .::
NP_001 QAITALVVVSIVALAVLII-TCVLIHCCQ-VRKHCEWCRALICRHEKPSALLKGRTACCH
110 120 130 140 150 160
pF1KB8 TNIA
NP_001 SETVV
>>NP_003683 (OMIM: 603421) tomoregulin-1 precursor [Homo (380 aa)
initn: 197 init1: 170 opt: 238 Z-score: 269.3 bits: 57.5 E(85289): 2.9e-08
Smith-Waterman score: 238; 28.1% identity (60.7% similar) in 135 aa overlap (27-154:234-366)
10 20 30 40 50
pF1KB8 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAAT
::. .: .: . . .:: :. . :.
NP_003 ASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQY-RPDVKDASD
210 220 230 240 250 260
60 70 80 90 100 110
pF1KB8 TTQSKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVD--LFYLRG
.. :. ::.. . :::.:.:.:. . : :: :. :: : .::..: ..:.
NP_003 QREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVP
270 280 290 300 310 320
120 130 140 150 160
pF1KB8 DRGQILVICMIAVM-VVFIILVIGVCTC----CHPLRKRRKRKKKEEEMETLGKDITPIN
.: .. . . :.. .: : ..... : : : .: .:.:.
NP_003 SRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKC-PKNNRGRRQKQNLGHFTSDTSSRMV
330 340 350 360 370 380
170
pF1KB8 EDIEETNIA
>>XP_011509192 (OMIM: 605734) PREDICTED: tomoregulin-2 i (365 aa)
initn: 247 init1: 172 opt: 228 Z-score: 258.6 bits: 55.4 E(85289): 1.2e-07
Smith-Waterman score: 228; 32.1% identity (58.8% similar) in 131 aa overlap (32-154:220-347)
10 20 30 40 50 60
pF1KB8 DRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLC-GDPEENCAATTTQS
:...: . .: : :: : .:
XP_011 GKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAEN-ANKLEES
190 200 210 220 230 240
70 80 90 100 110
pF1KB8 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVD---LFYLRGD-R
:. :. ::..:. .:..:.:. . : ::: :: :: : .::. : :. . : :
XP_011 AREHHIP-CPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVR
250 260 270 280 290 300
120 130 140 150 160 170
pF1KB8 GQ-ILVICMIAVMVVFIILVIGVCTC--CHPLRKRRKRKKKEEEMETLGKDITPINEDIE
: .:. .:... . .: :. .: : : .: .:.:.
XP_011 FQYVLIAAVIGTIQIAVICVVVLCITRKC-PRSNRIHRQKQNTGHYSSDNTTRASTRLI
310 320 330 340 350 360
pF1KB8 ETNIA
178 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 12:16:46 2016 done: Fri Nov 4 12:16:47 2016
Total Scan time: 5.870 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]