FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8370, 161 aa 1>>>pF1KB8370 161 - 161 aa - 161 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0087+/-0.000241; mu= 0.9733+/- 0.015 mean_var=141.0478+/-28.165, 0's: 0 Z-trim(125.5): 19 B-trim: 0 in 0/61 Lambda= 0.107992 statistics sampled from 49385 (49404) to 49385 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.865), E-opt: 0.2 (0.579), width: 16 Scan time: 6.440 The best scores are: opt bits E(85289) NP_001184069 (OMIM: 611453) dysbindin domain-conta ( 161) 1080 178.1 5.6e-45 NP_001184068 (OMIM: 611453) dysbindin domain-conta ( 161) 1080 178.1 5.6e-45 NP_001041688 (OMIM: 611453) dysbindin domain-conta ( 161) 1080 178.1 5.6e-45 NP_001041686 (OMIM: 611453) dysbindin domain-conta ( 161) 1080 178.1 5.6e-45 NP_060948 (OMIM: 611453) dysbindin domain-containi ( 259) 1080 178.1 8.4e-45 NP_001041690 (OMIM: 611453) dysbindin domain-conta ( 263) 1080 178.1 8.5e-45 NP_001041687 (OMIM: 611453) dysbindin domain-conta ( 112) 645 110.2 1e-24 NP_001041689 (OMIM: 611453) dysbindin domain-conta ( 112) 645 110.2 1e-24 NP_001041691 (OMIM: 611453) dysbindin domain-conta ( 214) 645 110.3 1.8e-24 XP_011513239 (OMIM: 181500,607145,614076) PREDICTE ( 195) 344 63.4 2.2e-10 XP_016866838 (OMIM: 181500,607145,614076) PREDICTE ( 200) 344 63.4 2.2e-10 XP_016866837 (OMIM: 181500,607145,614076) PREDICTE ( 201) 344 63.4 2.2e-10 NP_001258596 (OMIM: 181500,607145,614076) dysbindi ( 270) 344 63.5 2.9e-10 NP_001258598 (OMIM: 181500,607145,614076) dysbindi ( 316) 344 63.5 3.3e-10 XP_011513238 (OMIM: 181500,607145,614076) PREDICTE ( 321) 344 63.5 3.3e-10 NP_001258597 (OMIM: 181500,607145,614076) dysbindi ( 334) 344 63.5 3.4e-10 XP_005249504 (OMIM: 181500,607145,614076) PREDICTE ( 338) 344 63.5 3.5e-10 NP_115498 (OMIM: 181500,607145,614076) dysbindin i ( 351) 344 63.5 3.6e-10 NP_898861 (OMIM: 181500,607145,614076) dysbindin i ( 303) 260 50.4 2.8e-06 >>NP_001184069 (OMIM: 611453) dysbindin domain-containin (161 aa) initn: 1080 init1: 1080 opt: 1080 Z-score: 928.5 bits: 178.1 E(85289): 5.6e-45 Smith-Waterman score: 1080; 99.4% identity (100.0% similar) in 161 aa overlap (1-161:1-161) 10 20 30 40 50 60 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGVDNHLEELSLPVPTSDRTTSRTSSSSS :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGMDNHLEELSLPVPTSDRTTSRTSSSSS 70 80 90 100 110 120 130 140 150 160 pF1KB8 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS ::::::::::::::::::::::::::::::::::::::::: NP_001 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS 130 140 150 160 >>NP_001184068 (OMIM: 611453) dysbindin domain-containin (161 aa) initn: 1080 init1: 1080 opt: 1080 Z-score: 928.5 bits: 178.1 E(85289): 5.6e-45 Smith-Waterman score: 1080; 99.4% identity (100.0% similar) in 161 aa overlap (1-161:1-161) 10 20 30 40 50 60 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGVDNHLEELSLPVPTSDRTTSRTSSSSS :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGMDNHLEELSLPVPTSDRTTSRTSSSSS 70 80 90 100 110 120 130 140 150 160 pF1KB8 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS ::::::::::::::::::::::::::::::::::::::::: NP_001 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS 130 140 150 160 >>NP_001041688 (OMIM: 611453) dysbindin domain-containin (161 aa) initn: 1080 init1: 1080 opt: 1080 Z-score: 928.5 bits: 178.1 E(85289): 5.6e-45 Smith-Waterman score: 1080; 99.4% identity (100.0% similar) in 161 aa overlap (1-161:1-161) 10 20 30 40 50 60 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGVDNHLEELSLPVPTSDRTTSRTSSSSS :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGMDNHLEELSLPVPTSDRTTSRTSSSSS 70 80 90 100 110 120 130 140 150 160 pF1KB8 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS ::::::::::::::::::::::::::::::::::::::::: NP_001 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS 130 140 150 160 >>NP_001041686 (OMIM: 611453) dysbindin domain-containin (161 aa) initn: 1080 init1: 1080 opt: 1080 Z-score: 928.5 bits: 178.1 E(85289): 5.6e-45 Smith-Waterman score: 1080; 99.4% identity (100.0% similar) in 161 aa overlap (1-161:1-161) 10 20 30 40 50 60 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGVDNHLEELSLPVPTSDRTTSRTSSSSS :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGMDNHLEELSLPVPTSDRTTSRTSSSSS 70 80 90 100 110 120 130 140 150 160 pF1KB8 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS ::::::::::::::::::::::::::::::::::::::::: NP_001 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS 130 140 150 160 >>NP_060948 (OMIM: 611453) dysbindin domain-containing p (259 aa) initn: 1080 init1: 1080 opt: 1080 Z-score: 925.3 bits: 178.1 E(85289): 8.4e-45 Smith-Waterman score: 1080; 99.4% identity (100.0% similar) in 161 aa overlap (1-161:99-259) 10 20 30 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPE :::::::::::::::::::::::::::::: NP_060 QWGAPSPGPLCLLFRLCSCTCFAPLPAGADMDPNPRAALERQQLRLRERQKFFEDILQPE 70 80 90 100 110 120 40 50 60 70 80 90 pF1KB8 TEFVFPLSHLHLESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPCEDPPPTPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TEFVFPLSHLHLESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPCEDPPPTPQ 130 140 150 160 170 180 100 110 120 130 140 150 pF1KB8 SSGVDNHLEELSLPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLAQSDEEEER :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SSGMDNHLEELSLPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLAQSDEEEER 190 200 210 220 230 240 160 pF1KB8 GDGGAEPGACS ::::::::::: NP_060 GDGGAEPGACS 250 >>NP_001041690 (OMIM: 611453) dysbindin domain-containin (263 aa) initn: 1080 init1: 1080 opt: 1080 Z-score: 925.2 bits: 178.1 E(85289): 8.5e-45 Smith-Waterman score: 1080; 99.4% identity (100.0% similar) in 161 aa overlap (1-161:103-263) 10 20 30 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPE :::::::::::::::::::::::::::::: NP_001 QWGAPSPGPLCLLFRLCSCTCFAPLPAGADMDPNPRAALERQQLRLRERQKFFEDILQPE 80 90 100 110 120 130 40 50 60 70 80 90 pF1KB8 TEFVFPLSHLHLESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPCEDPPPTPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEFVFPLSHLHLESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPCEDPPPTPQ 140 150 160 170 180 190 100 110 120 130 140 150 pF1KB8 SSGVDNHLEELSLPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLAQSDEEEER :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSGMDNHLEELSLPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLAQSDEEEER 200 210 220 230 240 250 160 pF1KB8 GDGGAEPGACS ::::::::::: NP_001 GDGGAEPGACS 260 >>NP_001041687 (OMIM: 611453) dysbindin domain-containin (112 aa) initn: 637 init1: 637 opt: 645 Z-score: 564.7 bits: 110.2 E(85289): 1e-24 Smith-Waterman score: 645; 88.1% identity (91.7% similar) in 109 aa overlap (1-109:1-109) 10 20 30 40 50 60 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGVDNHLEELSLPVPTSDRTTSRTSSSSS :::::::::::::::::::::::::::::::::. . ..: : : NP_001 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGMPLCFGDFSASQPEPDVRL 70 80 90 100 110 130 140 150 160 pF1KB8 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS >>NP_001041689 (OMIM: 611453) dysbindin domain-containin (112 aa) initn: 637 init1: 637 opt: 645 Z-score: 564.7 bits: 110.2 E(85289): 1e-24 Smith-Waterman score: 645; 88.1% identity (91.7% similar) in 109 aa overlap (1-109:1-109) 10 20 30 40 50 60 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGVDNHLEELSLPVPTSDRTTSRTSSSSS :::::::::::::::::::::::::::::::::. . ..: : : NP_001 TLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGMPLCFGDFSASQPEPDVRL 70 80 90 100 110 130 140 150 160 pF1KB8 SDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS >>NP_001041691 (OMIM: 611453) dysbindin domain-containin (214 aa) initn: 637 init1: 637 opt: 645 Z-score: 560.3 bits: 110.3 E(85289): 1.8e-24 Smith-Waterman score: 645; 88.1% identity (91.7% similar) in 109 aa overlap (1-109:103-211) 10 20 30 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPE :::::::::::::::::::::::::::::: NP_001 QWGAPSPGPLCLLFRLCSCTCFAPLPAGADMDPNPRAALERQQLRLRERQKFFEDILQPE 80 90 100 110 120 130 40 50 60 70 80 90 pF1KB8 TEFVFPLSHLHLESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPCEDPPPTPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEFVFPLSHLHLESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPCEDPPPTPQ 140 150 160 170 180 190 100 110 120 130 140 150 pF1KB8 SSGVDNHLEELSLPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLAQSDEEEER :::. . ..: : : NP_001 SSGMPLCFGDFSASQPEPDVRL 200 210 >>XP_011513239 (OMIM: 181500,607145,614076) PREDICTED: d (195 aa) initn: 347 init1: 253 opt: 344 Z-score: 307.5 bits: 63.4 E(85289): 2.2e-10 Smith-Waterman score: 344; 42.6% identity (68.9% similar) in 148 aa overlap (12-152:32-173) 10 20 30 40 pF1KB8 MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLH ::..:.:::::::. .: . : . ..:. XP_011 SSPGLTENSQRDPSELDAEHAQKVLEMEHTQQMKLKERQKFFEEAFQQDMEQYLSTGYLQ 10 20 30 40 50 60 50 60 70 80 90 pF1KB8 LESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPC--ED-----PPPTPQSSGV . .: ::::.:::::::: :::..:.:..: .: :::: :. : :.:: XP_011 IAERREPIGSMSSMEVNVDMLEQMDLMDISDQEALDVFLNSGGEENTVLSPALGPESSTC 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 DNHLEELSLPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGG .:.. :..: :. :. .:::. .::.: : .:...:..:::::: . : XP_011 QNEIT-LQVPNPSELRAKPPSSSSTCTDSATRDIS-----EGGESPVVQSDEEEVQVDTA 130 140 150 160 170 160 pF1KB8 AEPGACS XP_011 LATSHTDREATPDGGEDSDS 180 190 161 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:19:40 2016 done: Fri Nov 4 12:19:41 2016 Total Scan time: 6.440 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]