FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8387, 568 aa 1>>>pF1KB8387 568 - 568 aa - 568 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7729+/-0.000447; mu= 16.9388+/- 0.028 mean_var=81.9732+/-16.473, 0's: 0 Z-trim(111.7): 23 B-trim: 144 in 1/50 Lambda= 0.141657 statistics sampled from 20386 (20406) to 20386 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.605), E-opt: 0.2 (0.239), width: 16 Scan time: 7.580 The best scores are: opt bits E(85289) NP_006336 (OMIM: 604604) zinc transporter 9 [Homo ( 568) 3698 766.0 0 XP_016863143 (OMIM: 604604) PREDICTED: zinc transp ( 591) 3610 748.0 1.9e-215 XP_016870603 (OMIM: 278700,611153) PREDICTED: DNA ( 231) 167 44.1 0.00058 XP_006717341 (OMIM: 278700,611153) PREDICTED: DNA ( 262) 167 44.2 0.00064 NP_000371 (OMIM: 278700,611153) DNA repair protein ( 273) 167 44.2 0.00066 >>NP_006336 (OMIM: 604604) zinc transporter 9 [Homo sapi (568 aa) initn: 3698 init1: 3698 opt: 3698 Z-score: 4086.4 bits: 766.0 E(85289): 0 Smith-Waterman score: 3698; 99.6% identity (100.0% similar) in 568 aa overlap (1-568:1-568) 10 20 30 40 50 60 pF1KB8 MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNVVPCSHPYIGT :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: NP_006 MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNMVPCSHPYIGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LSQVKLYSTNVQKEGQGSQTLRVEKVPSFETAEGIGAELKAPLKQEPLQVRVKAVLKKRE ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: NP_006 LSQVKLYSTNVQKEGQGSQTLRVEKVPSFETAEGIGTELKAPLKQEPLQVRVKAVLKKRE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YGSKYTQNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHEDTESFTVYLRSDVEAKSLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YGSKYTQNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHEDTESFTVYLRSDVEAKSLEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 MVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LVAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LVAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 LYDSLGSLGVGTLLGMVSAFLIYTNTEALLGRSIQPEQVQRLTELLENDPSVRAIHDVKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LYDSLGSLGVGTLLGMVSAFLIYTNTEALLGRSIQPEQVQRLTELLENDPSVRAIHDVKA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 TDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIID 490 500 510 520 530 540 550 560 pF1KB8 TLGAEVDRLEKELKKRNPEVRHVDLEIL :::::::::::::::::::::::::::: NP_006 TLGAEVDRLEKELKKRNPEVRHVDLEIL 550 560 >>XP_016863143 (OMIM: 604604) PREDICTED: zinc transporte (591 aa) initn: 3610 init1: 3610 opt: 3610 Z-score: 3989.0 bits: 748.0 E(85289): 1.9e-215 Smith-Waterman score: 3610; 99.5% identity (99.8% similar) in 556 aa overlap (1-556:1-556) 10 20 30 40 50 60 pF1KB8 MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNVVPCSHPYIGT :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: XP_016 MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNMVPCSHPYIGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LSQVKLYSTNVQKEGQGSQTLRVEKVPSFETAEGIGAELKAPLKQEPLQVRVKAVLKKRE ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: XP_016 LSQVKLYSTNVQKEGQGSQTLRVEKVPSFETAEGIGTELKAPLKQEPLQVRVKAVLKKRE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YGSKYTQNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHEDTESFTVYLRSDVEAKSLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGSKYTQNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHEDTESFTVYLRSDVEAKSLEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 MVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LVAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 LYDSLGSLGVGTLLGMVSAFLIYTNTEALLGRSIQPEQVQRLTELLENDPSVRAIHDVKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYDSLGSLGVGTLLGMVSAFLIYTNTEALLGRSIQPEQVQRLTELLENDPSVRAIHDVKA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 TDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIID 490 500 510 520 530 540 550 560 pF1KB8 TLGAEVDRLEKELKKRNPEVRHVDLEIL :::::::::::::: : XP_016 TLGAEVDRLEKELKVRCIHKNNIMIMAAIFLSTYSTADTKCIHHMHALTHS 550 560 570 580 590 >>XP_016870603 (OMIM: 278700,611153) PREDICTED: DNA repa (231 aa) initn: 136 init1: 101 opt: 167 Z-score: 192.2 bits: 44.1 E(85289): 0.00058 Smith-Waterman score: 167; 33.7% identity (71.6% similar) in 95 aa overlap (127-216:93-185) 100 110 120 130 140 150 pF1KB8 AELKAPLKQEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINEFCLKSSDLEQ----LRK ....:: ..: .:. ::. :::. :. XP_016 CEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKF 70 80 90 100 110 120 160 170 180 190 200 210 pF1KB8 IRRRSPHEDTES-FTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKI : ...::.. . . .::. .. .::::::: ::: . :..:.: . ..... : .: XP_016 IVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKF--DKK 130 140 150 160 170 180 220 230 240 250 260 270 pF1KB8 LREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAI ..: : XP_016 VKELRRAVRSSVWKRETIVHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM 190 200 210 220 230 >>XP_006717341 (OMIM: 278700,611153) PREDICTED: DNA repa (262 aa) initn: 136 init1: 101 opt: 167 Z-score: 191.4 bits: 44.2 E(85289): 0.00064 Smith-Waterman score: 167; 33.7% identity (71.6% similar) in 95 aa overlap (127-216:135-227) 100 110 120 130 140 150 pF1KB8 AELKAPLKQEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINEFCLKSSDLEQ----LRK ....:: ..: .:. ::. :::. :. XP_006 CEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKF 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 IRRRSPHEDTES-FTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKI : ...::.. . . .::. .. .::::::: ::: . :..:.: . ..... : .: XP_006 IVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKF--DKK 170 180 190 200 210 220 220 230 240 250 260 270 pF1KB8 LREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAI ..: : XP_006 VKELRRAVRSSVWKRETIVHQHEYGPEENLEDDMYPLKYQ 230 240 250 260 >>NP_000371 (OMIM: 278700,611153) DNA repair protein com (273 aa) initn: 136 init1: 101 opt: 167 Z-score: 191.1 bits: 44.2 E(85289): 0.00066 Smith-Waterman score: 167; 33.7% identity (71.6% similar) in 95 aa overlap (127-216:135-227) 100 110 120 130 140 150 pF1KB8 AELKAPLKQEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINEFCLKSSDLEQ----LRK ....:: ..: .:. ::. :::. :. NP_000 CEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKF 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 IRRRSPHEDTES-FTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKI : ...::.. . . .::. .. .::::::: ::: . :..:.: . ..... : .: NP_000 IVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKF--DKK 170 180 190 200 210 220 220 230 240 250 260 270 pF1KB8 LREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAI ..: : NP_000 VKELRRAVRSSVWKRETIVHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM 230 240 250 260 270 568 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:27:58 2016 done: Fri Nov 4 12:27:59 2016 Total Scan time: 7.580 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]