Result of FASTA (omim) for
pF1KB8410
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8410, 316 aa
1>>>pF1KB8410 316 - 316 aa - 316 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6435+/-0.000357; mu= 9.2434+/- 0.022
mean_var=82.0345+/-16.298, 0's: 0 Z-trim(115.3): 37 B-trim: 0 in 0/55
Lambda= 0.141604
statistics sampled from 25701 (25737) to 25701 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.302), width: 16
Scan time: 7.730
The best scores are: opt bits E(85289)
NP_077308 (OMIM: 300617) lys-63-specific deubiquit ( 316) 2082 434.8 1.1e-121
XP_005274808 (OMIM: 300617) PREDICTED: lys-63-spec ( 317) 2070 432.4 6e-121
NP_001018065 (OMIM: 300617) lys-63-specific deubiq ( 291) 1197 254.0 2.7e-67
XP_016885327 (OMIM: 300617) PREDICTED: lys-63-spec ( 291) 1197 254.0 2.7e-67
NP_001229569 (OMIM: 300617) lys-63-specific deubiq ( 292) 1185 251.5 1.5e-66
NP_005796 (OMIM: 607173) 26S proteasome non-ATPase ( 310) 174 45.0 0.00024
NP_006828 (OMIM: 604850) COP9 signalosome complex ( 334) 157 41.5 0.0028
>>NP_077308 (OMIM: 300617) lys-63-specific deubiquitinas (316 aa)
initn: 2082 init1: 2082 opt: 2082 Z-score: 2305.6 bits: 434.8 E(85289): 1.1e-121
Smith-Waterman score: 2082; 100.0% identity (100.0% similar) in 316 aa overlap (1-316:1-316)
10 20 30 40 50 60
pF1KB8 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 TVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 TVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 YHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 YHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 SSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 SSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 QEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 QEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQE
250 260 270 280 290 300
310
pF1KB8 LQQEKEELMQELSSLE
::::::::::::::::
NP_077 LQQEKEELMQELSSLE
310
>>XP_005274808 (OMIM: 300617) PREDICTED: lys-63-specific (317 aa)
initn: 1799 init1: 1799 opt: 2070 Z-score: 2292.3 bits: 432.4 E(85289): 6e-121
Smith-Waterman score: 2070; 99.7% identity (99.7% similar) in 317 aa overlap (1-316:1-317)
10 20 30 40 50
pF1KB8 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDT-RSDSKFAYTGTEM
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_005 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTSRSDSKFAYTGTEM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 RTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 WYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB8 KSSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKIL
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB8 CQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQ
250 260 270 280 290 300
300 310
pF1KB8 ELQQEKEELMQELSSLE
:::::::::::::::::
XP_005 ELQQEKEELMQELSSLE
310
>>NP_001018065 (OMIM: 300617) lys-63-specific deubiquiti (291 aa)
initn: 1227 init1: 1197 opt: 1197 Z-score: 1329.1 bits: 254.0 E(85289): 2.7e-67
Smith-Waterman score: 1847; 92.1% identity (92.1% similar) in 316 aa overlap (1-316:1-291)
10 20 30 40 50 60
pF1KB8 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 TVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 YHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 SSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILC
::: ::::::::::::::::::::::::::::::::
NP_001 SSE-------------------------YERIEIPIHIVPHVTIGKVCLESAVELPKILC
190 200 210
250 260 270 280 290 300
pF1KB8 QEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQE
220 230 240 250 260 270
310
pF1KB8 LQQEKEELMQELSSLE
::::::::::::::::
NP_001 LQQEKEELMQELSSLE
280 290
>>XP_016885327 (OMIM: 300617) PREDICTED: lys-63-specific (291 aa)
initn: 1227 init1: 1197 opt: 1197 Z-score: 1329.1 bits: 254.0 E(85289): 2.7e-67
Smith-Waterman score: 1847; 92.1% identity (92.1% similar) in 316 aa overlap (1-316:1-291)
10 20 30 40 50 60
pF1KB8 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 TVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 YHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 SSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILC
::: ::::::::::::::::::::::::::::::::
XP_016 SSE-------------------------YERIEIPIHIVPHVTIGKVCLESAVELPKILC
190 200 210
250 260 270 280 290 300
pF1KB8 QEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQE
220 230 240 250 260 270
310
pF1KB8 LQQEKEELMQELSSLE
::::::::::::::::
XP_016 LQQEKEELMQELSSLE
280 290
>>NP_001229569 (OMIM: 300617) lys-63-specific deubiquiti (292 aa)
initn: 991 init1: 914 opt: 1185 Z-score: 1315.8 bits: 251.5 E(85289): 1.5e-66
Smith-Waterman score: 1835; 91.8% identity (91.8% similar) in 317 aa overlap (1-316:1-292)
10 20 30 40 50
pF1KB8 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDT-RSDSKFAYTGTEM
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_001 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTSRSDSKFAYTGTEM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 RTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 WYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB8 KSSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKIL
:::: :::::::::::::::::::::::::::::::
NP_001 KSSE-------------------------YERIEIPIHIVPHVTIGKVCLESAVELPKIL
190 200 210
240 250 260 270 280 290
pF1KB8 CQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQ
220 230 240 250 260 270
300 310
pF1KB8 ELQQEKEELMQELSSLE
:::::::::::::::::
NP_001 ELQQEKEELMQELSSLE
280 290
>>NP_005796 (OMIM: 607173) 26S proteasome non-ATPase reg (310 aa)
initn: 191 init1: 146 opt: 174 Z-score: 199.2 bits: 45.0 E(85289): 0.00024
Smith-Waterman score: 197; 27.3% identity (53.6% similar) in 194 aa overlap (6-199:25-185)
10 20 30 40
pF1KB8 MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGE
:.... :.. : :.: :.:. . ::::: .::
NP_005 MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB8 LNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAAS
. :: :: ::.. .:. . .: . ..: . .
NP_005 FVDD--------YT-------------VRVI---DVFAMPQSGTGVSVEAVDP----VFQ
70 80 90
110 120 130 140 150 160
pF1KB8 TEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDK
.. . . :::: ::::::::: . : : ::. :: .. ... :... ..
NP_005 AKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVV----VDPI
100 110 120 130 140
170 180 190 200 210 220
pF1KB8 NTKTGRVLYTCFQSIQAQKSSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPH
.. :.:. :. :.:. . : ::. :. :..
NP_005 QSVKGKVVIDAFRLINANMMVLG-HEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINY
150 160 170 180 190 200
230 240 250 260 270 280
pF1KB8 VTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSG
NP_005 RKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTP
210 220 230 240 250 260
>>NP_006828 (OMIM: 604850) COP9 signalosome complex subu (334 aa)
initn: 202 init1: 139 opt: 157 Z-score: 179.9 bits: 41.5 E(85289): 0.0028
Smith-Waterman score: 157; 24.6% identity (56.9% similar) in 130 aa overlap (65-193:84-205)
40 50 60 70 80 90
pF1KB8 MGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
:::. .. . : . .. . . .. .
NP_006 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB8 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
. :: : :. .:: ..::::::: : : .:: :: . :.... ::....
NP_006 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB8 SCFIEDKNTKTGRVLYTCFQSI-QAQKSSESLHGPRDFWSSSQHISIEGQKEEERYERIE
. .. ..:.: :.. .. : . .:: .. .
NP_006 D---PTRTISAGKVNLGAFRTYPKGYKPPD--EGPSEYQTIPLNKIEDFGVHCKQYYALE
180 190 200 210 220
220 230 240 250 260 270
pF1KB8 IPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLC
NP_006 VSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSF
230 240 250 260 270 280
316 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 12:42:22 2016 done: Fri Nov 4 12:42:23 2016
Total Scan time: 7.730 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]