FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8425, 688 aa 1>>>pF1KB8425 688 - 688 aa - 688 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5774+/-0.000975; mu= 13.9734+/- 0.058 mean_var=99.4171+/-20.187, 0's: 0 Z-trim(107.6): 34 B-trim: 335 in 1/50 Lambda= 0.128630 statistics sampled from 9692 (9709) to 9692 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.298), width: 16 Scan time: 4.100 The best scores are: opt bits E(32554) CCDS1286.1 SCYL3 gene_id:57147|Hs108|chr1 ( 688) 4542 853.7 0 CCDS1287.1 SCYL3 gene_id:57147|Hs108|chr1 ( 742) 2827 535.5 1e-151 CCDS44646.1 SCYL1 gene_id:57410|Hs108|chr11 ( 791) 428 90.3 1.1e-17 CCDS41672.1 SCYL1 gene_id:57410|Hs108|chr11 ( 808) 428 90.3 1.2e-17 >>CCDS1286.1 SCYL3 gene_id:57147|Hs108|chr1 (688 aa) initn: 4542 init1: 4542 opt: 4542 Z-score: 4557.6 bits: 853.7 E(32554): 0 Smith-Waterman score: 4542; 99.7% identity (99.9% similar) in 688 aa overlap (1-688:1-688) 10 20 30 40 50 60 pF1KB8 MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 RHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 THNNVCLSSVFVSEDEHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTT ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: CCDS12 THNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LPECHGHARDAFSFGTLVESLLTILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 LPECHGHARDAFSFGTLVESLLTILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 SHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 AEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 AEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 IEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 IEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 FKRTAPSFTKNTDLSLEGDPFSQPIKFPINGLSDVKNTSEDSENFPSSSKKSEEWPDWSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 FKRTAPSFTKNTDLSLEGDPFSQPIKFPINGLSDVKNTSEDSENFPSSSKKSEEWPDWSE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 PEEPENQTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 PEEPENQTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 TSAEQKPIPALLSLTEESMPWKSSLPQKISLVQRGDDADQIEPPKVSSQERPLKVPSELG ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 TSGEQKPIPALLSLTEESMPWKSSLPQKISLVQRGDDADQIEPPKVSSQERPLKVPSELG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 LGEEFTIQVKKKPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 LGEEFTIQVKKKPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSS 610 620 630 640 650 660 670 680 pF1KB8 KFAAAEITEGEAEGWEEEGELNWEDNNW :::::::::::::::::::::::::::: CCDS12 KFAAAEITEGEAEGWEEEGELNWEDNNW 670 680 >>CCDS1287.1 SCYL3 gene_id:57147|Hs108|chr1 (742 aa) initn: 2827 init1: 2827 opt: 2827 Z-score: 2837.1 bits: 535.5 E(32554): 1e-151 Smith-Waterman score: 4258; 92.2% identity (92.4% similar) in 720 aa overlap (1-666:1-720) 10 20 30 40 50 60 pF1KB8 MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 RHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 THNNVCLSSVFVSEDEHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTT ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: CCDS12 THNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LPECHGHARDAFSFGTLVESLLTILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 LPECHGHARDAFSFGTLVESLLTILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 SHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 AEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 AEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 IEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 IEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKI 370 380 390 400 410 420 430 pF1KB8 FKRTAPSFTKNTDLSLE------------------------------------------- ::::::::::::::::: CCDS12 FKRTAPSFTKNTDLSLEDSPMCVVCSHHSQISPILENPFSSIFPKCFFSGSTPINSKKHI 430 440 450 460 470 480 440 450 460 470 480 pF1KB8 -----------GDPFSQPIKFPINGLSDVKNTSEDSENFPSSSKKSEEWPDWSEPEEPEN ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 QRDYYNTLLQTGDPFSQPIKFPINGLSDVKNTSEDSENFPSSSKKSEEWPDWSEPEEPEN 490 500 510 520 530 540 490 500 510 520 530 540 pF1KB8 QTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPVTSAEQK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: CCDS12 QTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPVTSGEQK 550 560 570 580 590 600 550 560 570 580 590 600 pF1KB8 PIPALLSLTEESMPWKSSLPQKISLVQRGDDADQIEPPKVSSQERPLKVPSELGLGEEFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 PIPALLSLTEESMPWKSSLPQKISLVQRGDDADQIEPPKVSSQERPLKVPSELGLGEEFT 610 620 630 640 650 660 610 620 630 640 650 660 pF1KB8 IQVKKKPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSSKFAAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 IQVKKKPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSSKFAAAE 670 680 690 700 710 720 670 680 pF1KB8 ITEGEAEGWEEEGELNWEDNNW CCDS12 ITEGEAEGWEEEGELNWEDNNW 730 740 >>CCDS44646.1 SCYL1 gene_id:57410|Hs108|chr11 (791 aa) initn: 309 init1: 123 opt: 428 Z-score: 430.7 bits: 90.3 E(32554): 1.1e-17 Smith-Waterman score: 449; 28.1% identity (57.8% similar) in 431 aa overlap (15-423:19-434) 10 20 30 40 50 pF1KB8 MGSENSALKSYTLREPPFT-LPSGLAVYPAVLQ-DGKFASVFVYK----RENEDKV ::: ::. :.. . . :. .:.::: :.. .: CCDS44 MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQV 10 20 30 40 50 60 60 70 80 90 100 pF1KB8 NKAA-KHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALET------LSSAEVCAG ::: :..:::::: .: ... .:.::: : :: . :.. :. :. : CCDS44 AKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB8 IYDILLALIFLHDRGHLTHNNVCLSSVFVSEDEHWKLGGMETVCKVSQATPEFLRSIQSI ...:. :: :: . : :::::...:::.. .:::::.. . ... : ..: CCDS44 LHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPR--KGI 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 RDPASIPPEEMSPEFTTLPECHGHARDAFSFGTLV-ESLLTILNEQVSADVLSSFQQTL- . . : :.. . . . : : . .: :. : . : . .. ... .:: CCDS44 PELEQYDPPELADSSGRVVREKWSA-DMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLV 180 190 200 210 220 230 230 240 250 260 270 pF1KB8 --HSTLLNPIPKCRPALCTLLSH-----DFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFL . :.. :: :: .:.. :. : :.:. ::. . .: :: .::. : CCDS44 PHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQEL 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 LDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALF .. . :.. ...: ::. . :.. :: .: : :. .:: . CCDS44 SKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAV------VLTPL--FKVGK---FLSAEEY 300 310 320 330 340 340 350 360 370 380 390 pF1KB8 QSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVA :...:::....: .. .:. ::...: ..... . .. :.:.:. :. ::. .: CCDS44 QQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIRE 350 360 370 380 390 400 400 410 420 430 440 450 pF1KB8 ITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKNTDLSLEGDPFSQPIKFPINGLSD :..:. .:. :. :. .. : : : : CCDS44 QTVKSMLLLAPKLN-EANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRH 410 420 430 440 450 460 >>CCDS41672.1 SCYL1 gene_id:57410|Hs108|chr11 (808 aa) initn: 309 init1: 123 opt: 428 Z-score: 430.5 bits: 90.3 E(32554): 1.2e-17 Smith-Waterman score: 449; 28.1% identity (57.8% similar) in 431 aa overlap (15-423:19-434) 10 20 30 40 50 pF1KB8 MGSENSALKSYTLREPPFT-LPSGLAVYPAVLQ-DGKFASVFVYK----RENEDKV ::: ::. :.. . . :. .:.::: :.. .: CCDS41 MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQV 10 20 30 40 50 60 60 70 80 90 100 pF1KB8 NKAA-KHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALET------LSSAEVCAG ::: :..:::::: .: ... .:.::: : :: . :.. :. :. : CCDS41 AKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB8 IYDILLALIFLHDRGHLTHNNVCLSSVFVSEDEHWKLGGMETVCKVSQATPEFLRSIQSI ...:. :: :: . : :::::...:::.. .:::::.. . ... : ..: CCDS41 LHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPR--KGI 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 RDPASIPPEEMSPEFTTLPECHGHARDAFSFGTLV-ESLLTILNEQVSADVLSSFQQTL- . . : :.. . . . : : . .: :. : . : . .. ... .:: CCDS41 PELEQYDPPELADSSGRVVREKWSA-DMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLV 180 190 200 210 220 230 230 240 250 260 270 pF1KB8 --HSTLLNPIPKCRPALCTLLSH-----DFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFL . :.. :: :: .:.. :. : :.:. ::. . .: :: .::. : CCDS41 PHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQEL 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 LDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALF .. . :.. ...: ::. . :.. :: .: : :. .:: . CCDS41 SKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAV------VLTPL--FKVGK---FLSAEEY 300 310 320 330 340 340 350 360 370 380 390 pF1KB8 QSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVA :...:::....: .. .:. ::...: ..... . .. :.:.:. :. ::. .: CCDS41 QQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIRE 350 360 370 380 390 400 400 410 420 430 440 450 pF1KB8 ITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKNTDLSLEGDPFSQPIKFPINGLSD :..:. .:. :. :. .. : : : : CCDS41 QTVKSMLLLAPKLN-EANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRH 410 420 430 440 450 460 688 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:47:32 2016 done: Fri Nov 4 12:47:33 2016 Total Scan time: 4.100 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]