FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8433, 283 aa 1>>>pF1KB8433 283 - 283 aa - 283 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 16.0667+/-0.000644; mu= -40.6007+/- 0.037 mean_var=954.2038+/-221.274, 0's: 0 Z-trim(115.2): 582 B-trim: 1456 in 1/57 Lambda= 0.041520 statistics sampled from 24808 (25431) to 24808 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.298), width: 16 Scan time: 7.260 The best scores are: opt bits E(85289) XP_016879298 (OMIM: 603464) PREDICTED: cyclin-depe ( 283) 1915 130.6 3.4e-30 NP_001092003 (OMIM: 603464) cyclin-dependent kinas ( 283) 1915 130.6 3.4e-30 XP_006721371 (OMIM: 603464) PREDICTED: cyclin-depe ( 354) 1915 130.7 3.9e-30 NP_001153839 (OMIM: 603464) cyclin-dependent kinas ( 289) 1893 129.3 8.5e-30 XP_016879297 (OMIM: 603464) PREDICTED: cyclin-depe ( 289) 1893 129.3 8.5e-30 NP_443714 (OMIM: 603464) cyclin-dependent kinase 1 ( 360) 1893 129.4 9.9e-30 XP_016879296 (OMIM: 603464) PREDICTED: cyclin-depe ( 337) 1675 116.3 8e-26 NP_443713 (OMIM: 603464) cyclin-dependent kinase 1 ( 272) 1653 114.9 1.7e-25 XP_016879299 (OMIM: 603464) PREDICTED: cyclin-depe ( 272) 1653 114.9 1.7e-25 XP_006721373 (OMIM: 603464) PREDICTED: cyclin-depe ( 343) 1653 115.0 2e-25 XP_011521715 (OMIM: 603464) PREDICTED: cyclin-depe ( 321) 1005 76.1 9.4e-14 XP_011521712 (OMIM: 603464) PREDICTED: cyclin-depe ( 321) 1005 76.1 9.4e-14 XP_011521718 (OMIM: 603464) PREDICTED: cyclin-depe ( 321) 1005 76.1 9.4e-14 XP_011521717 (OMIM: 603464) PREDICTED: cyclin-depe ( 321) 1005 76.1 9.4e-14 XP_011521716 (OMIM: 603464) PREDICTED: cyclin-depe ( 321) 1005 76.1 9.4e-14 XP_011521714 (OMIM: 603464) PREDICTED: cyclin-depe ( 321) 1005 76.1 9.4e-14 XP_011521713 (OMIM: 603464) PREDICTED: cyclin-depe ( 321) 1005 76.1 9.4e-14 XP_016879295 (OMIM: 603464) PREDICTED: cyclin-depe ( 355) 1005 76.2 1e-13 XP_011521710 (OMIM: 603464) PREDICTED: cyclin-depe ( 369) 1005 76.2 1e-13 XP_011521709 (OMIM: 603464) PREDICTED: cyclin-depe ( 375) 1005 76.2 1e-13 XP_011521719 (OMIM: 603464) PREDICTED: cyclin-depe ( 261) 999 75.7 1e-13 XP_011521708 (OMIM: 603464) PREDICTED: cyclin-depe ( 386) 1005 76.2 1.1e-13 XP_011521707 (OMIM: 603464) PREDICTED: cyclin-depe ( 392) 1005 76.2 1.1e-13 NP_277022 (OMIM: 176873) cyclin-dependent kinase 1 ( 526) 984 75.1 3.1e-13 NP_277025 (OMIM: 176873) cyclin-dependent kinase 1 ( 565) 984 75.1 3.3e-13 XP_011540798 (OMIM: 176873) PREDICTED: cyclin-depe ( 578) 984 75.2 3.3e-13 NP_277024 (OMIM: 176873) cyclin-dependent kinase 1 ( 748) 984 75.3 3.9e-13 XP_011540797 (OMIM: 176873) PREDICTED: cyclin-depe ( 760) 984 75.3 4e-13 XP_016858417 (OMIM: 176873) PREDICTED: cyclin-depe ( 761) 984 75.3 4e-13 XP_011540796 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 984 75.3 4e-13 XP_016858416 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 984 75.3 4e-13 NP_001278274 (OMIM: 176873) cyclin-dependent kinas ( 772) 984 75.3 4e-13 XP_016858415 (OMIM: 176873) PREDICTED: cyclin-depe ( 781) 984 75.3 4.1e-13 NP_277021 (OMIM: 176873) cyclin-dependent kinase 1 ( 782) 984 75.3 4.1e-13 XP_006711128 (OMIM: 176873) PREDICTED: cyclin-depe ( 785) 984 75.3 4.1e-13 XP_016858414 (OMIM: 176873) PREDICTED: cyclin-depe ( 791) 984 75.3 4.1e-13 XP_011540795 (OMIM: 176873) PREDICTED: cyclin-depe ( 794) 984 75.3 4.1e-13 NP_001778 (OMIM: 176873) cyclin-dependent kinase 1 ( 795) 984 75.3 4.1e-13 XP_011540794 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 984 75.3 4.1e-13 XP_011540792 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 984 75.3 4.1e-13 XP_011540793 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 984 75.3 4.1e-13 NP_277071 (OMIM: 116951) cyclin-dependent kinase 1 ( 770) 982 75.2 4.4e-13 NP_001300911 (OMIM: 116951) cyclin-dependent kinas ( 779) 982 75.2 4.4e-13 NP_076916 (OMIM: 116951) cyclin-dependent kinase 1 ( 780) 982 75.2 4.4e-13 NP_001300825 (OMIM: 116951) cyclin-dependent kinas ( 783) 982 75.2 4.4e-13 NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 677 56.5 7.5e-08 NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298) 672 56.1 9e-08 NP_001310998 (OMIM: 601955) cyclin-dependent kinas ( 305) 659 55.4 1.6e-07 NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346) 659 55.4 1.7e-07 NP_004926 (OMIM: 123831,616342) cyclin-dependent-l ( 292) 632 53.7 4.7e-07 >>XP_016879298 (OMIM: 603464) PREDICTED: cyclin-dependen (283 aa) initn: 1915 init1: 1915 opt: 1915 Z-score: 663.2 bits: 130.6 E(85289): 3.4e-30 Smith-Waterman score: 1915; 100.0% identity (100.0% similar) in 283 aa overlap (1-283:1-283) 10 20 30 40 50 60 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMATAGDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMATAGDC 190 200 210 220 230 240 250 260 270 280 pF1KB8 LESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP ::::::::::::::::::::::::::::::::::::::::::: XP_016 LESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 250 260 270 280 >>NP_001092003 (OMIM: 603464) cyclin-dependent kinase 10 (283 aa) initn: 1915 init1: 1915 opt: 1915 Z-score: 663.2 bits: 130.6 E(85289): 3.4e-30 Smith-Waterman score: 1915; 100.0% identity (100.0% similar) in 283 aa overlap (1-283:1-283) 10 20 30 40 50 60 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMATAGDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMATAGDC 190 200 210 220 230 240 250 260 270 280 pF1KB8 LESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP ::::::::::::::::::::::::::::::::::::::::::: NP_001 LESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 250 260 270 280 >>XP_006721371 (OMIM: 603464) PREDICTED: cyclin-dependen (354 aa) initn: 1915 init1: 1915 opt: 1915 Z-score: 662.0 bits: 130.7 E(85289): 3.9e-30 Smith-Waterman score: 1915; 100.0% identity (100.0% similar) in 283 aa overlap (1-283:72-354) 10 20 30 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVEL :::::::::::::::::::::::::::::: XP_006 LNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVEL 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB8 KEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIH 110 120 130 140 150 160 100 110 120 130 140 150 pF1KB8 RDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSID 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB8 MWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQP 230 240 250 260 270 280 220 230 240 250 260 270 pF1KB8 YNNLKHKFPWLSEAGLRLLHFLFMATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YNNLKHKFPWLSEAGLRLLHFLFMATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAA 290 300 310 320 330 340 280 pF1KB8 PATSEGQSKRCKP ::::::::::::: XP_006 PATSEGQSKRCKP 350 >>NP_001153839 (OMIM: 603464) cyclin-dependent kinase 10 (289 aa) initn: 1901 init1: 1561 opt: 1893 Z-score: 655.9 bits: 129.3 E(85289): 8.5e-30 Smith-Waterman score: 1893; 97.9% identity (97.9% similar) in 289 aa overlap (1-283:1-289) 10 20 30 40 50 60 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 190 200 210 220 230 240 240 250 260 270 280 pF1KB8 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 250 260 270 280 >>XP_016879297 (OMIM: 603464) PREDICTED: cyclin-dependen (289 aa) initn: 1901 init1: 1561 opt: 1893 Z-score: 655.9 bits: 129.3 E(85289): 8.5e-30 Smith-Waterman score: 1893; 97.9% identity (97.9% similar) in 289 aa overlap (1-283:1-289) 10 20 30 40 50 60 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 190 200 210 220 230 240 240 250 260 270 280 pF1KB8 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 250 260 270 280 >>NP_443714 (OMIM: 603464) cyclin-dependent kinase 10 is (360 aa) initn: 1901 init1: 1561 opt: 1893 Z-score: 654.8 bits: 129.4 E(85289): 9.9e-30 Smith-Waterman score: 1893; 97.9% identity (97.9% similar) in 289 aa overlap (1-283:72-360) 10 20 30 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVEL :::::::::::::::::::::::::::::: NP_443 LNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVEL 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB8 KEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 KEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIH 110 120 130 140 150 160 100 110 120 130 140 150 pF1KB8 RDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 RDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSID 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB8 MWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQP 230 240 250 260 270 280 220 230 240 250 260 pF1KB8 YNNLKHKFPWLSEAGLRLLHFLFM------ATAGDCLESSYFKEKPLPCEPELMPTFPHH :::::::::::::::::::::::: :::::::::::::::::::::::::::::: NP_443 YNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHH 290 300 310 320 330 340 270 280 pF1KB8 RNKRAAPATSEGQSKRCKP ::::::::::::::::::: NP_443 RNKRAAPATSEGQSKRCKP 350 360 >>XP_016879296 (OMIM: 603464) PREDICTED: cyclin-dependen (337 aa) initn: 1675 init1: 1675 opt: 1675 Z-score: 584.6 bits: 116.3 E(85289): 8e-26 Smith-Waterman score: 1675; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:72-322) 10 20 30 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVEL :::::::::::::::::::::::::::::: XP_016 LNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVEL 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB8 KEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIH 110 120 130 140 150 160 100 110 120 130 140 150 pF1KB8 RDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSID 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB8 MWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQP 230 240 250 260 270 280 220 230 240 250 260 270 pF1KB8 YNNLKHKFPWLSEAGLRLLHFLFMATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAA ::::::::::::::::::::::::::::::::::::::::: XP_016 YNNLKHKFPWLSEAGLRLLHFLFMATAGDCLESSYFKEKPLRLPISGVCEGCREPG 290 300 310 320 330 280 pF1KB8 PATSEGQSKRCKP >>NP_443713 (OMIM: 603464) cyclin-dependent kinase 10 is (272 aa) initn: 1661 init1: 1561 opt: 1653 Z-score: 578.5 bits: 114.9 E(85289): 1.7e-25 Smith-Waterman score: 1653; 97.7% identity (97.7% similar) in 257 aa overlap (1-251:1-257) 10 20 30 40 50 60 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 190 200 210 220 230 240 240 250 260 270 280 pF1KB8 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP ::::::::::::::::: NP_443 ATAGDCLESSYFKEKPLRLPISGVCEGCREPG 250 260 270 >>XP_016879299 (OMIM: 603464) PREDICTED: cyclin-dependen (272 aa) initn: 1661 init1: 1561 opt: 1653 Z-score: 578.5 bits: 114.9 E(85289): 1.7e-25 Smith-Waterman score: 1653; 97.7% identity (97.7% similar) in 257 aa overlap (1-251:1-257) 10 20 30 40 50 60 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 190 200 210 220 230 240 240 250 260 270 280 pF1KB8 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP ::::::::::::::::: XP_016 ATAGDCLESSYFKEKPLRLPISGVCEGCREPG 250 260 270 >>XP_006721373 (OMIM: 603464) PREDICTED: cyclin-dependen (343 aa) initn: 1661 init1: 1561 opt: 1653 Z-score: 577.3 bits: 115.0 E(85289): 2e-25 Smith-Waterman score: 1653; 97.7% identity (97.7% similar) in 257 aa overlap (1-251:72-328) 10 20 30 pF1KB8 MDKEKDGIPISSLREITLLLRLRHPNIVEL :::::::::::::::::::::::::::::: XP_006 LNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVEL 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB8 KEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIH 110 120 130 140 150 160 100 110 120 130 140 150 pF1KB8 RDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSID 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB8 MWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQP 230 240 250 260 270 280 220 230 240 250 260 pF1KB8 YNNLKHKFPWLSEAGLRLLHFLFM------ATAGDCLESSYFKEKPLPCEPELMPTFPHH :::::::::::::::::::::::: ::::::::::::::::: XP_006 YNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLRLPISGVCEGCRE 290 300 310 320 330 340 270 280 pF1KB8 RNKRAAPATSEGQSKRCKP XP_006 PG 283 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:52:46 2016 done: Fri Nov 4 12:52:47 2016 Total Scan time: 7.260 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]