FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8458, 339 aa 1>>>pF1KB8458 339 - 339 aa - 339 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3692+/-0.00048; mu= 11.5299+/- 0.029 mean_var=182.8477+/-40.074, 0's: 0 Z-trim(113.4): 269 B-trim: 55 in 1/54 Lambda= 0.094848 statistics sampled from 22376 (22753) to 22376 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.267), width: 16 Scan time: 7.960 The best scores are: opt bits E(85289) NP_000622 (OMIM: 601488,613960) neutrophil cytosol ( 339) 2221 316.8 4.2e-86 NP_038202 (OMIM: 601488,613960) neutrophil cytosol ( 348) 1673 241.8 1.6e-63 XP_016884297 (OMIM: 601488,613960) PREDICTED: neut ( 236) 1563 226.6 4.3e-59 NP_000256 (OMIM: 233700,608512) neutrophil cytosol ( 390) 240 45.8 0.00018 NP_001295104 (OMIM: 249420,613293) SH3 and PX doma ( 430) 231 44.6 0.00045 XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 ( 939) 232 45.2 0.00066 NP_001017995 (OMIM: 249420,613293) SH3 and PX doma ( 911) 231 45.1 0.00071 NP_001288037 (OMIM: 603362) endophilin-A3 isoform ( 278) 197 39.7 0.0088 NP_001311114 (OMIM: 603362) endophilin-A3 isoform ( 278) 197 39.7 0.0088 XP_016877975 (OMIM: 603362) PREDICTED: endophilin- ( 278) 197 39.7 0.0088 NP_001311116 (OMIM: 603362) endophilin-A3 isoform ( 278) 197 39.7 0.0088 NP_001311115 (OMIM: 603362) endophilin-A3 isoform ( 312) 197 39.8 0.0094 NP_001311113 (OMIM: 603362) endophilin-A3 isoform ( 312) 197 39.8 0.0094 >>NP_000622 (OMIM: 601488,613960) neutrophil cytosol fac (339 aa) initn: 2221 init1: 2221 opt: 2221 Z-score: 1666.8 bits: 316.8 E(85289): 4.2e-86 Smith-Waterman score: 2221; 100.0% identity (100.0% similar) in 339 aa overlap (1-339:1-339) 10 20 30 40 50 60 pF1KB8 MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 FTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSD 250 260 270 280 290 300 310 320 330 pF1KB8 EDVALMVRQARGLPSQKRLFPWKLHITQKDNYRVYNTMP ::::::::::::::::::::::::::::::::::::::: NP_000 EDVALMVRQARGLPSQKRLFPWKLHITQKDNYRVYNTMP 310 320 330 >>NP_038202 (OMIM: 601488,613960) neutrophil cytosol fac (348 aa) initn: 1673 init1: 1673 opt: 1673 Z-score: 1261.4 bits: 241.8 E(85289): 1.6e-63 Smith-Waterman score: 1673; 98.8% identity (99.6% similar) in 258 aa overlap (1-258:1-258) 10 20 30 40 50 60 pF1KB8 MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 QFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 VWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 FTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 FTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSD :::::::::::::..: : NP_038 RCYYYEDTISTIKSVAWEGGACPAFLPSLRPLPLTSPSHGSLSHSKAPSGSQMSHNAVTS 250 260 270 280 290 300 >>XP_016884297 (OMIM: 601488,613960) PREDICTED: neutroph (236 aa) initn: 1563 init1: 1563 opt: 1563 Z-score: 1181.9 bits: 226.6 E(85289): 4.3e-59 Smith-Waterman score: 1563; 100.0% identity (100.0% similar) in 236 aa overlap (104-339:1-236) 80 90 100 110 120 130 pF1KB8 GPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFF :::::::::::::::::::::::::::::: XP_016 MRIPALNAYMKSLLSLPVWVLMDEDVRIFF 10 20 30 140 150 160 170 180 190 pF1KB8 YQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKA 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB8 GDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIK 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB8 DIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSDEDVALMVRQARGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSDEDVALMVRQARGL 160 170 180 190 200 210 320 330 pF1KB8 PSQKRLFPWKLHITQKDNYRVYNTMP :::::::::::::::::::::::::: XP_016 PSQKRLFPWKLHITQKDNYRVYNTMP 220 230 >>NP_000256 (OMIM: 233700,608512) neutrophil cytosol fac (390 aa) initn: 200 init1: 98 opt: 240 Z-score: 201.2 bits: 45.8 E(85289): 0.00018 Smith-Waterman score: 240; 26.0% identity (53.0% similar) in 319 aa overlap (31-334:15-319) 10 20 30 40 50 pF1KB8 MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTS-HFVFVIEVKTKGGSKYLIYRRY ::: : :.:... :: . :. ..:::. NP_000 MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRF 10 20 30 40 60 70 80 90 100 110 pF1KB8 RQFHALQSKLEERFGPDSKS-SALACTLPTLPA-KVYVGVKQEIAEMRIPALNAYMKSLL ... ... :.: : .. . . .: ::: : . : :. :: : .:. : ..:. NP_000 TEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDG--QRAAENRQGTLTEYCSTLM 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 SLPVWVLMDEDVRIFFYQSPYD-----SEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAA :::. . . :: : : ..:. . : :. : ... : . . . NP_000 SLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPII--LQT 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 PRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPE :: : .. :..: :. ...:::. .. . .. : ... : .: ::.. : : :. NP_000 YRAIANYEKTSGS--EMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPL-DSPD 170 180 190 200 210 240 250 260 270 280 pF1KB8 E-DDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQ-----REDIALN : .:: : : .. ::: : : : . .:. .. .. :.: . . NP_000 ETEDPEP---NYAGEPYVAIKAYTAVEGDEVSL-LEGEAVEVIHKLLDGWWVIRKDDVTG 220 230 240 250 260 270 290 300 310 320 330 pF1KB8 YRDAEGDLVRLLSDEDVALMVRQA-RGLPSQKRLFPWKLHITQKDNYRVYNTMP : . . : .::. :: :: : .. . : :.. :. NP_000 YFPS---MYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVR 280 290 300 310 320 330 NP_000 FLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV 340 350 360 370 380 390 >>NP_001295104 (OMIM: 249420,613293) SH3 and PX domain-c (430 aa) initn: 130 init1: 74 opt: 231 Z-score: 194.0 bits: 44.6 E(85289): 0.00045 Smith-Waterman score: 231; 22.8% identity (56.8% similar) in 241 aa overlap (17-247:3-236) 10 20 30 40 50 60 pF1KB8 MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYR : . ... :....: ..:.:..:.: ..:: ::::: NP_001 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYS 10 20 30 40 70 80 90 100 110 pF1KB8 QFHALQSKLEERFGPDS-KSSALACTLPTLPAKVYVGVKQ--EIAEMRIPALNAYMKSLL .: :: .. ..: .. ... .: ::.:. .. ..: :. .. : :.:. NP_001 KFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALI 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 SLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEA .:: .. . ..: :: : : . :. . . : :: . : .::: :. . . NP_001 QLPPYISQCDEVLQFFETRPEDLNP-PK-----EEHIGKKKSGGDQ-TSVDPMVLEQYVV 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 LFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVK----ILKDF--- . .. . . :.....:.:. .. . .. : .. : : . .. . .: NP_001 VANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQ 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB8 PEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDA :::.. . . : .: NP_001 PEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNS 220 230 240 250 260 270 >>XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 and (939 aa) initn: 98 init1: 74 opt: 232 Z-score: 191.1 bits: 45.2 E(85289): 0.00066 Smith-Waterman score: 232; 22.2% identity (57.4% similar) in 230 aa overlap (17-239:3-225) 10 20 30 40 50 60 pF1KB8 MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYR : . ... :....: ..:.:..:.: ..:: ::::: XP_016 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYS 10 20 30 40 70 80 90 100 110 pF1KB8 QFHALQSKLEERFGPDS-KSSALACTLPTLPAKVYVGVKQ--EIAEMRIPALNAYMKSLL .: :: .. ..: .. ... .: ::.:. .. ..: :. .. : :.:. XP_016 KFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALI 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 SLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEA .:: .. . ..: :: : : . :. . . : :: . : .::: :. . . XP_016 QLPPYISQCDEVLQFFETRPEDLNP-PK-----EEHIGKKKSGGDQ-TSVDPMVLEQYVV 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 LFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVK----ILKDFPEE . .. . . :.....:.:. .. . .. : .. : : . .. . .: . XP_016 VANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQ 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB8 DDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGD . ..: XP_016 PEEVSWRYWSLPRPVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVI 220 230 240 250 260 270 >>NP_001017995 (OMIM: 249420,613293) SH3 and PX domain-c (911 aa) initn: 98 init1: 74 opt: 231 Z-score: 190.5 bits: 45.1 E(85289): 0.00071 Smith-Waterman score: 231; 22.8% identity (56.8% similar) in 241 aa overlap (17-247:3-236) 10 20 30 40 50 60 pF1KB8 MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYR : . ... :....: ..:.:..:.: ..:: ::::: NP_001 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYS 10 20 30 40 70 80 90 100 110 pF1KB8 QFHALQSKLEERFGPDS-KSSALACTLPTLPAKVYVGVKQ--EIAEMRIPALNAYMKSLL .: :: .. ..: .. ... .: ::.:. .. ..: :. .. : :.:. NP_001 KFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALI 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 SLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEA .:: .. . ..: :: : : . :. . . : :: . : .::: :. . . NP_001 QLPPYISQCDEVLQFFETRPEDLNP-PK-----EEHIGKKKSGGDQ-TSVDPMVLEQYVV 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 LFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVK----ILKDF--- . .. . . :.....:.:. .. . .. : .. : : . .. . .: NP_001 VANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQ 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB8 PEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDA :::.. . . : .: NP_001 PEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNS 220 230 240 250 260 270 >>NP_001288037 (OMIM: 603362) endophilin-A3 isoform b [H (278 aa) initn: 210 init1: 187 opt: 197 Z-score: 171.0 bits: 39.7 E(85289): 0.0088 Smith-Waterman score: 197; 29.9% identity (64.5% similar) in 107 aa overlap (129-232:173-278) 100 110 120 130 140 150 pF1KB8 QEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVK .:: .: : :. ..: . :. NP_001 VSQLAVFIEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRPVKRSSSELNGVS 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB8 SVS---PQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGA ..: :... : : ..:.:: ... ::.:: ::.: : ..:...: :: ..: NP_001 TTSVVKTTGSNIP-MDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGE 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB8 TGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTR .:.::...:... .:. NP_001 SGFFPINYVEVIVPLPQ 270 >>NP_001311114 (OMIM: 603362) endophilin-A3 isoform f [H (278 aa) initn: 210 init1: 187 opt: 197 Z-score: 171.0 bits: 39.7 E(85289): 0.0088 Smith-Waterman score: 197; 29.9% identity (64.5% similar) in 107 aa overlap (129-232:173-278) 100 110 120 130 140 150 pF1KB8 QEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVK .:: .: : :. ..: . :. NP_001 VSQLAVFIEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRPVKRSSSELNGVS 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB8 SVS---PQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGA ..: :... : : ..:.:: ... ::.:: ::.: : ..:...: :: ..: NP_001 TTSVVKTTGSNIP-MDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGE 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB8 TGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTR .:.::...:... .:. NP_001 SGFFPINYVEVIVPLPQ 270 >>XP_016877975 (OMIM: 603362) PREDICTED: endophilin-A3 i (278 aa) initn: 210 init1: 187 opt: 197 Z-score: 171.0 bits: 39.7 E(85289): 0.0088 Smith-Waterman score: 197; 29.9% identity (64.5% similar) in 107 aa overlap (129-232:173-278) 100 110 120 130 140 150 pF1KB8 QEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVK .:: .: : :. ..: . :. XP_016 VSQLAVFIEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRPVKRSSSELNGVS 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB8 SVS---PQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGA ..: :... : : ..:.:: ... ::.:: ::.: : ..:...: :: ..: XP_016 TTSVVKTTGSNIP-MDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGE 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB8 TGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTR .:.::...:... .:. XP_016 SGFFPINYVEVIVPLPQ 270 339 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:05:48 2016 done: Fri Nov 4 13:05:49 2016 Total Scan time: 7.960 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]