FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8461, 192 aa 1>>>pF1KB8461 192 - 192 aa - 192 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6633+/-0.000834; mu= 16.6513+/- 0.051 mean_var=71.6668+/-14.165, 0's: 0 Z-trim(108.9): 173 B-trim: 347 in 1/50 Lambda= 0.151501 statistics sampled from 10332 (10533) to 10332 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.324), width: 16 Scan time: 2.000 The best scores are: opt bits E(32554) CCDS13945.1 RAC2 gene_id:5880|Hs108|chr22 ( 192) 1290 290.6 4e-79 CCDS5348.1 RAC1 gene_id:5879|Hs108|chr7 ( 192) 1211 273.3 6.3e-74 CCDS11798.1 RAC3 gene_id:5881|Hs108|chr17 ( 192) 1185 267.6 3.3e-72 CCDS222.1 CDC42 gene_id:998|Hs108|chr1 ( 191) 925 210.8 4.1e-55 CCDS221.1 CDC42 gene_id:998|Hs108|chr1 ( 191) 916 208.8 1.6e-54 CCDS7748.1 RHOG gene_id:391|Hs108|chr11 ( 191) 913 208.2 2.6e-54 CCDS33191.1 RHOQ gene_id:23433|Hs108|chr2 ( 205) 802 184.0 5.4e-47 CCDS9757.1 RHOJ gene_id:57381|Hs108|chr14 ( 214) 766 176.1 1.3e-44 CCDS5349.1 RAC1 gene_id:5879|Hs108|chr7 ( 211) 719 165.8 1.6e-41 CCDS1575.1 RHOU gene_id:58480|Hs108|chr1 ( 258) 710 163.9 7.2e-41 CCDS854.1 RHOC gene_id:389|Hs108|chr1 ( 193) 702 162.1 2e-40 CCDS2795.1 RHOA gene_id:387|Hs108|chr3 ( 193) 700 161.6 2.7e-40 CCDS10068.1 RHOV gene_id:171177|Hs108|chr15 ( 236) 690 159.5 1.4e-39 CCDS1699.1 RHOB gene_id:388|Hs108|chr2 ( 196) 684 158.1 3e-39 CCDS9222.1 RHOF gene_id:54509|Hs108|chr12 ( 211) 650 150.7 5.5e-37 CCDS8155.1 RHOD gene_id:29984|Hs108|chr11 ( 210) 635 147.5 5.3e-36 CCDS82775.1 RHOA gene_id:387|Hs108|chr3 ( 187) 587 136.9 7.1e-33 CCDS11452.1 RND2 gene_id:8153|Hs108|chr17 ( 227) 559 130.9 5.6e-31 CCDS2190.1 RND3 gene_id:390|Hs108|chr2 ( 244) 543 127.4 6.7e-30 CCDS3458.1 RHOH gene_id:399|Hs108|chr4 ( 191) 523 122.9 1.2e-28 CCDS8771.1 RND1 gene_id:27289|Hs108|chr12 ( 232) 495 116.9 9.3e-27 CCDS7261.1 RHOBTB1 gene_id:9886|Hs108|chr10 ( 696) 352 86.1 5.2e-17 CCDS6034.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 727) 351 85.9 6.2e-17 CCDS55211.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 734) 351 85.9 6.3e-17 CCDS55210.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 749) 351 85.9 6.4e-17 CCDS73330.1 RHOD gene_id:29984|Hs108|chr11 ( 144) 266 66.7 7.8e-12 CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX ( 183) 263 66.1 1.5e-11 CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 ( 183) 263 66.1 1.5e-11 CCDS1123.1 RIT1 gene_id:6016|Hs108|chr1 ( 219) 263 66.2 1.6e-11 CCDS58037.1 RIT1 gene_id:6016|Hs108|chr1 ( 236) 263 66.2 1.7e-11 CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 ( 183) 260 65.4 2.3e-11 CCDS41846.1 RAB35 gene_id:11021|Hs108|chr12 ( 201) 257 64.8 3.8e-11 CCDS10460.1 RAB26 gene_id:25837|Hs108|chr16 ( 256) 255 64.5 6.2e-11 CCDS9271.1 RAN gene_id:5901|Hs108|chr12 ( 216) 252 63.8 8.6e-11 >>CCDS13945.1 RAC2 gene_id:5880|Hs108|chr22 (192 aa) initn: 1290 init1: 1290 opt: 1290 Z-score: 1534.0 bits: 290.6 E(32554): 4e-79 Smith-Waterman score: 1290; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ 130 140 150 160 170 180 190 pF1KB8 PTRQQKRACSLL :::::::::::: CCDS13 PTRQQKRACSLL 190 >>CCDS5348.1 RAC1 gene_id:5879|Hs108|chr7 (192 aa) initn: 1211 init1: 1211 opt: 1211 Z-score: 1440.7 bits: 273.3 E(32554): 6.3e-74 Smith-Waterman score: 1211; 92.2% identity (97.9% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: CCDS53 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::::::::::::.:::::::.::::::::.::::::::::::: CCDS53 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ ::::::::::::::.:::::::::.:::: .:::::::::::::::::::::::::::: CCDS53 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB8 PTRQQKRACSLL :....:: : :: CCDS53 PVKKRKRKCLLL 190 >>CCDS11798.1 RAC3 gene_id:5881|Hs108|chr17 (192 aa) initn: 1220 init1: 1185 opt: 1185 Z-score: 1409.9 bits: 267.6 E(32554): 3.3e-72 Smith-Waterman score: 1185; 88.5% identity (96.9% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: CCDS11 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::::::::::::.:::::::.:::::::: :::.::::::::: CCDS11 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :::::::.:..:::::::::::::.:.:: ::::::::::::::::::::::::::::: CCDS11 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB8 PTRQQKRACSLL :... . :... CCDS11 PVKKPGKKCTVF 190 >>CCDS222.1 CDC42 gene_id:998|Hs108|chr1 (191 aa) initn: 954 init1: 919 opt: 925 Z-score: 1102.9 bits: 210.8 E(32554): 4.1e-55 Smith-Waterman score: 925; 69.3% identity (87.5% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. ..: .:::.:::: CCDS22 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::.:::.:::.:.:::. :: ::. ::::.::..::::..::: CCDS22 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :: .::::: ..: ::: . ::... .:::.:::::::::::.:::::: :.: : CCDS22 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEP- 130 140 150 160 170 190 pF1KB8 PTRQQKRACSLL : : :: : .. CCDS22 PETQPKRKCCIF 180 190 >>CCDS221.1 CDC42 gene_id:998|Hs108|chr1 (191 aa) initn: 939 init1: 904 opt: 916 Z-score: 1092.2 bits: 208.8 E(32554): 1.6e-54 Smith-Waterman score: 916; 68.8% identity (88.0% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. ..: .:::.:::: CCDS22 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::.:::.:::.:.:::. :: ::. ::::.::..::::..::: CCDS22 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :: .::::: ..: ::: . ::... .:::.:::::::.:::.:::::: :.: : CCDS22 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEP- 130 140 150 160 170 190 pF1KB8 PTRQQKRACSLL : ...: : :: CCDS22 PEPKKSRRCVLL 180 190 >>CCDS7748.1 RHOG gene_id:391|Hs108|chr11 (191 aa) initn: 941 init1: 900 opt: 913 Z-score: 1088.7 bits: 208.2 E(32554): 2.6e-54 Smith-Waterman score: 913; 71.4% identity (84.9% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. ::.. :::.:::::: CCDS77 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR ::.::::: ::::::.::.::::..:: :::::: :: ::: ::::..::.::::: ::: CCDS77 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ . ::...:::. :::: :: ::::.: .:.::::::: : :.: :: ::.:::: : CCDS77 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB8 PTRQQKRACSLL : .. :.: :: CCDS77 PIKRG-RSCILL 190 >>CCDS33191.1 RHOQ gene_id:23433|Hs108|chr2 (205 aa) initn: 838 init1: 800 opt: 802 Z-score: 957.2 bits: 184.0 E(32554): 5.4e-47 Smith-Waterman score: 802; 62.0% identity (83.4% similar) in 187 aa overlap (4-190:10-196) 10 20 30 40 50 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLG .::::::::::::::::.::...::: ::.:::::.:...: : .: :: CCDS33 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 LWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVG :.:::::::::::::::::.:::::::::.:.:::..::. .: ::.... :..:..:.: CCDS33 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 TKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIR :..::::: :. .:.. : :: :: ::::: . :.:::::::.:::::::::: CCDS33 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII 130 140 150 160 170 180 180 190 pF1KB8 AVLCPQPTRQQKRACSLL :.: :. .:: : CCDS33 AILTPKKHTVKKRIGSRCINCCLIT 190 200 >>CCDS9757.1 RHOJ gene_id:57381|Hs108|chr14 (214 aa) initn: 793 init1: 753 opt: 766 Z-score: 914.4 bits: 176.1 E(32554): 1.3e-44 Smith-Waterman score: 766; 59.3% identity (82.0% similar) in 189 aa overlap (2-190:20-205) 10 20 30 40 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSA . .::::::::::::::::.::...::: ::.:::::.:.. CCDS97 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 NVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVR .: : .: :::.::::::::..:::::::.:::::::::.:.::::.::. .: ::.. CCDS97 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB8 HHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQ : .: .:.::..::::: :. .: : :.:: .:. ::: : . ::::::::: CCDS97 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ 130 140 150 160 170 180 170 180 190 pF1KB8 RGLKTVFDEAIRAVLCPQPTRQQKRACSLL .:::.:::::: ... : ...:. :: CCDS97 KGLKAVFDEAILTIFHP---KKKKKRCSEGHSCCSII 190 200 210 >>CCDS5349.1 RAC1 gene_id:5879|Hs108|chr7 (211 aa) initn: 713 init1: 713 opt: 719 Z-score: 859.0 bits: 165.8 E(32554): 1.6e-41 Smith-Waterman score: 1163; 83.9% identity (89.1% similar) in 211 aa overlap (1-192:1-211) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: CCDS53 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 pF1KB8 QEDYDRLRPLSYPQT-------------------DVFLICFSLVSPASYENVRAKWFPEV ::::::::::::::: ::::::::::::::.:::::::.::: CCDS53 QEDYDRLRPLSYPQTVGETYGKDITSRGKDKPIADVFLICFSLVSPASFENVRAKWYPEV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB8 RHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALT :::::.:::::::::::::::::::::::::::.:::::::::.:::: .:::::::::: CCDS53 RHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALT 130 140 150 160 170 180 170 180 190 pF1KB8 QRGLKTVFDEAIRAVLCPQPTRQQKRACSLL :::::::::::::::::: :....:: : :: CCDS53 QRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL 190 200 210 >>CCDS1575.1 RHOU gene_id:58480|Hs108|chr1 (258 aa) initn: 723 init1: 705 opt: 710 Z-score: 847.2 bits: 163.9 E(32554): 7.2e-41 Smith-Waterman score: 710; 55.9% identity (80.1% similar) in 186 aa overlap (2-187:48-233) 10 20 30 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGE ...:::.::::::::: :..:::::..: : CCDS15 PVPPRRERGGRGGRGPGEPGGRGRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTE 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB8 YIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYE ::::.:::.:: : ::..:: : : :::::...:.:::: : .::.::.:::.:::.:.. CCDS15 YIPTAFDNFSAVVSVDGRPVRLQLCDTAGQDEFDKLRPLCYTNTDIFLLCFSVVSPSSFQ 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB8 NVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDS :: :: ::.: :::..:::::::. :::.: .. .: . : :. . :.:: . CCDS15 NVSEKWVPEIRCHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAAKLCAEEIKA 140 150 160 170 180 190 160 170 180 190 pF1KB8 VKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRACSLL ..:.:::::::..:: ::: :: : . . :.:: . CCDS15 ASYIECSALTQKNLKEVFDAAIVAGIQYSDTQQQPKKSKSRTPDKMKNLSKSWWKKYCCF 200 210 220 230 240 250 CCDS15 V 192 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:08:10 2016 done: Fri Nov 4 13:08:11 2016 Total Scan time: 2.000 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]