FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8461, 192 aa 1>>>pF1KB8461 192 - 192 aa - 192 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8574+/-0.000356; mu= 15.5762+/- 0.023 mean_var=71.7210+/-14.329, 0's: 0 Z-trim(116.0): 396 B-trim: 1327 in 2/49 Lambda= 0.151444 statistics sampled from 26364 (26838) to 26364 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.315), width: 16 Scan time: 5.590 The best scores are: opt bits E(85289) NP_002863 (OMIM: 602049,608203) ras-related C3 bot ( 192) 1290 290.5 1.1e-78 NP_008839 (OMIM: 602048) ras-related C3 botulinum ( 192) 1211 273.3 1.7e-73 NP_005043 (OMIM: 602050) ras-related C3 botulinum ( 192) 1185 267.6 8.8e-72 XP_006724349 (OMIM: 602049,608203) PREDICTED: ras- ( 161) 1007 228.6 3.9e-60 NP_001303236 (OMIM: 602050) ras-related C3 botulin ( 170) 968 220.1 1.5e-57 NP_426359 (OMIM: 116952,616737) cell division cont ( 191) 925 210.8 1.1e-54 NP_001782 (OMIM: 116952,616737) cell division cont ( 191) 916 208.8 4.3e-54 NP_001034891 (OMIM: 116952,616737) cell division c ( 191) 916 208.8 4.3e-54 NP_001656 (OMIM: 179505) rho-related GTP-binding p ( 191) 913 208.2 6.8e-54 XP_016873208 (OMIM: 179505) PREDICTED: rho-related ( 191) 913 208.2 6.8e-54 XP_005252973 (OMIM: 179505) PREDICTED: rho-related ( 191) 913 208.2 6.8e-54 NP_036381 (OMIM: 605857) rho-related GTP-binding p ( 205) 802 183.9 1.4e-46 NP_065714 (OMIM: 607653) rho-related GTP-binding p ( 214) 766 176.1 3.4e-44 NP_061485 (OMIM: 602048) ras-related C3 botulinum ( 211) 719 165.8 4.2e-41 NP_067028 (OMIM: 606366) rho-related GTP-binding p ( 258) 710 163.9 1.9e-40 NP_001036144 (OMIM: 165380) rho-related GTP-bindin ( 193) 702 162.1 5.2e-40 NP_786886 (OMIM: 165380) rho-related GTP-binding p ( 193) 702 162.1 5.2e-40 NP_001036143 (OMIM: 165380) rho-related GTP-bindin ( 193) 702 162.1 5.2e-40 NP_001655 (OMIM: 165390) transforming protein RhoA ( 193) 700 161.6 7e-40 NP_001300870 (OMIM: 165390) transforming protein R ( 193) 700 161.6 7e-40 NP_004031 (OMIM: 165370) rho-related GTP-binding p ( 196) 684 158.1 8e-39 XP_011531028 (OMIM: 605857) PREDICTED: rho-related ( 192) 659 152.7 3.5e-37 XP_016859205 (OMIM: 605857) PREDICTED: rho-related ( 172) 658 152.4 3.7e-37 NP_055393 (OMIM: 605781) rho-related GTP-binding p ( 210) 635 147.5 1.4e-35 XP_006720277 (OMIM: 607653) PREDICTED: rho-related ( 176) 631 146.5 2.3e-35 NP_001300872 (OMIM: 165390) transforming protein R ( 187) 587 136.9 1.8e-32 NP_005431 (OMIM: 601555) rho-related GTP-binding p ( 227) 559 130.9 1.5e-30 XP_011523618 (OMIM: 601555) PREDICTED: rho-related ( 234) 559 130.9 1.5e-30 NP_001241667 (OMIM: 602924) rho-related GTP-bindin ( 244) 543 127.4 1.8e-29 NP_005159 (OMIM: 602924) rho-related GTP-binding p ( 244) 543 127.4 1.8e-29 XP_011531030 (OMIM: 605857) PREDICTED: rho-related ( 157) 537 125.9 3.2e-29 NP_001265297 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 NP_001265290 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 NP_001265289 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 XP_016863678 (OMIM: 602037) PREDICTED: rho-related ( 191) 523 123.0 3e-28 NP_001265295 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 NP_001265298 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 XP_016863677 (OMIM: 602037) PREDICTED: rho-related ( 191) 523 123.0 3e-28 NP_001265296 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 XP_011511994 (OMIM: 602037) PREDICTED: rho-related ( 191) 523 123.0 3e-28 NP_001265288 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 NP_001265293 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 NP_001265291 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 NP_004301 (OMIM: 602037) rho-related GTP-binding p ( 191) 523 123.0 3e-28 NP_001265294 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 NP_001265292 (OMIM: 602037) rho-related GTP-bindin ( 191) 523 123.0 3e-28 NP_055285 (OMIM: 609038) rho-related GTP-binding p ( 232) 495 116.9 2.4e-26 XP_011523619 (OMIM: 601555) PREDICTED: rho-related ( 206) 470 111.4 9.8e-25 NP_001300873 (OMIM: 165390) transforming protein R ( 173) 444 105.7 4.4e-23 XP_011538730 (OMIM: 607351) PREDICTED: rho-related ( 530) 352 86.0 1.1e-16 >>NP_002863 (OMIM: 602049,608203) ras-related C3 botulin (192 aa) initn: 1290 init1: 1290 opt: 1290 Z-score: 1533.7 bits: 290.5 E(85289): 1.1e-78 Smith-Waterman score: 1290; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ 130 140 150 160 170 180 190 pF1KB8 PTRQQKRACSLL :::::::::::: NP_002 PTRQQKRACSLL 190 >>NP_008839 (OMIM: 602048) ras-related C3 botulinum toxi (192 aa) initn: 1211 init1: 1211 opt: 1211 Z-score: 1440.4 bits: 273.3 E(85289): 1.7e-73 Smith-Waterman score: 1211; 92.2% identity (97.9% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: NP_008 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::::::::::::.:::::::.::::::::.::::::::::::: NP_008 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ ::::::::::::::.:::::::::.:::: .:::::::::::::::::::::::::::: NP_008 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB8 PTRQQKRACSLL :....:: : :: NP_008 PVKKRKRKCLLL 190 >>NP_005043 (OMIM: 602050) ras-related C3 botulinum toxi (192 aa) initn: 1220 init1: 1185 opt: 1185 Z-score: 1409.7 bits: 267.6 E(85289): 8.8e-72 Smith-Waterman score: 1185; 88.5% identity (96.9% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: NP_005 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::::::::::::.:::::::.:::::::: :::.::::::::: NP_005 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :::::::.:..:::::::::::::.:.:: ::::::::::::::::::::::::::::: NP_005 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB8 PTRQQKRACSLL :... . :... NP_005 PVKKPGKKCTVF 190 >>XP_006724349 (OMIM: 602049,608203) PREDICTED: ras-rela (161 aa) initn: 1042 init1: 1007 opt: 1007 Z-score: 1200.5 bits: 228.6 E(85289): 3.9e-60 Smith-Waterman score: 1007; 99.3% identity (100.0% similar) in 150 aa overlap (1-150:1-150) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :::::::::::::::::::::::::::::. XP_006 DDKDTIEKLKEKKLAPITYPQGLALAKEIEKHQNSRPPSTD 130 140 150 160 >>NP_001303236 (OMIM: 602050) ras-related C3 botulinum t (170 aa) initn: 968 init1: 968 opt: 968 Z-score: 1154.2 bits: 220.1 E(85289): 1.5e-57 Smith-Waterman score: 968; 93.3% identity (99.3% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: NP_001 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::::::::::::.:::::::.:::::::: :::.::::::::: NP_001 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :::::::.:..:::::::::::::.:.:: NP_001 DDKDTIERLRDKKLAPITYPQGLAMAREIGGLCEIPGVLSPDPAGPEDSV 130 140 150 160 170 >>NP_426359 (OMIM: 116952,616737) cell division control (191 aa) initn: 954 init1: 919 opt: 925 Z-score: 1102.7 bits: 210.8 E(85289): 1.1e-54 Smith-Waterman score: 925; 69.3% identity (87.5% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. ..: .:::.:::: NP_426 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::.:::.:::.:.:::. :: ::. ::::.::..::::..::: NP_426 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :: .::::: ..: ::: . ::... .:::.:::::::::::.:::::: :.: : NP_426 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEP- 130 140 150 160 170 190 pF1KB8 PTRQQKRACSLL : : :: : .. NP_426 PETQPKRKCCIF 180 190 >>NP_001782 (OMIM: 116952,616737) cell division control (191 aa) initn: 939 init1: 904 opt: 916 Z-score: 1092.1 bits: 208.8 E(85289): 4.3e-54 Smith-Waterman score: 916; 68.8% identity (88.0% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. ..: .:::.:::: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::.:::.:::.:.:::. :: ::. ::::.::..::::..::: NP_001 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :: .::::: ..: ::: . ::... .:::.:::::::.:::.:::::: :.: : NP_001 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEP- 130 140 150 160 170 190 pF1KB8 PTRQQKRACSLL : ...: : :: NP_001 PEPKKSRRCVLL 180 190 >>NP_001034891 (OMIM: 116952,616737) cell division contr (191 aa) initn: 939 init1: 904 opt: 916 Z-score: 1092.1 bits: 208.8 E(85289): 4.3e-54 Smith-Waterman score: 916; 68.8% identity (88.0% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. ..: .:::.:::: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR :::::::::::::::::::.:::.:::.:.:::. :: ::. ::::.::..::::..::: NP_001 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ :: .::::: ..: ::: . ::... .:::.:::::::.:::.:::::: :.: : NP_001 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEP- 130 140 150 160 170 190 pF1KB8 PTRQQKRACSLL : ...: : :: NP_001 PEPKKSRRCVLL 180 190 >>NP_001656 (OMIM: 179505) rho-related GTP-binding prote (191 aa) initn: 941 init1: 900 opt: 913 Z-score: 1088.6 bits: 208.2 E(85289): 6.8e-54 Smith-Waterman score: 913; 71.4% identity (84.9% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. ::.. :::.:::::: NP_001 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR ::.::::: ::::::.::.::::..:: :::::: :: ::: ::::..::.::::: ::: NP_001 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ . ::...:::. :::: :: ::::.: .:.::::::: : :.: :: ::.:::: : NP_001 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB8 PTRQQKRACSLL : .. :.: :: NP_001 PIKRG-RSCILL 190 >>XP_016873208 (OMIM: 179505) PREDICTED: rho-related GTP (191 aa) initn: 941 init1: 900 opt: 913 Z-score: 1088.6 bits: 208.2 E(85289): 6.8e-54 Smith-Waterman score: 913; 71.4% identity (84.9% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. ::.. :::.:::::: XP_016 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR ::.::::: ::::::.::.::::..:: :::::: :: ::: ::::..::.::::: ::: XP_016 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ . ::...:::. :::: :: ::::.: .:.::::::: : :.: :: ::.:::: : XP_016 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB8 PTRQQKRACSLL : .. :.: :: XP_016 PIKRG-RSCILL 190 192 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:08:11 2016 done: Fri Nov 4 13:08:12 2016 Total Scan time: 5.590 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]