FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8468, 297 aa 1>>>pF1KB8468 297 - 297 aa - 297 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.4825+/-0.000742; mu= -21.8755+/- 0.043 mean_var=716.6701+/-158.180, 0's: 0 Z-trim(112.9): 1780 B-trim: 0 in 0/56 Lambda= 0.047909 statistics sampled from 19611 (22054) to 19611 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.259), width: 16 Scan time: 7.380 The best scores are: opt bits E(85289) XP_005270360 (OMIM: 116940) PREDICTED: cyclin-depe ( 297) 1956 151.0 2.6e-36 NP_001307847 (OMIM: 116940) cyclin-dependent kinas ( 297) 1956 151.0 2.6e-36 NP_001777 (OMIM: 116940) cyclin-dependent kinase 1 ( 297) 1956 151.0 2.6e-36 NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298) 1327 107.5 3.2e-23 NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 1322 107.2 4.1e-23 NP_004926 (OMIM: 123831,616342) cyclin-dependent-l ( 292) 1099 91.8 1.8e-18 NP_001163935 (OMIM: 603440) cyclin-dependent kinas ( 523) 1101 92.2 2.3e-18 NP_002586 (OMIM: 603440) cyclin-dependent kinase 1 ( 523) 1101 92.2 2.3e-18 XP_016874894 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 1101 92.2 2.3e-18 XP_016874895 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 1101 92.2 2.3e-18 XP_016885061 (OMIM: 311550) PREDICTED: cyclin-depe ( 496) 1058 89.2 1.7e-17 XP_016885060 (OMIM: 311550) PREDICTED: cyclin-depe ( 496) 1058 89.2 1.7e-17 NP_006192 (OMIM: 311550) cyclin-dependent kinase 1 ( 496) 1058 89.2 1.7e-17 XP_016885062 (OMIM: 311550) PREDICTED: cyclin-depe ( 496) 1058 89.2 1.7e-17 XP_016885059 (OMIM: 311550) PREDICTED: cyclin-depe ( 496) 1058 89.2 1.7e-17 XP_011542226 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 1058 89.2 1.7e-17 XP_011542228 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 1058 89.2 1.7e-17 XP_011542229 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 1058 89.2 1.7e-17 XP_011542230 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 1058 89.2 1.7e-17 XP_011542227 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 1058 89.2 1.7e-17 NP_148978 (OMIM: 311550) cyclin-dependent kinase 1 ( 502) 1058 89.2 1.7e-17 XP_011542225 (OMIM: 311550) PREDICTED: cyclin-depe ( 503) 1058 89.2 1.7e-17 XP_011542224 (OMIM: 311550) PREDICTED: cyclin-depe ( 540) 1058 89.3 1.8e-17 XP_016885058 (OMIM: 311550) PREDICTED: cyclin-depe ( 543) 1058 89.3 1.8e-17 XP_011542223 (OMIM: 311550) PREDICTED: cyclin-depe ( 544) 1058 89.3 1.8e-17 NP_001163931 (OMIM: 311550) cyclin-dependent kinas ( 570) 1058 89.3 1.9e-17 XP_011542222 (OMIM: 311550) PREDICTED: cyclin-depe ( 571) 1058 89.3 1.9e-17 NP_002587 (OMIM: 169190) cyclin-dependent kinase 1 ( 474) 1050 88.7 2.5e-17 NP_997667 (OMIM: 169190) cyclin-dependent kinase 1 ( 474) 1050 88.7 2.5e-17 NP_997668 (OMIM: 169190) cyclin-dependent kinase 1 ( 504) 1050 88.7 2.6e-17 XP_011507904 (OMIM: 169190) PREDICTED: cyclin-depe ( 542) 1050 88.7 2.7e-17 XP_016856912 (OMIM: 169190) PREDICTED: cyclin-depe ( 572) 1050 88.8 2.8e-17 XP_011536034 (OMIM: 116953) PREDICTED: cyclin-depe ( 346) 939 80.8 4.2e-15 XP_005250496 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 920 79.6 1.2e-14 XP_016867809 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 920 79.6 1.2e-14 XP_005250495 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 920 79.6 1.2e-14 XP_016867810 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 920 79.6 1.2e-14 XP_016867811 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 920 79.6 1.2e-14 NP_001274065 (OMIM: 610679) cyclin-dependent kinas ( 423) 920 79.6 1.2e-14 XP_005250493 (OMIM: 610679) PREDICTED: cyclin-depe ( 450) 920 79.6 1.2e-14 NP_036527 (OMIM: 610679) cyclin-dependent kinase 1 ( 451) 920 79.6 1.2e-14 XP_011514608 (OMIM: 610679) PREDICTED: cyclin-depe ( 469) 920 79.7 1.2e-14 NP_001274064 (OMIM: 610679) cyclin-dependent kinas ( 469) 920 79.7 1.2e-14 NP_203698 (OMIM: 116940) cyclin-dependent kinase 1 ( 240) 902 78.0 2e-14 NP_001250 (OMIM: 603368,616080) cyclin-dependent k ( 326) 885 77.0 5.3e-14 NP_001138778 (OMIM: 603368,616080) cyclin-dependen ( 326) 885 77.0 5.3e-14 XP_006715898 (OMIM: 603368,616080) PREDICTED: cycl ( 326) 885 77.0 5.3e-14 NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346) 852 74.8 2.7e-13 NP_631897 (OMIM: 616147) cyclin-dependent kinase 1 ( 384) 839 74.0 5.3e-13 XP_005246839 (OMIM: 616147) PREDICTED: cyclin-depe ( 384) 839 74.0 5.3e-13 >>XP_005270360 (OMIM: 116940) PREDICTED: cyclin-dependen (297 aa) initn: 1956 init1: 1956 opt: 1956 Z-score: 772.8 bits: 151.0 E(85289): 2.6e-36 Smith-Waterman score: 1956; 99.7% identity (99.7% similar) in 297 aa overlap (1-297:1-297) 10 20 30 40 50 60 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 FPKWKPGSLASHVKNLDENGLDLLSKMLTYDPAKRISGKMALNHPYFNDLDNQIKKM :::::::::::::::::::::::::::: :::::::::::::::::::::::::::: XP_005 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 250 260 270 280 290 >>NP_001307847 (OMIM: 116940) cyclin-dependent kinase 1 (297 aa) initn: 1956 init1: 1956 opt: 1956 Z-score: 772.8 bits: 151.0 E(85289): 2.6e-36 Smith-Waterman score: 1956; 99.7% identity (99.7% similar) in 297 aa overlap (1-297:1-297) 10 20 30 40 50 60 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 FPKWKPGSLASHVKNLDENGLDLLSKMLTYDPAKRISGKMALNHPYFNDLDNQIKKM :::::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_001 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 250 260 270 280 290 >>NP_001777 (OMIM: 116940) cyclin-dependent kinase 1 iso (297 aa) initn: 1956 init1: 1956 opt: 1956 Z-score: 772.8 bits: 151.0 E(85289): 2.6e-36 Smith-Waterman score: 1956; 99.7% identity (99.7% similar) in 297 aa overlap (1-297:1-297) 10 20 30 40 50 60 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 FPKWKPGSLASHVKNLDENGLDLLSKMLTYDPAKRISGKMALNHPYFNDLDNQIKKM :::::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_001 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 250 260 270 280 290 >>NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 iso (298 aa) initn: 1327 init1: 899 opt: 1327 Z-score: 537.8 bits: 107.5 E(85289): 3.2e-23 Smith-Waterman score: 1327; 65.8% identity (85.2% similar) in 298 aa overlap (1-297:1-296) 10 20 30 40 50 60 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH ::.. :.:::::::::::::.:.: ::.:::.:::::..: ::::::::::::::::: : NP_001 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQYMDSSLVKSYLYQILQGIVFC ::::.: ::. ...:::.:::: .::::..: : : . :.::::.:.:::..:: NP_001 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFC 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA ::.::::::::::::::. .:.:::::::::::::.:.:.:::::::::::.::.::: NP_001 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN ::: :::::.: ::::..:.. :: :::::::::::::.::::.. ::: : :. ::: NP_001 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 TFPKWKPGSLASHVKNLDENGLDLLSKMLTYDPAKRISGKMALNHPYFNDLDNQIKKM .:::: .... : :::.: .:::.:: ::: ::::.: :: ::.:.:. . . .. NP_001 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 240 250 260 270 280 290 >>NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 [Ho (305 aa) initn: 1312 init1: 900 opt: 1322 Z-score: 535.9 bits: 107.2 E(85289): 4.1e-23 Smith-Waterman score: 1322; 67.0% identity (86.1% similar) in 288 aa overlap (1-288:1-287) 10 20 30 40 50 60 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH :. . :.:::::::::::::.... :::.::.:::::. : :::::::::::::::::.: NP_001 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH :::: : ::. .. .:::.:::::.:::::.:: : :. . :.::::.:.:::. ::: NP_001 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTP-GSELPLHLIKSYLFQLLQGVSFCH 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR :.::.:::::::::::.. :.:::::::::::::.:.:.:::::::::::.::.:::: NP_001 SHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT :.: ::::::: ::::..:.: :: ::::::::::::: ::::....:: : .: :::.. NP_001 YTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGS 180 190 200 210 220 230 250 260 270 280 290 pF1KB8 FPKWKPGSLASHVKNLDENGLDLLSKMLTYDPAKRISGKMALNHPYFNDLDNQIKKM :::: .: : ::. .: ::: ..: :::..::..: :: ::::. NP_001 FPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYV 240 250 260 270 280 290 NP_001 LQRFRH 300 >>NP_004926 (OMIM: 123831,616342) cyclin-dependent-like (292 aa) initn: 1095 init1: 483 opt: 1099 Z-score: 452.8 bits: 91.8 E(85289): 1.8e-18 Smith-Waterman score: 1099; 57.3% identity (82.3% similar) in 293 aa overlap (1-290:1-289) 10 20 30 40 50 60 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH :. : :.:::::::::.:.:.... : ..::.:..::....:::::.:.::: :::::.: NP_004 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH ::: :.::: .:..: :.::: ..:::::.:: :. .: .:::.:.:.:.:. ::: NP_004 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GD-LDPEIVKSFLFQLLKGLGFCH 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR :: :::::::::::::. .: .::::::::::::::.: :. :::::::: :.::.:. NP_004 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 120 130 140 150 160 170 190 200 210 220 230 pF1KB8 YSTPVDIWSIGTIFAELATK-KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN ::: .:.:: : ::::::. .::: :.. ::: :::: ::::..: :: . .: ::: NP_004 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK- 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 TFPKWKPG--SLASHVKNLDENGLDLLSKMLTYDPAKRISGKMALNHPYFNDLDNQIKKM .: . :. ::.. : .:. .: :::...: .:..:::.. ::.::::.:. NP_004 PYPMY-PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 240 250 260 270 280 290 >>NP_001163935 (OMIM: 603440) cyclin-dependent kinase 17 (523 aa) initn: 1103 init1: 593 opt: 1101 Z-score: 450.8 bits: 92.2 E(85289): 2.3e-18 Smith-Waterman score: 1101; 54.4% identity (81.5% similar) in 298 aa overlap (1-297:189-483) 10 20 30 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVV :: : :.::.:::::..::::: : : ..: NP_001 EKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLV 160 170 180 190 200 210 40 50 60 70 80 90 pF1KB8 AMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKY :.:.:::: .:::.: :::::.::::.:.: :::.:.:.. :. : :.::.:. :::.: NP_001 ALKEIRLE-HEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQY 220 230 240 250 260 270 100 110 120 130 140 150 pF1KB8 LDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLA .:. :. :. :: .:::::.:...:: :.:::::::::::::..:: .:::::::: NP_001 MDDC--GNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLA 280 290 300 310 320 330 160 170 180 190 200 210 pF1KB8 RAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI :: ..: ..:..:::::::: :.:::::..::: .:.:..: :: :.:. .::: :.. NP_001 RAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVE 340 350 360 370 380 390 220 230 240 250 260 pF1KB8 DQLFRIFRALGTPNNEVWPEVESLQDYKN-TFPKWKPGSLASHVKNLDENGLDLLSKMLT :.: ::: ::::..:.:: . : ...:: .:::.:: : .:. :: .:..:..:.: NP_001 DELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQ 400 410 420 430 440 450 270 280 290 pF1KB8 YDPAKRISGKMALNHPYFNDLDNQIKKM :. ::.:.. :..: :: .: .:. . NP_001 YESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGVFV 460 470 480 490 500 510 >>NP_002586 (OMIM: 603440) cyclin-dependent kinase 17 is (523 aa) initn: 1103 init1: 593 opt: 1101 Z-score: 450.8 bits: 92.2 E(85289): 2.3e-18 Smith-Waterman score: 1101; 54.4% identity (81.5% similar) in 298 aa overlap (1-297:189-483) 10 20 30 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVV :: : :.::.:::::..::::: : : ..: NP_002 EKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLV 160 170 180 190 200 210 40 50 60 70 80 90 pF1KB8 AMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKY :.:.:::: .:::.: :::::.::::.:.: :::.:.:.. :. : :.::.:. :::.: NP_002 ALKEIRLE-HEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQY 220 230 240 250 260 270 100 110 120 130 140 150 pF1KB8 LDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLA .:. :. :. :: .:::::.:...:: :.:::::::::::::..:: .:::::::: NP_002 MDDC--GNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLA 280 290 300 310 320 330 160 170 180 190 200 210 pF1KB8 RAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI :: ..: ..:..:::::::: :.:::::..::: .:.:..: :: :.:. .::: :.. NP_002 RAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVE 340 350 360 370 380 390 220 230 240 250 260 pF1KB8 DQLFRIFRALGTPNNEVWPEVESLQDYKN-TFPKWKPGSLASHVKNLDENGLDLLSKMLT :.: ::: ::::..:.:: . : ...:: .:::.:: : .:. :: .:..:..:.: NP_002 DELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQ 400 410 420 430 440 450 270 280 290 pF1KB8 YDPAKRISGKMALNHPYFNDLDNQIKKM :. ::.:.. :..: :: .: .:. . NP_002 YESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGK 460 470 480 490 500 510 >>XP_016874894 (OMIM: 603440) PREDICTED: cyclin-dependen (523 aa) initn: 1103 init1: 593 opt: 1101 Z-score: 450.8 bits: 92.2 E(85289): 2.3e-18 Smith-Waterman score: 1101; 54.4% identity (81.5% similar) in 298 aa overlap (1-297:189-483) 10 20 30 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVV :: : :.::.:::::..::::: : : ..: XP_016 EKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLV 160 170 180 190 200 210 40 50 60 70 80 90 pF1KB8 AMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKY :.:.:::: .:::.: :::::.::::.:.: :::.:.:.. :. : :.::.:. :::.: XP_016 ALKEIRLE-HEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQY 220 230 240 250 260 270 100 110 120 130 140 150 pF1KB8 LDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLA .:. :. :. :: .:::::.:...:: :.:::::::::::::..:: .:::::::: XP_016 MDDC--GNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLA 280 290 300 310 320 330 160 170 180 190 200 210 pF1KB8 RAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI :: ..: ..:..:::::::: :.:::::..::: .:.:..: :: :.:. .::: :.. XP_016 RAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVE 340 350 360 370 380 390 220 230 240 250 260 pF1KB8 DQLFRIFRALGTPNNEVWPEVESLQDYKN-TFPKWKPGSLASHVKNLDENGLDLLSKMLT :.: ::: ::::..:.:: . : ...:: .:::.:: : .:. :: .:..:..:.: XP_016 DELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQ 400 410 420 430 440 450 270 280 290 pF1KB8 YDPAKRISGKMALNHPYFNDLDNQIKKM :. ::.:.. :..: :: .: .:. . XP_016 YESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGK 460 470 480 490 500 510 >>XP_016874895 (OMIM: 603440) PREDICTED: cyclin-dependen (523 aa) initn: 1103 init1: 593 opt: 1101 Z-score: 450.8 bits: 92.2 E(85289): 2.3e-18 Smith-Waterman score: 1101; 54.4% identity (81.5% similar) in 298 aa overlap (1-297:189-483) 10 20 30 pF1KB8 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVV :: : :.::.:::::..::::: : : ..: XP_016 EKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLV 160 170 180 190 200 210 40 50 60 70 80 90 pF1KB8 AMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKY :.:.:::: .:::.: :::::.::::.:.: :::.:.:.. :. : :.::.:. :::.: XP_016 ALKEIRLE-HEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQY 220 230 240 250 260 270 100 110 120 130 140 150 pF1KB8 LDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLA .:. :. :. :: .:::::.:...:: :.:::::::::::::..:: .:::::::: XP_016 MDDC--GNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLA 280 290 300 310 320 330 160 170 180 190 200 210 pF1KB8 RAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI :: ..: ..:..:::::::: :.:::::..::: .:.:..: :: :.:. .::: :.. XP_016 RAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVE 340 350 360 370 380 390 220 230 240 250 260 pF1KB8 DQLFRIFRALGTPNNEVWPEVESLQDYKN-TFPKWKPGSLASHVKNLDENGLDLLSKMLT :.: ::: ::::..:.:: . : ...:: .:::.:: : .:. :: .:..:..:.: XP_016 DELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQ 400 410 420 430 440 450 270 280 290 pF1KB8 YDPAKRISGKMALNHPYFNDLDNQIKKM :. ::.:.. :..: :: .: .:. . XP_016 YESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGK 460 470 480 490 500 510 297 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:18:54 2016 done: Sat Nov 5 23:18:55 2016 Total Scan time: 7.380 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]