FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8499, 932 aa 1>>>pF1KB8499 932 - 932 aa - 932 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8068+/-0.000577; mu= 15.3762+/- 0.035 mean_var=149.6677+/-30.777, 0's: 0 Z-trim(108.8): 108 B-trim: 840 in 1/52 Lambda= 0.104836 statistics sampled from 16841 (16929) to 16841 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.521), E-opt: 0.2 (0.198), width: 16 Scan time: 10.810 The best scores are: opt bits E(85289) NP_001307974 (OMIM: 120435,600258) PMS1 protein ho ( 932) 6068 931.3 0 NP_000525 (OMIM: 120435,600258) PMS1 protein homol ( 932) 6068 931.3 0 NP_001307977 (OMIM: 120435,600258) PMS1 protein ho ( 932) 6068 931.3 0 NP_001307976 (OMIM: 120435,600258) PMS1 protein ho ( 932) 6068 931.3 0 NP_001307975 (OMIM: 120435,600258) PMS1 protein ho ( 871) 5413 832.2 0 XP_016859835 (OMIM: 120435,600258) PREDICTED: PMS1 ( 871) 5413 832.2 0 XP_016859834 (OMIM: 120435,600258) PREDICTED: PMS1 ( 871) 5413 832.2 0 NP_001276337 (OMIM: 120435,600258) PMS1 protein ho ( 756) 4962 763.9 0 XP_011509658 (OMIM: 120435,600258) PREDICTED: PMS1 ( 756) 4962 763.9 0 NP_001276338 (OMIM: 120435,600258) PMS1 protein ho ( 756) 4962 763.9 0 XP_006712659 (OMIM: 120435,600258) PREDICTED: PMS1 ( 747) 4842 745.8 1.9e-214 XP_016859838 (OMIM: 120435,600258) PREDICTED: PMS1 ( 717) 4593 708.1 4e-203 XP_016859836 (OMIM: 120435,600258) PREDICTED: PMS1 ( 832) 4593 708.2 4.4e-203 NP_001121615 (OMIM: 120435,600258) PMS1 protein ho ( 893) 4593 708.2 4.6e-203 XP_016859833 (OMIM: 120435,600258) PREDICTED: PMS1 ( 893) 4593 708.2 4.6e-203 NP_001121616 (OMIM: 120435,600258) PMS1 protein ho ( 770) 4003 618.9 3e-176 XP_016859837 (OMIM: 120435,600258) PREDICTED: PMS1 ( 770) 4003 618.9 3e-176 XP_016859839 (OMIM: 120435,600258) PREDICTED: PMS1 ( 709) 3348 519.8 1.9e-146 XP_016859840 (OMIM: 120435,600258) PREDICTED: PMS1 ( 594) 2897 451.5 5.7e-126 NP_001307973 (OMIM: 120435,600258) PMS1 protein ho ( 731) 2528 395.8 4.2e-109 NP_001307978 (OMIM: 120435,600258) PMS1 protein ho ( 181) 884 146.6 1.1e-34 NP_001307980 (OMIM: 120435,600258) PMS1 protein ho ( 165) 882 146.2 1.3e-34 NP_001308935 (OMIM: 276300,600259,614337) mismatch ( 810) 468 84.3 2.8e-15 NP_000526 (OMIM: 276300,600259,614337) mismatch re ( 862) 468 84.3 2.9e-15 NP_001308943 (OMIM: 276300,600259,614337) mismatch ( 873) 468 84.3 2.9e-15 NP_001245200 (OMIM: 120436,158320,276300,609310) D ( 687) 380 70.9 2.5e-11 NP_000240 (OMIM: 120436,158320,276300,609310) DNA ( 756) 380 70.9 2.7e-11 XP_005265218 (OMIM: 120436,158320,276300,609310) P ( 687) 351 66.5 5.3e-10 XP_011534950 (OMIM: 604395,608089,614385) PREDICTE (1157) 308 60.2 6.9e-08 XP_005267591 (OMIM: 604395,608089,614385) PREDICTE (1275) 308 60.2 7.4e-08 XP_005267590 (OMIM: 604395,608089,614385) PREDICTE (1394) 308 60.3 7.9e-08 XP_011534948 (OMIM: 604395,608089,614385) PREDICTE (1396) 308 60.3 7.9e-08 XP_005267589 (OMIM: 604395,608089,614385) PREDICTE (1418) 308 60.3 8e-08 NP_055196 (OMIM: 604395,608089,614385) DNA mismatc (1429) 308 60.3 8.1e-08 XP_016876708 (OMIM: 604395,608089,614385) PREDICTE (1429) 308 60.3 8.1e-08 NP_001035197 (OMIM: 604395,608089,614385) DNA mism (1453) 308 60.3 8.2e-08 XP_006720179 (OMIM: 604395,608089,614385) PREDICTE (1453) 308 60.3 8.2e-08 NP_001308942 (OMIM: 276300,600259,614337) mismatch ( 671) 204 44.2 0.0026 NP_001308934 (OMIM: 276300,600259,614337) mismatch ( 727) 204 44.3 0.0027 NP_001308932 (OMIM: 276300,600259,614337) mismatch ( 727) 204 44.3 0.0027 NP_001308933 (OMIM: 276300,600259,614337) mismatch ( 727) 204 44.3 0.0027 NP_001308938 (OMIM: 276300,600259,614337) mismatch ( 738) 204 44.3 0.0027 NP_001308937 (OMIM: 276300,600259,614337) mismatch ( 756) 204 44.3 0.0028 NP_001308936 (OMIM: 276300,600259,614337) mismatch ( 756) 204 44.3 0.0028 NP_001308944 (OMIM: 276300,600259,614337) mismatch ( 759) 204 44.3 0.0028 >>NP_001307974 (OMIM: 120435,600258) PMS1 protein homolo (932 aa) initn: 6068 init1: 6068 opt: 6068 Z-score: 4972.0 bits: 931.3 E(85289): 0 Smith-Waterman score: 6068; 100.0% identity (100.0% similar) in 932 aa overlap (1-932:1-932) 10 20 30 40 50 60 pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI 850 860 870 880 890 900 910 920 930 pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT :::::::::::::::::::::::::::::::: NP_001 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT 910 920 930 >>NP_000525 (OMIM: 120435,600258) PMS1 protein homolog 1 (932 aa) initn: 6068 init1: 6068 opt: 6068 Z-score: 4972.0 bits: 931.3 E(85289): 0 Smith-Waterman score: 6068; 100.0% identity (100.0% similar) in 932 aa overlap (1-932:1-932) 10 20 30 40 50 60 pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI 850 860 870 880 890 900 910 920 930 pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT :::::::::::::::::::::::::::::::: NP_000 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT 910 920 930 >>NP_001307977 (OMIM: 120435,600258) PMS1 protein homolo (932 aa) initn: 6068 init1: 6068 opt: 6068 Z-score: 4972.0 bits: 931.3 E(85289): 0 Smith-Waterman score: 6068; 100.0% identity (100.0% similar) in 932 aa overlap (1-932:1-932) 10 20 30 40 50 60 pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI 850 860 870 880 890 900 910 920 930 pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT :::::::::::::::::::::::::::::::: NP_001 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT 910 920 930 >>NP_001307976 (OMIM: 120435,600258) PMS1 protein homolo (932 aa) initn: 6068 init1: 6068 opt: 6068 Z-score: 4972.0 bits: 931.3 E(85289): 0 Smith-Waterman score: 6068; 100.0% identity (100.0% similar) in 932 aa overlap (1-932:1-932) 10 20 30 40 50 60 pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI 850 860 870 880 890 900 910 920 930 pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT :::::::::::::::::::::::::::::::: NP_001 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT 910 920 930 >>NP_001307975 (OMIM: 120435,600258) PMS1 protein homolo (871 aa) initn: 5648 init1: 5413 opt: 5413 Z-score: 4437.0 bits: 832.2 E(85289): 0 Smith-Waterman score: 5530; 93.5% identity (93.5% similar) in 932 aa overlap (1-932:1-871) 10 20 30 40 50 60 pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG :::::::::::::::::::::::::::::::::::::::::::: NP_001 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL---------------- 10 20 30 40 70 80 90 100 110 120 pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ ::::::::::::::: NP_001 ---------------------------------------------VLITTRTAADNFSTQ 50 130 140 150 160 170 180 pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL 240 250 260 270 280 290 370 380 390 400 410 420 pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE 360 370 380 390 400 410 490 500 510 520 530 540 pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN 420 430 440 450 460 470 550 560 570 580 590 600 pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED 480 490 500 510 520 530 610 620 630 640 650 660 pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW 540 550 560 570 580 590 670 680 690 700 710 720 pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE 600 610 620 630 640 650 730 740 750 760 770 780 pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE 660 670 680 690 700 710 790 800 810 820 830 840 pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN 720 730 740 750 760 770 850 860 870 880 890 900 pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI 780 790 800 810 820 830 910 920 930 pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT :::::::::::::::::::::::::::::::: NP_001 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT 840 850 860 870 >>XP_016859835 (OMIM: 120435,600258) PREDICTED: PMS1 pro (871 aa) initn: 5648 init1: 5413 opt: 5413 Z-score: 4437.0 bits: 832.2 E(85289): 0 Smith-Waterman score: 5530; 93.5% identity (93.5% similar) in 932 aa overlap (1-932:1-871) 10 20 30 40 50 60 pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG :::::::::::::::::::::::::::::::::::::::::::: XP_016 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL---------------- 10 20 30 40 70 80 90 100 110 120 pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ ::::::::::::::: XP_016 ---------------------------------------------VLITTRTAADNFSTQ 50 130 140 150 160 170 180 pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL 240 250 260 270 280 290 370 380 390 400 410 420 pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE 360 370 380 390 400 410 490 500 510 520 530 540 pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN 420 430 440 450 460 470 550 560 570 580 590 600 pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED 480 490 500 510 520 530 610 620 630 640 650 660 pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW 540 550 560 570 580 590 670 680 690 700 710 720 pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE 600 610 620 630 640 650 730 740 750 760 770 780 pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE 660 670 680 690 700 710 790 800 810 820 830 840 pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN 720 730 740 750 760 770 850 860 870 880 890 900 pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI 780 790 800 810 820 830 910 920 930 pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT :::::::::::::::::::::::::::::::: XP_016 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT 840 850 860 870 >>XP_016859834 (OMIM: 120435,600258) PREDICTED: PMS1 pro (871 aa) initn: 5648 init1: 5413 opt: 5413 Z-score: 4437.0 bits: 832.2 E(85289): 0 Smith-Waterman score: 5530; 93.5% identity (93.5% similar) in 932 aa overlap (1-932:1-871) 10 20 30 40 50 60 pF1KB8 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG :::::::::::::::::::::::::::::::::::::::::::: XP_016 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKL---------------- 10 20 30 40 70 80 90 100 110 120 pF1KB8 IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ ::::::::::::::: XP_016 ---------------------------------------------VLITTRTAADNFSTQ 50 130 140 150 160 170 180 pF1KB8 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB8 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB8 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB8 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL 240 250 260 270 280 290 370 380 390 400 410 420 pF1KB8 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB8 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE 360 370 380 390 400 410 490 500 510 520 530 540 pF1KB8 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN 420 430 440 450 460 470 550 560 570 580 590 600 pF1KB8 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED 480 490 500 510 520 530 610 620 630 640 650 660 pF1KB8 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW 540 550 560 570 580 590 670 680 690 700 710 720 pF1KB8 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE 600 610 620 630 640 650 730 740 750 760 770 780 pF1KB8 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE 660 670 680 690 700 710 790 800 810 820 830 840 pF1KB8 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN 720 730 740 750 760 770 850 860 870 880 890 900 pF1KB8 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI 780 790 800 810 820 830 910 920 930 pF1KB8 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT :::::::::::::::::::::::::::::::: XP_016 IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT 840 850 860 870 >>NP_001276337 (OMIM: 120435,600258) PMS1 protein homolo (756 aa) initn: 4962 init1: 4962 opt: 4962 Z-score: 4069.1 bits: 763.9 E(85289): 0 Smith-Waterman score: 4962; 100.0% identity (100.0% similar) in 756 aa overlap (177-932:1-756) 150 160 170 180 190 200 pF1KB8 RLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDH :::::::::::::::::::::::::::::: NP_001 MSFGILKPDLRIVFVHNKAVIWQKSRVSDH 10 20 30 210 220 230 240 250 260 pF1KB8 KMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRP 40 50 60 70 80 90 270 280 290 300 310 320 pF1KB8 VHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVL 100 110 120 130 140 150 330 340 350 360 370 380 pF1KB8 IALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTS 160 170 180 190 200 210 390 400 410 420 430 440 pF1KB8 VIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSW 220 230 240 250 260 270 450 460 470 480 490 500 pF1KB8 ENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKN 280 290 300 310 320 330 510 520 530 540 550 560 pF1KB8 SVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL 340 350 360 370 380 390 570 580 590 600 610 620 pF1KB8 SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATK 400 410 420 430 440 450 630 640 650 660 670 680 pF1KB8 DLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQI 460 470 480 490 500 510 690 700 710 720 730 740 pF1KB8 EKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVML 520 530 540 550 560 570 750 760 770 780 790 800 pF1KB8 LNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGST 580 590 600 610 620 630 810 820 830 840 850 860 pF1KB8 YLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVY 640 650 660 670 680 690 870 880 890 900 910 920 pF1KB8 ECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLT 700 710 720 730 740 750 930 pF1KB8 YLPETT :::::: NP_001 YLPETT >>XP_011509658 (OMIM: 120435,600258) PREDICTED: PMS1 pro (756 aa) initn: 4962 init1: 4962 opt: 4962 Z-score: 4069.1 bits: 763.9 E(85289): 0 Smith-Waterman score: 4962; 100.0% identity (100.0% similar) in 756 aa overlap (177-932:1-756) 150 160 170 180 190 200 pF1KB8 RLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDH :::::::::::::::::::::::::::::: XP_011 MSFGILKPDLRIVFVHNKAVIWQKSRVSDH 10 20 30 210 220 230 240 250 260 pF1KB8 KMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRP 40 50 60 70 80 90 270 280 290 300 310 320 pF1KB8 VHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVL 100 110 120 130 140 150 330 340 350 360 370 380 pF1KB8 IALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTS 160 170 180 190 200 210 390 400 410 420 430 440 pF1KB8 VIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSW 220 230 240 250 260 270 450 460 470 480 490 500 pF1KB8 ENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKN 280 290 300 310 320 330 510 520 530 540 550 560 pF1KB8 SVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL 340 350 360 370 380 390 570 580 590 600 610 620 pF1KB8 SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATK 400 410 420 430 440 450 630 640 650 660 670 680 pF1KB8 DLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQI 460 470 480 490 500 510 690 700 710 720 730 740 pF1KB8 EKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVML 520 530 540 550 560 570 750 760 770 780 790 800 pF1KB8 LNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGST 580 590 600 610 620 630 810 820 830 840 850 860 pF1KB8 YLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVY 640 650 660 670 680 690 870 880 890 900 910 920 pF1KB8 ECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLT 700 710 720 730 740 750 930 pF1KB8 YLPETT :::::: XP_011 YLPETT >>NP_001276338 (OMIM: 120435,600258) PMS1 protein homolo (756 aa) initn: 4962 init1: 4962 opt: 4962 Z-score: 4069.1 bits: 763.9 E(85289): 0 Smith-Waterman score: 4962; 100.0% identity (100.0% similar) in 756 aa overlap (177-932:1-756) 150 160 170 180 190 200 pF1KB8 RLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHNKAVIWQKSRVSDH :::::::::::::::::::::::::::::: NP_001 MSFGILKPDLRIVFVHNKAVIWQKSRVSDH 10 20 30 210 220 230 240 250 260 pF1KB8 KMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRP 40 50 60 70 80 90 270 280 290 300 310 320 pF1KB8 VHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHQKDILKLIRHHYNLKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVL 100 110 120 130 140 150 330 340 350 360 370 380 pF1KB8 IALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IALENLMTTCYGPLPSTNSYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTS 160 170 180 190 200 210 390 400 410 420 430 440 pF1KB8 VIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSW 220 230 240 250 260 270 450 460 470 480 490 500 pF1KB8 ENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENSQTEYSKTCFISSVKHTQSENGNKDHIDESGENEEEAGLENSSEISADEWSRGNILKN 280 290 300 310 320 330 510 520 530 540 550 560 pF1KB8 SVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLL 340 350 360 370 380 390 570 580 590 600 610 620 pF1KB8 SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNRVIKKPMSASALFVQDHRPQFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATK 400 410 420 430 440 450 630 640 650 660 670 680 pF1KB8 DLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLAQKHKLKTSLSNQPKLDELLQSQI 460 470 480 490 500 510 690 700 710 720 730 740 pF1KB8 EKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVML 520 530 540 550 560 570 750 760 770 780 790 800 pF1KB8 LNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGST 580 590 600 610 620 630 810 820 830 840 850 860 pF1KB8 YLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVY 640 650 660 670 680 690 870 880 890 900 910 920 pF1KB8 ECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNEIKECVHGRPFFHHLT 700 710 720 730 740 750 930 pF1KB8 YLPETT :::::: NP_001 YLPETT 932 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:09:56 2016 done: Sun Nov 6 18:09:58 2016 Total Scan time: 10.810 Total Display time: 0.300 Function used was FASTA [36.3.4 Apr, 2011]