FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8500, 862 aa 1>>>pF1KB8500 862 - 862 aa - 862 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3393+/-0.000477; mu= 5.5488+/- 0.030 mean_var=143.8366+/-28.676, 0's: 0 Z-trim(113.2): 58 B-trim: 86 in 1/52 Lambda= 0.106940 statistics sampled from 22435 (22493) to 22435 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.612), E-opt: 0.2 (0.264), width: 16 Scan time: 13.230 The best scores are: opt bits E(85289) NP_000526 (OMIM: 276300,600259,614337) mismatch re ( 862) 5683 889.5 0 NP_001308943 (OMIM: 276300,600259,614337) mismatch ( 873) 4964 778.6 0 NP_001308944 (OMIM: 276300,600259,614337) mismatch ( 759) 4950 776.4 0 NP_001308936 (OMIM: 276300,600259,614337) mismatch ( 756) 4945 775.6 0 NP_001308937 (OMIM: 276300,600259,614337) mismatch ( 756) 4945 775.6 0 NP_001308932 (OMIM: 276300,600259,614337) mismatch ( 727) 4832 758.2 3.1e-218 NP_001308933 (OMIM: 276300,600259,614337) mismatch ( 727) 4832 758.2 3.1e-218 NP_001308934 (OMIM: 276300,600259,614337) mismatch ( 727) 4832 758.2 3.1e-218 NP_001308942 (OMIM: 276300,600259,614337) mismatch ( 671) 4164 655.1 3.1e-187 NP_001308938 (OMIM: 276300,600259,614337) mismatch ( 738) 4113 647.2 7.9e-185 XP_006715807 (OMIM: 276300,600259,614337) PREDICTE ( 551) 3617 570.7 6.6e-162 NP_001308941 (OMIM: 276300,600259,614337) mismatch ( 551) 3617 570.7 6.6e-162 XP_016867831 (OMIM: 276300,600259,614337) PREDICTE ( 551) 3617 570.7 6.6e-162 NP_001308940 (OMIM: 276300,600259,614337) mismatch ( 551) 3617 570.7 6.6e-162 NP_001308939 (OMIM: 276300,600259,614337) mismatch ( 675) 3170 501.7 4.5e-141 NP_001308935 (OMIM: 276300,600259,614337) mismatch ( 810) 3170 501.8 5.3e-141 NP_001307973 (OMIM: 120435,600258) PMS1 protein ho ( 731) 468 84.9 1.5e-15 NP_001121616 (OMIM: 120435,600258) PMS1 protein ho ( 770) 468 84.9 1.6e-15 XP_016859837 (OMIM: 120435,600258) PREDICTED: PMS1 ( 770) 468 84.9 1.6e-15 XP_016859833 (OMIM: 120435,600258) PREDICTED: PMS1 ( 893) 468 84.9 1.8e-15 NP_001121615 (OMIM: 120435,600258) PMS1 protein ho ( 893) 468 84.9 1.8e-15 NP_000525 (OMIM: 120435,600258) PMS1 protein homol ( 932) 468 84.9 1.9e-15 NP_001307974 (OMIM: 120435,600258) PMS1 protein ho ( 932) 468 84.9 1.9e-15 NP_001307976 (OMIM: 120435,600258) PMS1 protein ho ( 932) 468 84.9 1.9e-15 NP_001307977 (OMIM: 120435,600258) PMS1 protein ho ( 932) 468 84.9 1.9e-15 NP_001245200 (OMIM: 120436,158320,276300,609310) D ( 687) 449 81.9 1.1e-14 NP_000240 (OMIM: 120436,158320,276300,609310) DNA ( 756) 449 82.0 1.2e-14 XP_005265218 (OMIM: 120436,158320,276300,609310) P ( 687) 446 81.5 1.5e-14 NP_001307978 (OMIM: 120435,600258) PMS1 protein ho ( 181) 386 72.0 2.8e-12 NP_001307980 (OMIM: 120435,600258) PMS1 protein ho ( 165) 385 71.8 2.9e-12 XP_011534950 (OMIM: 604395,608089,614385) PREDICTE (1157) 274 55.0 2.3e-06 XP_005267591 (OMIM: 604395,608089,614385) PREDICTE (1275) 274 55.0 2.5e-06 XP_005267590 (OMIM: 604395,608089,614385) PREDICTE (1394) 274 55.1 2.7e-06 XP_011534948 (OMIM: 604395,608089,614385) PREDICTE (1396) 274 55.1 2.7e-06 XP_005267589 (OMIM: 604395,608089,614385) PREDICTE (1418) 274 55.1 2.8e-06 XP_016876708 (OMIM: 604395,608089,614385) PREDICTE (1429) 274 55.1 2.8e-06 NP_055196 (OMIM: 604395,608089,614385) DNA mismatc (1429) 274 55.1 2.8e-06 XP_006720179 (OMIM: 604395,608089,614385) PREDICTE (1453) 274 55.1 2.8e-06 NP_001035197 (OMIM: 604395,608089,614385) DNA mism (1453) 274 55.1 2.8e-06 XP_016859838 (OMIM: 120435,600258) PREDICTED: PMS1 ( 717) 219 46.5 0.00054 XP_016859840 (OMIM: 120435,600258) PREDICTED: PMS1 ( 594) 204 44.1 0.0023 XP_006712659 (OMIM: 120435,600258) PREDICTED: PMS1 ( 747) 204 44.2 0.0028 NP_001276338 (OMIM: 120435,600258) PMS1 protein ho ( 756) 204 44.2 0.0028 XP_011509658 (OMIM: 120435,600258) PREDICTED: PMS1 ( 756) 204 44.2 0.0028 NP_001276337 (OMIM: 120435,600258) PMS1 protein ho ( 756) 204 44.2 0.0028 >>NP_000526 (OMIM: 276300,600259,614337) mismatch repair (862 aa) initn: 5683 init1: 5683 opt: 5683 Z-score: 4747.3 bits: 889.5 E(85289): 0 Smith-Waterman score: 5683; 99.8% identity (99.9% similar) in 862 aa overlap (1-862:1-862) 10 20 30 40 50 60 pF1KB8 MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 YGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 YAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 KVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 GMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 REAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRSQKEAVSSSHG ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: NP_000 REAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 PSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 ETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDM .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 SASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 EDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 QRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 QDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHP 790 800 810 820 830 840 850 860 pF1KB8 WNCPHGRPTMRHIANLGVISQN :::::::::::::::::::::: NP_000 WNCPHGRPTMRHIANLGVISQN 850 860 >>NP_001308943 (OMIM: 276300,600259,614337) mismatch rep (873 aa) initn: 5669 init1: 4964 opt: 4964 Z-score: 4147.7 bits: 778.6 E(85289): 0 Smith-Waterman score: 5651; 98.5% identity (98.6% similar) in 873 aa overlap (1-862:1-873) 10 20 30 40 50 60 pF1KB8 MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 YGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 YAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 KVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 GMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 REAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRSQKEAVSSSHG ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: NP_001 REAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 PSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 ETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDM .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 SASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 EDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQG 670 680 690 700 710 720 730 740 750 760 pF1KB8 QRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDEN-----------APVTERAKLIS :::::::::::::::::::::::::::::::::::::: ::::::::::: NP_001 QRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENVMDFSQNCILLAPVTERAKLIS 730 740 750 760 770 780 770 780 790 800 810 820 pF1KB8 LPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKK 790 800 810 820 830 840 830 840 850 860 pF1KB8 LITHMGEMDHPWNCPHGRPTMRHIANLGVISQN ::::::::::::::::::::::::::::::::: NP_001 LITHMGEMDHPWNCPHGRPTMRHIANLGVISQN 850 860 870 >>NP_001308944 (OMIM: 276300,600259,614337) mismatch rep (759 aa) initn: 4944 init1: 4944 opt: 4950 Z-score: 4137.0 bits: 776.4 E(85289): 0 Smith-Waterman score: 4950; 98.4% identity (99.1% similar) in 758 aa overlap (108-862:2-759) 80 90 100 110 120 130 pF1KB8 ENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCAL---SDVTISTCHASAKVGTR : .:.. : . ::::::::::::::::: NP_001 MGLSLNTPCLVFSHSDVTISTCHASAKVGTR 10 20 30 140 150 160 170 180 190 pF1KB8 LMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCII 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB8 SAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB8 YGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYN 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB8 RHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQ 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB8 QPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKP 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB8 HSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRSQKEAVSSSHGPSDPTDRAEVEKDS ::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::: NP_001 HSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDS 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB8 GHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPETDDSFSDVDCHSN ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_001 GHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSN 400 410 420 430 440 450 560 570 580 590 600 610 pF1KB8 QEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKK 460 470 480 490 500 510 620 630 640 650 660 670 pF1KB8 VVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFA 520 530 540 550 560 570 680 690 700 710 720 730 pF1KB8 EMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAV 580 590 600 610 620 630 740 750 760 770 780 790 pF1KB8 NEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSP 640 650 660 670 680 690 800 810 820 830 840 850 pF1KB8 GVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIA 700 710 720 730 740 750 860 pF1KB8 NLGVISQN :::::::: NP_001 NLGVISQN >>NP_001308936 (OMIM: 276300,600259,614337) mismatch rep (756 aa) initn: 4945 init1: 4945 opt: 4945 Z-score: 4132.9 bits: 775.6 E(85289): 0 Smith-Waterman score: 4945; 99.6% identity (99.9% similar) in 746 aa overlap (117-862:11-756) 90 100 110 120 130 140 pF1KB8 HHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQK :.:::::::::::::::::::::::::::: NP_001 MWGRRRKLRRLNDVTISTCHASAKVGTRLMFDHNGKIIQK 10 20 30 40 150 160 170 180 190 200 pF1KB8 TPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQL 50 60 70 80 90 100 210 220 230 240 250 260 pF1KB8 GQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KB8 FYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNIS 170 180 190 200 210 220 330 340 350 360 370 380 pF1KB8 VDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIK 230 240 250 260 270 280 390 400 410 420 430 440 pF1KB8 MHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSP 290 300 310 320 330 340 450 460 470 480 490 500 pF1KB8 LGQKRGMLSSSTSGAISDKGVLRSQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGF ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: NP_001 LGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGF 350 360 370 380 390 400 510 520 530 540 550 560 pF1KB8 SIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLP ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: NP_001 SIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLP 410 420 430 440 450 460 570 580 590 600 610 620 pF1KB8 QPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLA 470 480 490 500 510 520 630 640 650 660 670 680 pF1KB8 KRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGF 530 540 550 560 570 580 690 700 710 720 730 740 pF1KB8 IITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIF 590 600 610 620 630 640 750 760 770 780 790 800 pF1KB8 RKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQM 650 660 670 680 690 700 810 820 830 840 850 860 pF1KB8 FASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN 710 720 730 740 750 >>NP_001308937 (OMIM: 276300,600259,614337) mismatch rep (756 aa) initn: 4945 init1: 4945 opt: 4945 Z-score: 4132.9 bits: 775.6 E(85289): 0 Smith-Waterman score: 4945; 99.6% identity (99.9% similar) in 746 aa overlap (117-862:11-756) 90 100 110 120 130 140 pF1KB8 HHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQK :.:::::::::::::::::::::::::::: NP_001 MWGRRRKLRRLNDVTISTCHASAKVGTRLMFDHNGKIIQK 10 20 30 40 150 160 170 180 190 200 pF1KB8 TPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQL 50 60 70 80 90 100 210 220 230 240 250 260 pF1KB8 GQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KB8 FYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNIS 170 180 190 200 210 220 330 340 350 360 370 380 pF1KB8 VDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIK 230 240 250 260 270 280 390 400 410 420 430 440 pF1KB8 MHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSP 290 300 310 320 330 340 450 460 470 480 490 500 pF1KB8 LGQKRGMLSSSTSGAISDKGVLRSQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGF ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: NP_001 LGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGF 350 360 370 380 390 400 510 520 530 540 550 560 pF1KB8 SIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLP ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: NP_001 SIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLP 410 420 430 440 450 460 570 580 590 600 610 620 pF1KB8 QPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLA 470 480 490 500 510 520 630 640 650 660 670 680 pF1KB8 KRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGF 530 540 550 560 570 580 690 700 710 720 730 740 pF1KB8 IITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIF 590 600 610 620 630 640 750 760 770 780 790 800 pF1KB8 RKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQM 650 660 670 680 690 700 810 820 830 840 850 860 pF1KB8 FASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN 710 720 730 740 750 >>NP_001308932 (OMIM: 276300,600259,614337) mismatch rep (727 aa) initn: 4832 init1: 4832 opt: 4832 Z-score: 4038.9 bits: 758.2 E(85289): 3.1e-218 Smith-Waterman score: 4832; 99.7% identity (99.9% similar) in 727 aa overlap (136-862:1-727) 110 120 130 140 150 160 pF1KB8 FRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFST :::::::::::::::::::::::::::::: NP_001 MFDHNGKIIQKTPYPRPRGTTVSVQQLFST 10 20 30 170 180 190 200 210 220 pF1KB8 LPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKE 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB8 NIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST 100 110 120 130 140 150 290 300 310 320 330 340 pF1KB8 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL 160 170 180 190 200 210 350 360 370 380 390 400 pF1KB8 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS 220 230 240 250 260 270 410 420 430 440 450 460 pF1KB8 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK 280 290 300 310 320 330 470 480 490 500 510 520 pF1KB8 GVLRSQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG 340 350 360 370 380 390 530 540 550 560 570 580 pF1KB8 DRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_001 DRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL 400 410 420 430 440 450 590 600 610 620 630 640 pF1KB8 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY 460 470 480 490 500 510 650 660 670 680 690 700 pF1KB8 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE 520 530 540 550 560 570 710 720 730 740 750 760 pF1KB8 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERA 580 590 600 610 620 630 770 780 790 800 810 820 pF1KB8 KLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTS 640 650 660 670 680 690 830 840 850 860 pF1KB8 EMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN ::::::::::::::::::::::::::::::::::::: NP_001 EMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN 700 710 720 >>NP_001308933 (OMIM: 276300,600259,614337) mismatch rep (727 aa) initn: 4832 init1: 4832 opt: 4832 Z-score: 4038.9 bits: 758.2 E(85289): 3.1e-218 Smith-Waterman score: 4832; 99.7% identity (99.9% similar) in 727 aa overlap (136-862:1-727) 110 120 130 140 150 160 pF1KB8 FRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFST :::::::::::::::::::::::::::::: NP_001 MFDHNGKIIQKTPYPRPRGTTVSVQQLFST 10 20 30 170 180 190 200 210 220 pF1KB8 LPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKE 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB8 NIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST 100 110 120 130 140 150 290 300 310 320 330 340 pF1KB8 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL 160 170 180 190 200 210 350 360 370 380 390 400 pF1KB8 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS 220 230 240 250 260 270 410 420 430 440 450 460 pF1KB8 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK 280 290 300 310 320 330 470 480 490 500 510 520 pF1KB8 GVLRSQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG 340 350 360 370 380 390 530 540 550 560 570 580 pF1KB8 DRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_001 DRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL 400 410 420 430 440 450 590 600 610 620 630 640 pF1KB8 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY 460 470 480 490 500 510 650 660 670 680 690 700 pF1KB8 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE 520 530 540 550 560 570 710 720 730 740 750 760 pF1KB8 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERA 580 590 600 610 620 630 770 780 790 800 810 820 pF1KB8 KLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTS 640 650 660 670 680 690 830 840 850 860 pF1KB8 EMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN ::::::::::::::::::::::::::::::::::::: NP_001 EMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN 700 710 720 >>NP_001308934 (OMIM: 276300,600259,614337) mismatch rep (727 aa) initn: 4832 init1: 4832 opt: 4832 Z-score: 4038.9 bits: 758.2 E(85289): 3.1e-218 Smith-Waterman score: 4832; 99.7% identity (99.9% similar) in 727 aa overlap (136-862:1-727) 110 120 130 140 150 160 pF1KB8 FRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFST :::::::::::::::::::::::::::::: NP_001 MFDHNGKIIQKTPYPRPRGTTVSVQQLFST 10 20 30 170 180 190 200 210 220 pF1KB8 LPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKE 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB8 NIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST 100 110 120 130 140 150 290 300 310 320 330 340 pF1KB8 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL 160 170 180 190 200 210 350 360 370 380 390 400 pF1KB8 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS 220 230 240 250 260 270 410 420 430 440 450 460 pF1KB8 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK 280 290 300 310 320 330 470 480 490 500 510 520 pF1KB8 GVLRSQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG 340 350 360 370 380 390 530 540 550 560 570 580 pF1KB8 DRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_001 DRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL 400 410 420 430 440 450 590 600 610 620 630 640 pF1KB8 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY 460 470 480 490 500 510 650 660 670 680 690 700 pF1KB8 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE 520 530 540 550 560 570 710 720 730 740 750 760 pF1KB8 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERA 580 590 600 610 620 630 770 780 790 800 810 820 pF1KB8 KLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTS 640 650 660 670 680 690 830 840 850 860 pF1KB8 EMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN ::::::::::::::::::::::::::::::::::::: NP_001 EMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN 700 710 720 >>NP_001308942 (OMIM: 276300,600259,614337) mismatch rep (671 aa) initn: 4164 init1: 4164 opt: 4164 Z-score: 3482.5 bits: 655.1 E(85289): 3.1e-187 Smith-Waterman score: 4333; 92.0% identity (92.2% similar) in 727 aa overlap (136-862:1-671) 110 120 130 140 150 160 pF1KB8 FRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFST :::::::::::::::::::::::::::::: NP_001 MFDHNGKIIQKTPYPRPRGTTVSVQQLFST 10 20 30 170 180 190 200 210 220 pF1KB8 LPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKE :::::::::::::: NP_001 LPVRHKEFQRNIKK---------------------------------------------- 40 230 240 250 260 270 280 pF1KB8 NIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ----------LQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST 50 60 70 80 90 290 300 310 320 330 340 pF1KB8 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL 100 110 120 130 140 150 350 360 370 380 390 400 pF1KB8 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS 160 170 180 190 200 210 410 420 430 440 450 460 pF1KB8 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK 220 230 240 250 260 270 470 480 490 500 510 520 pF1KB8 GVLRSQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG 280 290 300 310 320 330 530 540 550 560 570 580 pF1KB8 DRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_001 DRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL 340 350 360 370 380 390 590 600 610 620 630 640 pF1KB8 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY 400 410 420 430 440 450 650 660 670 680 690 700 pF1KB8 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE 460 470 480 490 500 510 710 720 730 740 750 760 pF1KB8 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERA 520 530 540 550 560 570 770 780 790 800 810 820 pF1KB8 KLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTS 580 590 600 610 620 630 830 840 850 860 pF1KB8 EMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN ::::::::::::::::::::::::::::::::::::: NP_001 EMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN 640 650 660 670 >>NP_001308938 (OMIM: 276300,600259,614337) mismatch rep (738 aa) initn: 4818 init1: 4113 opt: 4113 Z-score: 3439.3 bits: 647.2 E(85289): 7.9e-185 Smith-Waterman score: 4800; 98.2% identity (98.4% similar) in 738 aa overlap (136-862:1-738) 110 120 130 140 150 160 pF1KB8 FRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFST :::::::::::::::::::::::::::::: NP_001 MFDHNGKIIQKTPYPRPRGTTVSVQQLFST 10 20 30 170 180 190 200 210 220 pF1KB8 LPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKE 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB8 NIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSST 100 110 120 130 140 150 290 300 310 320 330 340 pF1KB8 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILL 160 170 180 190 200 210 350 360 370 380 390 400 pF1KB8 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPS 220 230 240 250 260 270 410 420 430 440 450 460 pF1KB8 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDK 280 290 300 310 320 330 470 480 490 500 510 520 pF1KB8 GVLRSQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPG 340 350 360 370 380 390 530 540 550 560 570 580 pF1KB8 DRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_001 DRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEIL 400 410 420 430 440 450 590 600 610 620 630 640 pF1KB8 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNY 460 470 480 490 500 510 650 660 670 680 690 700 pF1KB8 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDE 520 530 540 550 560 570 710 720 730 740 750 pF1KB8 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDEN------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENVMDFSQN 580 590 600 610 620 630 760 770 780 790 800 810 pF1KB8 ----APVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CILLAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRK 640 650 660 670 680 690 820 830 840 850 860 pF1KB8 SVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN 700 710 720 730 862 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 20:40:36 2016 done: Sat Nov 5 20:40:38 2016 Total Scan time: 13.230 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]