FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8528, 885 aa 1>>>pF1KB8528 885 - 885 aa - 885 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7526+/-0.00043; mu= 15.3148+/- 0.027 mean_var=123.9535+/-25.151, 0's: 0 Z-trim(115.1): 20 B-trim: 1208 in 1/49 Lambda= 0.115198 statistics sampled from 25278 (25296) to 25278 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.297), width: 16 Scan time: 13.290 The best scores are: opt bits E(85289) NP_001001998 (OMIM: 605960) exosome component 10 i ( 885) 5937 998.7 0 XP_005263532 (OMIM: 605960) PREDICTED: exosome com ( 890) 5917 995.4 0 NP_002676 (OMIM: 605960) exosome component 10 isof ( 860) 4739 799.6 0 XP_016856984 (OMIM: 605960) PREDICTED: exosome com ( 469) 3064 521.0 5.1e-147 XP_016856983 (OMIM: 605960) PREDICTED: exosome com ( 474) 3044 517.7 5.1e-146 XP_016856986 (OMIM: 605960) PREDICTED: exosome com ( 453) 3026 514.7 3.9e-145 XP_016856985 (OMIM: 605960) PREDICTED: exosome com ( 458) 3006 511.4 4e-144 >>NP_001001998 (OMIM: 605960) exosome component 10 isofo (885 aa) initn: 5937 init1: 5937 opt: 5937 Z-score: 5337.1 bits: 998.7 E(85289): 0 Smith-Waterman score: 5937; 100.0% identity (100.0% similar) in 885 aa overlap (1-885:1-885) 10 20 30 40 50 60 pF1KB8 MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 DFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 IRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 IHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 IVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 LADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 FIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 AEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 FNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEI 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 SNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 ERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQF 790 800 810 820 830 840 850 860 870 880 pF1KB8 DPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR ::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR 850 860 870 880 >>XP_005263532 (OMIM: 605960) PREDICTED: exosome compone (890 aa) initn: 5923 init1: 5026 opt: 5917 Z-score: 5319.2 bits: 995.4 E(85289): 0 Smith-Waterman score: 5917; 99.4% identity (99.4% similar) in 890 aa overlap (1-885:1-890) 10 20 30 40 50 60 pF1KB8 MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 DFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 IRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 IHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 IVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 LADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 FIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 AEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 FNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEI 670 680 690 700 710 720 730 740 750 760 770 pF1KB8 SNRWKLAQVQVQKDSKEAVKKKAAEQT-----AAREQAKEACKAAAEQAISVRQQVVLEN ::::::::::::::::::::::::::: :::::::::::::::::::::::::::: XP_005 SNRWKLAQVQVQKDSKEAVKKKAAEQTVLSLAAAREQAKEACKAAAEQAISVRQQVVLEN 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB8 AAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSK 790 800 810 820 830 840 840 850 860 870 880 pF1KB8 VSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR 850 860 870 880 890 >>NP_002676 (OMIM: 605960) exosome component 10 isoform (860 aa) initn: 5756 init1: 4686 opt: 4739 Z-score: 4261.3 bits: 799.6 E(85289): 0 Smith-Waterman score: 5710; 97.2% identity (97.2% similar) in 885 aa overlap (1-885:1-860) 10 20 30 40 50 60 pF1KB8 MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 DFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 IRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 IHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 IVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 LADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 FIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 AEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 FNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEI :::::::::::::::::::::::::::::::::: : NP_002 FNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRM-------------------------I 670 680 690 730 740 750 760 770 780 pF1KB8 SNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKR 700 710 720 730 740 750 790 800 810 820 830 840 pF1KB8 ERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQF 760 770 780 790 800 810 850 860 870 880 pF1KB8 DPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR ::::::::::::::::::::::::::::::::::::::::::::: NP_002 DPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR 820 830 840 850 860 >>XP_016856984 (OMIM: 605960) PREDICTED: exosome compone (469 aa) initn: 3064 init1: 3064 opt: 3064 Z-score: 2760.5 bits: 521.0 E(85289): 5.1e-147 Smith-Waterman score: 3064; 99.6% identity (99.8% similar) in 460 aa overlap (426-885:10-469) 400 410 420 430 440 450 pF1KB8 LNLGRHSLDHLLKLYCNVDSNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEM . :::::::::::::::::::::::::::: XP_016 MRASQTQPSLSPLPEEMLSYARDDTHYLLYIYDKMRLEM 10 20 30 460 470 480 490 500 510 pF1KB8 WERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFA 40 50 60 70 80 90 520 530 540 550 560 570 pF1KB8 WRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQ 100 110 120 130 140 150 580 590 600 610 620 630 pF1KB8 AREMPLLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AREMPLLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQA 160 170 180 190 200 210 640 650 660 670 680 690 pF1KB8 SLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMF 220 230 240 250 260 270 700 710 720 730 740 750 pF1KB8 LPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKE 280 290 300 310 320 330 760 770 780 790 800 810 pF1KB8 ACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEF 340 350 360 370 380 390 820 830 840 850 860 870 pF1KB8 TPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSD 400 410 420 430 440 450 880 pF1KB8 RGFRYNWPQR :::::::::: XP_016 RGFRYNWPQR 460 >>XP_016856983 (OMIM: 605960) PREDICTED: exosome compone (474 aa) initn: 3050 init1: 2153 opt: 3044 Z-score: 2742.5 bits: 517.7 E(85289): 5.1e-146 Smith-Waterman score: 3044; 98.5% identity (98.7% similar) in 465 aa overlap (426-885:10-474) 400 410 420 430 440 450 pF1KB8 LNLGRHSLDHLLKLYCNVDSNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEM . :::::::::::::::::::::::::::: XP_016 MRASQTQPSLSPLPEEMLSYARDDTHYLLYIYDKMRLEM 10 20 30 460 470 480 490 500 510 pF1KB8 WERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFA 40 50 60 70 80 90 520 530 540 550 560 570 pF1KB8 WRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQ 100 110 120 130 140 150 580 590 600 610 620 630 pF1KB8 AREMPLLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AREMPLLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQA 160 170 180 190 200 210 640 650 660 670 680 690 pF1KB8 SLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMF 220 230 240 250 260 270 700 710 720 730 740 750 pF1KB8 LPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQT-----AAR :::::::::::::::::::::::::::::::::::::::::::::::::::: ::: XP_016 LPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTVLSLAAAR 280 290 300 310 320 330 760 770 780 790 800 810 pF1KB8 EQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEP 340 350 360 370 380 390 820 830 840 850 860 870 pF1KB8 PEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFP 400 410 420 430 440 450 880 pF1KB8 TGKSDRGFRYNWPQR ::::::::::::::: XP_016 TGKSDRGFRYNWPQR 460 470 >>XP_016856986 (OMIM: 605960) PREDICTED: exosome compone (453 aa) initn: 3026 init1: 3026 opt: 3026 Z-score: 2726.6 bits: 514.7 E(85289): 3.9e-145 Smith-Waterman score: 3026; 100.0% identity (100.0% similar) in 453 aa overlap (433-885:1-453) 410 420 430 440 450 460 pF1KB8 LDHLLKLYCNVDSNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQ :::::::::::::::::::::::::::::: XP_016 MLSYARDDTHYLLYIYDKMRLEMWERGNGQ 10 20 30 470 480 490 500 510 520 pF1KB8 PVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTAR 40 50 60 70 80 90 530 540 550 560 570 580 pF1KB8 REDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLL 100 110 120 130 140 150 590 600 610 620 630 640 pF1KB8 KSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEK 160 170 180 190 200 210 650 660 670 680 690 700 pF1KB8 EDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHR 220 230 240 250 260 270 710 720 730 740 750 760 pF1KB8 APVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAE 280 290 300 310 320 330 770 780 790 800 810 820 pF1KB8 QAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQ 340 350 360 370 380 390 830 840 850 860 870 880 pF1KB8 SDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNW 400 410 420 430 440 450 pF1KB8 PQR ::: XP_016 PQR >>XP_016856985 (OMIM: 605960) PREDICTED: exosome compone (458 aa) initn: 3012 init1: 2115 opt: 3006 Z-score: 2708.5 bits: 511.4 E(85289): 4e-144 Smith-Waterman score: 3006; 98.9% identity (98.9% similar) in 458 aa overlap (433-885:1-458) 410 420 430 440 450 460 pF1KB8 LDHLLKLYCNVDSNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQ :::::::::::::::::::::::::::::: XP_016 MLSYARDDTHYLLYIYDKMRLEMWERGNGQ 10 20 30 470 480 490 500 510 520 pF1KB8 PVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTAR 40 50 60 70 80 90 530 540 550 560 570 580 pF1KB8 REDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLL 100 110 120 130 140 150 590 600 610 620 630 640 pF1KB8 KSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEK 160 170 180 190 200 210 650 660 670 680 690 700 pF1KB8 EDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHR 220 230 240 250 260 270 710 720 730 740 750 pF1KB8 APVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQT-----AAREQAKEAC ::::::::::::::::::::::::::::::::::::::::::::: :::::::::: XP_016 APVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTVLSLAAAREQAKEAC 280 290 300 310 320 330 760 770 780 790 800 810 pF1KB8 KAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTP 340 350 360 370 380 390 820 830 840 850 860 870 pF1KB8 YDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRG 400 410 420 430 440 450 880 pF1KB8 FRYNWPQR :::::::: XP_016 FRYNWPQR 885 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 16:35:36 2016 done: Sat Nov 5 16:35:38 2016 Total Scan time: 13.290 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]