FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8532, 898 aa 1>>>pF1KB8532 898 - 898 aa - 898 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4148+/-0.000475; mu= 4.3463+/- 0.030 mean_var=355.9974+/-73.237, 0's: 0 Z-trim(120.5): 220 B-trim: 1840 in 1/52 Lambda= 0.067975 statistics sampled from 35549 (35814) to 35549 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.42), width: 16 Scan time: 15.680 The best scores are: opt bits E(85289) XP_016882252 (OMIM: 603182) PREDICTED: interleukin ( 898) 6087 611.9 4.2e-174 NP_060090 (OMIM: 603182) interleukin enhancer-bind ( 898) 6087 611.9 4.2e-174 XP_011526286 (OMIM: 603182) PREDICTED: interleukin ( 898) 6087 611.9 4.2e-174 NP_036350 (OMIM: 603182) interleukin enhancer-bind ( 894) 6044 607.7 7.8e-173 XP_006722805 (OMIM: 603182) PREDICTED: interleukin ( 855) 5522 556.5 2e-157 XP_011526287 (OMIM: 603182) PREDICTED: interleukin ( 777) 4700 475.8 3.4e-133 NP_001131145 (OMIM: 603182) interleukin enhancer-b ( 706) 4606 466.6 1.9e-130 NP_004507 (OMIM: 603182) interleukin enhancer-bind ( 702) 4563 462.4 3.5e-129 NP_703194 (OMIM: 603182) interleukin enhancer-bind ( 690) 4547 460.8 1e-128 XP_016882253 (OMIM: 603182) PREDICTED: interleukin ( 633) 4354 441.8 4.9e-123 XP_011526289 (OMIM: 603182) PREDICTED: interleukin ( 563) 3887 395.9 2.8e-109 XP_016882254 (OMIM: 603182) PREDICTED: interleukin ( 563) 3887 395.9 2.8e-109 XP_016870387 (OMIM: 611138) PREDICTED: spermatid p ( 648) 1979 208.9 6.4e-53 XP_016870386 (OMIM: 611138) PREDICTED: spermatid p ( 657) 1979 208.9 6.5e-53 XP_016870385 (OMIM: 611138) PREDICTED: spermatid p ( 672) 1979 208.9 6.6e-53 XP_016870383 (OMIM: 611138) PREDICTED: spermatid p ( 672) 1979 208.9 6.6e-53 XP_016870384 (OMIM: 611138) PREDICTED: spermatid p ( 672) 1979 208.9 6.6e-53 NP_060857 (OMIM: 611138) spermatid perinuclear RNA ( 672) 1979 208.9 6.6e-53 XP_016870380 (OMIM: 611138) PREDICTED: spermatid p ( 674) 1979 208.9 6.6e-53 XP_016870382 (OMIM: 611138) PREDICTED: spermatid p ( 674) 1979 208.9 6.6e-53 XP_016870381 (OMIM: 611138) PREDICTED: spermatid p ( 674) 1979 208.9 6.6e-53 XP_016870379 (OMIM: 611138) PREDICTED: spermatid p ( 674) 1979 208.9 6.6e-53 NP_001164608 (OMIM: 611138) spermatid perinuclear ( 658) 1907 201.9 8.7e-51 NP_057191 (OMIM: 615635) zinc finger RNA-binding p (1074) 1077 120.7 3.8e-26 NP_001164408 (OMIM: 137070,608030,614782) RNA-bind ( 522) 374 51.4 1.3e-05 NP_004951 (OMIM: 137070,608030,614782) RNA-binding ( 526) 370 51.0 1.8e-05 NP_001164105 (OMIM: 137070,608030,614782) RNA-bind ( 525) 367 50.7 2.2e-05 XP_011507833 (OMIM: 616284) PREDICTED: filaggrin-2 (2239) 358 50.6 0.0001 XP_016883742 (OMIM: 601218) PREDICTED: double-stra ( 723) 345 48.7 0.00012 XP_016883741 (OMIM: 601218) PREDICTED: double-stra ( 733) 345 48.7 0.00012 XP_016883734 (OMIM: 601218) PREDICTED: double-stra ( 750) 345 48.7 0.00012 XP_016883733 (OMIM: 601218) PREDICTED: double-stra ( 763) 345 48.7 0.00012 XP_016883731 (OMIM: 601218) PREDICTED: double-stra ( 790) 345 48.8 0.00013 XP_016883745 (OMIM: 601218) PREDICTED: double-stra ( 674) 343 48.5 0.00013 NP_001153702 (OMIM: 601218) double-stranded RNA-sp ( 674) 343 48.5 0.00013 NP_001103 (OMIM: 601218) double-stranded RNA-speci ( 701) 343 48.5 0.00013 XP_016883744 (OMIM: 601218) PREDICTED: double-stra ( 701) 343 48.5 0.00013 NP_056649 (OMIM: 601218) double-stranded RNA-speci ( 714) 343 48.5 0.00014 XP_016883743 (OMIM: 601218) PREDICTED: double-stra ( 714) 343 48.5 0.00014 NP_056648 (OMIM: 601218) double-stranded RNA-speci ( 741) 343 48.5 0.00014 XP_016883739 (OMIM: 601218) PREDICTED: double-stra ( 741) 343 48.5 0.00014 XP_016883738 (OMIM: 601218) PREDICTED: double-stra ( 741) 343 48.5 0.00014 XP_016883740 (OMIM: 601218) PREDICTED: double-stra ( 741) 343 48.5 0.00014 XP_016883737 (OMIM: 601218) PREDICTED: double-stra ( 741) 343 48.5 0.00014 XP_016883736 (OMIM: 601218) PREDICTED: double-stra ( 741) 343 48.5 0.00014 XP_016883735 (OMIM: 601218) PREDICTED: double-stra ( 742) 343 48.5 0.00014 XP_016883732 (OMIM: 601218) PREDICTED: double-stra ( 769) 343 48.6 0.00014 XP_006724017 (OMIM: 601218) PREDICTED: double-stra ( 769) 343 48.6 0.00014 XP_011527727 (OMIM: 601218) PREDICTED: double-stra ( 772) 343 48.6 0.00014 NP_001254738 (OMIM: 603181) interleukin enhancer-b ( 352) 326 46.5 0.00027 >>XP_016882252 (OMIM: 603182) PREDICTED: interleukin enh (898 aa) initn: 6087 init1: 6087 opt: 6087 Z-score: 3246.6 bits: 611.9 E(85289): 4.2e-174 Smith-Waterman score: 6087; 100.0% identity (100.0% similar) in 898 aa overlap (1-898:1-898) 10 20 30 40 50 60 pF1KB8 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY 790 800 810 820 830 840 850 860 870 880 890 pF1KB8 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR 850 860 870 880 890 >>NP_060090 (OMIM: 603182) interleukin enhancer-binding (898 aa) initn: 6087 init1: 6087 opt: 6087 Z-score: 3246.6 bits: 611.9 E(85289): 4.2e-174 Smith-Waterman score: 6087; 100.0% identity (100.0% similar) in 898 aa overlap (1-898:1-898) 10 20 30 40 50 60 pF1KB8 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY 790 800 810 820 830 840 850 860 870 880 890 pF1KB8 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR 850 860 870 880 890 >>XP_011526286 (OMIM: 603182) PREDICTED: interleukin enh (898 aa) initn: 6087 init1: 6087 opt: 6087 Z-score: 3246.6 bits: 611.9 E(85289): 4.2e-174 Smith-Waterman score: 6087; 100.0% identity (100.0% similar) in 898 aa overlap (1-898:1-898) 10 20 30 40 50 60 pF1KB8 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY 790 800 810 820 830 840 850 860 870 880 890 pF1KB8 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR 850 860 870 880 890 >>NP_036350 (OMIM: 603182) interleukin enhancer-binding (894 aa) initn: 3505 init1: 3396 opt: 6044 Z-score: 3223.9 bits: 607.7 E(85289): 7.8e-173 Smith-Waterman score: 6044; 99.6% identity (99.6% similar) in 898 aa overlap (1-898:1-894) 10 20 30 40 50 60 pF1KB8 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR :::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_036 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAE----QGPILTKHGKNPVMELNEKR 490 500 510 520 530 550 560 570 580 590 600 pF1KB8 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB8 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB8 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB8 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB8 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY 780 790 800 810 820 830 850 860 870 880 890 pF1KB8 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR 840 850 860 870 880 890 >>XP_006722805 (OMIM: 603182) PREDICTED: interleukin enh (855 aa) initn: 5644 init1: 5466 opt: 5522 Z-score: 2947.4 bits: 556.5 E(85289): 2e-157 Smith-Waterman score: 5675; 95.1% identity (95.1% similar) in 898 aa overlap (1-898:1-855) 10 20 30 40 50 60 pF1KB8 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY ::::::::::::::::::::::::::::::: XP_006 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFR---------------------------- 790 800 810 850 860 870 880 890 pF1KB8 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR ::::::::::::::::::::::::::::::::::::::::::: XP_006 ---------------GYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR 820 830 840 850 >>XP_011526287 (OMIM: 603182) PREDICTED: interleukin enh (777 aa) initn: 4754 init1: 4626 opt: 4700 Z-score: 2512.3 bits: 475.8 E(85289): 3.4e-133 Smith-Waterman score: 4951; 86.5% identity (86.5% similar) in 898 aa overlap (1-898:1-777) 10 20 30 40 50 60 pF1KB8 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY :::::::::::::::::::::::::::::: XP_011 FGGANHGGYMNAGAGYGSYGYGGNSATAGY------------------------------ 670 680 690 730 740 750 760 770 780 pF1KB8 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG XP_011 ------------------------------------------------------------ 790 800 810 820 830 840 pF1KB8 YNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGY ::::::::::::::::::::::::::::: XP_011 -------------------------------NYSGSGGRSGGNSYGSGGASYNPGSHGGY 700 710 850 860 870 880 890 pF1KB8 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR 720 730 740 750 760 770 >>NP_001131145 (OMIM: 603182) interleukin enhancer-bindi (706 aa) initn: 4962 init1: 4603 opt: 4606 Z-score: 2462.9 bits: 466.6 E(85289): 1.9e-130 Smith-Waterman score: 4606; 98.4% identity (99.4% similar) in 706 aa overlap (1-704:1-706) 10 20 30 40 50 60 pF1KB8 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG 610 620 630 640 650 660 670 680 690 700 710 pF1KB8 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSN--GGHSGNASGGGGGGGGGSSGYG :::::::::::::::::::::::::::::::.:... : :. ..: NP_001 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSDFFTDCYGYHDFGSS 670 680 690 700 720 730 740 750 760 770 pF1KB8 SYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQ >>NP_004507 (OMIM: 603182) interleukin enhancer-binding (702 aa) initn: 4722 init1: 3379 opt: 4563 Z-score: 2440.2 bits: 462.4 E(85289): 3.5e-129 Smith-Waterman score: 4563; 97.9% identity (98.9% similar) in 706 aa overlap (1-704:1-702) 10 20 30 40 50 60 pF1KB8 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR :::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_004 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAE----QGPILTKHGKNPVMELNEKR 490 500 510 520 530 550 560 570 580 590 600 pF1KB8 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB8 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG 600 610 620 630 640 650 670 680 690 700 710 pF1KB8 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSN--GGHSGNASGGGGGGGGGSSGYG :::::::::::::::::::::::::::::::.:... : :. ..: NP_004 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSDFFTDCYGYHDFGSS 660 670 680 690 700 720 730 740 750 760 770 pF1KB8 SYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQ >>NP_703194 (OMIM: 603182) interleukin enhancer-binding (690 aa) initn: 4740 init1: 3379 opt: 4547 Z-score: 2431.8 bits: 460.8 E(85289): 1e-128 Smith-Waterman score: 4547; 99.1% identity (99.3% similar) in 693 aa overlap (1-693:1-689) 10 20 30 40 50 60 pF1KB8 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 ESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 TTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 EKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 PTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 DAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 PSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 VSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVMELNEKR :::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_703 DSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAE----QGPILTKHGKNPVMELNEKR 490 500 510 520 530 550 560 570 580 590 600 pF1KB8 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 RGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLAL 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB8 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_703 DANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRG 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB8 FGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSY ::::::::::::::::::::::::::::::. : NP_703 FGGANHGGYMNAGAGYGSYGYGGNSATAGYTGFV 660 670 680 690 730 740 750 760 770 780 pF1KB8 YQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKG >>XP_016882253 (OMIM: 603182) PREDICTED: interleukin enh (633 aa) initn: 4354 init1: 4354 opt: 4354 Z-score: 2329.9 bits: 441.8 E(85289): 4.9e-123 Smith-Waterman score: 4354; 100.0% identity (100.0% similar) in 633 aa overlap (266-898:1-633) 240 250 260 270 280 290 pF1KB8 LCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPC :::::::::::::::::::::::::::::: XP_016 MGAGEALRRVLECLASGIVMPDGSGIYDPC 10 20 30 300 310 320 330 340 350 pF1KB8 EKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDY 40 50 60 70 80 90 360 370 380 390 400 410 pF1KB8 TVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPG 100 110 120 130 140 150 420 430 440 450 460 470 pF1KB8 LQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRD 160 170 180 190 200 210 480 490 500 510 520 530 pF1KB8 SSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVKQQGPILTKHGKNPVME 220 230 240 250 260 270 540 550 560 570 580 590 pF1KB8 LNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPD 280 290 300 310 320 330 600 610 620 630 640 650 pF1KB8 TPLALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPLALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGR 340 350 360 370 380 390 660 670 680 690 700 710 pF1KB8 GRGRGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRGRGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSS 400 410 420 430 440 450 720 730 740 750 760 770 pF1KB8 GYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQ 460 470 480 490 500 510 780 790 800 810 820 830 pF1KB8 GKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPG 520 530 540 550 560 570 840 850 860 870 880 890 pF1KB8 SHGGYGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHGGYGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNY 580 590 600 610 620 630 pF1KB8 QYR ::: XP_016 QYR 898 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:50:35 2016 done: Sat Nov 5 18:50:37 2016 Total Scan time: 15.680 Total Display time: 0.300 Function used was FASTA [36.3.4 Apr, 2011]