FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8576, 186 aa 1>>>pF1KB8576 186 - 186 aa - 186 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.4006+/-0.000392; mu= 18.5225+/- 0.025 mean_var=85.9536+/-18.574, 0's: 0 Z-trim(113.3): 239 B-trim: 630 in 1/49 Lambda= 0.138338 statistics sampled from 22259 (22588) to 22259 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.265), width: 16 Scan time: 5.740 The best scores are: opt bits E(85289) XP_016862800 (OMIM: 209900,268000,600151,608845,61 ( 186) 1215 252.0 4e-67 NP_001265222 (OMIM: 209900,268000,600151,608845,61 ( 186) 1215 252.0 4e-67 NP_816931 (OMIM: 209900,268000,600151,608845,61357 ( 186) 1215 252.0 4e-67 NP_115522 (OMIM: 209900,268000,600151,608845,61357 ( 186) 1215 252.0 4e-67 NP_001310442 (OMIM: 209900,268000,600151,608845,61 ( 193) 1173 243.7 1.4e-64 XP_016862801 (OMIM: 209900,268000,600151,608845,61 ( 159) 1032 215.4 3.6e-56 NP_001310443 (OMIM: 209900,268000,600151,608845,61 ( 159) 1032 215.4 3.6e-56 XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 181) 467 102.7 3.4e-22 NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 ( 181) 467 102.7 3.4e-22 NP_001019399 (OMIM: 103180) ADP-ribosylation facto ( 181) 463 101.9 5.9e-22 NP_001019398 (OMIM: 103180) ADP-ribosylation facto ( 181) 463 101.9 5.9e-22 NP_001019397 (OMIM: 103180) ADP-ribosylation facto ( 181) 463 101.9 5.9e-22 NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 ( 181) 463 101.9 5.9e-22 NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 ( 175) 443 97.9 9.3e-21 NP_001651 (OMIM: 601177) ADP-ribosylation factor 4 ( 180) 436 96.5 2.5e-20 NP_001653 (OMIM: 103188) ADP-ribosylation factor 5 ( 180) 423 93.9 1.5e-19 NP_848930 (OMIM: 608909) ADP-ribosylation factor-l ( 179) 422 93.7 1.7e-19 NP_004302 (OMIM: 604695) ADP-ribosylation factor-l ( 182) 421 93.6 2e-19 XP_016871749 (OMIM: 604695) PREDICTED: ADP-ribosyl ( 182) 421 93.6 2e-19 NP_036229 (OMIM: 608960) ADP-ribosylation factor-l ( 179) 420 93.3 2.3e-19 XP_005248554 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 398) 422 94.2 2.8e-19 NP_001647 (OMIM: 601747) E3 ubiquitin-protein liga ( 574) 422 94.4 3.5e-19 NP_001168 (OMIM: 603425) ADP-ribosylation factor-l ( 181) 411 91.6 7.9e-19 NP_001658 (OMIM: 601175) ADP-ribosylation factor-l ( 184) 401 89.6 3.2e-18 NP_001032241 (OMIM: 604786) ADP-ribosylation facto ( 200) 382 85.8 4.6e-17 NP_005729 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 382 85.8 4.6e-17 NP_997625 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 382 85.8 4.6e-17 NP_001182325 (OMIM: 604786) ADP-ribosylation facto ( 200) 382 85.8 4.6e-17 XP_005252458 (OMIM: 608909) PREDICTED: ADP-ribosyl ( 142) 378 84.8 6.5e-17 NP_817114 (OMIM: 608960) ADP-ribosylation factor-l ( 142) 367 82.6 3e-16 NP_001032251 (OMIM: 608960) ADP-ribosylation facto ( 142) 367 82.6 3e-16 XP_016864933 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 569) 358 81.6 2.4e-15 NP_150230 (OMIM: 601747) E3 ubiquitin-protein liga ( 569) 358 81.6 2.4e-15 XP_005266310 (OMIM: 609351) PREDICTED: ADP-ribosyl ( 196) 348 79.0 5.1e-15 NP_612459 (OMIM: 609351) ADP-ribosylation factor-l ( 196) 348 79.0 5.1e-15 NP_079323 (OMIM: 614439) ADP-ribosylation factor-l ( 192) 343 78.0 1e-14 NP_150231 (OMIM: 601747) E3 ubiquitin-protein liga ( 546) 341 78.2 2.5e-14 NP_001287997 (OMIM: 603425) ADP-ribosylation facto ( 135) 332 75.6 3.7e-14 NP_878899 (OMIM: 608922,612291) ADP-ribosylation f ( 428) 336 77.1 4.3e-14 NP_001167621 (OMIM: 608922,612291) ADP-ribosylatio ( 428) 336 77.1 4.3e-14 XP_006719454 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 137) 325 74.2 9.8e-14 NP_060654 (OMIM: 616596) ADP-ribosylation factor-l ( 186) 326 74.6 1e-13 XP_011510837 (OMIM: 608922,612291) PREDICTED: ADP- ( 403) 328 75.4 1.2e-13 XP_016856722 (OMIM: 103180) PREDICTED: ADP-ribosyl ( 212) 321 73.7 2.2e-13 NP_005728 (OMIM: 604787) ADP-ribosylation factor-l ( 192) 318 73.0 3.2e-13 NP_001269360 (OMIM: 604787) ADP-ribosylation facto ( 201) 318 73.1 3.3e-13 NP_620150 (OMIM: 616597) ADP-ribosylation factor-l ( 186) 315 72.4 4.7e-13 NP_001652 (OMIM: 600732) ADP-ribosylation factor-l ( 201) 300 69.5 3.9e-12 XP_011523084 (OMIM: 600732) PREDICTED: ADP-ribosyl ( 201) 300 69.5 3.9e-12 XP_011510836 (OMIM: 608922,612291) PREDICTED: ADP- ( 413) 300 69.9 6.1e-12 >>XP_016862800 (OMIM: 209900,268000,600151,608845,613575 (186 aa) initn: 1215 init1: 1215 opt: 1215 Z-score: 1326.1 bits: 252.0 E(85289): 4e-67 Smith-Waterman score: 1215; 99.5% identity (100.0% similar) in 186 aa overlap (1-186:1-186) 10 20 30 40 50 60 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_016 MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ 130 140 150 160 170 180 pF1KB8 IQTVKT :::::: XP_016 IQTVKT >>NP_001265222 (OMIM: 209900,268000,600151,608845,613575 (186 aa) initn: 1215 init1: 1215 opt: 1215 Z-score: 1326.1 bits: 252.0 E(85289): 4e-67 Smith-Waterman score: 1215; 99.5% identity (100.0% similar) in 186 aa overlap (1-186:1-186) 10 20 30 40 50 60 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_001 MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ 130 140 150 160 170 180 pF1KB8 IQTVKT :::::: NP_001 IQTVKT >>NP_816931 (OMIM: 209900,268000,600151,608845,613575) A (186 aa) initn: 1215 init1: 1215 opt: 1215 Z-score: 1326.1 bits: 252.0 E(85289): 4e-67 Smith-Waterman score: 1215; 99.5% identity (100.0% similar) in 186 aa overlap (1-186:1-186) 10 20 30 40 50 60 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_816 MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_816 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_816 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ 130 140 150 160 170 180 pF1KB8 IQTVKT :::::: NP_816 IQTVKT >>NP_115522 (OMIM: 209900,268000,600151,608845,613575) A (186 aa) initn: 1215 init1: 1215 opt: 1215 Z-score: 1326.1 bits: 252.0 E(85289): 4e-67 Smith-Waterman score: 1215; 99.5% identity (100.0% similar) in 186 aa overlap (1-186:1-186) 10 20 30 40 50 60 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_115 MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ 130 140 150 160 170 180 pF1KB8 IQTVKT :::::: NP_115 IQTVKT >>NP_001310442 (OMIM: 209900,268000,600151,608845,613575 (193 aa) initn: 1187 init1: 1171 opt: 1173 Z-score: 1280.6 bits: 243.7 E(85289): 1.4e-64 Smith-Waterman score: 1173; 97.3% identity (99.5% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_001 MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.. NP_001 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQEK 130 140 150 160 170 180 pF1KB8 -IQTVKT ::. NP_001 TIQSDPDCEDMKR 190 >>XP_016862801 (OMIM: 209900,268000,600151,608845,613575 (159 aa) initn: 1032 init1: 1032 opt: 1032 Z-score: 1129.5 bits: 215.4 E(85289): 3.6e-56 Smith-Waterman score: 1032; 99.4% identity (100.0% similar) in 159 aa overlap (1-159:1-159) 10 20 30 40 50 60 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_016 MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ ::::::::::::::::::::::::::::::::::::::: XP_016 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHI 130 140 150 pF1KB8 IQTVKT >>NP_001310443 (OMIM: 209900,268000,600151,608845,613575 (159 aa) initn: 1032 init1: 1032 opt: 1032 Z-score: 1129.5 bits: 215.4 E(85289): 3.6e-56 Smith-Waterman score: 1032; 99.4% identity (100.0% similar) in 159 aa overlap (1-159:1-159) 10 20 30 40 50 60 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_001 MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ ::::::::::::::::::::::::::::::::::::::: NP_001 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHI 130 140 150 pF1KB8 IQTVKT >>XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosylatio (181 aa) initn: 475 init1: 229 opt: 467 Z-score: 519.4 bits: 102.7 E(85289): 3.4e-22 Smith-Waterman score: 467; 41.9% identity (75.4% similar) in 179 aa overlap (7-185:9-181) 10 20 30 40 50 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKF :. :.: :::.. : .::: .:::::. ::: .. . .:::::..: XP_005 MGNIFGNLLKSLIG--KKEMRILMVGLDAAGKTTILYKLKLGEIVTT--IPTIGFNVETV 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 KSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDI . ...::::.:..:: . : ::.::... :..:::.::.:: :. :.::: .: . .. XP_005 EYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDEL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 KHRRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQ : .: ::::.:: .:........ : :.... . :.: :. : .:.:: ::.::: XP_005 --RDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLA 120 130 140 150 160 170 180 pF1KB8 DQIQTVKT .:... : XP_005 NQLKNKK 180 >>NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 [Ho (181 aa) initn: 475 init1: 229 opt: 467 Z-score: 519.4 bits: 102.7 E(85289): 3.4e-22 Smith-Waterman score: 467; 41.9% identity (75.4% similar) in 179 aa overlap (7-185:9-181) 10 20 30 40 50 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKF :. :.: :::.. : .::: .:::::. ::: .. . .:::::..: NP_001 MGNIFGNLLKSLIG--KKEMRILMVGLDAAGKTTILYKLKLGEIVTT--IPTIGFNVETV 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 KSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDI . ...::::.:..:: . : ::.::... :..:::.::.:: :. :.::: .: . .. NP_001 EYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDEL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 KHRRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQ : .: ::::.:: .:........ : :.... . :.: :. : .:.:: ::.::: NP_001 --RDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLA 120 130 140 150 160 170 180 pF1KB8 DQIQTVKT .:... : NP_001 NQLKNKK 180 >>NP_001019399 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 475 init1: 229 opt: 463 Z-score: 515.1 bits: 101.9 E(85289): 5.9e-22 Smith-Waterman score: 463; 42.1% identity (76.6% similar) in 171 aa overlap (15-185:15-181) 10 20 30 40 50 60 pF1KB8 MGLLDRLSVLLGLKKKEVHALCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKS :::.. : .::: .:::::. ::: .. . .:::::..: . NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTT--IPTIGFNVETVEY 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 SSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKH ...::::.:..:: . : ::.::... :..:::.::.:: :. :.::: .: . .. NP_001 KNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDEL-- 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 RRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQ : .: ::::.:: .:........ : :.... . :.: :. : .:.:: ::.:::..: NP_001 RDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQ 120 130 140 150 160 170 pF1KB8 IQTVKT ... : NP_001 LRNQK 180 186 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:29:25 2016 done: Fri Nov 4 13:29:26 2016 Total Scan time: 5.740 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]