FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8585, 796 aa 1>>>pF1KB8585 796 - 796 aa - 796 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2565+/-0.000459; mu= 21.3042+/- 0.029 mean_var=77.4236+/-17.195, 0's: 0 Z-trim(109.3): 46 B-trim: 1050 in 1/50 Lambda= 0.145760 statistics sampled from 17475 (17481) to 17475 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.551), E-opt: 0.2 (0.205), width: 16 Scan time: 11.870 The best scores are: opt bits E(85289) NP_060676 (OMIM: 601501,614203) vacuolar protein s ( 796) 5201 1104.2 0 XP_011521529 (OMIM: 601501,614203) PREDICTED: vacu ( 767) 5016 1065.3 0 XP_005256102 (OMIM: 601501,614203) PREDICTED: vacu ( 729) 4771 1013.8 0 >>NP_060676 (OMIM: 601501,614203) vacuolar protein sorti (796 aa) initn: 5201 init1: 5201 opt: 5201 Z-score: 5909.1 bits: 1104.2 E(85289): 0 Smith-Waterman score: 5201; 99.9% identity (100.0% similar) in 796 aa overlap (1-796:1-796) 10 20 30 40 50 60 pF1KB8 MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDSLKHASNMLGELRTSMLSP :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: NP_060 MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 KSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 DFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 IVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 IVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIII 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 ALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 CYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 CYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 FHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 FHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 PEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 FRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 FRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 TVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 LKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 IEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 IEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLR 730 740 750 760 770 780 790 pF1KB8 RESPESEGPIYEGLIL :::::::::::::::: NP_060 RESPESEGPIYEGLIL 790 >>XP_011521529 (OMIM: 601501,614203) PREDICTED: vacuolar (767 aa) initn: 5016 init1: 5016 opt: 5016 Z-score: 5699.1 bits: 1065.3 E(85289): 0 Smith-Waterman score: 5016; 99.9% identity (100.0% similar) in 767 aa overlap (30-796:1-767) 10 20 30 40 50 60 pF1KB8 MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDSLKHASNMLGELRTSMLSP ::::::::::::.:::::::::::::::::: XP_011 MKRCLDKNKLMDALKHASNMLGELRTSMLSP 10 20 30 70 80 90 100 110 120 pF1KB8 KSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVK 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 SFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSM 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 DFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 IVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIII 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 ALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMK 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB8 CYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKH 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB8 FHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPD 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB8 PEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLA 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB8 FRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHE 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB8 TVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKL 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB8 LKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLF 640 650 660 670 680 690 730 740 750 760 770 780 pF1KB8 IEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLR 700 710 720 730 740 750 790 pF1KB8 RESPESEGPIYEGLIL :::::::::::::::: XP_011 RESPESEGPIYEGLIL 760 >>XP_005256102 (OMIM: 601501,614203) PREDICTED: vacuolar (729 aa) initn: 4771 init1: 4771 opt: 4771 Z-score: 5420.9 bits: 1013.8 E(85289): 0 Smith-Waterman score: 4771; 100.0% identity (100.0% similar) in 729 aa overlap (68-796:1-729) 40 50 60 70 80 90 pF1KB8 KLMDSLKHASNMLGELRTSMLSPKSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYEL :::::::::::::::::::::::::::::: XP_005 MAISDELHYLEVYLTDEFAKGRKVADLYEL 10 20 30 100 110 120 130 140 150 pF1KB8 VQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCT 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB8 RNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELR 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB8 ILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQ 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB8 TLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQ 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB8 SRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKE 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB8 LTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQV 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB8 DSIMNLVSTLIQDQPDQPVEDPDPEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSIMNLVSTLIQDQPDQPVEDPDPEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHF 400 410 420 430 440 450 520 530 540 550 560 570 pF1KB8 GAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELA 460 470 480 490 500 510 580 590 600 610 620 630 pF1KB8 ELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFER 520 530 540 550 560 570 640 650 660 670 680 690 pF1KB8 MKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVM 580 590 600 610 620 630 700 710 720 730 740 750 pF1KB8 ECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNL 640 650 660 670 680 690 760 770 780 790 pF1KB8 ESSEETEQINKHFHNTLEHLRLRRESPESEGPIYEGLIL ::::::::::::::::::::::::::::::::::::::: XP_005 ESSEETEQINKHFHNTLEHLRLRRESPESEGPIYEGLIL 700 710 720 796 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:33:19 2016 done: Fri Nov 4 13:33:20 2016 Total Scan time: 11.870 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]