FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8607, 686 aa 1>>>pF1KB8607 686 - 686 aa - 686 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8815+/-0.000369; mu= 21.8958+/- 0.023 mean_var=60.6387+/-12.253, 0's: 0 Z-trim(113.6): 100 B-trim: 236 in 1/55 Lambda= 0.164702 statistics sampled from 22862 (22973) to 22862 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.269), width: 16 Scan time: 9.890 The best scores are: opt bits E(85289) NP_694999 (OMIM: 612879) MAM domain-containing pro ( 686) 4703 1126.3 0 XP_011516773 (OMIM: 612879) PREDICTED: MAM domain- ( 583) 3790 909.3 0 XP_016870076 (OMIM: 612879) PREDICTED: MAM domain- ( 566) 3787 908.6 0 XP_011516777 (OMIM: 612879) PREDICTED: MAM domain- ( 551) 3782 907.4 0 XP_011514857 (OMIM: 602372) PREDICTED: zonadhesin (2498) 367 96.4 1.4e-18 NP_775082 (OMIM: 602372) zonadhesin isoform 6 prec (2721) 367 96.4 1.5e-18 NP_003377 (OMIM: 602372) zonadhesin isoform 3 prec (2812) 367 96.4 1.6e-18 NP_705691 (OMIM: 609626) MAM domain-containing gly ( 955) 333 88.0 1.8e-16 XP_016866223 (OMIM: 609626) PREDICTED: MAM domain- ( 961) 333 88.0 1.8e-16 XP_006715119 (OMIM: 609626) PREDICTED: MAM domain- ( 973) 333 88.0 1.8e-16 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 293 78.5 1.4e-13 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 293 78.5 1.4e-13 XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 293 78.5 1.4e-13 XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 293 78.5 1.4e-13 XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 293 78.5 1.4e-13 XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 293 78.5 1.4e-13 XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 293 78.5 1.4e-13 XP_006717585 (OMIM: 602069) PREDICTED: neuropilin- ( 907) 270 73.0 5.5e-12 XP_006717587 (OMIM: 602069) PREDICTED: neuropilin- ( 889) 262 71.1 2e-11 NP_001231901 (OMIM: 602069) neuropilin-1 isoform d ( 917) 260 70.7 2.9e-11 XP_006717584 (OMIM: 602069) PREDICTED: neuropilin- ( 924) 260 70.7 2.9e-11 XP_016872354 (OMIM: 602069) PREDICTED: neuropilin- ( 899) 258 70.2 4e-11 NP_001316997 (OMIM: 602069) neuropilin-1 isoform f ( 906) 258 70.2 4e-11 XP_011534827 (OMIM: 611128) PREDICTED: MAM domain- ( 516) 251 68.4 8e-11 XP_016876549 (OMIM: 611128) PREDICTED: MAM domain- ( 571) 251 68.4 8.7e-11 NP_878250 (OMIM: 611128) MAM domain-containing gly ( 727) 251 68.4 1.1e-10 NP_001106970 (OMIM: 611128) MAM domain-containing ( 956) 251 68.5 1.3e-10 XP_011534821 (OMIM: 611128) PREDICTED: MAM domain- ( 980) 251 68.5 1.3e-10 XP_006717588 (OMIM: 602069) PREDICTED: neuropilin- ( 888) 250 68.3 1.5e-10 XP_016872355 (OMIM: 602069) PREDICTED: neuropilin- ( 742) 248 67.7 1.8e-10 NP_001231902 (OMIM: 602069) neuropilin-1 isoform e ( 916) 248 67.8 2.1e-10 NP_003864 (OMIM: 602069) neuropilin-1 isoform a pr ( 923) 248 67.8 2.1e-10 NP_003863 (OMIM: 602070) neuropilin-2 isoform 2 pr ( 926) 233 64.2 2.5e-09 XP_016860674 (OMIM: 602070) PREDICTED: neuropilin- ( 926) 233 64.2 2.5e-09 XP_016860677 (OMIM: 602070) PREDICTED: neuropilin- ( 848) 224 62.1 1e-08 NP_958436 (OMIM: 602070) neuropilin-2 isoform 3 pr ( 909) 222 61.6 1.5e-08 XP_016860676 (OMIM: 602070) PREDICTED: neuropilin- ( 853) 219 60.9 2.3e-08 NP_957719 (OMIM: 602070) neuropilin-2 isoform 5 pr ( 901) 219 60.9 2.4e-08 XP_016860675 (OMIM: 602070) PREDICTED: neuropilin- ( 901) 219 60.9 2.4e-08 NP_061004 (OMIM: 602070) neuropilin-2 isoform 4 pr ( 906) 219 60.9 2.5e-08 XP_005246990 (OMIM: 602070) PREDICTED: neuropilin- ( 931) 219 60.9 2.5e-08 NP_957718 (OMIM: 602070) neuropilin-2 isoform 1 pr ( 931) 219 60.9 2.5e-08 XP_005246991 (OMIM: 602070) PREDICTED: neuropilin- ( 931) 219 60.9 2.5e-08 XP_016881389 (OMIM: 176888) PREDICTED: receptor-ty (1472) 220 61.3 3.1e-08 XP_016881387 (OMIM: 176888) PREDICTED: receptor-ty (1481) 220 61.3 3.1e-08 XP_016881386 (OMIM: 176888) PREDICTED: receptor-ty (1485) 220 61.3 3.1e-08 XP_016881385 (OMIM: 176888) PREDICTED: receptor-ty (1489) 220 61.3 3.1e-08 XP_016881384 (OMIM: 176888) PREDICTED: receptor-ty (1498) 220 61.3 3.1e-08 XP_016881383 (OMIM: 176888) PREDICTED: receptor-ty (1502) 220 61.3 3.1e-08 XP_016883102 (OMIM: 608712) PREDICTED: receptor-ty (1436) 219 61.0 3.5e-08 >>NP_694999 (OMIM: 612879) MAM domain-containing protein (686 aa) initn: 4703 init1: 4703 opt: 4703 Z-score: 6030.7 bits: 1126.3 E(85289): 0 Smith-Waterman score: 4703; 99.9% identity (100.0% similar) in 686 aa overlap (1-686:1-686) 10 20 30 40 50 60 pF1KB8 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFNAPYPME :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: NP_694 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 GPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 GPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVY 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 LKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 LKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQ 610 620 630 640 650 660 670 680 pF1KB8 AGPCGEMEDTTQQSSGYSEDLNEIEY :::::::::::::::::::::::::: NP_694 AGPCGEMEDTTQQSSGYSEDLNEIEY 670 680 >>XP_011516773 (OMIM: 612879) PREDICTED: MAM domain-cont (583 aa) initn: 3893 init1: 3788 opt: 3790 Z-score: 4859.2 bits: 909.3 E(85289): 0 Smith-Waterman score: 3790; 97.7% identity (98.9% similar) in 563 aa overlap (1-563:1-559) 10 20 30 40 50 60 pF1KB8 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFNAPYPME :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: XP_011 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 GPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVY :::::::::.. .. ::.. XP_011 GPKGDHTTGMAAFLL----HMAFPLCQCTPDMYLLVSSPVIMNYSPP 550 560 570 580 >>XP_016870076 (OMIM: 612879) PREDICTED: MAM domain-cont (566 aa) initn: 3787 init1: 3787 opt: 3787 Z-score: 4855.6 bits: 908.6 E(85289): 0 Smith-Waterman score: 3787; 99.8% identity (100.0% similar) in 550 aa overlap (1-550:1-550) 10 20 30 40 50 60 pF1KB8 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFNAPYPME :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: XP_016 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 GPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVY :::::::::: XP_016 GPKGDHTTGVWQLKVQDQDVGRVGSF 550 560 >>XP_011516777 (OMIM: 612879) PREDICTED: MAM domain-cont (551 aa) initn: 3782 init1: 3782 opt: 3782 Z-score: 4849.3 bits: 907.4 E(85289): 0 Smith-Waterman score: 3782; 99.8% identity (100.0% similar) in 549 aa overlap (1-549:1-549) 10 20 30 40 50 60 pF1KB8 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFNAPYPME :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: XP_011 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 GPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVY ::::::::: XP_011 GPKGDHTTGFK 550 >>XP_011514857 (OMIM: 602372) PREDICTED: zonadhesin isof (2498 aa) initn: 254 init1: 114 opt: 367 Z-score: 454.4 bits: 96.4 E(85289): 1.4e-18 Smith-Waterman score: 448; 24.9% identity (51.7% similar) in 522 aa overlap (169-664:40-534) 140 150 160 170 180 190 pF1KB8 FKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENH--LCGFVNRWNPNVNWFVGGGS .::::.. :: . . . .: ..: XP_011 LLVGAALFRKEKPPDQKLVVRSSRDNYVLTQCDFEDDAKPLCDWSQVSADDEDWVRASGP 10 20 30 40 50 60 200 210 220 230 240 250 pF1KB8 IRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSF---YYQI . . : . . : :....: : ::.:.:: :. : .. . XP_011 SPTGSTGAPGG--YPNGEGSYLHMESNSF-HRGGVARLLSPDLWEQGPLCVHFAHHMFGL 70 80 90 100 110 120 260 270 280 290 300 310 pF1KB8 QQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFNAPYPMEVIFEVAFNGPKGG . : . . : . . . . .:: .: :. : : . . . .. :.: .:. XP_011 SWGAQLRLLLLSGEEGRRPDVLWKHWNTQRPSWMLTTVTVPAGFTLPT--RLMFEGTRGS 130 140 150 160 170 180 320 330 340 350 360 pF1KB8 Y----VALDDISFSPVHCQNQTELLFSAVEASCNFE--QDLCNF--YQDKEGPGWTRVKV .::: .:. : :.. .. .:.:. .:::.. : ::. : XP_011 TAYLDIALDALSIRRGSC-NRVCMM-----QTCSFDIPNDLCDWTWIPTASGAKWTQKKG 190 200 210 220 230 370 380 390 400 410 pF1KB8 ---KPNMYRAGDHTT-GLGYYLLANTKFTSQPGYIGRLYGP-SLP-GNLQYCLRFHYAIY ::.. :: .. : : :.: . : ...:: . : .: :: : :.. ::: . XP_011 SSGKPGVGPDGDFSSPGSGCYMLLDPK-NARPGQKAVLLSPVSLSSGCLSF--SFHYILR 240 250 260 270 280 290 420 430 440 450 460 470 pF1KB8 GFLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFW : . . .: .: . . .. ..: .: :. . ... . . ... . XP_011 G-QSPGAALHIYASVLGSIRKHTLFSGQPGPN--WQAVSVNYTAVGRIQFAVVGVFGKTP 300 310 320 330 340 350 480 490 500 510 520 530 pF1KB8 DCGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDE---CTFTQEKRNRSSWHRRRGETP . ::.: .: . :. : .: .: ::.. : ..: . . . : . . : XP_011 E-PAVAVDATSI--APCG--EGFP----QCDFEDNAHPFCDWVQTSGDGGHWALGHKNGP 360 370 380 390 400 540 550 560 570 580 590 pF1KB8 TSYTGPKGDHTTGVGYYMYIEASHMVY-GQKARLLSRPLRGVSGKHCLTFFYHMYGGGTG . :: : .. :.:.:.::... ::..::.:::. . : :. : ::::: : : XP_011 VHGMGPAGGFPNAGGHYIYLEADEFSQAGQSVRLVSRPF-CAPGDICVEFAYHMYGLGEG 410 420 430 440 450 460 600 610 620 630 640 650 pF1KB8 -LLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQH--QIIFEAIRGVSIRSDI .: . : . : ::.: : : : . . .:. :.::..:.: . : . XP_011 TMLELLLGSPAGSPPIPLWKRVGSQRPYWQNTSVTVPSGHQQPMQLIFKGIQGSNTASVV 470 480 490 500 510 520 660 670 680 pF1KB8 AIDDVKFQAGPCGEMEDTTQQSSGYSEDLNEIEY :. . .. : : XP_011 AMGFILINPGTCPVKVLPELPPVSPVSSTGPSETTGLTENPTISTKKPTVSIEKPSVTTE 530 540 550 560 570 580 >>NP_775082 (OMIM: 602372) zonadhesin isoform 6 precurso (2721 aa) initn: 254 init1: 114 opt: 367 Z-score: 453.8 bits: 96.4 E(85289): 1.5e-18 Smith-Waterman score: 448; 24.9% identity (51.7% similar) in 522 aa overlap (169-664:40-534) 140 150 160 170 180 190 pF1KB8 FKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENH--LCGFVNRWNPNVNWFVGGGS .::::.. :: . . . .: ..: NP_775 LLVGAALFRKEKPPDQKLVVRSSRDNYVLTQCDFEDDAKPLCDWSQVSADDEDWVRASGP 10 20 30 40 50 60 200 210 220 230 240 250 pF1KB8 IRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSF---YYQI . . : . . : :....: : ::.:.:: :. : .. . NP_775 SPTGSTGAPGG--YPNGEGSYLHMESNSF-HRGGVARLLSPDLWEQGPLCVHFAHHMFGL 70 80 90 100 110 120 260 270 280 290 300 310 pF1KB8 QQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFNAPYPMEVIFEVAFNGPKGG . : . . : . . . . .:: .: :. : : . . . .. :.: .:. NP_775 SWGAQLRLLLLSGEEGRRPDVLWKHWNTQRPSWMLTTVTVPAGFTLPT--RLMFEGTRGS 130 140 150 160 170 180 320 330 340 350 360 pF1KB8 Y----VALDDISFSPVHCQNQTELLFSAVEASCNFE--QDLCNF--YQDKEGPGWTRVKV .::: .:. : :.. .. .:.:. .:::.. : ::. : NP_775 TAYLDIALDALSIRRGSC-NRVCMM-----QTCSFDIPNDLCDWTWIPTASGAKWTQKKG 190 200 210 220 230 370 380 390 400 410 pF1KB8 ---KPNMYRAGDHTT-GLGYYLLANTKFTSQPGYIGRLYGP-SLP-GNLQYCLRFHYAIY ::.. :: .. : : :.: . : ...:: . : .: :: : :.. ::: . NP_775 SSGKPGVGPDGDFSSPGSGCYMLLDPK-NARPGQKAVLLSPVSLSSGCLSF--SFHYILR 240 250 260 270 280 290 420 430 440 450 460 470 pF1KB8 GFLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFW : . . .: .: . . .. ..: .: :. . ... . . ... . NP_775 G-QSPGAALHIYASVLGSIRKHTLFSGQPGPN--WQAVSVNYTAVGRIQFAVVGVFGKTP 300 310 320 330 340 350 480 490 500 510 520 530 pF1KB8 DCGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDE---CTFTQEKRNRSSWHRRRGETP . ::.: .: . :. : .: .: ::.. : ..: . . . : . . : NP_775 E-PAVAVDATSI--APCG--EGFP----QCDFEDNAHPFCDWVQTSGDGGHWALGHKNGP 360 370 380 390 400 540 550 560 570 580 590 pF1KB8 TSYTGPKGDHTTGVGYYMYIEASHMVY-GQKARLLSRPLRGVSGKHCLTFFYHMYGGGTG . :: : .. :.:.:.::... ::..::.:::. . : :. : ::::: : : NP_775 VHGMGPAGGFPNAGGHYIYLEADEFSQAGQSVRLVSRPF-CAPGDICVEFAYHMYGLGEG 410 420 430 440 450 460 600 610 620 630 640 650 pF1KB8 -LLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQH--QIIFEAIRGVSIRSDI .: . : . : ::.: : : : . . .:. :.::..:.: . : . NP_775 TMLELLLGSPAGSPPIPLWKRVGSQRPYWQNTSVTVPSGHQQPMQLIFKGIQGSNTASVV 470 480 490 500 510 520 660 670 680 pF1KB8 AIDDVKFQAGPCGEMEDTTQQSSGYSEDLNEIEY :. . .. : : NP_775 AMGFILINPGTCPVKVLPELPPVSPVSSTGPSETTGLTENPTISTKKPTVSIEKPSVTTE 530 540 550 560 570 580 >>NP_003377 (OMIM: 602372) zonadhesin isoform 3 precurso (2812 aa) initn: 254 init1: 114 opt: 367 Z-score: 453.6 bits: 96.4 E(85289): 1.6e-18 Smith-Waterman score: 448; 24.9% identity (51.7% similar) in 522 aa overlap (169-664:40-534) 140 150 160 170 180 190 pF1KB8 FKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENH--LCGFVNRWNPNVNWFVGGGS .::::.. :: . . . .: ..: NP_003 LLVGAALFRKEKPPDQKLVVRSSRDNYVLTQCDFEDDAKPLCDWSQVSADDEDWVRASGP 10 20 30 40 50 60 200 210 220 230 240 250 pF1KB8 IRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSF---YYQI . . : . . : :....: : ::.:.:: :. : .. . NP_003 SPTGSTGAPGG--YPNGEGSYLHMESNSF-HRGGVARLLSPDLWEQGPLCVHFAHHMFGL 70 80 90 100 110 120 260 270 280 290 300 310 pF1KB8 QQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFNAPYPMEVIFEVAFNGPKGG . : . . : . . . . .:: .: :. : : . . . .. :.: .:. NP_003 SWGAQLRLLLLSGEEGRRPDVLWKHWNTQRPSWMLTTVTVPAGFTLPT--RLMFEGTRGS 130 140 150 160 170 180 320 330 340 350 360 pF1KB8 Y----VALDDISFSPVHCQNQTELLFSAVEASCNFE--QDLCNF--YQDKEGPGWTRVKV .::: .:. : :.. .. .:.:. .:::.. : ::. : NP_003 TAYLDIALDALSIRRGSC-NRVCMM-----QTCSFDIPNDLCDWTWIPTASGAKWTQKKG 190 200 210 220 230 370 380 390 400 410 pF1KB8 ---KPNMYRAGDHTT-GLGYYLLANTKFTSQPGYIGRLYGP-SLP-GNLQYCLRFHYAIY ::.. :: .. : : :.: . : ...:: . : .: :: : :.. ::: . NP_003 SSGKPGVGPDGDFSSPGSGCYMLLDPK-NARPGQKAVLLSPVSLSSGCLSF--SFHYILR 240 250 260 270 280 290 420 430 440 450 460 470 pF1KB8 GFLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFW : . . .: .: . . .. ..: .: :. . ... . . ... . NP_003 G-QSPGAALHIYASVLGSIRKHTLFSGQPGPN--WQAVSVNYTAVGRIQFAVVGVFGKTP 300 310 320 330 340 350 480 490 500 510 520 530 pF1KB8 DCGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDE---CTFTQEKRNRSSWHRRRGETP . ::.: .: . :. : .: .: ::.. : ..: . . . : . . : NP_003 E-PAVAVDATSI--APCG--EGFP----QCDFEDNAHPFCDWVQTSGDGGHWALGHKNGP 360 370 380 390 400 540 550 560 570 580 590 pF1KB8 TSYTGPKGDHTTGVGYYMYIEASHMVY-GQKARLLSRPLRGVSGKHCLTFFYHMYGGGTG . :: : .. :.:.:.::... ::..::.:::. . : :. : ::::: : : NP_003 VHGMGPAGGFPNAGGHYIYLEADEFSQAGQSVRLVSRPF-CAPGDICVEFAYHMYGLGEG 410 420 430 440 450 460 600 610 620 630 640 650 pF1KB8 -LLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQH--QIIFEAIRGVSIRSDI .: . : . : ::.: : : : . . .:. :.::..:.: . : . NP_003 TMLELLLGSPAGSPPIPLWKRVGSQRPYWQNTSVTVPSGHQQPMQLIFKGIQGSNTASVV 470 480 490 500 510 520 660 670 680 pF1KB8 AIDDVKFQAGPCGEMEDTTQQSSGYSEDLNEIEY :. . .. : : NP_003 AMGFILINPGTCPVKVLPELPPVSPVSSTGPSETTGLTENPTISTKKPTVSIEKPSVTTE 530 540 550 560 570 580 >>NP_705691 (OMIM: 609626) MAM domain-containing glycosy (955 aa) initn: 255 init1: 108 opt: 333 Z-score: 416.7 bits: 88.0 E(85289): 1.8e-16 Smith-Waterman score: 333; 37.6% identity (64.2% similar) in 165 aa overlap (509-664:753-916) 480 490 500 510 520 530 pF1KB8 WDCGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDE-CTFTQEKRNRSSWHRRRGET-- : ::... : .::. . .: :. . : NP_705 PYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQN 730 740 750 760 770 780 540 550 560 570 580 590 pF1KB8 P--TSYTGPKGDHT-TGVGYYMYIEASH-MVYGQKARLLSRPLRGVSGK-HCLTFFYHMY : . ::: : . : ::::.::.:. :..:::.: :: ..:.: .:..:::::: NP_705 PKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVS-PLYNASAKFYCVSFFYHMY 790 800 810 820 830 840 600 610 620 630 640 pF1KB8 GGGTGLLSVYLK-KEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIR : : :.. .. ... . .. : :... : .: . : :::::..:: . NP_705 GKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYL 850 860 870 880 890 900 650 660 670 680 pF1KB8 SDIAIDDVKFQAGPCGEMEDTTQQSSGYSEDLNEIEY .::::::: .. : : NP_705 GDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR 910 920 930 940 950 >>XP_016866223 (OMIM: 609626) PREDICTED: MAM domain-cont (961 aa) initn: 255 init1: 108 opt: 333 Z-score: 416.7 bits: 88.0 E(85289): 1.8e-16 Smith-Waterman score: 333; 37.6% identity (64.2% similar) in 165 aa overlap (509-664:753-916) 480 490 500 510 520 530 pF1KB8 WDCGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDE-CTFTQEKRNRSSWHRRRGET-- : ::... : .::. . .: :. . : XP_016 PYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQN 730 740 750 760 770 780 540 550 560 570 580 590 pF1KB8 P--TSYTGPKGDHT-TGVGYYMYIEASH-MVYGQKARLLSRPLRGVSGK-HCLTFFYHMY : . ::: : . : ::::.::.:. :..:::.: :: ..:.: .:..:::::: XP_016 PKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVS-PLYNASAKFYCVSFFYHMY 790 800 810 820 830 840 600 610 620 630 640 pF1KB8 GGGTGLLSVYLK-KEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIR : : :.. .. ... . .. : :... : .: . : :::::..:: . XP_016 GKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYL 850 860 870 880 890 900 650 660 670 680 pF1KB8 SDIAIDDVKFQAGPCGEMEDTTQQSSGYSEDLNEIEY .::::::: .. : : XP_016 GDIAIDDVTLKKGECPRKQTDPNKGARREGVVVMPGSGAPCQSSPQLWGPMAIFLLALQR 910 920 930 940 950 960 >>XP_006715119 (OMIM: 609626) PREDICTED: MAM domain-cont (973 aa) initn: 255 init1: 108 opt: 333 Z-score: 416.6 bits: 88.0 E(85289): 1.8e-16 Smith-Waterman score: 333; 37.6% identity (64.2% similar) in 165 aa overlap (509-664:753-916) 480 490 500 510 520 530 pF1KB8 WDCGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDE-CTFTQEKRNRSSWHRRRGET-- : ::... : .::. . .: :. . : XP_006 PYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQN 730 740 750 760 770 780 540 550 560 570 580 590 pF1KB8 P--TSYTGPKGDHT-TGVGYYMYIEASH-MVYGQKARLLSRPLRGVSGK-HCLTFFYHMY : . ::: : . : ::::.::.:. :..:::.: :: ..:.: .:..:::::: XP_006 PKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVS-PLYNASAKFYCVSFFYHMY 790 800 810 820 830 840 600 610 620 630 640 pF1KB8 GGGTGLLSVYLK-KEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIR : : :.. .. ... . .. : :... : .: . : :::::..:: . XP_006 GKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYL 850 860 870 880 890 900 650 660 670 680 pF1KB8 SDIAIDDVKFQAGPCGEMEDTTQQSSGYSEDLNEIEY .::::::: .. : : XP_006 GDIAIDDVTLKKGECPRKQTDPNKGARREGGGGAESGGSCAWRGFLSVEGGCLGLNRGSE 910 920 930 940 950 960 686 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 01:25:49 2016 done: Sat Nov 5 01:25:51 2016 Total Scan time: 9.890 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]