FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8627, 774 aa 1>>>pF1KB8627 774 - 774 aa - 774 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8560+/-0.000904; mu= 17.4845+/- 0.054 mean_var=76.9491+/-15.567, 0's: 0 Z-trim(106.5): 39 B-trim: 0 in 0/51 Lambda= 0.146208 statistics sampled from 8968 (9000) to 8968 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.276), width: 16 Scan time: 2.950 The best scores are: opt bits E(32554) CCDS10591.1 LOC81691 gene_id:81691|Hs108|chr16 ( 774) 5182 1103.0 0 CCDS45437.1 LOC81691 gene_id:81691|Hs108|chr16 ( 743) 3621 773.8 0 CCDS32866.1 REXO1 gene_id:57455|Hs108|chr19 (1221) 364 86.9 2.2e-16 >>CCDS10591.1 LOC81691 gene_id:81691|Hs108|chr16 (774 aa) initn: 5182 init1: 5182 opt: 5182 Z-score: 5903.1 bits: 1103.0 E(32554): 0 Smith-Waterman score: 5182; 100.0% identity (100.0% similar) in 774 aa overlap (1-774:1-774) 10 20 30 40 50 60 pF1KB8 MEPEREGTERHPRKVRESRQAPNKLVGAAEAMKAGWDLEESQPEAKKARLSTILFTDNCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MEPEREGTERHPRKVRESRQAPNKLVGAAEAMKAGWDLEESQPEAKKARLSTILFTDNCE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VTHDQLCELLKYAVLGKSNVPKPSWCQLFHQNHLNNVVVFVLQGMSQLHFYRFYLEFGCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VTHDQLCELLKYAVLGKSNVPKPSWCQLFHQNHLNNVVVFVLQGMSQLHFYRFYLEFGCL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RKAFRHKFRLPPPSSDFLADVVGLQTEQRAGDLPKTMEGPLPSNAKAAINLQDDPIIQKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 RKAFRHKFRLPPPSSDFLADVVGLQTEQRAGDLPKTMEGPLPSNAKAAINLQDDPIIQKY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GSKKVGLTRCLLTKEEMRTFHFPLQGFPDCENFLLTKCNGSIADNSPLFGLDCEMCLTSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 GSKKVGLTRCLLTKEEMRTFHFPLQGFPDCENFLLTKCNGSIADNSPLFGLDCEMCLTSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GRELTRISLVAEGGCCVMDELVKPENKILDYLTSFSGITKKILNPVTTKLKDVQRQLKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 GRELTRISLVAEGGCCVMDELVKPENKILDYLTSFSGITKKILNPVTTKLKDVQRQLKAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 LPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKVILGKDIQCPDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKVILGKDIQCPDR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LGHDATEDARTILELARYFLKHGPKKIAELNLEALANHQEIQAAGQEPKNTAEVLQHPNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LGHDATEDARTILELARYFLKHGPKKIAELNLEALANHQEIQAAGQEPKNTAEVLQHPNT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 SVLECLDSVGQKLLFLTRETDAGELPSSRNCQTIKCLSNKEVLEQARVEIPLFPFSIVQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 SVLECLDSVGQKLLFLTRETDAGELPSSRNCQTIKCLSNKEVLEQARVEIPLFPFSIVQF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 SFKAFSPVLTEEMNKRMRIKWTEISTVYAGPFSKNCNLRALKRLFKSFGPVQSMTFVLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 SFKAFSPVLTEEMNKRMRIKWTEISTVYAGPFSKNCNLRALKRLFKSFGPVQSMTFVLET 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 RQPHLCIQYEVLEAAQLAIESLDGILVDGICIKVQRPVTELTLDCDTLVNELEGDSENQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 RQPHLCIQYEVLEAAQLAIESLDGILVDGICIKVQRPVTELTLDCDTLVNELEGDSENQG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 SIYLSGVSETFKEQLLQEPRLFLGLEAVILPKDLKSGKQKKYCFLKFKSFGSAQQALNIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 SIYLSGVSETFKEQLLQEPRLFLGLEAVILPKDLKSGKQKKYCFLKFKSFGSAQQALNIL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 TGKDWKLKGRHALTPRHLHAWLRGLPPESTRLPGLRVVPPPFEQEALQTLKLDHPKIAAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 TGKDWKLKGRHALTPRHLHAWLRGLPPESTRLPGLRVVPPPFEQEALQTLKLDHPKIAAW 670 680 690 700 710 720 730 740 750 760 770 pF1KB8 RWSRKIGKLYNSLCPGTLCLILLPGTKSTHGSLSGLGLMGIKEEEESAGPGLCS :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 RWSRKIGKLYNSLCPGTLCLILLPGTKSTHGSLSGLGLMGIKEEEESAGPGLCS 730 740 750 760 770 >>CCDS45437.1 LOC81691 gene_id:81691|Hs108|chr16 (743 aa) initn: 3618 init1: 3618 opt: 3621 Z-score: 4123.8 bits: 773.8 E(32554): 0 Smith-Waterman score: 4906; 96.0% identity (96.0% similar) in 774 aa overlap (1-774:1-743) 10 20 30 40 50 60 pF1KB8 MEPEREGTERHPRKVRESRQAPNKLVGAAEAMKAGWDLEESQPEAKKARLSTILFTDNCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MEPEREGTERHPRKVRESRQAPNKLVGAAEAMKAGWDLEESQPEAKKARLSTILFTDNCE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VTHDQLCELLKYAVLGKSNVPKPSWCQLFHQNHLNNVVVFVLQGMSQLHFYRFYLEFGCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VTHDQLCELLKYAVLGKSNVPKPSWCQLFHQNHLNNVVVFVLQGMSQLHFYRFYLEFGCL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RKAFRHKFRLPPPSSDFLADVVGLQTEQRAGDLPKTMEGPLPSNAKAAINLQDDPIIQKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 RKAFRHKFRLPPPSSDFLADVVGLQTEQRAGDLPKTMEGPLPSNAKAAINLQDDPIIQKY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GSKKVGLTRCLLTKEEMRTFHFPLQGFPDCENFLLTKCNGSIADNSPLFGLDCEMCLTSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 GSKKVGLTRCLLTKEEMRTFHFPLQGFPDCENFLLTKCNGSIADNSPLFGLDCEMCLTSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GRELTRISLVAEGGCCVMDELVKPENKILDYLTSFSGITKKILNPVTTKLKDVQRQLKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 GRELTRISLVAEGGCCVMDELVKPENKILDYLTSFSGITKKILNPVTTKLKDVQRQLKAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 LPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKVILGKDIQCPDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKVILGKDIQCPDR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LGHDATEDARTILELARYFLKHGPKKIAELNLEALANHQEIQAAGQEPKNTAEVLQHPNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LGHDATEDARTILELARYFLKHGPKKIAELNLEALANHQEIQAAGQEPKNTAEVLQHPNT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 SVLECLDSVGQKLLFLTRETDAGELPSSRNCQTIKCLSNKEVLEQARVEIPLFPFSIVQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SVLECLDSVGQKLLFLTRETDAGELPSSRNCQTIKCLSNKEVLEQARVEIPLFPFSIVQF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 SFKAFSPVLTEEMNKRMRIKWTEISTVYAGPFSKNCNLRALKRLFKSFGPVQSMTFVLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SFKAFSPVLTEEMNKRMRIKWTEISTVYAGPFSKNCNLRALKRLFKSFGPVQSMTFVLET 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 RQPHLCIQYEVLEAAQLAIESLDGILVDGICIKVQRPVTELTLDCDTLVNELEGDSENQG :: ::::::::::::::::::::::::::: CCDS45 RQ-------------------------------VQRPVTELTLDCDTLVNELEGDSENQG 550 560 610 620 630 640 650 660 pF1KB8 SIYLSGVSETFKEQLLQEPRLFLGLEAVILPKDLKSGKQKKYCFLKFKSFGSAQQALNIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SIYLSGVSETFKEQLLQEPRLFLGLEAVILPKDLKSGKQKKYCFLKFKSFGSAQQALNIL 570 580 590 600 610 620 670 680 690 700 710 720 pF1KB8 TGKDWKLKGRHALTPRHLHAWLRGLPPESTRLPGLRVVPPPFEQEALQTLKLDHPKIAAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TGKDWKLKGRHALTPRHLHAWLRGLPPESTRLPGLRVVPPPFEQEALQTLKLDHPKIAAW 630 640 650 660 670 680 730 740 750 760 770 pF1KB8 RWSRKIGKLYNSLCPGTLCLILLPGTKSTHGSLSGLGLMGIKEEEESAGPGLCS :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 RWSRKIGKLYNSLCPGTLCLILLPGTKSTHGSLSGLGLMGIKEEEESAGPGLCS 690 700 710 720 730 740 >>CCDS32866.1 REXO1 gene_id:57455|Hs108|chr19 (1221 aa) initn: 318 init1: 318 opt: 364 Z-score: 407.6 bits: 86.9 E(32554): 2.2e-16 Smith-Waterman score: 364; 38.8% identity (67.4% similar) in 178 aa overlap (211-385:1042-1218) 190 200 210 220 230 pF1KB8 GSKKVGLTRCLLTKEEMRTFHFPLQGFPDCENFLLTKCNGSIADNSP-LFGLDCEMCLTS :.:. : . .:. : ...::::: :. CCDS32 TQYMCCSAAAGSVGCQVAKQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTT 1020 1030 1040 1050 1060 1070 240 250 260 270 280 290 pF1KB8 KGRELTRISLVAEGGCCVMDELVKPENKILDYLTSFSGITKKILNPVTTKLKDVQRQLKA : ::::...: :.: .:::.:.:.:: : :::.:. : ... :.::: : . CCDS32 YGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLS 1080 1090 1100 1110 1120 1130 300 310 320 330 340 350 pF1KB8 LLPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFK--LKFLAKVILGKDIQC .. :..:.::::. :: :::.:: :.:::.:. .. : .: :. : : . :: CCDS32 MFSADTILIGHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQ- 1140 1150 1160 1170 1180 1190 360 370 380 390 400 410 pF1KB8 PDRLGHDATEDARTILELARYFLKHGPKKIAELNLEALANHQEIQAAGQEPKNTAEVLQH . ::...::: . ..:. . ... : CCDS32 DNVDGHSSSEDAGACMHLVIWKVREDAKTKR 1200 1210 1220 774 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:55:44 2016 done: Fri Nov 4 13:55:45 2016 Total Scan time: 2.950 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]