FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8631, 464 aa 1>>>pF1KB8631 464 - 464 aa - 464 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0367+/-0.000894; mu= 14.0099+/- 0.054 mean_var=76.1797+/-15.093, 0's: 0 Z-trim(107.0): 34 B-trim: 0 in 0/51 Lambda= 0.146945 statistics sampled from 9306 (9335) to 9306 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.287), width: 16 Scan time: 3.020 The best scores are: opt bits E(32554) CCDS45030.1 CCNA1 gene_id:8900|Hs108|chr13 ( 464) 3091 664.8 5.2e-191 CCDS9357.1 CCNA1 gene_id:8900|Hs108|chr13 ( 465) 3079 662.3 3.1e-190 CCDS45031.1 CCNA1 gene_id:8900|Hs108|chr13 ( 421) 2775 597.8 7e-171 CCDS3723.1 CCNA2 gene_id:890|Hs108|chr4 ( 432) 1149 253.1 4.2e-67 CCDS10170.1 CCNB2 gene_id:9133|Hs108|chr15 ( 398) 605 137.8 2e-32 CCDS3997.1 CCNB1 gene_id:891|Hs108|chr5 ( 433) 572 130.8 2.8e-30 CCDS14331.1 CCNB3 gene_id:85417|Hs108|chrX (1395) 526 121.2 6.8e-27 CCDS14332.1 CCNB3 gene_id:85417|Hs108|chrX ( 291) 387 91.5 1.3e-18 CCDS10467.1 CCNF gene_id:899|Hs108|chr16 ( 786) 387 91.7 3.1e-18 CCDS4863.1 CCND3 gene_id:896|Hs108|chr6 ( 292) 337 80.9 2e-15 CCDS12419.1 CCNE1 gene_id:898|Hs108|chr19 ( 410) 331 79.7 6.4e-15 CCDS34157.1 CCNO gene_id:10309|Hs108|chr5 ( 350) 320 77.3 2.8e-14 CCDS6264.1 CCNE2 gene_id:9134|Hs108|chr8 ( 404) 319 77.1 3.7e-14 CCDS8191.1 CCND1 gene_id:595|Hs108|chr11 ( 295) 308 74.7 1.4e-13 CCDS8524.1 CCND2 gene_id:894|Hs108|chr12 ( 289) 291 71.1 1.7e-12 CCDS12551.2 CNTD2 gene_id:79935|Hs108|chr19 ( 307) 288 70.5 2.8e-12 >>CCDS45030.1 CCNA1 gene_id:8900|Hs108|chr13 (464 aa) initn: 3091 init1: 3091 opt: 3091 Z-score: 3542.7 bits: 664.8 E(32554): 5.2e-191 Smith-Waterman score: 3091; 99.8% identity (99.8% similar) in 464 aa overlap (1-464:1-464) 10 20 30 40 50 60 pF1KB8 METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQPVESEAMHCSNPKSGVVLATVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQPVESEAMHCSNPKSGVVLATVAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 GPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GMRTILVDWLVEVGEEYKLRAETLYLAVNFLVRFLSCMSVLRGKLQLVGTAAMLLASKYE ::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::: CCDS45 GMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 EIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 EIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 ENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 ENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVP 370 380 390 400 410 420 430 440 450 460 pF1KB8 CLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ :::::::::::::::::::::::::::::::::::::::::::: CCDS45 CLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ 430 440 450 460 >>CCDS9357.1 CCNA1 gene_id:8900|Hs108|chr13 (465 aa) initn: 2826 init1: 2826 opt: 3079 Z-score: 3528.9 bits: 662.3 E(32554): 3.1e-190 Smith-Waterman score: 3079; 99.6% identity (99.6% similar) in 465 aa overlap (1-464:1-465) 10 20 30 40 50 pF1KB8 METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQ-PVESEAMHCSNPKSGVVLATVA ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::: CCDS93 METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 RGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS93 RGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 ALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS93 ALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 TVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS93 TVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDIT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 EGMRTILVDWLVEVGEEYKLRAETLYLAVNFLVRFLSCMSVLRGKLQLVGTAAMLLASKY :::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: CCDS93 EGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS93 EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVR 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 TENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS93 TENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIV 370 380 390 400 410 420 420 430 440 450 460 pF1KB8 PCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ ::::::::::::::::::::::::::::::::::::::::::::: CCDS93 PCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ 430 440 450 460 >>CCDS45031.1 CCNA1 gene_id:8900|Hs108|chr13 (421 aa) initn: 2775 init1: 2775 opt: 2775 Z-score: 3181.3 bits: 597.8 E(32554): 7e-171 Smith-Waterman score: 2775; 99.8% identity (99.8% similar) in 421 aa overlap (44-464:1-421) 20 30 40 50 60 70 pF1KB8 FIGGWGEEYLSWEGPGLPDFVFQQPVESEAMHCSNPKSGVVLATVARGPDACQILTRAPL :::::::::::::::::::::::::::::: CCDS45 MHCSNPKSGVVLATVARGPDACQILTRAPL 10 20 30 80 90 100 110 120 130 pF1KB8 GQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 GQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQG 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB8 FDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 FDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQ 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB8 SEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEV 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB8 GEEYKLRAETLYLAVNFLVRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYI :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: CCDS45 GEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYI 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB8 TDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLL 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB8 EADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 EADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIP 340 350 360 370 380 390 440 450 460 pF1KB8 HRPQQAIREKYKASKYLCVSLMEPPAVLLLQ ::::::::::::::::::::::::::::::: CCDS45 HRPQQAIREKYKASKYLCVSLMEPPAVLLLQ 400 410 420 >>CCDS3723.1 CCNA2 gene_id:890|Hs108|chr4 (432 aa) initn: 1065 init1: 699 opt: 1149 Z-score: 1318.2 bits: 253.1 E(32554): 4.2e-67 Smith-Waterman score: 1154; 51.6% identity (71.4% similar) in 409 aa overlap (71-463:39-432) 50 60 70 80 90 100 pF1KB8 SEAMHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGI ::. :.: :..:..: . :. : : CCDS37 PATREAGSALLALQQTALQEDQENINPEKAAPV-QQPRTRAALAVLKS-GNPRGLAQQQR 10 20 30 40 50 60 110 120 130 140 150 pF1KB8 TRIRCYSGSENAFPPAGKKALP--DCGVQEPP-----KQ-GFDIYMDELEQGDRDSCSVR . : : : :: : : :: :: .: :..:: :. . . . CCDS37 PKTRRV---------APLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAES 70 80 90 100 110 160 170 180 190 200 pF1KB8 EGMAFEDVYEVDT-----GTLKS--DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVI . . ::. .. : : : . .: . :: .: :.. ..: : : CCDS37 QKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVS----VN 120 130 140 150 160 170 210 220 230 240 250 260 pF1KB8 NVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLY .: .: :.:. :::: :.. .::. :::::::::..::.:::::::::::::::. :::. CCDS37 EVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLH 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB8 LAVNFLVRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLK ::::.. :::: :::::::::::::::::::::.:::::::: ::::::::::::.:.:. CCDS37 LAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLR 240 250 260 270 280 290 330 340 350 360 370 380 pF1KB8 MEHLLLKVLAFDLTVPTTNQFLLQY-LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPS ::::.::::.:::..::.:::: :: :..: . ..:.:: ...::::..:::.:::::: CCDS37 MEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPS 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB8 LIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKY .::.::: :: :::. . :::.: :::.: . ::: .::..:: :.. ::.::::: CCDS37 VIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKY 360 370 380 390 400 410 450 460 pF1KB8 KASKYLCVSLMEPPAVLLLQ : ::: :::..:: .: : CCDS37 KNSKYHGVSLLNPPETLNL 420 430 >>CCDS10170.1 CCNB2 gene_id:9133|Hs108|chr15 (398 aa) initn: 575 init1: 417 opt: 605 Z-score: 695.4 bits: 137.8 E(32554): 2e-32 Smith-Waterman score: 605; 39.3% identity (70.7% similar) in 270 aa overlap (189-455:112-379) 160 170 180 190 200 210 pF1KB8 DVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINV-TEYAEEIYQY .:: . :::.. . .. ..:...:::: CCDS10 QMEKLAPKGPSPTPEDVSMKEENLCQAFSDALLCKIEDIDNEDWENPQLCSDYVKDIYQY 90 100 110 120 130 140 220 230 240 250 260 270 pF1KB8 LREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLVRFLSC ::. :. . . :.. . ::. ::.:::::::.: ...: ::::. :... :::. CCDS10 LRQLEVLQSINPHFLDGR-DINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQV 150 160 170 180 190 200 280 290 300 310 320 330 pF1KB8 MSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFD . : : :::::: .:.::::::::.. :....::::::..::. :. .:: :.:: : :. CCDS10 QPVSRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFE 210 220 230 240 250 260 340 350 360 370 380 390 pF1KB8 LTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYT : : .:: . . : :. ..::::. ::.:.. : ...: :: .:::: ::.. . CCDS10 LGRPLPLHFLRRASKAGEVDVEQHTLAKYLMELTLIDYD-MVHYHPSKVAAAASCLSQKV 270 280 290 300 310 400 410 420 430 440 450 pF1KB8 VNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQ--AIREKYKASKYLCVSLM ... : .:::. .:.. .... : . . . . ::..:: .:: : .:.. CCDS10 LGQGKWNLKQQYYTGYTENEVLEVMQHMAKNVVKVNENLTKFIAIKNKYASSKLLKISMI 320 330 340 350 360 370 460 pF1KB8 EPPAVLLLQ CCDS10 PQLNSKAVKDLASPLIGRS 380 390 >>CCDS3997.1 CCNB1 gene_id:891|Hs108|chr5 (433 aa) initn: 508 init1: 393 opt: 572 Z-score: 657.1 bits: 130.8 E(32554): 2.8e-30 Smith-Waterman score: 572; 36.5% identity (69.2% similar) in 266 aa overlap (201-464:161-424) 180 190 200 210 220 230 pF1KB8 DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAH :.: .::...:: :::. : .. . . CCDS39 ETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPK 140 150 160 170 180 190 240 250 260 270 280 290 pF1KB8 YMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLVRFLSCMSVLRGKLQLVGT :. . ..: .::.::.::::.: ...: ::.:..:... ::.. : . :::::. CCDS39 YLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGV 200 210 220 230 240 300 310 320 330 340 350 pF1KB8 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQY .::..::::::.::::. .:...::.::::.:. .:: .:..: : : : .:: . CCDS39 TAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRA 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB8 LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAF . : :. ..::::. ::..:. : .... :: :::.::::: ... : :: . CCDS39 SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHY 310 320 330 340 350 360 420 430 440 450 460 pF1KB8 TGYSLSEIVPCLSELHKAYLDIPH--RPQQAIREKYKASKYLCVSLMEPPAVLLLQ .:. ..: ...: : . . . ......:: .::. .: . :.: CCDS39 LSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAK 370 380 390 400 410 420 CCDS39 AVAKV 430 >>CCDS14331.1 CCNB3 gene_id:85417|Hs108|chrX (1395 aa) initn: 432 init1: 385 opt: 526 Z-score: 596.3 bits: 121.2 E(32554): 6.8e-27 Smith-Waterman score: 526; 35.1% identity (65.3% similar) in 285 aa overlap (181-464:1099-1379) 160 170 180 190 200 pF1KB8 VREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDS-SLLSQSEDISSLGTDVINVTE :::. . . .. :::. ..: CCDS14 EKSSIATMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPM 1070 1080 1090 1100 1110 1120 210 220 230 240 250 260 pF1KB8 YAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVN ::.::..:..: : .. . ::..: .:: ::.::::::::: ... :::::::. CCDS14 YAKEIFSYMKERE-EQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVK 1130 1140 1150 1160 1170 1180 270 280 290 300 310 320 pF1KB8 FLVRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHL .. .: . ::::.:..:...:.:.:: :.::.:::: ::.: . ..:.:: CCDS14 LVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEIN 1190 1200 1210 1220 1230 1240 330 340 350 360 370 380 pF1KB8 LLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAA .:.:: :...: . .:: .: : . ..: .:..:. :..: : ... : .::: CCDS14 ILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYH-YVQEKASKLAAA 1250 1260 1270 1280 1290 1300 390 400 410 420 430 440 pF1KB8 AFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKY .. :: : . .: : ..:::.::. : . .:.: . .:. ::. . CCDS14 SLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVF 1310 1320 1330 1340 1350 1360 450 460 pF1KB8 LCVSLMEPPAVLLLQ . :. . ::. .:. CCDS14 FEVAKI--PALDMLKLEEILNCDCEAQGLVL 1370 1380 1390 >>CCDS14332.1 CCNB3 gene_id:85417|Hs108|chrX (291 aa) initn: 281 init1: 281 opt: 387 Z-score: 447.8 bits: 91.5 E(32554): 1.3e-18 Smith-Waterman score: 387; 32.2% identity (64.8% similar) in 236 aa overlap (232-464:46-275) 210 220 230 240 250 pF1KB8 TDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGM---RTILVDWLVEVGEEYK ....:. .: :. . : :..:. .. CCDS14 KSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKRSAFED-LTNVS--FE 20 30 40 50 60 70 260 270 280 290 300 310 pF1KB8 LRAETLYLAVNFLVRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTY . :::::::... .: . ::::.:..:...:.:.:: :.::.:::: ::.: CCDS14 MTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNY 80 90 100 110 120 130 320 330 340 350 360 370 pF1KB8 TKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPF . ..:.:: .:.:: :...: . .:: .: : . ..: .:..:. :..: : . CCDS14 QRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYH-Y 140 150 160 170 180 190 380 390 400 410 420 430 pF1KB8 LKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQ .. : .:::.. :: : . .: : ..:::.::. : . .:.: . . CCDS14 VQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLK 200 210 220 230 240 250 440 450 460 pF1KB8 AIREKYKASKYLCVSLMEPPAVLLLQ :. ::. .. :. . ::. .:. CCDS14 AVYYKYSHPVFFEVAKI--PALDMLKLEEILNCDCEAQGLVL 260 270 280 290 >>CCDS10467.1 CCNF gene_id:899|Hs108|chr16 (786 aa) initn: 294 init1: 294 opt: 387 Z-score: 441.0 bits: 91.7 E(32554): 3.1e-18 Smith-Waterman score: 387; 27.4% identity (57.9% similar) in 340 aa overlap (127-456:200-529) 100 110 120 130 140 150 pF1KB8 GQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMA .: .:. :.. . .:: : . . CCDS10 ESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQG----CLTSSYLL 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB8 FEDVYEVDTGTLKSDLH-F--LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEE .:. ..:.. :: : : :. . . .. :: . . ..:: .: .: . . CCDS10 WESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQ 230 240 250 260 270 280 220 230 240 250 260 270 pF1KB8 IYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLVR ..: . . : . .. : ... :: ::.::::::. . . :.:.:. . : CCDS10 LFQASQAVS-----KQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDR 290 300 310 320 330 340 280 290 300 310 320 330 pF1KB8 FLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKV .: : : .:::.: : :.. ... . : :..::.:: ..:..: .... CCDS10 YLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSA 350 360 370 380 390 400 340 350 360 370 380 390 pF1KB8 LAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCL : . :::. .. : : .::..: ... :::::... . : :. .::::. : CCDS10 LEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTS-LSAYAPARLAAAALLL 410 420 430 440 450 400 410 420 430 440 pF1KB8 ANYTVNK-HFWPETLAAFTGYSLSEIVPCLSELHKAYL--DIPHRPQQ----AIREKYKA : : .. . : : .::.: ...::. ::: . : :. .: :...... CCDS10 ARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFED 460 470 480 490 500 510 450 460 pF1KB8 SKYLCVSLMEPPAVLLLQ ..: .: : CCDS10 KRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSLQ 520 530 540 550 560 570 >>CCDS4863.1 CCND3 gene_id:896|Hs108|chr6 (292 aa) initn: 258 init1: 258 opt: 337 Z-score: 390.5 bits: 80.9 E(32554): 2e-15 Smith-Waterman score: 337; 33.2% identity (61.5% similar) in 226 aa overlap (212-428:25-250) 190 200 210 220 230 240 pF1KB8 SPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKK-QPDITE ... : : . : :. :.: :.. : .: CCDS48 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKP 10 20 30 40 50 250 260 270 280 290 300 pF1KB8 GMRTILVDWLVEVGEEYKLRAETLYLAVNFLVRFLSCMSVLRGKLQLVGTAAMLLASKYE :: .:. :..:: :: . . :.. ::.:.: :.:::. . ...:::.:.. :::::: . CCDS48 HMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLR 60 70 80 90 100 110 310 320 330 340 350 360 pF1KB8 EIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRT : : .... :: . . ::: : :.: : .::.. ...:: :.: .. CCDS48 ETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDR 120 130 140 150 160 170 370 380 390 400 410 pF1KB8 ENLAKYVAE--LSLLEAD-PFLKYLPSLIA-----AAAFCLANYTVNKHFWPETLAAFTG . :.: :. :.: .: : : ::.:: ::. :. ... : ::..:: CCDS48 QALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITG 180 190 200 210 220 230 420 430 440 450 460 pF1KB8 YSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ .. . : ... : CCDS48 TEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL 240 250 260 270 280 290 464 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:59:32 2016 done: Fri Nov 4 13:59:32 2016 Total Scan time: 3.020 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]