FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8639, 328 aa 1>>>pF1KB8639 328 - 328 aa - 328 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1512+/-0.000487; mu= 5.9099+/- 0.030 mean_var=130.7891+/-27.073, 0's: 0 Z-trim(111.4): 225 B-trim: 38 in 2/54 Lambda= 0.112147 statistics sampled from 19704 (19980) to 19704 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.585), E-opt: 0.2 (0.234), width: 16 Scan time: 7.020 The best scores are: opt bits E(85289) NP_003847 (OMIM: 601203) interleukin-1 receptor-li ( 328) 2216 370.5 2.7e-102 XP_011510453 (OMIM: 601203) PREDICTED: interleukin ( 328) 2216 370.5 2.7e-102 XP_006712902 (OMIM: 601203) PREDICTED: interleukin ( 556) 2178 364.5 2.9e-100 NP_057316 (OMIM: 601203) interleukin-1 receptor-li ( 556) 2178 364.5 2.9e-100 NP_001269337 (OMIM: 601203) interleukin-1 receptor ( 211) 1428 242.9 4.5e-64 XP_011510106 (OMIM: 147811) PREDICTED: interleukin ( 398) 354 69.3 1.5e-11 XP_006712797 (OMIM: 147811) PREDICTED: interleukin ( 398) 354 69.3 1.5e-11 NP_004624 (OMIM: 147811) interleukin-1 receptor ty ( 398) 354 69.3 1.5e-11 XP_006712799 (OMIM: 147811) PREDICTED: interleukin ( 423) 354 69.3 1.6e-11 XP_011510103 (OMIM: 147811) PREDICTED: interleukin ( 441) 354 69.3 1.6e-11 NP_001275635 (OMIM: 147810) interleukin-1 receptor ( 538) 346 68.1 4.7e-11 NP_001307907 (OMIM: 147810) interleukin-1 receptor ( 569) 346 68.1 5e-11 XP_011509417 (OMIM: 147810) PREDICTED: interleukin ( 569) 346 68.1 5e-11 NP_001307910 (OMIM: 147810) interleukin-1 receptor ( 569) 346 68.1 5e-11 NP_001307909 (OMIM: 147810) interleukin-1 receptor ( 569) 346 68.1 5e-11 XP_011509420 (OMIM: 147810) PREDICTED: interleukin ( 569) 346 68.1 5e-11 NP_001307911 (OMIM: 147810) interleukin-1 receptor ( 569) 346 68.1 5e-11 XP_005263987 (OMIM: 147810) PREDICTED: interleukin ( 569) 346 68.1 5e-11 XP_016859478 (OMIM: 147810) PREDICTED: interleukin ( 569) 346 68.1 5e-11 XP_005263991 (OMIM: 147810) PREDICTED: interleukin ( 569) 346 68.1 5e-11 XP_011509419 (OMIM: 147810) PREDICTED: interleukin ( 569) 346 68.1 5e-11 NP_000868 (OMIM: 147810) interleukin-1 receptor ty ( 569) 346 68.1 5e-11 XP_011509418 (OMIM: 147810) PREDICTED: interleukin ( 569) 346 68.1 5e-11 XP_011510107 (OMIM: 147811) PREDICTED: interleukin ( 378) 318 63.5 8.3e-10 XP_011510105 (OMIM: 147811) PREDICTED: interleukin ( 404) 318 63.5 8.7e-10 XP_011510398 (OMIM: 604512) PREDICTED: interleukin ( 569) 319 63.8 1e-09 NP_003845 (OMIM: 604512) interleukin-1 receptor-li ( 575) 319 63.8 1e-09 XP_005264093 (OMIM: 604512) PREDICTED: interleukin ( 575) 319 63.8 1e-09 XP_011510396 (OMIM: 604512) PREDICTED: interleukin ( 595) 319 63.8 1.1e-09 XP_005264092 (OMIM: 604512) PREDICTED: interleukin ( 603) 319 63.8 1.1e-09 XP_016860663 (OMIM: 604512) PREDICTED: interleukin ( 606) 319 63.8 1.1e-09 XP_011510394 (OMIM: 604512) PREDICTED: interleukin ( 617) 319 63.8 1.1e-09 XP_011510393 (OMIM: 604512) PREDICTED: interleukin ( 622) 313 62.8 2.2e-09 NP_001248348 (OMIM: 147811) interleukin-1 receptor ( 296) 306 61.5 2.6e-09 NP_001161401 (OMIM: 602626) interleukin-1 receptor ( 570) 300 60.7 8.6e-09 NP_001161400 (OMIM: 602626) interleukin-1 receptor ( 570) 300 60.7 8.6e-09 NP_002173 (OMIM: 602626) interleukin-1 receptor ac ( 570) 300 60.7 8.6e-09 XP_016861836 (OMIM: 602626) PREDICTED: interleukin ( 385) 297 60.1 8.8e-09 NP_001161403 (OMIM: 602626) interleukin-1 receptor ( 687) 300 60.7 1e-08 NP_001161402 (OMIM: 602626) interleukin-1 receptor ( 356) 292 59.3 1.5e-08 NP_608273 (OMIM: 602626) interleukin-1 receptor ac ( 356) 292 59.3 1.5e-08 NP_059112 (OMIM: 300277) X-linked interleukin-1 re ( 686) 290 59.1 3.1e-08 XP_016884892 (OMIM: 300277) PREDICTED: X-linked in ( 686) 290 59.1 3.1e-08 XP_016860378 (OMIM: 147811) PREDICTED: interleukin ( 313) 273 56.1 1.1e-07 XP_016884729 (OMIM: 300143,300206) PREDICTED: inte ( 696) 276 56.9 1.5e-07 NP_055086 (OMIM: 300143,300206) interleukin-1 rece ( 696) 276 56.9 1.5e-07 XP_011510109 (OMIM: 147811) PREDICTED: interleukin ( 274) 241 50.9 3.6e-06 XP_011510395 (OMIM: 604512) PREDICTED: interleukin ( 598) 241 51.1 6.7e-06 NP_003844 (OMIM: 604509) interleukin-18 receptor a ( 599) 236 50.3 1.2e-05 XP_011510401 (OMIM: 604494) PREDICTED: interleukin ( 487) 233 49.8 1.4e-05 >>NP_003847 (OMIM: 601203) interleukin-1 receptor-like 1 (328 aa) initn: 2216 init1: 2216 opt: 2216 Z-score: 1957.6 bits: 370.5 E(85289): 2.7e-102 Smith-Waterman score: 2216; 100.0% identity (100.0% similar) in 328 aa overlap (1-328:1-328) 10 20 30 40 50 60 pF1KB8 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ 250 260 270 280 290 300 310 320 pF1KB8 YDCLALNLHGLRRHTVRLSRKNPSKECF :::::::::::::::::::::::::::: NP_003 YDCLALNLHGLRRHTVRLSRKNPSKECF 310 320 >>XP_011510453 (OMIM: 601203) PREDICTED: interleukin-1 r (328 aa) initn: 2216 init1: 2216 opt: 2216 Z-score: 1957.6 bits: 370.5 E(85289): 2.7e-102 Smith-Waterman score: 2216; 100.0% identity (100.0% similar) in 328 aa overlap (1-328:1-328) 10 20 30 40 50 60 pF1KB8 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ 250 260 270 280 290 300 310 320 pF1KB8 YDCLALNLHGLRRHTVRLSRKNPSKECF :::::::::::::::::::::::::::: XP_011 YDCLALNLHGLRRHTVRLSRKNPSKECF 310 320 >>XP_006712902 (OMIM: 601203) PREDICTED: interleukin-1 r (556 aa) initn: 2178 init1: 2178 opt: 2178 Z-score: 1921.1 bits: 364.5 E(85289): 2.9e-100 Smith-Waterman score: 2178; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KB8 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ 250 260 270 280 290 300 310 320 pF1KB8 YDCLALNLHGLRRHTVRLSRKNPSKECF ::::::::::::::::::::::: XP_006 YDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLL 310 320 330 340 350 360 >>NP_057316 (OMIM: 601203) interleukin-1 receptor-like 1 (556 aa) initn: 2178 init1: 2178 opt: 2178 Z-score: 1921.1 bits: 364.5 E(85289): 2.9e-100 Smith-Waterman score: 2178; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KB8 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ 250 260 270 280 290 300 310 320 pF1KB8 YDCLALNLHGLRRHTVRLSRKNPSKECF ::::::::::::::::::::::: NP_057 YDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLL 310 320 330 340 350 360 >>NP_001269337 (OMIM: 601203) interleukin-1 receptor-lik (211 aa) initn: 1428 init1: 1428 opt: 1428 Z-score: 1271.3 bits: 242.9 E(85289): 4.5e-64 Smith-Waterman score: 1428; 100.0% identity (100.0% similar) in 211 aa overlap (118-328:1-211) 90 100 110 120 130 140 pF1KB8 IVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEW :::::::::::::::::::::::::::::: NP_001 MYSTVSGSEKNSKIYCPTIDLYNWTAPLEW 10 20 30 150 160 170 180 190 200 pF1KB8 FKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQG 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB8 FSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQ 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB8 QEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPSKEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPSKEC 160 170 180 190 200 210 pF1KB8 F : NP_001 F >>XP_011510106 (OMIM: 147811) PREDICTED: interleukin-1 r (398 aa) initn: 131 init1: 67 opt: 354 Z-score: 328.3 bits: 69.3 E(85289): 1.5e-11 Smith-Waterman score: 354; 24.1% identity (57.5% similar) in 320 aa overlap (22-324:36-345) 10 20 30 40 pF1KB8 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPR-------QGKPSY :. . ::.: . .:::. . .: XP_011 VLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 TVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTI .. :. ... ...: .:..:..:. : .::: ::: :.: .:. .. .. . XP_011 NLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRV 70 80 90 100 110 120 110 120 130 140 150 pF1KB8 YKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWT-----APLEWFKNCQALQ--GS ... .: .: .. : . .. . :: :: ..: . ..:.:. :. . XP_011 FEN-TDAFLP-FISYPQILTLSTSGVLVCP--DLSEFTRDKTDVKIQWYKDSLLLDKDNE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB8 RYRAHK--SFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIG .. . . . :.. .: :::: : : . ..: .:..: . . .: .. .. ::: XP_011 KFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVII 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB8 APAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQS .: .. . .:. .. :.. .: :: . . . : : :.: . . : . :: : XP_011 SPLKT--ISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHI-ESAYPGGRVTEGPRQE 250 260 270 280 290 280 290 300 310 320 pF1KB8 FS-NGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPSKECF .: :. ... : . : .::: ... :.. : : .:.: . :. : XP_011 YSENNENYIEVPLIFDPVTREDLHMDFKCVVHNT--LSFQTLRTTVKEASSTFSWGIVLA 300 310 320 330 340 350 XP_011 PLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK 360 370 380 390 >>XP_006712797 (OMIM: 147811) PREDICTED: interleukin-1 r (398 aa) initn: 131 init1: 67 opt: 354 Z-score: 328.3 bits: 69.3 E(85289): 1.5e-11 Smith-Waterman score: 354; 24.1% identity (57.5% similar) in 320 aa overlap (22-324:36-345) 10 20 30 40 pF1KB8 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPR-------QGKPSY :. . ::.: . .:::. . .: XP_006 VLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 TVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTI .. :. ... ...: .:..:..:. : .::: ::: :.: .:. .. .. . XP_006 NLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRV 70 80 90 100 110 120 110 120 130 140 150 pF1KB8 YKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWT-----APLEWFKNCQALQ--GS ... .: .: .. : . .. . :: :: ..: . ..:.:. :. . XP_006 FEN-TDAFLP-FISYPQILTLSTSGVLVCP--DLSEFTRDKTDVKIQWYKDSLLLDKDNE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB8 RYRAHK--SFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIG .. . . . :.. .: :::: : : . ..: .:..: . . .: .. .. ::: XP_006 KFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVII 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB8 APAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQS .: .. . .:. .. :.. .: :: . . . : : :.: . . : . :: : XP_006 SPLKT--ISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHI-ESAYPGGRVTEGPRQE 250 260 270 280 290 280 290 300 310 320 pF1KB8 FS-NGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPSKECF .: :. ... : . : .::: ... :.. : : .:.: . :. : XP_006 YSENNENYIEVPLIFDPVTREDLHMDFKCVVHNT--LSFQTLRTTVKEASSTFSWGIVLA 300 310 320 330 340 350 XP_006 PLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK 360 370 380 390 >>NP_004624 (OMIM: 147811) interleukin-1 receptor type 2 (398 aa) initn: 131 init1: 67 opt: 354 Z-score: 328.3 bits: 69.3 E(85289): 1.5e-11 Smith-Waterman score: 354; 24.1% identity (57.5% similar) in 320 aa overlap (22-324:36-345) 10 20 30 40 pF1KB8 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPR-------QGKPSY :. . ::.: . .:::. . .: NP_004 VLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 TVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTI .. :. ... ...: .:..:..:. : .::: ::: :.: .:. .. .. . NP_004 NLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRV 70 80 90 100 110 120 110 120 130 140 150 pF1KB8 YKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWT-----APLEWFKNCQALQ--GS ... .: .: .. : . .. . :: :: ..: . ..:.:. :. . NP_004 FEN-TDAFLP-FISYPQILTLSTSGVLVCP--DLSEFTRDKTDVKIQWYKDSLLLDKDNE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB8 RYRAHK--SFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIG .. . . . :.. .: :::: : : . ..: .:..: . . .: .. .. ::: NP_004 KFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVII 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB8 APAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQS .: .. . .:. .. :.. .: :: . . . : : :.: . . : . :: : NP_004 SPLKT--ISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHI-ESAYPGGRVTEGPRQE 250 260 270 280 290 280 290 300 310 320 pF1KB8 FS-NGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPSKECF .: :. ... : . : .::: ... :.. : : .:.: . :. : NP_004 YSENNENYIEVPLIFDPVTREDLHMDFKCVVHNT--LSFQTLRTTVKEASSTFSWGIVLA 300 310 320 330 340 350 NP_004 PLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK 360 370 380 390 >>XP_006712799 (OMIM: 147811) PREDICTED: interleukin-1 r (423 aa) initn: 131 init1: 67 opt: 354 Z-score: 327.9 bits: 69.3 E(85289): 1.6e-11 Smith-Waterman score: 354; 24.1% identity (57.5% similar) in 320 aa overlap (22-324:61-370) 10 20 30 40 pF1KB8 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPR-------QGKPSY :. . ::.: . .:::. . .: XP_006 VLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRI 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB8 TVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTI .. :. ... ...: .:..:..:. : .::: ::: :.: .:. .. .. . XP_006 NLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRV 100 110 120 130 140 150 110 120 130 140 150 pF1KB8 YKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWT-----APLEWFKNCQALQ--GS ... .: .: .. : . .. . :: :: ..: . ..:.:. :. . XP_006 FEN-TDAFLP-FISYPQILTLSTSGVLVCP--DLSEFTRDKTDVKIQWYKDSLLLDKDNE 160 170 180 190 200 160 170 180 190 200 210 pF1KB8 RYRAHK--SFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIG .. . . . :.. .: :::: : : . ..: .:..: . . .: .. .. ::: XP_006 KFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVII 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB8 APAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQS .: .. . .:. .. :.. .: :: . . . : : :.: . . : . :: : XP_006 SPLKT--ISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHI-ESAYPGGRVTEGPRQE 270 280 290 300 310 320 280 290 300 310 320 pF1KB8 FS-NGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPSKECF .: :. ... : . : .::: ... :.. : : .:.: . :. : XP_006 YSENNENYIEVPLIFDPVTREDLHMDFKCVVHNT--LSFQTLRTTVKEASSTFSWGIVLA 330 340 350 360 370 380 XP_006 PLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK 390 400 410 420 >>XP_011510103 (OMIM: 147811) PREDICTED: interleukin-1 r (441 aa) initn: 131 init1: 67 opt: 354 Z-score: 327.6 bits: 69.3 E(85289): 1.6e-11 Smith-Waterman score: 354; 24.1% identity (57.5% similar) in 320 aa overlap (22-324:79-388) 10 20 30 40 pF1KB8 MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPR-------QGKPSY :. . ::.: . .:::. . .: XP_011 VLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRI 50 60 70 80 90 100 50 60 70 80 90 100 pF1KB8 TVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTI .. :. ... ...: .:..:..:. : .::: ::: :.: .:. .. .. . XP_011 NLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRV 110 120 130 140 150 160 110 120 130 140 150 pF1KB8 YKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWT-----APLEWFKNCQALQ--GS ... .: .: .. : . .. . :: :: ..: . ..:.:. :. . XP_011 FEN-TDAFLP-FISYPQILTLSTSGVLVCP--DLSEFTRDKTDVKIQWYKDSLLLDKDNE 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB8 RYRAHK--SFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIG .. . . . :.. .: :::: : : . ..: .:..: . . .: .. .. ::: XP_011 KFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVII 230 240 250 260 270 280 220 230 240 250 260 270 pF1KB8 APAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQS .: .. . .:. .. :.. .: :: . . . : : :.: . . : . :: : XP_011 SPLKT--ISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHI-ESAYPGGRVTEGPRQE 290 300 310 320 330 340 280 290 300 310 320 pF1KB8 FS-NGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPSKECF .: :. ... : . : .::: ... :.. : : .:.: . :. : XP_011 YSENNENYIEVPLIFDPVTREDLHMDFKCVVHNT--LSFQTLRTTVKEASSTFSWGIVLA 350 360 370 380 390 XP_011 PLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK 400 410 420 430 440 328 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:50:24 2016 done: Sat Nov 5 21:50:25 2016 Total Scan time: 7.020 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]