FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8641, 859 aa 1>>>pF1KB8641 859 - 859 aa - 859 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2946+/-0.000916; mu= 13.2526+/- 0.056 mean_var=137.4123+/-27.400, 0's: 0 Z-trim(110.4): 64 B-trim: 109 in 2/51 Lambda= 0.109411 statistics sampled from 11525 (11589) to 11525 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.356), width: 16 Scan time: 3.590 The best scores are: opt bits E(32554) CCDS9918.1 DDX24 gene_id:57062|Hs108|chr14 ( 859) 5604 896.5 0 CCDS8770.1 DDX23 gene_id:9416|Hs108|chr12 ( 820) 397 74.6 8e-13 CCDS8655.1 DDX47 gene_id:51202|Hs108|chr12 ( 455) 379 71.6 3.6e-12 CCDS10858.1 DDX28 gene_id:55794|Hs108|chr16 ( 540) 365 69.4 1.9e-11 CCDS5492.1 DDX56 gene_id:54606|Hs108|chr7 ( 547) 350 67.1 9.9e-11 >>CCDS9918.1 DDX24 gene_id:57062|Hs108|chr14 (859 aa) initn: 5604 init1: 5604 opt: 5604 Z-score: 4785.3 bits: 896.5 E(32554): 0 Smith-Waterman score: 5604; 100.0% identity (100.0% similar) in 859 aa overlap (1-859:1-859) 10 20 30 40 50 60 pF1KB8 MKLKDTKSRPKQSSCGKFQTKGIKVVGKWKEVKIDPNMFADGQMDDLVCFEELTDYQLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 MKLKDTKSRPKQSSCGKFQTKGIKVVGKWKEVKIDPNMFADGQMDDLVCFEELTDYQLVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PAKNPSSLFSKEAPKRKAQAVSEEEEEEEGKSSSPKKKIKLKKSKNVATEGTSTQKEFEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 PAKNPSSLFSKEAPKRKAQAVSEEEEEEEGKSSSPKKKIKLKKSKNVATEGTSTQKEFEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 KDPELEAQGDDMVCDDPEAGEMTSENLVQTAPKKKKNKGKKGLEPSQSTAAKVPKKAKTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 KDPELEAQGDDMVCDDPEAGEMTSENLVQTAPKKKKNKGKKGLEPSQSTAAKVPKKAKTW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 IPEVHDQKADVSAWKDLFVPRPVLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 IPEVHDQKADVSAWKDLFVPRPVLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SGKTLAFAIPMIHAVLQWQKRNAAPPPSNTEAPPGETRTEAGAETRSPGKAEAESDALPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 SGKTLAFAIPMIHAVLQWQKRNAAPPPSNTEAPPGETRTEAGAETRSPGKAEAESDALPD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 DTVIESEALPSDIAAEARAKTGGTVSDQALLFGDDDAGEGPSSLIREKPVPKQNENEEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 DTVIESEALPSDIAAEARAKTGGTVSDQALLFGDDDAGEGPSSLIREKPVPKQNENEEEN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LDKEQTGNLKQELDDKSATCKAYPKRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 LDKEQTGNLKQELDDKSATCKAYPKRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 LVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQLRCLVVDEADRMVEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 LVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQLRCLVVDEADRMVEKG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 HFAELSQLLEMLNDSQYNPKRQTLVFSATLTLVHQAPARILHKKHTKKMDKTAKLDLLMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 HFAELSQLLEMLNDSQYNPKRQTLVFSATLTLVHQAPARILHKKHTKKMDKTAKLDLLMQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 KIGMRGKPKVIDLTRNEATVETLTETKIHCETDEKDFYLYYFLMQYPGRSLVFANSISCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 KIGMRGKPKVIDLTRNEATVETLTETKIHCETDEKDFYLYYFLMQYPGRSLVFANSISCI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 KRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 KRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 HYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKKDEDIPLFPVQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 HYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKKDEDIPLFPVQTK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 YMDVVKERIRLARQIEKSEYRNFQACLHNSWIEQAAAALEIELEEDMYKGGKADQQEERR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 YMDVVKERIRLARQIEKSEYRNFQACLHNSWIEQAAAALEIELEEDMYKGGKADQQEERR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 RQKQMKVLKKELRHLLSQPLFTESQKTKYPTQSGKPPLLVSAPSKSESALSCLSKQKKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 RQKQMKVLKKELRHLLSQPLFTESQKTKYPTQSGKPPLLVSAPSKSESALSCLSKQKKKK 790 800 810 820 830 840 850 pF1KB8 TKKPKEPQPEQPQPSTSAN ::::::::::::::::::: CCDS99 TKKPKEPQPEQPQPSTSAN 850 >>CCDS8770.1 DDX23 gene_id:9416|Hs108|chr12 (820 aa) initn: 611 init1: 190 opt: 397 Z-score: 343.7 bits: 74.6 E(32554): 8e-13 Smith-Waterman score: 398; 29.7% identity (56.8% similar) in 333 aa overlap (391-706:472-783) 370 380 390 400 410 420 pF1KB8 LDKEQTGNLKQELDDKSATCKAYPKRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAI ..:.:::::: :.... .. ::.:. CCDS87 TAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVA 450 460 470 480 490 500 430 440 450 460 470 pF1KB8 LVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQLRC--LVVDEADRMVE ..::.: . : : :::.:::::: ....... : :: .:.::::::.. CCDS87 VIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLS-----RCTYVVLDEADRMID 510 520 530 540 550 480 490 500 510 520 530 pF1KB8 KGHFAELSQLLEML--------NDSQYNPKRQTLVFSATLTLVHQAPARILHKKHTKKMD : .....:: . .: .:... : . .:. .. .. CCDS87 MGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQT--VMFTATMPPAVE 560 570 580 590 600 610 540 550 560 570 580 pF1KB8 KTAKLDL---LMQKIGMRGKPKVIDLTRNEATVETLTETKIHCETDEKDFYLYYFLMQ-Y . :. : . :: :::. : : : ..:. :: : .: : . CCDS87 RLARSYLRRPAVVYIGSAGKPH----ERVEQKVFLMSES-------EKRKKLLAILEQGF 620 630 640 650 660 590 600 610 620 630 640 pF1KB8 PGRSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQR---LRNLEQFARLEDCVLLA ..:.:. . :. :. . :::. :.:: : ::. :. : .:.: CCDS87 DPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAK--D-ILVA 670 680 690 700 710 720 650 660 670 680 690 700 pF1KB8 TDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIY ::::.::.:: :. :..:.. .. : :.:: :::.:: . :... .. :: : .. CCDS87 TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK 730 740 750 760 770 780 710 720 730 740 750 760 pF1KB8 KTLKKDEDIPLFPVQTKYMDVVKERIRLARQIEKSEYRNFQACLHNSWIEQAAAALEIEL ... CCDS87 QAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA 790 800 810 820 >>CCDS8655.1 DDX47 gene_id:51202|Hs108|chr12 (455 aa) initn: 692 init1: 280 opt: 379 Z-score: 332.0 bits: 71.6 E(32554): 3.6e-12 Smith-Waterman score: 639; 34.2% identity (64.7% similar) in 360 aa overlap (384-741:90-415) 360 370 380 390 400 410 pF1KB8 NENEEENLDKEQTGNLKQELDDKSATCKAYPKRPLLGLVLTPTRELAVQVKQHIDAVARF :.: :..:::::::::: :......:.. CCDS86 QGRDIIGLAETGSGKTGAFALPILNALLETPQR-LFALVLTPTRELAFQISEQFEALGSS 60 70 80 90 100 110 420 430 440 450 460 470 pF1KB8 TGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQLRCLVVDEA :...:..:::.....:. : ..:.:..:::::: . ... . ::: :. ::.::: CCDS86 IGVQSAVIVGGIDSMSQSLALAKKPHIIIATPGRLIDHLENTKGF--NLRALKYLVMDEA 120 130 140 150 160 170 480 490 500 510 520 530 pF1KB8 DRMVEKGHFAELSQLLEMLNDSQYNPK-RQTLVFSATLTLVHQAPARILHKKHTKKMDKT ::... .:....:... :. :.:..::::.: ::..: CCDS86 DRILNMDFETEVDKILKVI------PRDRKTFLFSATMT---------------KKVQK- 180 190 200 210 540 550 560 570 580 590 pF1KB8 AKLDLLMQKIGMRGKPKVIDLTRNEATVETLTETKIHCETDEKDFYLYYFLMQYPGRS-L .:. .... : .. . ::: : . : . :: :: :.: . : : . CCDS86 ------LQRAALKNPVKCA-VSSKYQTVEKLQQYYIFIPSKFKDTYLVYILNELAGNSFM 220 230 240 250 260 600 610 620 630 640 650 pF1KB8 VFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGL .: .. . .: . ::. : . . ::. : :..:: .:..: .:::::::.::: CCDS86 IFCSTCNNTQRTALLLRNLGFTAIPLHGQMSQSKRLGSLNKFKAKARSILLATDVASRGL 270 280 290 300 310 320 660 670 680 690 700 710 pF1KB8 DIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKKDED :::.:. :.....: :. :.:: :::::: : .. .. :: :..: . . : CCDS86 DIPHVDVVVNFDIPTHSKDYIHRVGRTARAGRSGKAITFVTQYDVELFQRIEHLIGKK-- 330 340 350 360 370 380 720 730 740 750 760 770 pF1KB8 IPLFPVQTKYMDVVKERIRLARQIEKSEYRNFQACLHNSWIEQAAAALEIELEEDMYKGG .: ::.: . .. ::. :... . : : CCDS86 LPGFPTQDDEVMMLTERVAEAQRFARMELREHGEKKKRSREDAGDNDDTEGAIGVRNKVA 390 400 410 420 430 440 >>CCDS10858.1 DDX28 gene_id:55794|Hs108|chr16 (540 aa) initn: 450 init1: 190 opt: 365 Z-score: 319.0 bits: 69.4 E(32554): 1.9e-11 Smith-Waterman score: 395; 29.3% identity (57.1% similar) in 338 aa overlap (390-713:206-526) 360 370 380 390 400 410 pF1KB8 NLDKEQTGNLKQELDDKSATCKAYPKRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTA ::::.:.:::: ::. . ..: :. . CCDS10 SGKTLSYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPLGRSLGLLVR 180 190 200 210 220 230 420 430 440 450 460 470 pF1KB8 ILVGGMSTQKQQRMLNRRP--EIVVATPGRLWELIKEKHYHLRNLRQLRCLVVDEADRMV : :: . .. . .:.:.: ...::::: ::. .: . : .:.:: ::.:::: .. CCDS10 DLEGGHGMRRIRLQLSRQPSADVLVATPGALWKALKSR---LISLEQLSFLVLDEADTLL 240 250 260 270 280 290 480 490 500 510 520 pF1KB8 EKGHFAELSQLLEMLN--------DSQYNPKRQTLVFSATLTL-VHQAPARILHKKHTKK ... . .. .:: . .. .::: : .. .::. : : .. . CCDS10 DESFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTT 300 310 320 330 340 350 530 540 550 560 570 580 pF1KB8 MDKTAKLDLLMQKIGMRGKPKVIDLTRNEATVETLTETKIHCETDEKDFYLYYFLMQYPG . ..:: .: .. : . : . ..: . : : . :. : CCDS10 IT-SSKLHCIMPHV----KQTFLRLKGADKVAELVHILK-HRDRAERT--------GPSG 360 370 380 390 590 600 610 620 630 640 pF1KB8 RSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAA ::: :: : .. :. .: :. : :.. : .:. ...: . .:: ::.:. CCDS10 TVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIAS 400 410 420 430 440 450 650 660 670 680 690 700 pF1KB8 RGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNE--GLSLMLIG-PEDVINFKKIYKT :::: :. :..:. : : . :.::.::..:. .: : . .. : :: .:: . CCDS10 RGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELA 460 470 480 490 500 510 710 720 730 740 750 760 pF1KB8 LKKDEDIPLFPVQTKYMDVVKERIRLARQIEKSEYRNFQACLHNSWIEQAAAALEIELEE .. ...: CCDS10 ARRRRSLPGLASSVKEPLPQAT 520 530 540 >>CCDS5492.1 DDX56 gene_id:54606|Hs108|chr7 (547 aa) initn: 385 init1: 168 opt: 350 Z-score: 306.1 bits: 67.1 E(32554): 9.9e-11 Smith-Waterman score: 456; 27.9% identity (54.3% similar) in 567 aa overlap (327-844:15-529) 300 310 320 330 340 350 pF1KB8 ALPDDTVIESEALPSDIAAEARAKTGGTVSDQALLFGDDDAGEGPSSLIREKPVPKQNEN : :: . : : . .::.:: .: :. CCDS54 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEG 10 20 30 40 360 370 380 390 400 pF1KB8 EEENLDKEQTGNLK---------QELDDKSATCKAYPKRPLLGLVLTPTRELAVQVKQHI .. : . .::. : : : ..:: . .. . ::::.::.::: :... : CCDS54 KDL-LARARTGSGKTAAYAIPMLQLLLHRKATGPVV-EQAVRGLVLVPTKELARQAQSMI 50 60 70 80 90 100 410 420 430 440 450 460 pF1KB8 DAVARFTG--IKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQL . .: . . ...: . .. .. .:. .: ..:..::.::.:. ... .::. .: CCDS54 QQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRD--SL 110 120 130 140 150 160 470 480 490 500 510 520 pF1KB8 RCLVVDEADRMVEKGHFAELSQLLEMLNDSQYNPK-RQTLVFSATLTLVHQAPAR-ILHK . ::::::: . : ::..:: : :. :....:::.. :: . :::. CCDS54 ELLVVDEADLLFSFGFEEELKSLLCHL------PRIYQAFLMSATFNEDVQALKELILHN 170 180 190 200 210 530 540 550 560 570 580 pF1KB8 KHTKKMDKTAKLDLLMQKIGMRGKPKVIDLTRNEATVETLTETKIHCETDEKDFYLYYFL : :.... : : : . : . .. :::.: : : : : CCDS54 PVTLKLQES-------QLPG----P------------DQLQQFQVVCETEEDKFLLLYAL 220 230 240 250 590 600 610 620 630 pF1KB8 MQYP---GRSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFAR-LEDC .. :.::.:.:.. :: .:. ..: .:.. . ..: . . :: . . :: CCDS54 LKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDC 260 270 280 290 300 310 640 650 660 670 pF1KB8 VLLATDV---------------------------AARGLDIPKVQHVIHYQVPRTSEIYV :. :::. .:::.:. .:. :.....: : : :. CCDS54 VI-ATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNFDLPPTPEAYI 320 330 340 350 360 370 680 690 700 710 720 730 pF1KB8 HRSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKKDEDIP-LFPVQTKYMDVVKERIRL ::.::::::.: :. : .. : . ... :: . :. .. : :.: : .. .. : : CCDS54 HRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPILLPYQFRMEEIEGFRYR- 380 390 400 410 420 740 750 760 770 780 790 pF1KB8 ARQIEKSEYRNFQACLHNSWIEQAAAALEIELEEDMYKGGKADQQ-EERRRQKQMKVLKK :. .: . :: :..: :..:.. .. : :. :. :. CCDS54 CRDAMRSVTK--QA------IREARLK---EIKEELLHSEKLKTYFEDNPRDLQL----- 430 440 450 460 470 800 810 820 830 840 pF1KB8 ELRHLLS-QPLFTESQKTKYPTQSGKPPL--LVSAPSKSESALSCLSKQKKKKTKKPKEP ::: : .: .. . . : : : :: .: .. : : :. :...: CCDS54 -LRHDLPLHPAVVKPHLGHVPDYLVPPALRGLVRPHKKRKKLSSSCRKAKRAKSQNPLRS 480 490 500 510 520 530 850 pF1KB8 QPEQPQPSTSAN CCDS54 FKHKGKKFRPTAKPS 540 859 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:06:33 2016 done: Fri Nov 4 14:06:34 2016 Total Scan time: 3.590 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]