FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8643, 517 aa 1>>>pF1KB8643 517 - 517 aa - 517 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9233+/-0.000867; mu= 7.4267+/- 0.053 mean_var=146.0100+/-29.540, 0's: 0 Z-trim(111.6): 30 B-trim: 178 in 1/53 Lambda= 0.106141 statistics sampled from 12460 (12485) to 12460 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.729), E-opt: 0.2 (0.384), width: 16 Scan time: 3.220 The best scores are: opt bits E(32554) CCDS14078.1 TBC1D22A gene_id:25771|Hs108|chr22 ( 517) 3497 547.0 1.9e-155 CCDS74877.1 TBC1D22A gene_id:25771|Hs108|chr22 ( 487) 3218 504.3 1.3e-142 CCDS63512.1 TBC1D22A gene_id:25771|Hs108|chr22 ( 470) 3170 496.9 2e-140 CCDS63511.1 TBC1D22A gene_id:25771|Hs108|chr22 ( 439) 2100 333.1 4.1e-91 CCDS4832.1 TBC1D22B gene_id:55633|Hs108|chr6 ( 505) 1805 287.9 1.8e-77 >>CCDS14078.1 TBC1D22A gene_id:25771|Hs108|chr22 (517 aa) initn: 3497 init1: 3497 opt: 3497 Z-score: 2904.4 bits: 547.0 E(32554): 1.9e-155 Smith-Waterman score: 3497; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517) 10 20 30 40 50 60 pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF 430 440 450 460 470 480 490 500 510 pF1KB8 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK ::::::::::::::::::::::::::::::::::::: CCDS14 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK 490 500 510 >>CCDS74877.1 TBC1D22A gene_id:25771|Hs108|chr22 (487 aa) initn: 3218 init1: 3218 opt: 3218 Z-score: 2673.9 bits: 504.3 E(32554): 1.3e-142 Smith-Waterman score: 3218; 99.8% identity (100.0% similar) in 479 aa overlap (39-517:9-487) 10 20 30 40 50 60 pF1KB8 QFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNT :.:::::::::::::::::::::::::::: CCDS74 MWEPQPDVGSLLRSTAKMPTTPVKAKRVSTFQEFESNT 10 20 30 70 80 90 100 110 120 pF1KB8 SDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 SDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 EPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 EPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 ALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 ALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPA 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 TLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 TLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFI 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 WAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 WAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB8 KLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 KLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMR 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB8 EVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 EVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAH 400 410 420 430 440 450 490 500 510 pF1KB8 WDDEDISLLLAEAYRLKFAFADAPNHYKK ::::::::::::::::::::::::::::: CCDS74 WDDEDISLLLAEAYRLKFAFADAPNHYKK 460 470 480 >>CCDS63512.1 TBC1D22A gene_id:25771|Hs108|chr22 (470 aa) initn: 3170 init1: 3170 opt: 3170 Z-score: 2634.4 bits: 496.9 E(32554): 2e-140 Smith-Waterman score: 3170; 100.0% identity (100.0% similar) in 470 aa overlap (48-517:1-470) 20 30 40 50 60 70 pF1KB8 LPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGED :::::::::::::::::::::::::::::: CCDS63 MPTTPVKAKRVSTFQEFESNTSDAWDAGED 10 20 30 80 90 100 110 120 130 pF1KB8 DDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 DDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGD 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB8 LRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASR 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB8 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB8 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASG 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB8 YVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 YVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDN 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB8 YTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 YTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIR 340 350 360 370 380 390 440 450 460 470 480 490 pF1KB8 LWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLL 400 410 420 430 440 450 500 510 pF1KB8 LAEAYRLKFAFADAPNHYKK :::::::::::::::::::: CCDS63 LAEAYRLKFAFADAPNHYKK 460 470 >>CCDS63511.1 TBC1D22A gene_id:25771|Hs108|chr22 (439 aa) initn: 2256 init1: 2100 opt: 2100 Z-score: 1749.3 bits: 333.1 E(32554): 4.1e-91 Smith-Waterman score: 2814; 84.9% identity (84.9% similar) in 517 aa overlap (1-517:1-439) 10 20 30 40 50 60 pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST ::::::::::::::::::::: :::::::::::::::::::: CCDS63 MASDGARKQFWKRSNSKLPGS-------------------LLRSTAKMPTTPVKAKRVST 10 20 30 40 70 80 90 100 110 120 pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS :::::::::::::::::::::::::::::::::: CCDS63 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAE-------------------------- 110 120 130 190 200 210 220 230 240 pF1KB8 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP ::::::::::::::::::::::::::: CCDS63 ---------------------------------ELRRLSWSGIPKPVRPMTWKLLSGYLP 140 150 160 250 260 270 280 290 300 pF1KB8 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE 170 180 190 200 210 220 310 320 330 340 350 360 pF1KB8 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE 230 240 250 260 270 280 370 380 390 400 410 420 pF1KB8 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR 290 300 310 320 330 340 430 440 450 460 470 480 pF1KB8 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF 350 360 370 380 390 400 490 500 510 pF1KB8 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK ::::::::::::::::::::::::::::::::::::: CCDS63 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK 410 420 430 >>CCDS4832.1 TBC1D22B gene_id:55633|Hs108|chr6 (505 aa) initn: 2100 init1: 1454 opt: 1805 Z-score: 1504.3 bits: 287.9 E(32554): 1.8e-77 Smith-Waterman score: 2145; 61.5% identity (82.1% similar) in 520 aa overlap (1-517:1-505) 10 20 30 40 50 60 pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST ::.... ::::::: .::::::: ::::::::.:: : .... .:. :.:.: :..:. CCDS48 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS 10 20 30 40 50 70 80 90 100 110 pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPG :.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::. CCDS48 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------ 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 LQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GG :. ::. : .. ...:: :... : . .. ::...:::: . : . CCDS48 LRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVAR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGY :: .. .. .. :: .::.::.:::.. ::::.:::. :: :.:. :::.::.::::: CCDS48 ISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGY 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB8 LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPK ::::..:: :::::..:::.:::.::::::.: :::::::::::::: .: :. :: CCDS48 LPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB8 VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLC : ::::::::::::::::::::::::::::::::::. ::.: :.:.. ::... ..: CCDS48 VQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLR 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB8 NIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQF .::::..:::::::::::::::::::::: ::: ::::::::::::: :. ..::.:::: CCDS48 SIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQF 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB8 AFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQEL ::::::::::::.::::::::::::::::.::::::::::::::..::::::.:.::: : CCDS48 AFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGL 410 420 430 440 450 460 480 490 500 510 pF1KB8 LLFLQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK :..:::::: :: .:.:.::::::::::. ::::::::.. CCDS48 LMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR 470 480 490 500 517 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:35:07 2016 done: Sat Nov 5 21:35:08 2016 Total Scan time: 3.220 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]