FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8648, 340 aa 1>>>pF1KB8648 340 - 340 aa - 340 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1441+/-0.000842; mu= 16.6574+/- 0.051 mean_var=57.5558+/-11.287, 0's: 0 Z-trim(104.8): 27 B-trim: 6 in 1/50 Lambda= 0.169056 statistics sampled from 8064 (8086) to 8064 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.248), width: 16 Scan time: 1.940 The best scores are: opt bits E(32554) CCDS13973.1 DMC1 gene_id:11144|Hs108|chr22 ( 340) 2192 542.9 1.4e-154 CCDS10062.1 RAD51 gene_id:5888|Hs108|chr15 ( 339) 1108 278.5 5.4e-75 CCDS53931.1 RAD51 gene_id:5888|Hs108|chr15 ( 340) 948 239.5 3e-63 CCDS63477.1 DMC1 gene_id:11144|Hs108|chr22 ( 285) 919 232.4 3.5e-61 CCDS53932.1 RAD51 gene_id:5888|Hs108|chr15 ( 280) 756 192.6 3.2e-49 CCDS9790.1 RAD51B gene_id:5890|Hs108|chr14 ( 350) 314 84.9 1.1e-16 CCDS9789.1 RAD51B gene_id:5890|Hs108|chr14 ( 384) 314 84.9 1.2e-16 CCDS81815.1 RAD51B gene_id:5890|Hs108|chr14 ( 425) 314 84.9 1.3e-16 >>CCDS13973.1 DMC1 gene_id:11144|Hs108|chr22 (340 aa) initn: 2192 init1: 2192 opt: 2192 Z-score: 2888.7 bits: 542.9 E(32554): 1.4e-154 Smith-Waterman score: 2192; 100.0% identity (100.0% similar) in 340 aa overlap (1-340:1-340) 10 20 30 40 50 60 pF1KB8 MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 ITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNVD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 HDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 HDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 ERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTR 250 260 270 280 290 300 310 320 330 340 pF1KB8 ISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE :::::::::::::::::::::::::::::::::::::::: CCDS13 ISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE 310 320 330 340 >>CCDS10062.1 RAD51 gene_id:5888|Hs108|chr15 (339 aa) initn: 1161 init1: 615 opt: 1108 Z-score: 1459.9 bits: 278.5 E(32554): 5.4e-75 Smith-Waterman score: 1108; 55.0% identity (79.5% similar) in 327 aa overlap (16-340:16-339) 10 20 30 40 50 pF1KB8 MKEDQVVAEEPGFQDEEESLF-QDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRAL ::::. : :. :.. :::. :.:::. .:. :.... .. .. : CCDS10 MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 CNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESM :.::.::::.::: : ::. :: :: :. ..:. ...:::::.:.:::: ::::. CCDS10 INIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 AITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNV .::: ::::::::::. ::: :: ::: : :: ..::::.::::.:: .:.:... CCDS10 SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DHDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGEL . . ::::: ::::....:: .:: : :. . :. . :::.:: ::.:.:.:::::: CCDS10 SGSDVLDNVAYARAFNTDHQTQLL-YQASAMMVESR-YALLIVDSATALYRTDYSGRGEL 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 AERQQKLAQMLSRLQKISEEYNVAVFVTNQMTAD-PGATMTFQADPKKPIGGHILAHAST . ::..::..: : ....:..::: .:::..:. ::.: : :::::::::.:.::::: CCDS10 SARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAM-FAADPKKPIGGNIIAHAST 240 250 260 270 280 290 300 310 320 330 340 pF1KB8 TRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE ::. ::::::: :: :::::: .:: :: :::.: :.::::. CCDS10 TRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD 300 310 320 330 >>CCDS53931.1 RAD51 gene_id:5888|Hs108|chr15 (340 aa) initn: 1033 init1: 497 opt: 948 Z-score: 1249.0 bits: 239.5 E(32554): 3e-63 Smith-Waterman score: 948; 50.1% identity (75.2% similar) in 335 aa overlap (16-340:16-340) 10 20 30 40 50 pF1KB8 MKEDQVVAEEPGFQDEEESLF-QDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRAL ::::. : :. :.. :::. :.:::. .:. :.... .. .. : CCDS53 MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 CNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHIT--TGSQEF----DKLLG :.::.::::.::: : : .. .: .. .:. .::.. ....: CCDS53 INIKGISEAKADKI------LTESRSVARLE-CNSVILVYCTLRLSGSSDSPASASRVVG 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 --GGIESMAITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLR ::::. .::: ::::::::::. ::: :: ::: : :: ..::::.::::.:: CCDS53 TTGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 DIADRFNVDHDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRV .:.:.... . ::::: ::::....:: .:: : :. . :. . :::.:: ::.:. CCDS53 AVAERYGLSGSDVLDNVAYARAFNTDHQTQLL-YQASAMMVESR-YALLIVDSATALYRT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 DFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTAD-PGATMTFQADPKKPIGG :.::::::. ::..::..: : ....:..::: .:::..:. ::.: : ::::::::: CCDS53 DYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAM-FAADPKKPIGG 240 250 260 270 280 290 300 310 320 330 340 pF1KB8 HILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE .:.:::::::. ::::::: :: :::::: .:: :: :::.: :.::::. CCDS53 NIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD 300 310 320 330 340 >>CCDS63477.1 DMC1 gene_id:11144|Hs108|chr22 (285 aa) initn: 1804 init1: 919 opt: 919 Z-score: 1211.9 bits: 232.4 E(32554): 3.5e-61 Smith-Waterman score: 1698; 83.5% identity (83.8% similar) in 340 aa overlap (1-340:1-285) 10 20 30 40 50 60 pF1KB8 MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNVD :::::::::::::::::::: CCDS63 ITEAFGEFRTGKTQLSHTLC---------------------------------------- 130 140 190 200 210 220 230 240 pF1KB8 HDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELA .:::::::::::::::::::::::::::::::::::::::::::: CCDS63 ---------------GEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELA 150 160 170 180 250 260 270 280 290 300 pF1KB8 ERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 ERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTR 190 200 210 220 230 240 310 320 330 340 pF1KB8 ISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE :::::::::::::::::::::::::::::::::::::::: CCDS63 ISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE 250 260 270 280 >>CCDS53932.1 RAD51 gene_id:5888|Hs108|chr15 (280 aa) initn: 788 init1: 615 opt: 756 Z-score: 997.2 bits: 192.6 E(32554): 3.2e-49 Smith-Waterman score: 756; 50.6% identity (77.6% similar) in 245 aa overlap (16-259:16-258) 10 20 30 40 50 pF1KB8 MKEDQVVAEEPGFQDEEESLF-QDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRAL ::::. : :. :.. :::. :.:::. .:. :.... .. .. : CCDS53 MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 CNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESM :.::.::::.::: : ::. :: :: :. ..:. ...:::::.:.:::: ::::. CCDS53 INIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 AITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNV .::: ::::::::::. ::: :: ::: : :: ..::::.::::.:: .:.:... CCDS53 SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DHDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGEL . . ::::: ::::....:: .:: : :. . :. . :::.:: ::.:.:.:::::: CCDS53 SGSDVLDNVAYARAFNTDHQTQLL-YQASAMMVESR-YALLIVDSATALYRTDYSGRGEL 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 AERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTT . ::..::..: : ....: CCDS53 SARQMHLARFLRMLLRLADEIVSEERKRGNQNLQNLRLSLSS 240 250 260 270 280 >>CCDS9790.1 RAD51B gene_id:5890|Hs108|chr14 (350 aa) initn: 256 init1: 137 opt: 314 Z-score: 413.1 bits: 84.9 E(32554): 1.1e-16 Smith-Waterman score: 323; 26.3% identity (54.3% similar) in 339 aa overlap (27-335:6-342) 10 20 30 40 50 60 pF1KB8 MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC :.. :.. .:. : : . . . : CCDS97 MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELM 10 20 30 70 80 90 100 110 pF1KB8 NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFH---ITTGSQEFDKLLGGGIE .: ::: : .. ... : . ::. . .:. : ..: . .:. : ::. CCDS97 KVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVA 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB8 SMAITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADR- ..:: : ::::. . . : :: : : ...::::..: .:: .::. CCDS97 CGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESR 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 ----FNVDHDAVLDN--VLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFR ::... .: . : : : .. .. .. . .. . :: ::.:.::. .. : CCDS97 FPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISK-GI-KLVILDSVASVVR 160 170 180 190 200 210 240 250 260 270 280 pF1KB8 VDFSGR--GELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPI .:... :.: ::.. ::. : :. ..::... :..:::.:. ..... ::: .: CCDS97 KEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPA 220 230 240 250 260 270 290 300 310 320 330 pF1KB8 G------------------GHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAI :. .:. .::. :. .: : : :: : . ...: CCDS97 DDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTI 280 290 300 310 320 330 340 pF1KB8 TAGGIGDAKE :. CCDS97 KEEGLVLQGQEKP 340 350 >>CCDS9789.1 RAD51B gene_id:5890|Hs108|chr14 (384 aa) initn: 256 init1: 137 opt: 314 Z-score: 412.4 bits: 84.9 E(32554): 1.2e-16 Smith-Waterman score: 323; 26.3% identity (54.3% similar) in 339 aa overlap (27-335:6-342) 10 20 30 40 50 60 pF1KB8 MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC :.. :.. .:. : : . . . : CCDS97 MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELM 10 20 30 70 80 90 100 110 pF1KB8 NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFH---ITTGSQEFDKLLGGGIE .: ::: : .. ... : . ::. . .:. : ..: . .:. : ::. CCDS97 KVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVA 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB8 SMAITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADR- ..:: : ::::. . . : :: : : ...::::..: .:: .::. CCDS97 CGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESR 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 ----FNVDHDAVLDN--VLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFR ::... .: . : : : .. .. .. . .. . :: ::.:.::. .. : CCDS97 FPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISK-GI-KLVILDSVASVVR 160 170 180 190 200 210 240 250 260 270 280 pF1KB8 VDFSGR--GELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPI .:... :.: ::.. ::. : :. ..::... :..:::.:. ..... ::: .: CCDS97 KEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPA 220 230 240 250 260 270 290 300 310 320 330 pF1KB8 G------------------GHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAI :. .:. .::. :. .: : : :: : . ...: CCDS97 DDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTI 280 290 300 310 320 330 340 pF1KB8 TAGGIGDAKE :. CCDS97 KEEGLVLQETTFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQLIF 340 350 360 370 380 >>CCDS81815.1 RAD51B gene_id:5890|Hs108|chr14 (425 aa) initn: 256 init1: 137 opt: 314 Z-score: 411.8 bits: 84.9 E(32554): 1.3e-16 Smith-Waterman score: 323; 26.3% identity (54.3% similar) in 339 aa overlap (27-335:6-342) 10 20 30 40 50 60 pF1KB8 MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC :.. :.. .:. : : . . . : CCDS81 MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELM 10 20 30 70 80 90 100 110 pF1KB8 NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFH---ITTGSQEFDKLLGGGIE .: ::: : .. ... : . ::. . .:. : ..: . .:. : ::. CCDS81 KVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVA 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB8 SMAITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADR- ..:: : ::::. . . : :: : : ...::::..: .:: .::. CCDS81 CGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESR 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 ----FNVDHDAVLDN--VLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFR ::... .: . : : : .. .. .. . .. . :: ::.:.::. .. : CCDS81 FPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISK-GI-KLVILDSVASVVR 160 170 180 190 200 210 240 250 260 270 280 pF1KB8 VDFSGR--GELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPI .:... :.: ::.. ::. : :. ..::... :..:::.:. ..... ::: .: CCDS81 KEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPA 220 230 240 250 260 270 290 300 310 320 330 pF1KB8 G------------------GHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAI :. .:. .::. :. .: : : :: : . ...: CCDS81 DDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTI 280 290 300 310 320 330 340 pF1KB8 TAGGIGDAKE :. CCDS81 KEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCPPQM 340 350 360 370 380 390 340 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:50:54 2016 done: Sat Nov 5 21:50:54 2016 Total Scan time: 1.940 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]