FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8657, 454 aa 1>>>pF1KB8657 454 - 454 aa - 454 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5388+/-0.000999; mu= 16.0773+/- 0.060 mean_var=70.8835+/-14.414, 0's: 0 Z-trim(104.5): 47 B-trim: 20 in 1/48 Lambda= 0.152336 statistics sampled from 7888 (7923) to 7888 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.243), width: 16 Scan time: 1.890 The best scores are: opt bits E(32554) CCDS5339.1 WIPI2 gene_id:26100|Hs108|chr7 ( 454) 2982 664.9 4.7e-191 CCDS34593.1 WIPI2 gene_id:26100|Hs108|chr7 ( 436) 2705 604.0 9.6e-173 CCDS47531.1 WIPI2 gene_id:26100|Hs108|chr7 ( 443) 2661 594.4 7.9e-170 CCDS47532.1 WIPI2 gene_id:26100|Hs108|chr7 ( 425) 2384 533.5 1.6e-151 CCDS47533.1 WIPI2 gene_id:26100|Hs108|chr7 ( 384) 2208 494.8 6.5e-140 CCDS11677.1 WIPI1 gene_id:55062|Hs108|chr17 ( 446) 1574 355.5 6.5e-98 CCDS82193.1 WIPI1 gene_id:55062|Hs108|chr17 ( 364) 1367 309.9 2.7e-84 CCDS11815.2 WDR45B gene_id:56270|Hs108|chr17 ( 344) 388 94.8 1.5e-19 CCDS35250.1 WDR45 gene_id:11152|Hs108|chrX ( 360) 319 79.6 5.8e-15 CCDS14318.1 WDR45 gene_id:11152|Hs108|chrX ( 361) 319 79.6 5.8e-15 >>CCDS5339.1 WIPI2 gene_id:26100|Hs108|chr7 (454 aa) initn: 2982 init1: 2982 opt: 2982 Z-score: 3543.6 bits: 664.9 E(32554): 4.7e-191 Smith-Waterman score: 2982; 100.0% identity (100.0% similar) in 454 aa overlap (1-454:1-454) 10 20 30 40 50 60 pF1KB8 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT 370 380 390 400 410 420 430 440 450 pF1KB8 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD :::::::::::::::::::::::::::::::::: CCDS53 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 430 440 450 >>CCDS34593.1 WIPI2 gene_id:26100|Hs108|chr7 (436 aa) initn: 2851 init1: 2705 opt: 2705 Z-score: 3214.8 bits: 604.0 E(32554): 9.6e-173 Smith-Waterman score: 2819; 96.0% identity (96.0% similar) in 454 aa overlap (1-454:1-436) 10 20 30 40 50 60 pF1KB8 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS ::::::::::::::::::::::::: ::::::::::::::::: CCDS34 MNLASQSGEAGAGQLLFANFNQDNT------------------SLAVGSKSGYKFFSLSS 10 20 30 40 70 80 90 100 110 120 pF1KB8 VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB8 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB8 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT 350 360 370 380 390 400 430 440 450 pF1KB8 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD :::::::::::::::::::::::::::::::::: CCDS34 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 410 420 430 >>CCDS47531.1 WIPI2 gene_id:26100|Hs108|chr7 (443 aa) initn: 2895 init1: 2661 opt: 2661 Z-score: 3162.5 bits: 594.4 E(32554): 7.9e-170 Smith-Waterman score: 2877; 97.6% identity (97.6% similar) in 454 aa overlap (1-454:1-443) 10 20 30 40 50 60 pF1KB8 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT :::::::::::::::::::::::::::::::::::::::::::::: ::: CCDS47 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK-----------AYT 370 380 390 400 430 440 450 pF1KB8 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD :::::::::::::::::::::::::::::::::: CCDS47 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 410 420 430 440 >>CCDS47532.1 WIPI2 gene_id:26100|Hs108|chr7 (425 aa) initn: 2764 init1: 2384 opt: 2384 Z-score: 2833.7 bits: 533.5 E(32554): 1.6e-151 Smith-Waterman score: 2714; 93.6% identity (93.6% similar) in 454 aa overlap (1-454:1-425) 10 20 30 40 50 60 pF1KB8 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS ::::::::::::::::::::::::: ::::::::::::::::: CCDS47 MNLASQSGEAGAGQLLFANFNQDNT------------------SLAVGSKSGYKFFSLSS 10 20 30 40 70 80 90 100 110 120 pF1KB8 VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB8 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB8 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT :::::::::::::::::::::::::::::::::::::::::::::: ::: CCDS47 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK-----------AYT 350 360 370 380 390 430 440 450 pF1KB8 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD :::::::::::::::::::::::::::::::::: CCDS47 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 400 410 420 >>CCDS47533.1 WIPI2 gene_id:26100|Hs108|chr7 (384 aa) initn: 2442 init1: 2208 opt: 2208 Z-score: 2625.3 bits: 494.8 E(32554): 6.5e-140 Smith-Waterman score: 2424; 97.1% identity (97.1% similar) in 383 aa overlap (72-454:13-384) 50 60 70 80 90 100 pF1KB8 VWSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKV :::::::::::::::::::::::::::::: CCDS47 MFTHVLPFVISADTEDVCIVERLFSSSLVAIVSLKAPRKLKV 10 20 30 40 110 120 130 140 150 160 pF1KB8 CHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 CHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGL 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB8 CALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 CALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATAS 110 120 130 140 150 160 230 240 250 260 270 280 pF1KB8 EKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 EKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 170 180 190 200 210 220 290 300 310 320 330 340 pF1KB8 EKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 EKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQK 230 240 250 260 270 280 350 360 370 380 390 400 pF1KB8 IPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 IPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYG 290 300 310 320 330 340 410 420 430 440 450 pF1KB8 AAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD ::::: ::::::::::::::::::::::::::::::::::::: CCDS47 AAAGK-----------AYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 350 360 370 380 >>CCDS11677.1 WIPI1 gene_id:55062|Hs108|chr17 (446 aa) initn: 1540 init1: 1499 opt: 1574 Z-score: 1871.3 bits: 355.5 E(32554): 6.5e-98 Smith-Waterman score: 1574; 58.9% identity (84.9% similar) in 411 aa overlap (44-451:28-434) 20 30 40 50 60 70 pF1KB8 QLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDKLEQIYECTDT :::.:.:.:::.::::::..:.:.. .. CCDS11 MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEI 10 20 30 40 50 80 90 100 110 120 130 pF1KB8 EDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCL :: :::::::::::..:: ::...: ::::::::::::::..::...::::::.::: CCDS11 PDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCL 60 70 80 90 100 110 140 150 160 170 180 190 pF1KB8 EESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLR :::.:::::.:::.:.:. . : ::.::::::::..: ::::::: : ::. ..: .:. CCDS11 EESIYIHNIKDMKLLKTLLDIPANPTGLCALSINHSNSYLAYPGSLTSGEIVLYDGNSLK 120 130 140 150 160 170 200 210 220 230 240 250 pF1KB8 AANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICS .. : ::.. :::..:.:::.:::.::::::::::::.:.::::.:::::.:: :.: : CCDS11 TVCTIAAHEGTLAAITFNASGSKLASASEKGTVIRVFSVPDGQKLYEFRRGMKRYVTISS 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB8 LAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEM :.::::..:: :::::::::::::: : .. ::::.::.::.::..::.:.:::.::..: CCDS11 LVFSMDSQFLCASSNTETVHIFKLEQVTNSRPEEPSTWSGYMGKMFMAATNYLPTQVSDM 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB8 FNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQH ..: :::::.:: : :..:::.:.::::.:::::....:.:::::::::.::::.:.: : CCDS11 MHQDRAFATARLNFSGQRNICTLSTIQKLPRLLVASSSGHLYMYNLDPQDGGECVLIKTH 300 310 320 330 340 350 380 390 400 410 420 430 pF1KB8 RLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLED : :: ::.: .. . : . :.:.:.... . . :. : .:..: ::. : . . CCDS11 SLLGS-GTTEE--NKENDLRPSLPQSYAATVARPS-ASSASTVPGYSEDGGALRGEVIPE 360 370 380 390 400 410 440 450 pF1KB8 EASA---LRLDEDSEHPPMILRTD . : . ::...: ::.:: CCDS11 HEFATGPVCLDDENEFPPIILCRGNQKGKTKQS 420 430 440 >>CCDS82193.1 WIPI1 gene_id:55062|Hs108|chr17 (364 aa) initn: 1333 init1: 1292 opt: 1367 Z-score: 1626.8 bits: 309.9 E(32554): 2.7e-84 Smith-Waterman score: 1367; 58.7% identity (84.8% similar) in 356 aa overlap (99-451:1-352) 70 80 90 100 110 120 pF1KB8 ECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQR ..: ::::::::::::::..::...::::: CCDS82 MNVYHFKKGTEICNYSYSSNILSIRLNRQR 10 20 30 130 140 150 160 170 180 pF1KB8 LIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFD :.::::::.:::::.:::.:.:. . : ::.::::::::..: ::::::: : ::. ..: CCDS82 LLVCLEESIYIHNIKDMKLLKTLLDIPANPTGLCALSINHSNSYLAYPGSLTSGEIVLYD 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB8 TINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRC .:... : ::.. :::..:.:::.:::.::::::::::::.:.::::.:::::.:: CCDS82 GNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTVIRVFSVPDGQKLYEFRRGMKRY 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB8 VSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPS :.: ::.::::..:: :::::::::::::: : .. ::::.::.::.::..::.:.:::. CCDS82 VTISSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRPEEPSTWSGYMGKMFMAATNYLPT 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB8 QVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECA ::..:..: :::::.:: : :..:::.:.::::.:::::....:.:::::::::.::::. CCDS82 QVSDMMHQDRAFATARLNFSGQRNICTLSTIQKLPRLLVASSSGHLYMYNLDPQDGGECV 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB8 LMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGG :.: : : :: ::.: .. . : . :.:.:.... . . :. : .:..: ::. : CCDS82 LIKTHSLLGS-GTTEE--NKENDLRPSLPQSYAATVARPS-ASSASTVPGYSEDGGALRG 280 290 300 310 320 430 440 450 pF1KB8 ACLEDEASA---LRLDEDSEHPPMILRTD . .. : . ::...: ::.:: CCDS82 EVIPEHEFATGPVCLDDENEFPPIILCRGNQKGKTKQS 330 340 350 360 >>CCDS11815.2 WDR45B gene_id:56270|Hs108|chr17 (344 aa) initn: 343 init1: 276 opt: 388 Z-score: 464.3 bits: 94.8 E(32554): 1.5e-19 Smith-Waterman score: 443; 31.0% identity (56.8% similar) in 368 aa overlap (11-367:10-328) 10 20 30 40 50 60 pF1KB8 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS : : ::.:.::::. : .: : ..:.. .. . CCDS11 MNLLPCNPHGNG-LLYAGFNQDH----GC--------------FACGMENGFRVYNTDP 10 20 30 40 70 80 90 100 110 pF1KB8 VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSL-KAPR----KLKVCHFKKGTEICNYSY . . :. : . : :: :: . .:.:. : :. :. . : . . . CCDS11 LKEKEK-QEFLEG-GVGHVEMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEF 50 60 70 80 90 120 130 140 150 160 170 pF1KB8 SNTILAVKLNRQRLIVCLEESL----YIHNIRDMKVLHTIRETPPNPAGLCALSINNDNC :. . :::: :.:..: :. . . :: ....:. :: :: :::.: :..: CCDS11 STEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVF----ETCYNPKGLCVLCPNSNNS 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 YLAYPGSATIGEVQVFDTINLRAANM-IPAHDSPLAALAFDASGTKLATASEKGTVIRVF ::.::. : :.::. : . . . ::::.. :. .:.. .::..::::::::.::.: CCDS11 LLAFPGTHT-GHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIF 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB8 SIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTT . :. . :.::: . : . :..:. .. .::. ::::: : :.. CCDS11 DTSSGHLIQELRRGSQAANIYC-INFNQDASLICVSSDHGTVHIFAAEDPKRNKQSS--- 220 230 240 250 260 300 310 320 330 340 pF1KB8 WTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGA- .::.:.:: ..:.. .:. ..: : ::...: : ... CCDS11 ---------LASASFLP----KYFSSKWSFSKFQVP-SGSPCICAFGT---EPNAVIAIC 270 280 290 300 310 350 360 370 380 390 400 pF1KB8 ADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTY ::: : . ..:. ::: CCDS11 ADGSYYKFLFNPK--GECIRDVYAQFLEMTDDKL 320 330 340 >>CCDS35250.1 WDR45 gene_id:11152|Hs108|chrX (360 aa) initn: 260 init1: 138 opt: 319 Z-score: 382.1 bits: 79.6 E(32554): 5.8e-15 Smith-Waterman score: 335; 26.6% identity (57.1% similar) in 308 aa overlap (78-367:53-343) 50 60 70 80 90 100 pF1KB8 GSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSL-KAPRKLKVCHF-- .:: : :.:.:.:. ..:. .. . CCDS35 CAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIW 30 40 50 60 70 80 110 120 130 140 150 pF1KB8 ---KKGTE-----ICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPP ..: . . ...... .:.:.. ...... :.. .:.... : .: CCDS35 DDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRD 90 100 110 120 130 140 160 170 180 190 200 210 pF1KB8 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLR-----AANMIPAHDSPLAALAFD :: ::: : . .. :..:: : .:. : . . : : ::.: .: .... CCDS35 NPKGLCDLCPSLEKQLLVFPGHKC-GSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLN 150 160 170 180 190 200 220 230 240 250 260 270 pF1KB8 ASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTET :: .:.::.:::.::.:. .:: :.:::. . : . :: :. :: :::. : CCDS35 QPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYC-INFSHDSSFLCASSDKGT 210 220 230 240 250 260 280 290 300 310 320 330 pF1KB8 VHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHK :::: :. .. . . . ::: .:. :: . .:. .: CCDS35 VHIFALKDTR----LNRRSALARVGKVGPMIGQYVDSQWS--------LASFTVP-AESA 270 280 290 300 340 350 360 370 380 pF1KB8 NICSLA--TIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSA ::... : ... ... .:: .. : . :. :.: CCDS35 CICAFGRNTSKNVNSVIAICVDGTFHKYVFTPD--GNCNREAFDVYLDICDDDDF 310 320 330 340 350 360 390 400 410 420 430 440 pF1KB8 SHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASALRLDEDSEHPPM >>CCDS14318.1 WDR45 gene_id:11152|Hs108|chrX (361 aa) initn: 260 init1: 138 opt: 319 Z-score: 382.1 bits: 79.6 E(32554): 5.8e-15 Smith-Waterman score: 333; 26.5% identity (56.6% similar) in 309 aa overlap (78-367:53-344) 50 60 70 80 90 100 pF1KB8 GSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSL-KAPRKLKVCHF-- .:: : :.:.:.:. ..:. .. CCDS14 CAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISAVLI 30 40 50 60 70 80 110 120 130 140 150 pF1KB8 ----KKGTE-----ICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETP ..: . . ...... .:.:.. ...... :.. .:.... : .: CCDS14 WDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTR 90 100 110 120 130 140 160 170 180 190 200 210 pF1KB8 PNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLR-----AANMIPAHDSPLAALAF :: ::: : . .. :..:: : .:. : . . : : ::.: .: ... CCDS14 DNPKGLCDLCPSLEKQLLVFPGHKC-GSLQLVDLASTKPGTSSAPFTINAHQSDIACVSL 150 160 170 180 190 200 220 230 240 250 260 270 pF1KB8 DASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTE . :: .:.::.:::.::.:. .:: :.:::. . : . :: :. :: :::. CCDS14 NQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYC-INFSHDSSFLCASSDKG 210 220 230 240 250 260 280 290 300 310 320 330 pF1KB8 TVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGH ::::: :. .. . . . ::: .:. :: . .:. .: CCDS14 TVHIFALKDTR----LNRRSALARVGKVGPMIGQYVDSQWS--------LASFTVP-AES 270 280 290 300 340 350 360 370 380 pF1KB8 KNICSLA--TIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDS ::... : ... ... .:: .. : . :. :.: CCDS14 ACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPD--GNCNREAFDVYLDICDDDDF 310 320 330 340 350 360 390 400 410 420 430 440 pF1KB8 ASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASALRLDEDSEHPP 454 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:14:15 2016 done: Fri Nov 4 14:14:15 2016 Total Scan time: 1.890 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]