FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8663, 558 aa 1>>>pF1KB8663 558 - 558 aa - 558 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.7588+/-0.000573; mu= -10.5983+/- 0.035 mean_var=513.4569+/-104.149, 0's: 0 Z-trim(117.9): 150 B-trim: 0 in 0/55 Lambda= 0.056601 statistics sampled from 30092 (30234) to 30092 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.354), width: 16 Scan time: 11.610 The best scores are: opt bits E(85289) NP_115517 (OMIM: 616173) nuclear speckle splicing ( 558) 3688 316.5 1.4e-85 XP_016880698 (OMIM: 616173) PREDICTED: nuclear spe ( 588) 3427 295.2 3.7e-79 XP_011523647 (OMIM: 616173) PREDICTED: nuclear spe ( 537) 3425 295.0 3.9e-79 XP_016880700 (OMIM: 616173) PREDICTED: nuclear spe ( 504) 3335 287.6 6.2e-77 XP_016880699 (OMIM: 616173) PREDICTED: nuclear spe ( 504) 3335 287.6 6.2e-77 XP_016880702 (OMIM: 616173) PREDICTED: nuclear spe ( 504) 3335 287.6 6.2e-77 XP_016880701 (OMIM: 616173) PREDICTED: nuclear spe ( 504) 3335 287.6 6.2e-77 XP_016880704 (OMIM: 616173) PREDICTED: nuclear spe ( 504) 3335 287.6 6.2e-77 XP_016880703 (OMIM: 616173) PREDICTED: nuclear spe ( 504) 3335 287.6 6.2e-77 NP_001248396 (OMIM: 616173) nuclear speckle splici ( 504) 3335 287.6 6.2e-77 NP_055885 (OMIM: 616453) zinc finger CCCH domain-c (1564) 376 46.6 0.00071 XP_005266369 (OMIM: 616453) PREDICTED: zinc finger (1564) 376 46.6 0.00071 NP_001317496 (OMIM: 616453) zinc finger CCCH domai (1668) 376 46.6 0.00074 NP_001317494 (OMIM: 616453) zinc finger CCCH domai (1668) 376 46.6 0.00074 NP_001317495 (OMIM: 616453) zinc finger CCCH domai (1668) 376 46.6 0.00074 XP_016875966 (OMIM: 616453) PREDICTED: zinc finger (1669) 376 46.6 0.00074 XP_005266367 (OMIM: 616453) PREDICTED: zinc finger (1669) 376 46.6 0.00074 XP_016875968 (OMIM: 616453) PREDICTED: zinc finger (1669) 376 46.6 0.00074 XP_016875967 (OMIM: 616453) PREDICTED: zinc finger (1669) 376 46.6 0.00074 NP_001317493 (OMIM: 616453) zinc finger CCCH domai (1669) 376 46.6 0.00074 NP_001070256 (OMIM: 616453) zinc finger CCCH domai (1669) 376 46.6 0.00074 XP_016875969 (OMIM: 616453) PREDICTED: zinc finger (1669) 376 46.6 0.00074 NP_001310464 (OMIM: 609268) splicing regulatory gl ( 358) 328 41.9 0.004 NP_001310463 (OMIM: 609268) splicing regulatory gl ( 359) 325 41.7 0.0048 XP_016864545 (OMIM: 609268) PREDICTED: splicing re ( 359) 325 41.7 0.0048 NP_001257421 (OMIM: 609268) splicing regulatory gl ( 507) 328 42.1 0.0051 NP_001310458 (OMIM: 609268) splicing regulatory gl ( 623) 328 42.2 0.0058 NP_001310456 (OMIM: 609268) splicing regulatory gl ( 508) 325 41.9 0.006 NP_631907 (OMIM: 609268) splicing regulatory gluta ( 508) 325 41.9 0.006 XP_011541473 (OMIM: 609268) PREDICTED: splicing re ( 508) 325 41.9 0.006 NP_001070667 (OMIM: 609268) splicing regulatory gl ( 624) 325 42.0 0.0069 >>NP_115517 (OMIM: 616173) nuclear speckle splicing regu (558 aa) initn: 3688 init1: 3688 opt: 3688 Z-score: 1657.5 bits: 316.5 E(85289): 1.4e-85 Smith-Waterman score: 3688; 100.0% identity (100.0% similar) in 558 aa overlap (1-558:1-558) 10 20 30 40 50 60 pF1KB8 MAIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MAIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 EIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 SGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 SGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 EENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 QEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 MKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 DKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYL 490 500 510 520 530 540 550 pF1KB8 ARQMARVNAKTYIEKEDD :::::::::::::::::: NP_115 ARQMARVNAKTYIEKEDD 550 >>XP_016880698 (OMIM: 616173) PREDICTED: nuclear speckle (588 aa) initn: 3427 init1: 3427 opt: 3427 Z-score: 1542.1 bits: 295.2 E(85289): 3.7e-79 Smith-Waterman score: 3427; 99.8% identity (100.0% similar) in 521 aa overlap (38-558:68-588) 10 20 30 40 50 60 pF1KB8 YGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALA .::::::::::::::::::::::::::::: XP_016 FKGKLLKFGIRVPELESCFAIHQLFVLKFSQTSVSESLQREAAKKQAMKQTKLEIQKALA 40 50 60 70 80 90 70 80 90 100 110 120 pF1KB8 EDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQ 100 110 120 130 140 150 130 140 150 160 170 180 pF1KB8 REREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHL 160 170 180 190 200 210 190 200 210 220 230 240 pF1KB8 LNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDAD 220 230 240 250 260 270 250 260 270 280 290 300 pF1KB8 SDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGS 280 290 300 310 320 330 310 320 330 340 350 360 pF1KB8 RTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRA 340 350 360 370 380 390 370 380 390 400 410 420 pF1KB8 RDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKER 400 410 420 430 440 450 430 440 450 460 470 480 pF1KB8 YENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQE 460 470 480 490 500 510 490 500 510 520 530 540 pF1KB8 KPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARV 520 530 540 550 560 570 550 pF1KB8 NAKTYIEKEDD ::::::::::: XP_016 NAKTYIEKEDD 580 >>XP_011523647 (OMIM: 616173) PREDICTED: nuclear speckle (537 aa) initn: 3460 init1: 3425 opt: 3425 Z-score: 1541.6 bits: 295.0 E(85289): 3.9e-79 Smith-Waterman score: 3425; 100.0% identity (100.0% similar) in 520 aa overlap (39-558:18-537) 10 20 30 40 50 60 pF1KB8 GLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAE :::::::::::::::::::::::::::::: XP_011 MAIPGRQNIVLRSHRKRTSVSESLQREAAKKQAMKQTKLEIQKALAE 10 20 30 40 70 80 90 100 110 120 pF1KB8 DATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQR 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 EREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 NQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADS 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 DFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB8 TSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRAR 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB8 DQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERY 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB8 ENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEK 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB8 PSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVN 470 480 490 500 510 520 550 pF1KB8 AKTYIEKEDD :::::::::: XP_011 AKTYIEKEDD 530 >>XP_016880700 (OMIM: 616173) PREDICTED: nuclear speckle (504 aa) initn: 3335 init1: 3335 opt: 3335 Z-score: 1502.3 bits: 287.6 E(85289): 6.2e-77 Smith-Waterman score: 3335; 100.0% identity (100.0% similar) in 504 aa overlap (55-558:1-504) 30 40 50 60 70 80 pF1KB8 KPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQK :::::::::::::::::::::::::::::: XP_016 MKQTKLEIQKALAEDATVYEYDSIYDEMQK 10 20 30 90 100 110 120 130 140 pF1KB8 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB8 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB8 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 400 410 420 430 440 450 510 520 530 540 550 pF1KB8 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 460 470 480 490 500 >>XP_016880699 (OMIM: 616173) PREDICTED: nuclear speckle (504 aa) initn: 3335 init1: 3335 opt: 3335 Z-score: 1502.3 bits: 287.6 E(85289): 6.2e-77 Smith-Waterman score: 3335; 100.0% identity (100.0% similar) in 504 aa overlap (55-558:1-504) 30 40 50 60 70 80 pF1KB8 KPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQK :::::::::::::::::::::::::::::: XP_016 MKQTKLEIQKALAEDATVYEYDSIYDEMQK 10 20 30 90 100 110 120 130 140 pF1KB8 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB8 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB8 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 400 410 420 430 440 450 510 520 530 540 550 pF1KB8 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 460 470 480 490 500 >>XP_016880702 (OMIM: 616173) PREDICTED: nuclear speckle (504 aa) initn: 3335 init1: 3335 opt: 3335 Z-score: 1502.3 bits: 287.6 E(85289): 6.2e-77 Smith-Waterman score: 3335; 100.0% identity (100.0% similar) in 504 aa overlap (55-558:1-504) 30 40 50 60 70 80 pF1KB8 KPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQK :::::::::::::::::::::::::::::: XP_016 MKQTKLEIQKALAEDATVYEYDSIYDEMQK 10 20 30 90 100 110 120 130 140 pF1KB8 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB8 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB8 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 400 410 420 430 440 450 510 520 530 540 550 pF1KB8 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 460 470 480 490 500 >>XP_016880701 (OMIM: 616173) PREDICTED: nuclear speckle (504 aa) initn: 3335 init1: 3335 opt: 3335 Z-score: 1502.3 bits: 287.6 E(85289): 6.2e-77 Smith-Waterman score: 3335; 100.0% identity (100.0% similar) in 504 aa overlap (55-558:1-504) 30 40 50 60 70 80 pF1KB8 KPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQK :::::::::::::::::::::::::::::: XP_016 MKQTKLEIQKALAEDATVYEYDSIYDEMQK 10 20 30 90 100 110 120 130 140 pF1KB8 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB8 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB8 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 400 410 420 430 440 450 510 520 530 540 550 pF1KB8 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 460 470 480 490 500 >>XP_016880704 (OMIM: 616173) PREDICTED: nuclear speckle (504 aa) initn: 3335 init1: 3335 opt: 3335 Z-score: 1502.3 bits: 287.6 E(85289): 6.2e-77 Smith-Waterman score: 3335; 100.0% identity (100.0% similar) in 504 aa overlap (55-558:1-504) 30 40 50 60 70 80 pF1KB8 KPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQK :::::::::::::::::::::::::::::: XP_016 MKQTKLEIQKALAEDATVYEYDSIYDEMQK 10 20 30 90 100 110 120 130 140 pF1KB8 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB8 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB8 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 400 410 420 430 440 450 510 520 530 540 550 pF1KB8 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 460 470 480 490 500 >>XP_016880703 (OMIM: 616173) PREDICTED: nuclear speckle (504 aa) initn: 3335 init1: 3335 opt: 3335 Z-score: 1502.3 bits: 287.6 E(85289): 6.2e-77 Smith-Waterman score: 3335; 100.0% identity (100.0% similar) in 504 aa overlap (55-558:1-504) 30 40 50 60 70 80 pF1KB8 KPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQK :::::::::::::::::::::::::::::: XP_016 MKQTKLEIQKALAEDATVYEYDSIYDEMQK 10 20 30 90 100 110 120 130 140 pF1KB8 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB8 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB8 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 400 410 420 430 440 450 510 520 530 540 550 pF1KB8 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 460 470 480 490 500 >>NP_001248396 (OMIM: 616173) nuclear speckle splicing r (504 aa) initn: 3335 init1: 3335 opt: 3335 Z-score: 1502.3 bits: 287.6 E(85289): 6.2e-77 Smith-Waterman score: 3335; 100.0% identity (100.0% similar) in 504 aa overlap (55-558:1-504) 30 40 50 60 70 80 pF1KB8 KPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQK :::::::::::::::::::::::::::::: NP_001 MKQTKLEIQKALAEDATVYEYDSIYDEMQK 10 20 30 90 100 110 120 130 140 pF1KB8 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFRE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETR 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB8 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB8 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 400 410 420 430 440 450 510 520 530 540 550 pF1KB8 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 460 470 480 490 500 558 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:20:45 2016 done: Fri Nov 4 14:20:46 2016 Total Scan time: 11.610 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]