FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8668, 463 aa 1>>>pF1KB8668 463 - 463 aa - 463 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1294+/-0.000352; mu= 18.8564+/- 0.022 mean_var=61.6793+/-12.584, 0's: 0 Z-trim(112.8): 69 B-trim: 1140 in 1/56 Lambda= 0.163307 statistics sampled from 21790 (21860) to 21790 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.256), width: 16 Scan time: 8.820 The best scores are: opt bits E(85289) NP_003959 (OMIM: 603172) NEDD8-activating enzyme E ( 463) 3097 738.3 1e-212 NP_937838 (OMIM: 603172) NEDD8-activating enzyme E ( 449) 2969 708.1 1.2e-203 XP_011532513 (OMIM: 603172) PREDICTED: NEDD8-activ ( 422) 2482 593.4 3.9e-169 XP_011532512 (OMIM: 603172) PREDICTED: NEDD8-activ ( 436) 2482 593.4 4e-169 NP_005490 (OMIM: 613295) SUMO-activating enzyme su ( 640) 380 98.3 6.7e-20 XP_011532374 (OMIM: 191325) PREDICTED: ubiquitin-l ( 796) 364 94.5 1.1e-18 XP_005265487 (OMIM: 191325) PREDICTED: ubiquitin-l ( 987) 364 94.6 1.3e-18 NP_003326 (OMIM: 191325) ubiquitin-like modifier-a (1012) 364 94.6 1.3e-18 XP_016863848 (OMIM: 611361) PREDICTED: ubiquitin-l (1009) 306 80.9 1.7e-14 NP_060697 (OMIM: 611361) ubiquitin-like modifier-a (1052) 306 80.9 1.8e-14 XP_016881623 (OMIM: 613295) PREDICTED: SUMO-activa ( 608) 244 66.2 2.8e-10 XP_011524606 (OMIM: 613295) PREDICTED: SUMO-activa ( 700) 244 66.2 3.2e-10 XP_005258461 (OMIM: 613295) PREDICTED: SUMO-activa ( 752) 244 66.2 3.4e-10 NP_055299 (OMIM: 609277) adenylyltransferase and s ( 460) 185 52.2 3.4e-06 NP_079094 (OMIM: 610552,617132,617133) ubiquitin-l ( 404) 183 51.7 4.3e-06 NP_001139186 (OMIM: 613294) SUMO-activating enzyme ( 266) 180 50.9 4.9e-06 XP_006723028 (OMIM: 613294) PREDICTED: SUMO-activa ( 281) 180 50.9 5.1e-06 NP_001139185 (OMIM: 613294) SUMO-activating enzyme ( 299) 180 51.0 5.4e-06 NP_005491 (OMIM: 613294) SUMO-activating enzyme su ( 346) 180 51.0 6.1e-06 XP_016881624 (OMIM: 613294) PREDICTED: SUMO-activa ( 349) 180 51.0 6.2e-06 XP_006723026 (OMIM: 613294) PREDICTED: SUMO-activa ( 378) 180 51.0 6.6e-06 NP_938143 (OMIM: 610552,617132,617133) ubiquitin-l ( 348) 172 49.1 2.3e-05 NP_001307139 (OMIM: 610552,617132,617133) ubiquiti ( 348) 172 49.1 2.3e-05 XP_016885269 (OMIM: 301830,314370) PREDICTED: ubiq (1058) 165 47.7 0.00018 XP_016885270 (OMIM: 301830,314370) PREDICTED: ubiq (1058) 165 47.7 0.00018 NP_695012 (OMIM: 301830,314370) ubiquitin-like mod (1058) 165 47.7 0.00018 NP_003325 (OMIM: 301830,314370) ubiquitin-like mod (1058) 165 47.7 0.00018 XP_005272706 (OMIM: 301830,314370) PREDICTED: ubiq (1064) 165 47.7 0.00018 XP_016885268 (OMIM: 301830,314370) PREDICTED: ubiq (1064) 165 47.7 0.00018 XP_011542256 (OMIM: 301830,314370) PREDICTED: ubiq (1072) 165 47.7 0.00018 XP_016885267 (OMIM: 301830,314370) PREDICTED: ubiq (1086) 165 47.7 0.00018 XP_016885266 (OMIM: 301830,314370) PREDICTED: ubiq (1109) 165 47.7 0.00019 NP_001018169 (OMIM: 603385) NEDD8-activating enzym ( 528) 155 45.2 0.00052 NP_003896 (OMIM: 603385) NEDD8-activating enzyme E ( 534) 155 45.2 0.00052 XP_016861043 (OMIM: 608760) PREDICTED: ubiquitin-l ( 390) 149 43.7 0.0011 XP_016861042 (OMIM: 608760) PREDICTED: ubiquitin-l ( 392) 149 43.7 0.0011 NP_001138384 (OMIM: 608760) ubiquitin-like modifie ( 623) 149 43.8 0.0016 XP_016861040 (OMIM: 608760) PREDICTED: ubiquitin-l ( 672) 149 43.8 0.0017 NP_001129503 (OMIM: 608760) ubiquitin-like modifie ( 676) 149 43.8 0.0017 XP_011531588 (OMIM: 608760) PREDICTED: ubiquitin-l ( 676) 149 43.8 0.0017 XP_011531586 (OMIM: 608760) PREDICTED: ubiquitin-l ( 694) 149 43.8 0.0017 XP_011531585 (OMIM: 608760) PREDICTED: ubiquitin-l ( 699) 149 43.8 0.0017 XP_016861037 (OMIM: 608760) PREDICTED: ubiquitin-l ( 699) 149 43.8 0.0017 XP_016861036 (OMIM: 608760) PREDICTED: ubiquitin-l ( 701) 149 43.8 0.0017 XP_016861035 (OMIM: 608760) PREDICTED: ubiquitin-l ( 703) 149 43.8 0.0018 XP_016861033 (OMIM: 608760) PREDICTED: ubiquitin-l ( 703) 149 43.8 0.0018 XP_016861034 (OMIM: 608760) PREDICTED: ubiquitin-l ( 703) 149 43.8 0.0018 NP_006386 (OMIM: 608760) ubiquitin-like modifier-a ( 703) 149 43.8 0.0018 XP_011531584 (OMIM: 608760) PREDICTED: ubiquitin-l ( 703) 149 43.8 0.0018 XP_011531583 (OMIM: 608760) PREDICTED: ubiquitin-l ( 710) 149 43.9 0.0018 >>NP_003959 (OMIM: 603172) NEDD8-activating enzyme E1 ca (463 aa) initn: 3097 init1: 3097 opt: 3097 Z-score: 3939.9 bits: 738.3 E(85289): 1e-212 Smith-Waterman score: 3097; 99.6% identity (99.6% similar) in 463 aa overlap (1-463:1-463) 10 20 30 40 50 60 pF1KB8 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 GRPKAEVAAEFLNDRVPNCNVVPHFYKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_003 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLGGDDPEHIQWIFQKSLERASQYNIRGVTYR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_003 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 370 380 390 400 410 420 430 440 450 460 pF1KB8 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS ::::::::::::::::::::::::::::::::::::::::::: NP_003 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 430 440 450 460 >>NP_937838 (OMIM: 603172) NEDD8-activating enzyme E1 ca (449 aa) initn: 2969 init1: 2969 opt: 2969 Z-score: 3777.1 bits: 708.1 E(85289): 1.2e-203 Smith-Waterman score: 2976; 96.5% identity (96.5% similar) in 463 aa overlap (1-463:1-449) 10 20 30 40 50 60 pF1KB8 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST ::::::: ::::::::::::::::::::::::::::::::::::::: NP_937 MADGEEP--------------MAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 10 20 30 40 70 80 90 100 110 120 pF1KB8 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 GRPKAEVAAEFLNDRVPNCNVVPHFYKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_937 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLGGDDPEHIQWIFQKSLERASQYNIRGVTYR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_937 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB8 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB8 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 350 360 370 380 390 400 430 440 450 460 pF1KB8 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS ::::::::::::::::::::::::::::::::::::::::::: NP_937 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 410 420 430 440 >>XP_011532513 (OMIM: 603172) PREDICTED: NEDD8-activatin (422 aa) initn: 2518 init1: 2482 opt: 2482 Z-score: 3157.5 bits: 593.4 E(85289): 3.9e-169 Smith-Waterman score: 2736; 90.7% identity (90.7% similar) in 463 aa overlap (1-463:1-422) 10 20 30 40 50 60 pF1KB8 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST ::::::: ::::::::::::::::::::::::::::::::::::::: XP_011 MADGEEP--------------MAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 10 20 30 40 70 80 90 100 110 120 pF1KB8 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI : :::::::::::::::::::::::::::::::: XP_011 E---------------------------ALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 50 60 70 130 140 150 160 170 180 pF1KB8 GRPKAEVAAEFLNDRVPNCNVVPHFYKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: XP_011 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 80 90 100 110 120 130 190 200 210 220 230 240 pF1KB8 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB8 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLGGDDPEHIQWIFQKSLERASQYNIRGVTYR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: XP_011 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB8 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB8 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 320 330 340 350 360 370 430 440 450 460 pF1KB8 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS ::::::::::::::::::::::::::::::::::::::::::: XP_011 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 380 390 400 410 420 >>XP_011532512 (OMIM: 603172) PREDICTED: NEDD8-activatin (436 aa) initn: 2482 init1: 2482 opt: 2482 Z-score: 3157.2 bits: 593.4 E(85289): 4e-169 Smith-Waterman score: 2857; 93.7% identity (93.7% similar) in 463 aa overlap (1-463:1-436) 10 20 30 40 50 60 pF1KB8 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI : :::::::::::::::::::::::::::::::: XP_011 E---------------------------ALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 70 80 90 130 140 150 160 170 180 pF1KB8 GRPKAEVAAEFLNDRVPNCNVVPHFYKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: XP_011 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLGGDDPEHIQWIFQKSLERASQYNIRGVTYR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: XP_011 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB8 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 340 350 360 370 380 390 430 440 450 460 pF1KB8 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS ::::::::::::::::::::::::::::::::::::::::::: XP_011 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 400 410 420 430 >>NP_005490 (OMIM: 613295) SUMO-activating enzyme subuni (640 aa) initn: 581 init1: 290 opt: 380 Z-score: 478.3 bits: 98.3 E(85289): 6.7e-20 Smith-Waterman score: 534; 41.9% identity (62.3% similar) in 236 aa overlap (71-302:19-239) 50 60 70 80 90 100 pF1KB8 VKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVID .:::.::::.::::::::.:.:: .: .:: NP_005 MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLID 10 20 30 40 110 120 130 140 150 pF1KB8 MDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFYKIQ--DFNDTFYRQ .::::::::::::::. : .:: ::.:: : . . :. :.: . .:. :.: :.:: NP_005 LDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQ 50 60 70 80 90 100 160 170 180 190 200 210 pF1KB8 FHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMT : ... .::. :: .: : .. : ::::..:: :. :.. .: :.: NP_005 FILVMNALDNRAARNHVNRMCLA----AD--------VPLIESGTAGYLGQVTTIKKGVT 110 120 130 140 150 220 230 240 250 260 270 pF1KB8 ACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRML--QWPKEQPFGEGVPLGGDDPE : :: . : : .:: ::: . : : ::: ....: : :. . : ::: NP_005 ECYECHPK--PTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPE 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB8 HIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAY : .. :: : : :.. NP_005 -AAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLW 220 230 240 250 260 270 >>XP_011532374 (OMIM: 191325) PREDICTED: ubiquitin-like (796 aa) initn: 316 init1: 188 opt: 364 Z-score: 456.5 bits: 94.5 E(85289): 1.1e-18 Smith-Waterman score: 367; 33.9% identity (57.3% similar) in 218 aa overlap (73-279:220-418) 50 60 70 80 90 pF1KB8 KFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQ-----IH :..:::..:::::: .:: :. . XP_011 EDCALRGSRYDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLT 190 200 210 220 230 240 100 110 120 130 140 150 pF1KB8 VIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFYKIQD-----FN :.::: :. :::.:::::: .:.::::::::: :. .:.: : .. .. XP_011 VVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYG 250 260 270 280 290 300 160 170 180 190 200 210 pF1KB8 DTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARV :.:. . .. .:::. :::.. . :. ::...:: : :.: : XP_011 DNFFSRVDGVAAALDSFQARRYVAARCTHYLK------------PLLEAGTSGTWGSATV 310 320 330 340 350 220 230 240 250 260 270 pF1KB8 ILPGMTACIECTLELYPPQ-VNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLG ..: .: . . . .:.::. .: :: ::: ... : : :. XP_011 FMPHVTEAYRAPASAAASEDAPYPVCTVRYFPSTAEHT------LQWARHE-FEELFRLS 360 370 380 390 400 410 280 290 300 310 320 330 pF1KB8 GDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKI .. .: : XP_011 AETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQNWQDCVAWALGHWKLCFHYGIK 420 430 440 450 460 470 >>XP_005265487 (OMIM: 191325) PREDICTED: ubiquitin-like (987 aa) initn: 249 init1: 188 opt: 364 Z-score: 455.1 bits: 94.6 E(85289): 1.3e-18 Smith-Waterman score: 367; 33.9% identity (57.3% similar) in 218 aa overlap (73-279:436-634) 50 60 70 80 90 pF1KB8 KFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQ-----IH :..:::..:::::: .:: :. . XP_005 EDCALRGSRYDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLT 410 420 430 440 450 460 100 110 120 130 140 150 pF1KB8 VIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFYKIQD-----FN :.::: :. :::.:::::: .:.::::::::: :. .:.: : .. .. XP_005 VVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYG 470 480 490 500 510 520 160 170 180 190 200 210 pF1KB8 DTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARV :.:. . .. .:::. :::.. . :. ::...:: : :.: : XP_005 DNFFSRVDGVAAALDSFQARRYVAARCTHYLK------------PLLEAGTSGTWGSATV 530 540 550 560 570 220 230 240 250 260 270 pF1KB8 ILPGMTACIECTLELYPPQ-VNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLG ..: .: . . . .:.::. .: :: ::: ... : : :. XP_005 FMPHVTEAYRAPASAAASEDAPYPVCTVRYFPSTAEHT------LQWARHE-FEELFRLS 580 590 600 610 620 280 290 300 310 320 330 pF1KB8 GDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKI .. .: : XP_005 AETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQNWQDCVAWALGHWKLCFHYGIK 630 640 650 660 670 680 >>NP_003326 (OMIM: 191325) ubiquitin-like modifier-activ (1012 aa) initn: 249 init1: 188 opt: 364 Z-score: 454.9 bits: 94.6 E(85289): 1.3e-18 Smith-Waterman score: 367; 33.9% identity (57.3% similar) in 218 aa overlap (73-279:436-634) 50 60 70 80 90 pF1KB8 KFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQ-----IH :..:::..:::::: .:: :. . NP_003 EDCALRGSRYDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLT 410 420 430 440 450 460 100 110 120 130 140 150 pF1KB8 VIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFYKIQD-----FN :.::: :. :::.:::::: .:.::::::::: :. .:.: : .. .. NP_003 VVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYG 470 480 490 500 510 520 160 170 180 190 200 210 pF1KB8 DTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARV :.:. . .. .:::. :::.. . :. ::...:: : :.: : NP_003 DNFFSRVDGVAAALDSFQARRYVAARCTHYLK------------PLLEAGTSGTWGSATV 530 540 550 560 570 220 230 240 250 260 270 pF1KB8 ILPGMTACIECTLELYPPQ-VNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLG ..: .: . . . .:.::. .: :: ::: ... : : :. NP_003 FMPHVTEAYRAPASAAASEDAPYPVCTVRYFPSTAEHT------LQWARHE-FEELFRLS 580 590 600 610 620 280 290 300 310 320 330 pF1KB8 GDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKI .. .: : NP_003 AETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQNWQDCVAWALGHWKLCFHYGIK 630 640 650 660 670 680 >>XP_016863848 (OMIM: 611361) PREDICTED: ubiquitin-like (1009 aa) initn: 460 init1: 139 opt: 306 Z-score: 381.1 bits: 80.9 E(85289): 1.7e-14 Smith-Waterman score: 372; 34.7% identity (61.8% similar) in 199 aa overlap (67-254:458-642) 40 50 60 70 80 90 pF1KB8 RWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFR-- :.. .....: :..:::.:::.:: : XP_016 LGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTS 430 440 450 460 470 480 100 110 120 130 140 150 pF1KB8 ----QIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFYKIQD .: : : : :. :::::::::::. : .::. .::. . .. :. :. XP_016 KEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCP 490 500 510 520 530 540 160 170 180 190 200 pF1KB8 -----FNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEG .:: :: . .:. .::.. :::.... .. : ::.:.:: : XP_016 TTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLR------------PLLDSGTMG 550 560 570 580 590 210 220 230 240 250 260 pF1KB8 FKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFG ::...::.: .: . . ::. ..:.::. :.: :: :...: XP_016 TKGHTEVIVPHLTESYNSHRD--PPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKP 600 610 620 630 640 650 270 280 290 300 310 320 pF1KB8 EGVPLGGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCA XP_016 SLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNH 660 670 680 690 700 710 >>NP_060697 (OMIM: 611361) ubiquitin-like modifier-activ (1052 aa) initn: 460 init1: 139 opt: 306 Z-score: 380.8 bits: 80.9 E(85289): 1.8e-14 Smith-Waterman score: 372; 34.7% identity (61.8% similar) in 199 aa overlap (67-254:458-642) 40 50 60 70 80 90 pF1KB8 RWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFR-- :.. .....: :..:::.:::.:: : NP_060 LGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTS 430 440 450 460 470 480 100 110 120 130 140 150 pF1KB8 ----QIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFYKIQD .: : : : :. :::::::::::. : .::. .::. . .. :. :. NP_060 KEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCP 490 500 510 520 530 540 160 170 180 190 200 pF1KB8 -----FNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEG .:: :: . .:. .::.. :::.... .. : ::.:.:: : NP_060 TTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLR------------PLLDSGTMG 550 560 570 580 590 210 220 230 240 250 260 pF1KB8 FKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFG ::...::.: .: . . ::. ..:.::. :.: :: :...: NP_060 TKGHTEVIVPHLTESYNSHRD--PPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKP 600 610 620 630 640 650 270 280 290 300 310 320 pF1KB8 EGVPLGGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCA NP_060 SLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNH 660 670 680 690 700 710 463 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:23:04 2016 done: Fri Nov 4 14:23:06 2016 Total Scan time: 8.820 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]