FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8673, 657 aa 1>>>pF1KB8673 657 - 657 aa - 657 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6553+/-0.000336; mu= 18.5797+/- 0.021 mean_var=87.7813+/-17.874, 0's: 0 Z-trim(116.4): 77 B-trim: 95 in 1/52 Lambda= 0.136890 statistics sampled from 27518 (27598) to 27518 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.681), E-opt: 0.2 (0.324), width: 16 Scan time: 11.400 The best scores are: opt bits E(85289) NP_001171646 (OMIM: 612480) TCDD-inducible poly [A ( 657) 4547 908.3 0 NP_056323 (OMIM: 612480) TCDD-inducible poly [ADP- ( 657) 4547 908.3 0 NP_001171647 (OMIM: 612480) TCDD-inducible poly [A ( 657) 4547 908.3 0 NP_073587 (OMIM: 612481) poly [ADP-ribose] polymer ( 701) 734 155.2 7.3e-37 XP_011510781 (OMIM: 612066) PREDICTED: poly [ADP-r ( 425) 486 106.1 2.7e-22 XP_011510780 (OMIM: 612066) PREDICTED: poly [ADP-r ( 425) 486 106.1 2.7e-22 XP_016861281 (OMIM: 612066) PREDICTED: poly [ADP-r ( 425) 486 106.1 2.7e-22 NP_689828 (OMIM: 612066) poly [ADP-ribose] polymer ( 444) 486 106.1 2.8e-22 NP_001295250 (OMIM: 612066) poly [ADP-ribose] poly ( 375) 484 105.7 3.3e-22 XP_011510779 (OMIM: 612066) PREDICTED: poly [ADP-r ( 552) 486 106.2 3.3e-22 XP_005247217 (OMIM: 612066) PREDICTED: poly [ADP-r ( 602) 486 106.2 3.6e-22 XP_011510778 (OMIM: 612066) PREDICTED: poly [ADP-r ( 628) 486 106.2 3.7e-22 XP_011510777 (OMIM: 612066) PREDICTED: poly [ADP-r ( 638) 486 106.2 3.7e-22 NP_001106995 (OMIM: 612066) poly [ADP-ribose] poly ( 678) 486 106.3 3.9e-22 NP_001295249 (OMIM: 612066) poly [ADP-ribose] poly ( 483) 484 105.8 4e-22 XP_016861280 (OMIM: 612066) PREDICTED: poly [ADP-r ( 533) 484 105.8 4.3e-22 XP_005247216 (OMIM: 612066) PREDICTED: poly [ADP-r ( 609) 484 105.8 4.7e-22 NP_060024 (OMIM: 610028) poly [ADP-ribose] polymer (1801) 451 99.7 1e-19 XP_011515638 (OMIM: 609564) PREDICTED: poly [ADP-r (1016) 383 86.0 7.1e-16 NP_116178 (OMIM: 609564) poly [ADP-ribose] polymer (1025) 383 86.0 7.2e-16 NP_001304824 (OMIM: 609564) poly [ADP-ribose] poly (1037) 383 86.1 7.2e-16 XP_016875160 (OMIM: 616706) PREDICTED: poly [ADP-r ( 257) 332 75.5 2.6e-13 NP_001273451 (OMIM: 616706) poly [ADP-ribose] poly ( 257) 332 75.5 2.6e-13 NP_001273450 (OMIM: 616706) poly [ADP-ribose] poly ( 257) 332 75.5 2.6e-13 XP_005253768 (OMIM: 616706) PREDICTED: poly [ADP-r ( 331) 332 75.6 3.2e-13 XP_011519273 (OMIM: 616706) PREDICTED: poly [ADP-r ( 331) 332 75.6 3.2e-13 XP_011519275 (OMIM: 616706) PREDICTED: poly [ADP-r ( 331) 332 75.6 3.2e-13 XP_011519272 (OMIM: 616706) PREDICTED: poly [ADP-r ( 331) 332 75.6 3.2e-13 XP_016875159 (OMIM: 616706) PREDICTED: poly [ADP-r ( 331) 332 75.6 3.2e-13 NP_065100 (OMIM: 616706) poly [ADP-ribose] polymer ( 338) 332 75.6 3.3e-13 NP_064504 (OMIM: 607312) zinc finger CCCH-type ant ( 902) 268 63.3 4.5e-09 XP_005250558 (OMIM: 607312) PREDICTED: zinc finger (1024) 268 63.3 4.9e-09 NP_001139575 (OMIM: 612065) poly [ADP-ribose] poly ( 819) 247 59.1 7.3e-08 XP_016862795 (OMIM: 612065) PREDICTED: poly [ADP-r ( 819) 247 59.1 7.3e-08 NP_001139577 (OMIM: 612065) poly [ADP-ribose] poly ( 819) 247 59.1 7.3e-08 NP_001139576 (OMIM: 612065) poly [ADP-ribose] poly ( 819) 247 59.1 7.3e-08 XP_016862794 (OMIM: 612065) PREDICTED: poly [ADP-r ( 819) 247 59.1 7.3e-08 XP_005247877 (OMIM: 612065) PREDICTED: poly [ADP-r ( 854) 247 59.1 7.6e-08 NP_113646 (OMIM: 612065) poly [ADP-ribose] polymer ( 854) 247 59.1 7.6e-08 NP_001139574 (OMIM: 612065) poly [ADP-ribose] poly ( 854) 247 59.1 7.6e-08 XP_016862793 (OMIM: 612065) PREDICTED: poly [ADP-r ( 854) 247 59.1 7.6e-08 XP_005250097 (OMIM: 612481) PREDICTED: poly [ADP-r ( 416) 220 53.6 1.8e-06 XP_005250096 (OMIM: 612481) PREDICTED: poly [ADP-r ( 420) 220 53.6 1.8e-06 XP_005250095 (OMIM: 612481) PREDICTED: poly [ADP-r ( 487) 220 53.6 2e-06 XP_011514793 (OMIM: 612481) PREDICTED: poly [ADP-r ( 535) 220 53.6 2.1e-06 XP_011538517 (OMIM: 607128) PREDICTED: tankyrase-2 ( 695) 190 47.8 0.00016 XP_016872189 (OMIM: 607128) PREDICTED: tankyrase-2 ( 977) 177 45.4 0.0012 XP_016872188 (OMIM: 607128) PREDICTED: tankyrase-2 (1059) 177 45.4 0.0013 XP_016872187 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 177 45.4 0.0013 XP_016872186 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 177 45.4 0.0013 >>NP_001171646 (OMIM: 612480) TCDD-inducible poly [ADP-r (657 aa) initn: 4547 init1: 4547 opt: 4547 Z-score: 4853.0 bits: 908.3 E(85289): 0 Smith-Waterman score: 4547; 100.0% identity (100.0% similar) in 657 aa overlap (1-657:1-657) 10 20 30 40 50 60 pF1KB8 MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS 550 560 570 580 590 600 610 620 630 640 650 pF1KB8 HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI 610 620 630 640 650 >>NP_056323 (OMIM: 612480) TCDD-inducible poly [ADP-ribo (657 aa) initn: 4547 init1: 4547 opt: 4547 Z-score: 4853.0 bits: 908.3 E(85289): 0 Smith-Waterman score: 4547; 100.0% identity (100.0% similar) in 657 aa overlap (1-657:1-657) 10 20 30 40 50 60 pF1KB8 MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS 550 560 570 580 590 600 610 620 630 640 650 pF1KB8 HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI 610 620 630 640 650 >>NP_001171647 (OMIM: 612480) TCDD-inducible poly [ADP-r (657 aa) initn: 4547 init1: 4547 opt: 4547 Z-score: 4853.0 bits: 908.3 E(85289): 0 Smith-Waterman score: 4547; 100.0% identity (100.0% similar) in 657 aa overlap (1-657:1-657) 10 20 30 40 50 60 pF1KB8 MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS 550 560 570 580 590 600 610 620 630 640 650 pF1KB8 HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI 610 620 630 640 650 >>NP_073587 (OMIM: 612481) poly [ADP-ribose] polymerase (701 aa) initn: 546 init1: 252 opt: 734 Z-score: 782.8 bits: 155.2 E(85289): 7.3e-37 Smith-Waterman score: 734; 33.4% identity (63.4% similar) in 434 aa overlap (236-652:269-681) 210 220 230 240 250 260 pF1KB8 LSTELFQDKSEEASLDLVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLP ::.: .::. .. .: . : . : :: NP_073 APSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLP 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB8 YHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDRMRMKYGGQEFWA---DLNAMNVYET :.::. ::... :..: .:. ::::. .:. . ... : . ..:::. : . NP_073 YRWQF--LDRGKWEDL--DNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMT-YGA 300 310 320 330 340 350 330 340 350 360 370 pF1KB8 TEFDQLRRLSTPPSSNVNSIYHTV----WKFFCRDHFG-WREYP-ESVIRLIEEANSRGL : : ::::: .:.:.. : . : .. :.:: :.:: ..... . ..: . NP_073 T---QARRLST--ASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDV 360 370 380 390 400 380 390 400 410 420 pF1KB8 KEVRFMMWNNHYILHNSFFRREIKRRPL---FRSCFIL--LPYLQT--LGGVPTQAPPPL ... . . . . . .. . .. :.. :. : : : . : . : NP_073 EKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKA-FVQKNLVYGTTKKVCRRPKYVSP-- 410 420 430 440 450 460 430 440 450 460 470 480 pF1KB8 EATSSSQIICPDGVTSANFYPETW-VYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEF . ... : : . . :. : :. : .. .:. .. :. ..:::..:.: : NP_073 QDVTTMQT-CNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLP-F 470 480 490 500 510 520 490 500 510 520 530 540 pF1KB8 KYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVDGICKHNFD : . .: :::: ::: :. .: :... :. ..::.:::::: ::.::..::: NP_073 -YFVQKIERVQNLALWEVYQWQKGQMQKQNGGK--AVDERQLFHGTSAIFVDAICQQNFD 530 540 550 560 570 580 550 560 570 580 590 600 pF1KB8 PRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPP :::: :.: .:.:::::. :.:::..::.... .: ::::.::.:... :. .. ::: NP_073 WRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQ-THTMFLARVLVGEFVRGNASFVRPP- 590 600 610 620 630 610 620 630 640 650 pF1KB8 VNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI .. : .. .:::::.. .:.:::::. : :: .:::: : NP_073 AKEG-WSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLF 640 650 660 670 680 690 NP_073 SSRQ 700 >>XP_011510781 (OMIM: 612066) PREDICTED: poly [ADP-ribos (425 aa) initn: 455 init1: 159 opt: 486 Z-score: 521.2 bits: 106.1 E(85289): 2.7e-22 Smith-Waterman score: 486; 41.1% identity (66.5% similar) in 209 aa overlap (443-648:224-423) 420 430 440 450 460 470 pF1KB8 PYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDK .:. :. :: :. :. : : .: . .. XP_011 IFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTCNL-PEHWTDMN-HQLFCMVQLEPGQS 200 210 220 230 240 250 480 490 500 510 520 530 pF1KB8 SYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFH : : . : .: .: : .: :.:: :::..:. ::. :. : :. ::: ::: XP_011 EYNTIKDKFTRTCS--SYAIEKIERIQNAFLWQSYQVKKRQMDIK---NDHKNNERLLFH 260 270 280 290 300 540 550 560 570 580 pF1KB8 GTSQDVVDGICKHNFDPRVC-GKHATMFGQGSYFAKKASYS--HNFSKKSSKGVHFMFLA ::. : : . .:.:. : : ::.:. .:.:.::: :::: ..:: .:.: . :... XP_011 GTDADSVPYVNQHGFN-RSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVV 310 320 330 340 350 360 590 600 610 620 630 640 pF1KB8 KVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYE .:::: .: : :. ::: :: . : ::.:: ..: :..::.: :.:.:: ..: . XP_011 RVLTGVFTKGRAGLVTPPPKNPHNPT-DLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFT 370 380 390 400 410 420 650 pF1KB8 EVSNTVSI XP_011 A >>XP_011510780 (OMIM: 612066) PREDICTED: poly [ADP-ribos (425 aa) initn: 455 init1: 159 opt: 486 Z-score: 521.2 bits: 106.1 E(85289): 2.7e-22 Smith-Waterman score: 486; 41.1% identity (66.5% similar) in 209 aa overlap (443-648:224-423) 420 430 440 450 460 470 pF1KB8 PYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDK .:. :. :: :. :. : : .: . .. XP_011 IFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTCNL-PEHWTDMN-HQLFCMVQLEPGQS 200 210 220 230 240 250 480 490 500 510 520 530 pF1KB8 SYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFH : : . : .: .: : .: :.:: :::..:. ::. :. : :. ::: ::: XP_011 EYNTIKDKFTRTCS--SYAIEKIERIQNAFLWQSYQVKKRQMDIK---NDHKNNERLLFH 260 270 280 290 300 540 550 560 570 580 pF1KB8 GTSQDVVDGICKHNFDPRVC-GKHATMFGQGSYFAKKASYS--HNFSKKSSKGVHFMFLA ::. : : . .:.:. : : ::.:. .:.:.::: :::: ..:: .:.: . :... XP_011 GTDADSVPYVNQHGFN-RSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVV 310 320 330 340 350 360 590 600 610 620 630 640 pF1KB8 KVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYE .:::: .: : :. ::: :: . : ::.:: ..: :..::.: :.:.:: ..: . XP_011 RVLTGVFTKGRAGLVTPPPKNPHNPT-DLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFT 370 380 390 400 410 420 650 pF1KB8 EVSNTVSI XP_011 A >>XP_016861281 (OMIM: 612066) PREDICTED: poly [ADP-ribos (425 aa) initn: 455 init1: 159 opt: 486 Z-score: 521.2 bits: 106.1 E(85289): 2.7e-22 Smith-Waterman score: 486; 41.1% identity (66.5% similar) in 209 aa overlap (443-648:224-423) 420 430 440 450 460 470 pF1KB8 PYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDK .:. :. :: :. :. : : .: . .. XP_016 IFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTCNL-PEHWTDMN-HQLFCMVQLEPGQS 200 210 220 230 240 250 480 490 500 510 520 530 pF1KB8 SYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFH : : . : .: .: : .: :.:: :::..:. ::. :. : :. ::: ::: XP_016 EYNTIKDKFTRTCS--SYAIEKIERIQNAFLWQSYQVKKRQMDIK---NDHKNNERLLFH 260 270 280 290 300 540 550 560 570 580 pF1KB8 GTSQDVVDGICKHNFDPRVC-GKHATMFGQGSYFAKKASYS--HNFSKKSSKGVHFMFLA ::. : : . .:.:. : : ::.:. .:.:.::: :::: ..:: .:.: . :... XP_016 GTDADSVPYVNQHGFN-RSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVV 310 320 330 340 350 360 590 600 610 620 630 640 pF1KB8 KVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYE .:::: .: : :. ::: :: . : ::.:: ..: :..::.: :.:.:: ..: . XP_016 RVLTGVFTKGRAGLVTPPPKNPHNPT-DLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFT 370 380 390 400 410 420 650 pF1KB8 EVSNTVSI XP_016 A >>NP_689828 (OMIM: 612066) poly [ADP-ribose] polymerase (444 aa) initn: 455 init1: 159 opt: 486 Z-score: 520.9 bits: 106.1 E(85289): 2.8e-22 Smith-Waterman score: 486; 41.1% identity (66.5% similar) in 209 aa overlap (443-648:243-442) 420 430 440 450 460 470 pF1KB8 PYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDK .:. :. :: :. :. : : .: . .. NP_689 IFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTCNL-PEHWTDMN-HQLFCMVQLEPGQS 220 230 240 250 260 270 480 490 500 510 520 530 pF1KB8 SYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFH : : . : .: .: : .: :.:: :::..:. ::. :. : :. ::: ::: NP_689 EYNTIKDKFTRTCS--SYAIEKIERIQNAFLWQSYQVKKRQMDIK---NDHKNNERLLFH 280 290 300 310 320 540 550 560 570 580 pF1KB8 GTSQDVVDGICKHNFDPRVC-GKHATMFGQGSYFAKKASYS--HNFSKKSSKGVHFMFLA ::. : : . .:.:. : : ::.:. .:.:.::: :::: ..:: .:.: . :... NP_689 GTDADSVPYVNQHGFN-RSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVV 330 340 350 360 370 380 590 600 610 620 630 640 pF1KB8 KVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYE .:::: .: : :. ::: :: . : ::.:: ..: :..::.: :.:.:: ..: . NP_689 RVLTGVFTKGRAGLVTPPPKNPHNPT-DLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFT 390 400 410 420 430 440 650 pF1KB8 EVSNTVSI NP_689 A >>NP_001295250 (OMIM: 612066) poly [ADP-ribose] polymera (375 aa) initn: 455 init1: 159 opt: 484 Z-score: 519.8 bits: 105.7 E(85289): 3.3e-22 Smith-Waterman score: 484; 39.2% identity (65.8% similar) in 222 aa overlap (430-648:162-373) 400 410 420 430 440 450 pF1KB8 KRRPLFRSCFILLPYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPS : . ... : .. ..:. :: :. :. NP_001 PGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLP-AIGTGNL-PEHWTDMN-H 140 150 160 170 180 460 470 480 490 500 510 pF1KB8 QDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMF : : .: . .. : : . : .: .: : .: :.:: :::..:. ::. :. : NP_001 QLFCMVQLEPGQSEYNTIKDKFTRTCS--SYAIEKIERIQNAFLWQSYQVKKRQMDIK-- 190 200 210 220 230 240 520 530 540 550 560 570 pF1KB8 GRDRIINERHLFHGTSQDVVDGICKHNFDPRVC-GKHATMFGQGSYFAKKASYS--HNFS :. ::: :::::. : : . .:.:. : : ::.:. .:.:.::: :::: ..: NP_001 -NDHKNNERLLFHGTDADSVPYVNQHGFN-RSCAGKNAVSYGKGTYFAVDASYSAKDTYS 250 260 270 280 290 300 580 590 600 610 620 630 pF1KB8 KKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFN : .:.: . :....:::: .: : :. ::: :: . : ::.:: ..: :..::.: NP_001 KPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPT-DLFDSVTNNTRSPKLFVVFF 310 320 330 340 350 360 640 650 pF1KB8 DDQSYPYFVIQYEEVSNTVSI :.:.:: ..: . NP_001 DNQAYPEYLITFTA 370 >>XP_011510779 (OMIM: 612066) PREDICTED: poly [ADP-ribos (552 aa) initn: 431 init1: 159 opt: 486 Z-score: 519.6 bits: 106.2 E(85289): 3.3e-22 Smith-Waterman score: 486; 41.1% identity (66.5% similar) in 209 aa overlap (443-648:351-550) 420 430 440 450 460 470 pF1KB8 PYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDK .:. :. :: :. :. : : .: . .. XP_011 IFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTCNL-PEHWTDMN-HQLFCMVQLEPGQS 330 340 350 360 370 480 490 500 510 520 530 pF1KB8 SYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFH : : . : .: .: : .: :.:: :::..:. ::. :. : :. ::: ::: XP_011 EYNTIKDKFTRTCS--SYAIEKIERIQNAFLWQSYQVKKRQMDIK---NDHKNNERLLFH 380 390 400 410 420 430 540 550 560 570 580 pF1KB8 GTSQDVVDGICKHNFDPRVC-GKHATMFGQGSYFAKKASYS--HNFSKKSSKGVHFMFLA ::. : : . .:.:. : : ::.:. .:.:.::: :::: ..:: .:.: . :... XP_011 GTDADSVPYVNQHGFN-RSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVV 440 450 460 470 480 490 590 600 610 620 630 640 pF1KB8 KVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYE .:::: .: : :. ::: :: . : ::.:: ..: :..::.: :.:.:: ..: . XP_011 RVLTGVFTKGRAGLVTPPPKNPHNPT-DLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFT 500 510 520 530 540 550 650 pF1KB8 EVSNTVSI XP_011 A 657 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:26:45 2016 done: Fri Nov 4 14:26:47 2016 Total Scan time: 11.400 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]