FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8676, 422 aa 1>>>pF1KB8676 422 - 422 aa - 422 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0776+/-0.000478; mu= 6.1298+/- 0.029 mean_var=635.6083+/-150.649, 0's: 0 Z-trim(118.8): 645 B-trim: 0 in 0/53 Lambda= 0.050872 statistics sampled from 31396 (32179) to 31396 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.725), E-opt: 0.2 (0.377), width: 16 Scan time: 10.230 The best scores are: opt bits E(85289) NP_060893 (OMIM: 611433) tyrosine-protein kinase S ( 422) 2811 222.0 2.3e-57 XP_011519039 (OMIM: 611433) PREDICTED: tyrosine-pr ( 422) 2811 222.0 2.3e-57 XP_011519040 (OMIM: 611433) PREDICTED: tyrosine-pr ( 422) 2811 222.0 2.3e-57 XP_011519038 (OMIM: 611433) PREDICTED: tyrosine-pr ( 422) 2811 222.0 2.3e-57 XP_005253474 (OMIM: 611433) PREDICTED: tyrosine-pr ( 422) 2811 222.0 2.3e-57 XP_016875068 (OMIM: 611433) PREDICTED: tyrosine-pr ( 290) 1933 157.2 5e-38 NP_075254 (OMIM: 100800,109800,114500,134934,14600 ( 694) 565 57.5 1.2e-07 NP_000133 (OMIM: 100800,109800,114500,134934,14600 ( 806) 565 57.7 1.3e-07 XP_006713935 (OMIM: 100800,109800,114500,134934,14 ( 807) 565 57.7 1.3e-07 NP_001156685 (OMIM: 100800,109800,114500,134934,14 ( 808) 565 57.7 1.3e-07 XP_006713932 (OMIM: 100800,109800,114500,134934,14 ( 810) 565 57.7 1.3e-07 XP_006713936 (OMIM: 100800,109800,114500,134934,14 ( 807) 563 57.5 1.4e-07 XP_011511724 (OMIM: 100800,109800,114500,134934,14 ( 808) 563 57.5 1.4e-07 XP_006713934 (OMIM: 100800,109800,114500,134934,14 ( 809) 563 57.5 1.4e-07 XP_011511722 (OMIM: 100800,109800,114500,134934,14 ( 809) 563 57.5 1.4e-07 XP_006713933 (OMIM: 100800,109800,114500,134934,14 ( 810) 563 57.5 1.4e-07 XP_006713931 (OMIM: 100800,109800,114500,134934,14 ( 811) 563 57.5 1.4e-07 XP_016868719 (OMIM: 101600,123150,136350,147950,16 ( 498) 544 55.7 3e-07 XP_016868718 (OMIM: 101600,123150,136350,147950,16 ( 508) 544 55.7 3.1e-07 XP_016868717 (OMIM: 101600,123150,136350,147950,16 ( 729) 544 56.0 3.5e-07 NP_075594 (OMIM: 101600,123150,136350,147950,16625 ( 731) 544 56.0 3.6e-07 NP_075593 (OMIM: 101600,123150,136350,147950,16625 ( 733) 544 56.0 3.6e-07 NP_001167537 (OMIM: 101600,123150,136350,147950,16 ( 733) 544 56.0 3.6e-07 XP_011542753 (OMIM: 101600,123150,136350,147950,16 ( 735) 544 56.0 3.6e-07 XP_006716377 (OMIM: 101600,123150,136350,147950,16 ( 741) 544 56.1 3.6e-07 XP_006716376 (OMIM: 101600,123150,136350,147950,16 ( 741) 544 56.1 3.6e-07 XP_006716375 (OMIM: 101600,123150,136350,147950,16 ( 743) 544 56.1 3.6e-07 XP_006716374 (OMIM: 101600,123150,136350,147950,16 ( 743) 544 56.1 3.6e-07 XP_006716373 (OMIM: 101600,123150,136350,147950,16 ( 743) 544 56.1 3.6e-07 XP_016868716 (OMIM: 101600,123150,136350,147950,16 ( 762) 544 56.1 3.6e-07 XP_016868715 (OMIM: 101600,123150,136350,147950,16 ( 764) 544 56.1 3.6e-07 XP_011542752 (OMIM: 101600,123150,136350,147950,16 ( 764) 544 56.1 3.6e-07 XP_011542751 (OMIM: 101600,123150,136350,147950,16 ( 774) 544 56.1 3.6e-07 XP_011542750 (OMIM: 101600,123150,136350,147950,16 ( 776) 544 56.1 3.6e-07 NP_001167535 (OMIM: 101600,123150,136350,147950,16 ( 812) 544 56.1 3.7e-07 XP_016868713 (OMIM: 101600,123150,136350,147950,16 ( 818) 544 56.1 3.7e-07 XP_016868714 (OMIM: 101600,123150,136350,147950,16 ( 818) 544 56.1 3.7e-07 NP_056934 (OMIM: 101600,123150,136350,147950,16625 ( 820) 544 56.1 3.7e-07 NP_001167536 (OMIM: 101600,123150,136350,147950,16 ( 820) 544 56.1 3.7e-07 NP_001167534 (OMIM: 101600,123150,136350,147950,16 ( 820) 544 56.1 3.7e-07 NP_075598 (OMIM: 101600,123150,136350,147950,16625 ( 822) 544 56.1 3.7e-07 XP_006716372 (OMIM: 101600,123150,136350,147950,16 ( 824) 544 56.1 3.7e-07 XP_016868712 (OMIM: 101600,123150,136350,147950,16 ( 828) 544 56.1 3.7e-07 XP_016868711 (OMIM: 101600,123150,136350,147950,16 ( 830) 544 56.1 3.7e-07 XP_006716369 (OMIM: 101600,123150,136350,147950,16 ( 830) 544 56.1 3.7e-07 XP_006716370 (OMIM: 101600,123150,136350,147950,16 ( 830) 544 56.1 3.7e-07 XP_006716367 (OMIM: 101600,123150,136350,147950,16 ( 832) 544 56.2 3.7e-07 XP_006716366 (OMIM: 101600,123150,136350,147950,16 ( 832) 544 56.2 3.7e-07 XP_016868710 (OMIM: 101600,123150,136350,147950,16 ( 832) 544 56.2 3.7e-07 XP_016868709 (OMIM: 101600,123150,136350,147950,16 ( 851) 544 56.2 3.8e-07 >>NP_060893 (OMIM: 611433) tyrosine-protein kinase STYK1 (422 aa) initn: 2811 init1: 2811 opt: 2811 Z-score: 1150.8 bits: 222.0 E(85289): 2.3e-57 Smith-Waterman score: 2811; 99.8% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KB8 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: NP_060 EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS 370 380 390 400 410 420 pF1KB8 ML :: NP_060 ML >>XP_011519039 (OMIM: 611433) PREDICTED: tyrosine-protei (422 aa) initn: 2811 init1: 2811 opt: 2811 Z-score: 1150.8 bits: 222.0 E(85289): 2.3e-57 Smith-Waterman score: 2811; 99.8% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KB8 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: XP_011 EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS 370 380 390 400 410 420 pF1KB8 ML :: XP_011 ML >>XP_011519040 (OMIM: 611433) PREDICTED: tyrosine-protei (422 aa) initn: 2811 init1: 2811 opt: 2811 Z-score: 1150.8 bits: 222.0 E(85289): 2.3e-57 Smith-Waterman score: 2811; 99.8% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KB8 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: XP_011 EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS 370 380 390 400 410 420 pF1KB8 ML :: XP_011 ML >>XP_011519038 (OMIM: 611433) PREDICTED: tyrosine-protei (422 aa) initn: 2811 init1: 2811 opt: 2811 Z-score: 1150.8 bits: 222.0 E(85289): 2.3e-57 Smith-Waterman score: 2811; 99.8% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KB8 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: XP_011 EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS 370 380 390 400 410 420 pF1KB8 ML :: XP_011 ML >>XP_005253474 (OMIM: 611433) PREDICTED: tyrosine-protei (422 aa) initn: 2811 init1: 2811 opt: 2811 Z-score: 1150.8 bits: 222.0 E(85289): 2.3e-57 Smith-Waterman score: 2811; 99.8% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KB8 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: XP_005 EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS 370 380 390 400 410 420 pF1KB8 ML :: XP_005 ML >>XP_016875068 (OMIM: 611433) PREDICTED: tyrosine-protei (290 aa) initn: 1933 init1: 1933 opt: 1933 Z-score: 803.7 bits: 157.2 E(85289): 5e-38 Smith-Waterman score: 1933; 99.7% identity (100.0% similar) in 290 aa overlap (133-422:1-290) 110 120 130 140 150 160 pF1KB8 LAKLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFL :::::::::::::::::::::::::::::: XP_016 MNTGDPSKPKSVILKALKEPAGLHEVQDFL 10 20 30 170 180 190 200 210 220 pF1KB8 GRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYD :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_016 GRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYD 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB8 LTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAI 100 110 120 130 140 150 290 300 310 320 330 340 pF1KB8 SSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRR 160 170 180 190 200 210 350 360 370 380 390 400 pF1KB8 KIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPE 220 230 240 250 260 270 410 420 pF1KB8 LYAAVAGIRVESLFYNYSML :::::::::::::::::::: XP_016 LYAAVAGIRVESLFYNYSML 280 290 >>NP_075254 (OMIM: 100800,109800,114500,134934,146000,14 (694 aa) initn: 572 init1: 304 opt: 565 Z-score: 258.3 bits: 57.5 E(85289): 1.2e-07 Smith-Waterman score: 582; 30.7% identity (61.4% similar) in 378 aa overlap (44-396:285-654) 20 30 40 50 60 70 pF1KB8 DKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQGIAPVPPPRDL : :: .. ... .. ::.: .: . NP_075 LQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL--KHVEVNGSKVGPDG-TPYVTVLKV 260 270 280 290 300 310 80 90 100 110 120 pF1KB8 SWEAGHGGNVALPL-KETSVENFLGATTPALAKLQVP----------REQLSEVLEQICS : :.. . . :: . . . . : : ...:..: : :.. : . : NP_075 SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCF 320 330 340 350 360 370 130 140 150 160 170 180 pF1KB8 GSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEG :. ... .:: .: .: ::. : ....:....... ...:::::...: : NP_075 GQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLG 380 390 400 410 420 430 190 200 210 220 230 pF1KB8 CCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYD----------LTEKQVYHIG ::. :::...: .:.:.: :: :: :: :. :: :.. . NP_075 ACTQGGPLYVLVEYAAKGNLREFL-RARRP----PGLDYSFDTCKPPEEQLTFKDLVSCA 440 450 460 470 480 240 250 260 270 280 290 pF1KB8 KQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--IPL :: ..:.: .. .: :.::::.:. : . :. .::: .:.. ..: . .:. NP_075 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 490 500 510 520 530 540 300 310 320 330 340 350 pF1KB8 KWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSS ::.::: :. : . ..::::::.::.:. :::. ::: .: ... :.. . : .:.. NP_075 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN 550 560 570 580 590 600 360 370 380 390 400 pF1KB8 CTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIK-TADDEAV-LQVPELVVPELYAAVA ::: .: ::. ::. ..::. ..: :. .. :. :: . :..: NP_075 CTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 610 620 630 640 650 660 410 420 pF1KB8 GIRVESLFYNYSML NP_075 SSSSSGDDSVFAHDLLPPAPPSSGGSRT 670 680 690 >>NP_000133 (OMIM: 100800,109800,114500,134934,146000,14 (806 aa) initn: 572 init1: 304 opt: 565 Z-score: 257.8 bits: 57.7 E(85289): 1.3e-07 Smith-Waterman score: 583; 30.2% identity (60.1% similar) in 391 aa overlap (34-396:381-766) 10 20 30 40 50 60 pF1KB8 TRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQG : .::..: : . : . .. : NP_000 SAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPT 360 370 380 390 400 410 70 80 90 100 pF1KB8 IAPV---PPPRDLSWEAGHGGNVALPL-KETSVENFLGATTPALAKLQVP---------- . . : :..: :.. . . :: . . . . : : ...:..: NP_000 VHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRA 420 430 440 450 460 470 110 120 130 140 150 160 pF1KB8 REQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQ : :.. : . : :. ... .:: .: .: ::. : ....:....... . NP_000 RLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 480 490 500 510 520 530 170 180 190 200 210 220 pF1KB8 YLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYD------- ..:::::...: : ::. :::...: .:.:.: :: :: :: :. NP_000 MIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL-RARRP----PGLDYSFDTCKPP 540 550 560 570 580 230 240 250 260 270 pF1KB8 ---LTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTR :: :.. . :: ..:.: .. .: :.::::.:. : . :. .::: .:.. NP_000 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNL 590 600 610 620 630 640 280 290 300 310 320 330 pF1KB8 GAISSTQT--IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILE ..: . .:.::.::: :. : . ..::::::.::.:. :::. ::: .: ... NP_000 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFK 650 660 670 680 690 700 340 350 360 370 380 390 pF1KB8 HLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIK-TADDEAV-LQV :.. . : .:..::: .: ::. ::. ..::. ..: :. .. :. :: . :.. NP_000 LLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSA 710 720 730 740 750 760 400 410 420 pF1KB8 PELVVPELYAAVAGIRVESLFYNYSML : NP_000 PFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 770 780 790 800 >>XP_006713935 (OMIM: 100800,109800,114500,134934,146000 (807 aa) initn: 572 init1: 304 opt: 565 Z-score: 257.8 bits: 57.7 E(85289): 1.3e-07 Smith-Waterman score: 572; 33.3% identity (64.1% similar) in 312 aa overlap (101-396:461-767) 80 90 100 110 120 pF1KB8 RDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLS--EVLEQICSGSCGPI :: : .. : .:. . : . : :. XP_006 SMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMA 440 450 460 470 480 490 130 140 150 160 170 180 pF1KB8 FRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKL ... .:: .: .: ::. : ....:....... ...:::::...: : ::. XP_006 EAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGG 500 510 520 530 540 550 190 200 210 220 230 pF1KB8 PLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYD----------LTEKQVYHIGKQVLLA :::...: .:.:.: :: :: :: :. :: :.. . :: . XP_006 PLYVLVEYAAKGNLREFL-RARRP----PGLDYSFDTCKPPEEQLTFKDLVSCAYQVARG 560 570 580 590 600 240 250 260 270 280 290 pF1KB8 LEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--IPLKWLAPE .:.: .. .: :.::::.:. : . :. .::: .:.. ..: . .:.::.::: XP_006 MEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 610 620 630 640 650 660 300 310 320 330 340 350 pF1KB8 RLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMY :. : . ..::::::.::.:. :::. ::: .: ... :.. . : .:..::: .: XP_006 ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLY 670 680 690 700 710 720 360 370 380 390 400 410 pF1KB8 SIMKSCWRWREADRPSPRELRLRLEAAIK-TADDEAV-LQVPELVVPELYAAVAGIRVES ::. ::. ..::. ..: :. .. :. :: . :..: XP_006 MIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSG 730 740 750 760 770 780 420 pF1KB8 LFYNYSML XP_006 DDSVFAHDLLPPAPPSSGGSRT 790 800 >>NP_001156685 (OMIM: 100800,109800,114500,134934,146000 (808 aa) initn: 572 init1: 304 opt: 565 Z-score: 257.8 bits: 57.7 E(85289): 1.3e-07 Smith-Waterman score: 583; 30.2% identity (60.1% similar) in 391 aa overlap (34-396:383-768) 10 20 30 40 50 60 pF1KB8 TRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQG : .::..: : . : . .. : NP_001 LSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPT 360 370 380 390 400 410 70 80 90 100 pF1KB8 IAPV---PPPRDLSWEAGHGGNVALPL-KETSVENFLGATTPALAKLQVP---------- . . : :..: :.. . . :: . . . . : : ...:..: NP_001 VHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRA 420 430 440 450 460 470 110 120 130 140 150 160 pF1KB8 REQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQ : :.. : . : :. ... .:: .: .: ::. : ....:....... . NP_001 RLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 480 490 500 510 520 530 170 180 190 200 210 220 pF1KB8 YLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLGFLWTCRRDVMTMDGLLYD------- ..:::::...: : ::. :::...: .:.:.: :: :: :: :. NP_001 MIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL-RARRP----PGLDYSFDTCKPP 540 550 560 570 580 230 240 250 260 270 pF1KB8 ---LTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTR :: :.. . :: ..:.: .. .: :.::::.:. : . :. .::: .:.. NP_001 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNL 590 600 610 620 630 640 280 290 300 310 320 330 pF1KB8 GAISSTQT--IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILE ..: . .:.::.::: :. : . ..::::::.::.:. :::. ::: .: ... NP_001 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFK 650 660 670 680 690 700 340 350 360 370 380 390 pF1KB8 HLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIK-TADDEAV-LQV :.. . : .:..::: .: ::. ::. ..::. ..: :. .. :. :: . :.. NP_001 LLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSA 710 720 730 740 750 760 400 410 420 pF1KB8 PELVVPELYAAVAGIRVESLFYNYSML : NP_001 PFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 770 780 790 800 422 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:29:26 2016 done: Fri Nov 4 14:29:28 2016 Total Scan time: 10.230 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]