FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8691, 693 aa 1>>>pF1KB8691 693 - 693 aa - 693 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.0379+/-0.000387; mu= -4.6202+/- 0.024 mean_var=356.4364+/-73.511, 0's: 0 Z-trim(123.7): 25 B-trim: 530 in 2/58 Lambda= 0.067933 statistics sampled from 43876 (43901) to 43876 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.515), width: 16 Scan time: 13.150 The best scores are: opt bits E(85289) NP_071400 (OMIM: 300564) testis-specific Y-encoded ( 693) 4744 479.0 2.6e-134 XP_006724655 (OMIM: 300564) PREDICTED: testis-spec ( 694) 4371 442.4 2.7e-123 XP_016885216 (OMIM: 300564) PREDICTED: testis-spec ( 737) 2749 283.5 2e-75 XP_016885215 (OMIM: 300564) PREDICTED: testis-spec ( 738) 2376 246.9 2e-64 NP_003300 (OMIM: 604714,608800) testis-specific Y- ( 437) 745 86.9 1.8e-16 NP_277047 (OMIM: 614721) testis-specific Y-encoded ( 417) 672 79.7 2.5e-14 NP_003299 (OMIM: 480100) testis-specific Y-encoded ( 308) 568 69.4 2.3e-11 NP_001307893 (OMIM: 480100) testis-specific Y-enco ( 221) 540 66.6 1.2e-10 NP_001184171 (OMIM: 480100) testis-specific Y-enco ( 294) 501 62.8 2.1e-09 NP_003002 (OMIM: 600960) protein SET isoform 2 [Ho ( 277) 405 53.4 1.4e-06 XP_016870505 (OMIM: 600960) PREDICTED: protein SET ( 296) 405 53.4 1.4e-06 NP_001234930 (OMIM: 600960) protein SET isoform 4 ( 266) 403 53.2 1.5e-06 NP_001234929 (OMIM: 600960) protein SET isoform 3 ( 268) 403 53.2 1.5e-06 NP_001116293 (OMIM: 600960) protein SET isoform 1 ( 290) 403 53.2 1.6e-06 XP_016870504 (OMIM: 600960) PREDICTED: protein SET ( 309) 403 53.2 1.7e-06 XP_016870502 (OMIM: 600960) PREDICTED: protein SET ( 309) 403 53.2 1.7e-06 XP_016870503 (OMIM: 600960) PREDICTED: protein SET ( 309) 403 53.2 1.7e-06 XP_016885553 (OMIM: 480100) PREDICTED: testis-spec ( 288) 366 49.6 2e-05 >>NP_071400 (OMIM: 300564) testis-specific Y-encoded-lik (693 aa) initn: 4744 init1: 4744 opt: 4744 Z-score: 2532.2 bits: 479.0 E(85289): 2.6e-134 Smith-Waterman score: 4744; 100.0% identity (100.0% similar) in 693 aa overlap (1-693:1-693) 10 20 30 40 50 60 pF1KB8 MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 PEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 ESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 KRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 KRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 HISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 HISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 SHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 VVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 NPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 NPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 NNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 NNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 RDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 RDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSED 610 620 630 640 650 660 670 680 690 pF1KB8 VWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG ::::::::::::::::::::::::::::::::: NP_071 VWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG 670 680 690 >>XP_006724655 (OMIM: 300564) PREDICTED: testis-specific (694 aa) initn: 4371 init1: 4371 opt: 4371 Z-score: 2334.6 bits: 442.4 E(85289): 2.7e-123 Smith-Waterman score: 4371; 100.0% identity (100.0% similar) in 640 aa overlap (1-640:1-640) 10 20 30 40 50 60 pF1KB8 MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 KRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 HISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 NPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 NNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 RDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSED :::::::::::::::::::::::::::::::::::::::: XP_006 RDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGELIPPHPCLPSFLFSEQAWP 610 620 630 640 650 660 670 680 690 pF1KB8 VWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG XP_006 RTGYQGMNTICFYGGKKKHSEQLFKQRKSSEHLT 670 680 690 >>XP_016885216 (OMIM: 300564) PREDICTED: testis-specific (737 aa) initn: 2745 init1: 2745 opt: 2749 Z-score: 1475.1 bits: 283.5 E(85289): 2e-75 Smith-Waterman score: 4556; 93.9% identity (93.9% similar) in 725 aa overlap (13-693:13-737) 10 20 30 40 50 60 pF1KB8 MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLAD :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRL 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 KRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQV---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVRPER 250 260 270 280 290 300 300 310 pF1KB8 ----------------------------------------QDLRHISMGYKMKLYFQTNP :::::::::::::::::::: XP_016 HFLVGSGTNLVLGGDGRWVGRAVVCWGGDRFHHHPHLEQVQDLRHISMGYKMKLYFQTNP 310 320 330 340 350 360 320 330 340 350 360 370 pF1KB8 YFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEA 370 380 390 400 410 420 380 390 400 410 420 430 pF1KB8 DRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDI 430 440 450 460 470 480 440 450 460 470 480 490 pF1KB8 FSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNN 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB8 ESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQ 550 560 570 580 590 600 560 570 580 590 600 610 pF1KB8 DSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKD 610 620 630 640 650 660 620 630 640 650 660 670 pF1KB8 QADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDV 670 680 690 700 710 720 680 690 pF1KB8 LQVPNGWANPGKRGKTG ::::::::::::::::: XP_016 LQVPNGWANPGKRGKTG 730 >>XP_016885215 (OMIM: 300564) PREDICTED: testis-specific (738 aa) initn: 2549 init1: 2372 opt: 2376 Z-score: 1277.5 bits: 246.9 E(85289): 2e-64 Smith-Waterman score: 4183; 93.5% identity (93.5% similar) in 672 aa overlap (13-640:13-684) 10 20 30 40 50 60 pF1KB8 MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLAD :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRL 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 KRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQV---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVRPER 250 260 270 280 290 300 300 310 pF1KB8 ----------------------------------------QDLRHISMGYKMKLYFQTNP :::::::::::::::::::: XP_016 HFLVGSGTNLVLGGDGRWVGRAVVCWGGDRFHHHPHLEQVQDLRHISMGYKMKLYFQTNP 310 320 330 340 350 360 320 330 340 350 360 370 pF1KB8 YFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEA 370 380 390 400 410 420 380 390 400 410 420 430 pF1KB8 DRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDI 430 440 450 460 470 480 440 450 460 470 480 490 pF1KB8 FSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNN 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB8 ESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQ 550 560 570 580 590 600 560 570 580 590 600 610 pF1KB8 DSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKD 610 620 630 640 650 660 620 630 640 650 660 670 pF1KB8 QADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDV :::::::::::::::::::::::: XP_016 QADYEDVIEIISDESVEEEGIEEGELIPPHPCLPSFLFSEQAWPRTGYQGMNTICFYGGK 670 680 690 700 710 720 >>NP_003300 (OMIM: 604714,608800) testis-specific Y-enco (437 aa) initn: 793 init1: 733 opt: 745 Z-score: 416.7 bits: 86.9 E(85289): 1.8e-16 Smith-Waterman score: 847; 40.0% identity (65.5% similar) in 400 aa overlap (43-407:31-420) 20 30 40 50 60 70 pF1KB8 RRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLADM-RGVGLGPALP .: ::....::.::.:. .: . ::: NP_003 MSGLDGVKRTTPLQTHSIIISDQVPSDQDAHQYLRLRDQSEATQVMAEPGEGGSETVALP 10 20 30 40 50 60 80 90 100 110 120 pF1KB8 PPPPYVILEEGGIRAYFTLGAECP-----GWDS--TIESGYGEAPPPTESLEALPTPEAS :::: ::::. . . : : . .:..: :. ::.:.: : . :. NP_003 PPPPS---EEGGVPQDAAGRGGTPQIRVVGGRGHVAIKAGQEEGQPPAEGLAAASVVMAA 70 80 90 100 110 130 140 150 160 170 pF1KB8 GGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAI----------IIVED ::. : ::: ::: :.: : . . ... : . ..: NP_003 DRSLKKGVQ-------GGEKALEICGAQRSASELTAGAEAEAEEVKTGKCATVSAAVAER 120 130 140 150 160 170 180 190 200 210 pF1KB8 EDED-------ERESMRSSRRRRRR-------RRRKQRKVKRESRERNAER--MESI-LQ :. . :.: :. . . ... . .. ....:.::... :.. .. NP_003 ESAEVVKEGLAEKEVMEEQMEVEEQPPEGEEIEVAEEDRLEEEAREEEGPWPLHEALRMD 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB8 ALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRIS :: :::.:..:: .: .:: .:..:: .::: .::::. :::.:::::. :: :::..: NP_003 PLEAIQLELDTVNAQADRAFQQLEHKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQLS 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 ILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVS .: .: ...::.:::.:..::: : :.:..:. :::: : .::::.. :::.:: NP_003 AMIRGQDAEMLRYITNLEVKELRHPRTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRVVS 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB8 HSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLR :::: :.::.:::. . ::: :::.:::.:::::.:.::::::.::: :::.::: NP_003 LSTPIIWRRGHEPQSFIRRNQDLICSFFTWFSDHSLPESDKIAEIIKEDLWPNPLQYYLL 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB8 ERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFME ..: : :.. NP_003 REGVRRARRRPLREPVEIPRPFGFQSG 420 430 >>NP_277047 (OMIM: 614721) testis-specific Y-encoded-lik (417 aa) initn: 735 init1: 659 opt: 672 Z-score: 378.3 bits: 79.7 E(85289): 2.5e-14 Smith-Waterman score: 733; 34.7% identity (63.2% similar) in 421 aa overlap (10-418:13-403) 10 20 30 40 50 pF1KB8 MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQV ::.: . ... : : : : : :.: : :.:.:::: NP_277 MSGRSRGRKSSRAKNRGKGRAKARVR-PAPDDAPRD------PDPSQYQSLGEDTQAAQV 10 20 30 40 50 60 70 80 90 100 pF1KB8 LADMRGVGLGPALPPPPPYVIL---EEGGIRAYFTLG----AECPG--WDSTIESGYGEA : :.: : .: .: ::.. : . : :. : ... . : :.: NP_277 QA---GAGWG-GLEAAASAQLLRLGEEAACRLPLDCGLALRARAAGDHGQAAARPGPGKA 60 70 80 90 100 110 120 130 140 150 160 pF1KB8 PPPTESLEALPTPEASGGSL---EIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSK .: : : . ...:.. . .: . . .:. : ::::..: .:: .. ..: NP_277 ASLSERLAADTVFVGTAGTVGRPKNAPRVGNRRGPAGKKAPETCSTAGRGPQVIAGGRQK 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB8 EEAIIIVEDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLD . : : :. ........: . . :. ...::..:: NP_277 KGAA--------GENTSVSAGEEKKEERDAGS----------GPPATEGSMDTLENVQLK 170 180 190 200 210 230 240 250 260 270 280 pF1KB8 LEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDE :: .: .: .:.:::.::: :.: ::::. .::.::::: .:: :::... ..: ... NP_277 LENMNAQADRAYLRLSRKFGQLRLQHLERRNHLIQNIPGFWGQAFQNHPQLASFLNSQEK 220 230 240 250 260 270 290 300 310 320 330 340 pF1KB8 DIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWH ... ::..:.:..: .:::.:.::. :::: : :..::. . ::..::.::::.: NP_277 EVLSYLNSLEVEELGLARLGYKIKFYFDRNPYFQNKVLIKEYGCGPSGQVVSRSTPIQWL 280 290 300 310 320 330 350 360 370 380 390 400 pF1KB8 RGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKR :.. :. .:: . ..:::.:::::: :.:.:.:::...:: :::..:: .:.:... NP_277 PGHDLQSLSQGNPENNRSFFGWFSNHSSIESDKIVEIINEELWPNPLQFYLLSEGARVEK 340 350 360 370 380 390 410 420 430 440 450 460 pF1KB8 KKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETT : : . :. :. NP_277 GK-EKEGRQGPGKQPMETTQPGVSQSN 400 410 >>NP_003299 (OMIM: 480100) testis-specific Y-encoded pro (308 aa) initn: 610 init1: 560 opt: 568 Z-score: 325.0 bits: 69.4 E(85289): 2.3e-11 Smith-Waterman score: 568; 38.9% identity (69.2% similar) in 234 aa overlap (166-399:61-292) 140 150 160 170 180 190 pF1KB8 QSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRR :::.....: : : . . .::.. NP_003 CASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDI-MAEVEVVAEEEGLVERREE 40 50 60 70 80 200 210 220 230 240 250 pF1KB8 KQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERR :: ... . :: . : .:..:: :: .: ::: : ..:. . :.: :.:: NP_003 AQR-AQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRR 90 100 110 120 130 140 260 270 280 290 300 310 pF1KB8 DLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTN .:: .::::.... :::..: ::. .:::.. :...:.: . .: :. :.:..: NP_003 GAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSN 150 160 170 180 190 200 320 330 340 350 360 370 pF1KB8 PYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPE ::: : ::.::. : . .::::::.:. : .: :. ....: .::.:::.:.. NP_003 PYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAG 210 220 230 240 250 260 380 390 400 410 420 430 pF1KB8 ADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVED ...::::. .::: :::.:: : . NP_003 SNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS 270 280 290 300 >>NP_001307893 (OMIM: 480100) testis-specific Y-encoded (221 aa) initn: 564 init1: 537 opt: 540 Z-score: 312.1 bits: 66.6 E(85289): 1.2e-10 Smith-Waterman score: 540; 43.8% identity (75.0% similar) in 176 aa overlap (224-399:30-205) 200 210 220 230 240 250 pF1KB8 RRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLE ..:: :: .: ::: : ..:. . :.: :. NP_001 MRPEGSLTYRVPERLRQGFCGVGRAAQALVELEPVNAQARKAFSRQREKMERRRKPHLD 10 20 30 40 50 260 270 280 290 300 310 pF1KB8 RRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQ :: .:: .::::.... :::..: ::. .:::.. :...:.: . .: :. :.:. NP_001 RRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFR 60 70 80 90 100 110 320 330 340 350 360 370 pF1KB8 TNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSL .:::: : ::.::. : . .::::::.:. : .: :. ....: .::.:::.:.. NP_001 SNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNF 120 130 140 150 160 170 380 390 400 410 420 430 pF1KB8 PEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAV ...::::. .::: :::.:: : . NP_001 AGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS 180 190 200 210 220 >>NP_001184171 (OMIM: 480100) testis-specific Y-encoded (294 aa) initn: 510 init1: 487 opt: 501 Z-score: 289.8 bits: 62.8 E(85289): 2.1e-09 Smith-Waterman score: 501; 36.4% identity (66.1% similar) in 236 aa overlap (166-401:61-286) 140 150 160 170 180 190 pF1KB8 QSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRR :::.....: : : . . .::.. NP_001 CASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDI-MAEVEVVAEEEGLVERREE 40 50 60 70 80 200 210 220 230 240 250 pF1KB8 KQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERR :: ... . :: . : .:..:: :: .: ::: : ..:. . :.: :.:: NP_001 AQR-AQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRR 90 100 110 120 130 140 260 270 280 290 300 310 pF1KB8 DLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTN .:: .::::.... :::..: ::. .:::.. :...:.: . .: :. :.:..: NP_001 GAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSN 150 160 170 180 190 200 320 330 340 350 360 370 pF1KB8 PYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPE ::: : ::.::. : . .::::::.:. : .: :. ....: .::.:::.:.. NP_001 PYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAG 210 220 230 240 250 260 380 390 400 410 420 430 pF1KB8 ADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVED ...::: .: : :.: :. NP_001 SNKIAE--------SPDRSYVRTCGAIPCNTTRG 270 280 290 >>NP_003002 (OMIM: 600960) protein SET isoform 2 [Homo s (277 aa) initn: 549 init1: 402 opt: 405 Z-score: 239.3 bits: 53.4 E(85289): 1.4e-06 Smith-Waterman score: 539; 37.9% identity (76.4% similar) in 203 aa overlap (203-396:22-221) 180 190 200 210 220 230 pF1KB8 EDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIK :. :. :..:.: . ....: ... .: . NP_003 MSAPAAKVSKKELNSNHDGADETSEK--EQQEAI-EHIDEVQNEIDRLNEQ 10 20 30 40 240 250 260 270 280 290 pF1KB8 AGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLT :.. .:....:. ..:.::...:. .: .::.::: .:.:::..: :....::. ..::: NP_003 ASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLT 50 60 70 80 90 100 300 310 320 330 340 pF1KB8 NLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQE--- ..: ... :. ::.. .::. :::: : :. :::. :.:: :.:: :.:. :.. NP_003 RVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTK 110 120 130 140 150 160 350 360 370 380 390 400 pF1KB8 ------PQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRI .: :. ... .:::.::..:: ::...:.::.:.: :::.::: NP_003 RSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDE 170 180 190 200 210 220 410 420 430 440 450 460 pF1KB8 KRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFE NP_003 EGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD 230 240 250 260 270 693 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:38:02 2016 done: Fri Nov 4 14:38:04 2016 Total Scan time: 13.150 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]