FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8695, 720 aa 1>>>pF1KB8695 720 - 720 aa - 720 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9440+/-0.00113; mu= 12.3082+/- 0.068 mean_var=98.1418+/-19.587, 0's: 0 Z-trim(104.9): 13 B-trim: 143 in 1/49 Lambda= 0.129463 statistics sampled from 8147 (8152) to 8147 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.25), width: 16 Scan time: 3.640 The best scores are: opt bits E(32554) CCDS59508.1 PNPLA8 gene_id:50640|Hs108|chr7 ( 720) 4714 891.4 0 CCDS34733.1 PNPLA8 gene_id:50640|Hs108|chr7 ( 782) 3677 697.8 1.6e-200 CCDS59075.1 PNPLA8 gene_id:50640|Hs108|chr7 ( 682) 2987 568.9 9e-162 >>CCDS59508.1 PNPLA8 gene_id:50640|Hs108|chr7 (720 aa) initn: 4714 init1: 4714 opt: 4714 Z-score: 4760.7 bits: 891.4 E(32554): 0 Smith-Waterman score: 4714; 100.0% identity (100.0% similar) in 720 aa overlap (1-720:1-720) 10 20 30 40 50 60 pF1KB8 MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 KSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 KSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 EMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 EEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 VEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 VEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 LVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 LVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSID 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 NRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 NRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 QAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 QAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYIC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 GVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 GVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 LKDRMGSALMIETARNPTCPKVAADGGLLLNNPSALAMHECKCLWPDVPLECIVSLGTGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 LKDRMGSALMIETARNPTCPKVAADGGLLLNNPSALAMHECKCLWPDVPLECIVSLGTGR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 YESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLDES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 YESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLDES 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 RNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 RNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFSKL 670 680 690 700 710 720 >>CCDS34733.1 PNPLA8 gene_id:50640|Hs108|chr7 (782 aa) initn: 4700 init1: 3677 opt: 3677 Z-score: 3713.3 bits: 697.8 E(32554): 1.6e-200 Smith-Waterman score: 4382; 91.8% identity (91.8% similar) in 752 aa overlap (1-690:1-752) 10 20 30 40 50 60 pF1KB8 MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 KSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 KSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 EMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 EEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 VEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 VEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 LVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 LVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSID 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 NRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 NRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 QAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 QAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYIC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 GVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENI 490 500 510 520 530 540 550 560 pF1KB8 LKDRMGSALMIETARNPTCPKVAA------------------------------------ :::::::::::::::::::::::: CCDS34 LKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYK 550 560 570 580 590 600 570 580 590 pF1KB8 --------------------------DGGLLLNNPSALAMHECKCLWPDVPLECIVSLGT :::::::::::::::::::::::::::::::::: CCDS34 MWQAIRASSAAPGYFAEYALGNDLHQDGGLLLNNPSALAMHECKCLWPDVPLECIVSLGT 610 620 630 640 650 660 600 610 620 630 640 650 pF1KB8 GRYESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GRYESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLD 670 680 690 700 710 720 660 670 680 690 700 710 pF1KB8 ESRNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFS :::::::::::::::::::::::::::::::: CCDS34 ESRNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFS 730 740 750 760 770 780 720 pF1KB8 KL CCDS34 KL >>CCDS59075.1 PNPLA8 gene_id:50640|Hs108|chr7 (682 aa) initn: 4010 init1: 2987 opt: 2987 Z-score: 3017.8 bits: 568.9 E(32554): 9e-162 Smith-Waterman score: 3692; 90.5% identity (90.5% similar) in 652 aa overlap (101-690:1-652) 80 90 100 110 120 130 pF1KB8 CYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQNEMISRLAQFK :::::::::::::::::::::::::::::: CCDS59 MSRIKSTLNSVSKAVFGNQNEMISRLAQFK 10 20 30 140 150 160 170 180 190 pF1KB8 PSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDKEEDIGKRSLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 PSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDKEEDIGKRSLF 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB8 HYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 HYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPD 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB8 PGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQALVGGYIGGLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 PGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQALVGGYIGGLV 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB8 PKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSIDNRTRALVQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 PKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSIDNRTRALVQAL 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB8 RRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 RRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILAL 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB8 IGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYICGVSTGAILAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 IGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYICGVSTGAILAF 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB8 MLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENILKDRMGSALM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENILKDRMGSALM 400 410 420 430 440 450 560 pF1KB8 IETARNPTCPKVAA---------------------------------------------- :::::::::::::: CCDS59 IETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYKMWQAIRASSA 460 470 480 490 500 510 570 580 590 600 pF1KB8 ----------------DGGLLLNNPSALAMHECKCLWPDVPLECIVSLGTGRYESDVRNT :::::::::::::::::::::::::::::::::::::::::::: CCDS59 APGYFAEYALGNDLHQDGGLLLNNPSALAMHECKCLWPDVPLECIVSLGTGRYESDVRNT 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB8 VTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLDESRNEKLDQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 VTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLDESRNEKLDQL 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB8 QLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFSKL :::::::::::::::::::::: CCDS59 QLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFSKL 640 650 660 670 680 720 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:41:08 2016 done: Fri Nov 4 14:41:09 2016 Total Scan time: 3.640 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]