FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8714, 443 aa 1>>>pF1KB8714 443 - 443 aa - 443 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.6359+/-0.000515; mu= -22.7105+/- 0.032 mean_var=756.2225+/-155.085, 0's: 0 Z-trim(124.7): 411 B-trim: 771 in 1/60 Lambda= 0.046639 statistics sampled from 46494 (46955) to 46494 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.805), E-opt: 0.2 (0.551), width: 16 Scan time: 11.060 The best scores are: opt bits E(85289) NP_597712 (OMIM: 608926) EMI domain-containing pro ( 443) 3265 234.5 4.3e-61 NP_001254824 (OMIM: 608926) EMI domain-containing ( 441) 3241 232.9 1.3e-60 XP_005261385 (OMIM: 608926) PREDICTED: EMI domain- ( 445) 3120 224.7 3.7e-58 XP_005261386 (OMIM: 608926) PREDICTED: EMI domain- ( 417) 2153 159.6 1.4e-38 XP_011528171 (OMIM: 608926) PREDICTED: EMI domain- ( 460) 1883 141.5 4.3e-33 XP_011528177 (OMIM: 608926) PREDICTED: EMI domain- ( 307) 1738 131.6 2.9e-30 XP_011528176 (OMIM: 608926) PREDICTED: EMI domain- ( 397) 1738 131.7 3.4e-30 XP_016884078 (OMIM: 608926) PREDICTED: EMI domain- ( 397) 1738 131.7 3.4e-30 XP_011528173 (OMIM: 608926) PREDICTED: EMI domain- ( 434) 1738 131.7 3.6e-30 XP_011528170 (OMIM: 608926) PREDICTED: EMI domain- ( 462) 1738 131.8 3.8e-30 XP_011528178 (OMIM: 608926) PREDICTED: EMI domain- ( 283) 1720 130.3 6.2e-30 XP_011528175 (OMIM: 608926) PREDICTED: EMI domain- ( 420) 1597 122.2 2.5e-27 XP_011528174 (OMIM: 608926) PREDICTED: EMI domain- ( 423) 1469 113.6 1e-24 XP_011528172 (OMIM: 608926) PREDICTED: EMI domain- ( 438) 1436 111.4 4.8e-24 XP_016869755 (OMIM: 120215,130000) PREDICTED: coll (1715) 670 60.5 4e-08 NP_000084 (OMIM: 120215,130000) collagen alpha-1(V (1838) 670 60.5 4.2e-08 NP_001265003 (OMIM: 120215,130000) collagen alpha- (1838) 670 60.5 4.2e-08 NP_000081 (OMIM: 120180,130020,130050) collagen al (1466) 637 58.2 1.7e-07 XP_016855830 (OMIM: 120326) PREDICTED: collagen al (1028) 613 56.4 4e-07 XP_016855829 (OMIM: 120326) PREDICTED: collagen al (1077) 613 56.5 4.1e-07 XP_011539030 (OMIM: 120326) PREDICTED: collagen al (1089) 613 56.5 4.1e-07 XP_011539029 (OMIM: 120326) PREDICTED: collagen al (1302) 613 56.5 4.7e-07 XP_011539028 (OMIM: 120326) PREDICTED: collagen al (1402) 613 56.6 4.9e-07 XP_011539026 (OMIM: 120326) PREDICTED: collagen al (1563) 613 56.6 5.3e-07 XP_011539025 (OMIM: 120326) PREDICTED: collagen al (1573) 613 56.6 5.3e-07 XP_005270538 (OMIM: 120326) PREDICTED: collagen al (1588) 613 56.6 5.4e-07 XP_011539024 (OMIM: 120326) PREDICTED: collagen al (1589) 613 56.6 5.4e-07 XP_016855828 (OMIM: 120326) PREDICTED: collagen al (1592) 613 56.6 5.4e-07 XP_016855827 (OMIM: 120326) PREDICTED: collagen al (1593) 613 56.6 5.4e-07 NP_001847 (OMIM: 120326) collagen alpha-1(XVI) cha (1604) 613 56.6 5.4e-07 XP_016884751 (OMIM: 301050,303630) PREDICTED: coll (1289) 604 55.9 7.1e-07 XP_016870728 (OMIM: 608461,615155) PREDICTED: coll (1214) 603 55.8 7.1e-07 XP_016884750 (OMIM: 301050,303630) PREDICTED: coll (1330) 604 55.9 7.2e-07 XP_011517446 (OMIM: 608461,615155) PREDICTED: coll (1352) 603 55.9 7.7e-07 XP_011517445 (OMIM: 608461,615155) PREDICTED: coll (1353) 603 55.9 7.7e-07 XP_011517444 (OMIM: 608461,615155) PREDICTED: coll (1401) 603 55.9 7.9e-07 XP_016874320 (OMIM: 108300,120140,132450,150600,15 (1305) 600 55.7 8.6e-07 XP_011539019 (OMIM: 120260,600204,603932,614284) P ( 508) 586 54.3 8.7e-07 NP_149162 (OMIM: 108300,120140,132450,150600,15121 (1418) 600 55.7 9.1e-07 XP_016871181 (OMIM: 120350,616720) PREDICTED: coll ( 651) 588 54.5 9.4e-07 XP_016874317 (OMIM: 108300,120140,132450,150600,15 (1535) 600 55.7 9.6e-07 XP_016855822 (OMIM: 120260,600204,603932,614284) P ( 595) 586 54.4 9.7e-07 XP_011539018 (OMIM: 120260,600204,603932,614284) P ( 599) 586 54.4 9.7e-07 XP_011539017 (OMIM: 120260,600204,603932,614284) P ( 599) 586 54.4 9.7e-07 XP_016855821 (OMIM: 120260,600204,603932,614284) P ( 693) 586 54.4 1.1e-06 NP_542992 (OMIM: 120350,616720) collagen alpha-1(X ( 668) 585 54.4 1.1e-06 XP_016858786 (OMIM: 120131,203780) PREDICTED: coll (1651) 598 55.6 1.1e-06 XP_016871173 (OMIM: 120350,616720) PREDICTED: coll ( 680) 585 54.4 1.1e-06 XP_011508859 (OMIM: 120131,203780) PREDICTED: coll (1663) 598 55.6 1.1e-06 XP_016871182 (OMIM: 120350,616720) PREDICTED: coll ( 649) 584 54.3 1.1e-06 >>NP_597712 (OMIM: 608926) EMI domain-containing protein (443 aa) initn: 3265 init1: 3265 opt: 3265 Z-score: 1217.8 bits: 234.5 E(85289): 4.3e-61 Smith-Waterman score: 3265; 100.0% identity (100.0% similar) in 443 aa overlap (1-443:1-443) 10 20 30 40 50 60 pF1KB8 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 GPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 GTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 PGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 PGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 PGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 PGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPSLL 370 380 390 400 410 420 430 440 pF1KB8 RGKRGGHATNYRIVAPRSRDERG ::::::::::::::::::::::: NP_597 RGKRGGHATNYRIVAPRSRDERG 430 440 >>NP_001254824 (OMIM: 608926) EMI domain-containing prot (441 aa) initn: 2466 init1: 2466 opt: 3241 Z-score: 1209.1 bits: 232.9 E(85289): 1.3e-60 Smith-Waterman score: 3241; 99.5% identity (99.5% similar) in 443 aa overlap (1-443:1-441) 10 20 30 40 50 60 pF1KB8 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG :::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: NP_001 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEE--ASSASLEPMWSG 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 GPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB8 GTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB8 PGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGE 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB8 PGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPSLL 360 370 380 390 400 410 430 440 pF1KB8 RGKRGGHATNYRIVAPRSRDERG ::::::::::::::::::::::: NP_001 RGKRGGHATNYRIVAPRSRDERG 420 430 440 >>XP_005261385 (OMIM: 608926) PREDICTED: EMI domain-cont (445 aa) initn: 2827 init1: 2827 opt: 3120 Z-score: 1165.0 bits: 224.7 E(85289): 3.7e-58 Smith-Waterman score: 3120; 95.3% identity (97.5% similar) in 446 aa overlap (1-443:1-445) 10 20 30 40 50 60 pF1KB8 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 PGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGE 310 320 330 340 350 360 370 380 390 400 410 pF1KB8 PGPKGDPGEKSHWGEGLH---QLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTP :::::::::::::. .:. : . :..::.:: .::..: :::::::::::::::: XP_005 PGPKGDPGEKSHWAPSLQSFLQQQAQLELLARRVTLLEAII-WPEPELGSGAGPAGTGTP 370 380 390 400 410 420 430 440 pF1KB8 SLLRGKRGGHATNYRIVAPRSRDERG :::::::::::::::::::::::::: XP_005 SLLRGKRGGHATNYRIVAPRSRDERG 420 430 440 >>XP_005261386 (OMIM: 608926) PREDICTED: EMI domain-cont (417 aa) initn: 2634 init1: 1859 opt: 2153 Z-score: 813.7 bits: 159.6 E(85289): 1.4e-38 Smith-Waterman score: 2875; 89.0% identity (91.3% similar) in 446 aa overlap (1-443:1-417) 10 20 30 40 50 60 pF1KB8 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG :::::::::::::::::::::::::::::::::::::::::::::: XP_005 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEE-------------- 70 80 90 100 130 140 150 160 170 180 pF1KB8 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW :::::::::::::::::::::::::::::::::::::::::::::: XP_005 --------------GCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 GPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 GTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGP 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 PGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGE 280 290 300 310 320 330 370 380 390 400 410 pF1KB8 PGPKGDPGEKSHWGEGLH---QLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTP :::::::::::::. .:. : . :..::.:: .::..: :::::::::::::::: XP_005 PGPKGDPGEKSHWAPSLQSFLQQQAQLELLARRVTLLEAII-WPEPELGSGAGPAGTGTP 340 350 360 370 380 390 420 430 440 pF1KB8 SLLRGKRGGHATNYRIVAPRSRDERG :::::::::::::::::::::::::: XP_005 SLLRGKRGGHATNYRIVAPRSRDERG 400 410 >>XP_011528171 (OMIM: 608926) PREDICTED: EMI domain-cont (460 aa) initn: 1897 init1: 1865 opt: 1883 Z-score: 715.0 bits: 141.5 E(85289): 4.3e-33 Smith-Waterman score: 3221; 96.3% identity (96.3% similar) in 460 aa overlap (1-443:1-460) 10 20 30 40 50 60 pF1KB8 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW 130 140 150 160 170 180 190 200 210 220 pF1KB8 GPPPAQGSPGDGGLQ-----------------DQVGAWGLPGPTGPKGDAGSRGPMGMRG ::::::::::::::: :::::::::::::::::::::::::::: XP_011 GPPPAQGSPGDGGLQGLPGAIESVRVPLLPRNDQVGAWGLPGPTGPKGDAGSRGPMGMRG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB8 PPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTF 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB8 TETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGER 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB8 GLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEP 370 380 390 400 410 420 410 420 430 440 pF1KB8 ELGSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSRDERG :::::::::::::::::::::::::::::::::::::::: XP_011 ELGSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSRDERG 430 440 450 460 >>XP_011528177 (OMIM: 608926) PREDICTED: EMI domain-cont (307 aa) initn: 1960 init1: 1427 opt: 1738 Z-score: 664.4 bits: 131.6 E(85289): 2.9e-30 Smith-Waterman score: 1974; 87.7% identity (90.9% similar) in 308 aa overlap (156-443:1-307) 130 140 150 160 170 180 pF1KB8 MALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPA :::::::::::::::::::::::::::::: XP_011 MTMLTVIEQPVPPTPATPEDPAPLWGPPPA 10 20 30 190 200 210 220 pF1KB8 QGSPGDGGLQ-----------------DQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQ :::::::::: ::::::::::::::::::::::::::::::::: XP_011 QGSPGDGGLQGLPGAIESVRVPLLPRNDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQ 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB8 GPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNN 100 110 120 130 140 150 290 300 310 320 330 340 pF1KB8 HWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGERGLRGE 160 170 180 190 200 210 350 360 370 380 390 400 pF1KB8 PGPQGSAGQRGEPGPKGDPGEKSHWGEGLH---QLREALKILAERVLILETMIGLYEPEL :::::::::::::::::::::::::. .:. : . :..::.:: .::..: :::: XP_011 PGPQGSAGQRGEPGPKGDPGEKSHWAPSLQSFLQQQAQLELLARRVTLLEAII-WPEPEL 220 230 240 250 260 410 420 430 440 pF1KB8 GSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSRDERG :::::::::::::::::::::::::::::::::::::: XP_011 GSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSRDERG 270 280 290 300 >>XP_011528176 (OMIM: 608926) PREDICTED: EMI domain-cont (397 aa) initn: 2575 init1: 1427 opt: 1738 Z-score: 663.1 bits: 131.7 E(85289): 3.4e-30 Smith-Waterman score: 2589; 90.5% identity (93.0% similar) in 398 aa overlap (66-443:1-397) 40 50 60 70 80 90 pF1KB8 WCSYVVTRTISCHVQNGTYLQRVLQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRC :::::::::::::::::::::::::::::: XP_011 MSCPGSSYRTVVRPTYKVMYKIVTAREWRC 10 20 30 100 110 120 130 140 150 pF1KB8 CPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTERLKVLEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTERLKVLEAK 40 50 60 70 80 90 160 170 180 190 pF1KB8 MTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQ-----------------DQV :::::::::::::::::::::::::::::::::::::::: ::: XP_011 MTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQGLPGAIESVRVPLLPRNDQV 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB8 GAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPP 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB8 GPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGS 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB8 PGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::. .:. XP_011 PGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWAPSLQ 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB8 ---QLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVA : . :..::.:: .::..: :::::::::::::::::::::::::::::::::: XP_011 SFLQQQAQLELLARRVTLLEAII-WPEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVA 340 350 360 370 380 440 pF1KB8 PRSRDERG :::::::: XP_011 PRSRDERG 390 >>XP_016884078 (OMIM: 608926) PREDICTED: EMI domain-cont (397 aa) initn: 2575 init1: 1427 opt: 1738 Z-score: 663.1 bits: 131.7 E(85289): 3.4e-30 Smith-Waterman score: 2589; 90.5% identity (93.0% similar) in 398 aa overlap (66-443:1-397) 40 50 60 70 80 90 pF1KB8 WCSYVVTRTISCHVQNGTYLQRVLQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRC :::::::::::::::::::::::::::::: XP_016 MSCPGSSYRTVVRPTYKVMYKIVTAREWRC 10 20 30 100 110 120 130 140 150 pF1KB8 CPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTERLKVLEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTERLKVLEAK 40 50 60 70 80 90 160 170 180 190 pF1KB8 MTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQ-----------------DQV :::::::::::::::::::::::::::::::::::::::: ::: XP_016 MTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQGLPGAIESVRVPLLPRNDQV 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB8 GAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPP 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB8 GPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGS 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB8 PGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::. .:. XP_016 PGHIGPPGPTGPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWAPSLQ 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB8 ---QLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVA : . :..::.:: .::..: :::::::::::::::::::::::::::::::::: XP_016 SFLQQQAQLELLARRVTLLEAII-WPEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVA 340 350 360 370 380 440 pF1KB8 PRSRDERG :::::::: XP_016 PRSRDERG 390 >>XP_011528173 (OMIM: 608926) PREDICTED: EMI domain-cont (434 aa) initn: 2869 init1: 1427 opt: 1738 Z-score: 662.6 bits: 131.7 E(85289): 3.6e-30 Smith-Waterman score: 2831; 85.7% identity (87.9% similar) in 463 aa overlap (1-443:1-434) 10 20 30 40 50 60 pF1KB8 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG :::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEE-------------- 70 80 90 100 130 140 150 160 170 180 pF1KB8 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW :::::::::::::::::::::::::::::::::::::::::::::: XP_011 --------------GCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW 110 120 130 140 150 190 200 210 220 pF1KB8 GPPPAQGSPGDGGLQ-----------------DQVGAWGLPGPTGPKGDAGSRGPMGMRG ::::::::::::::: :::::::::::::::::::::::::::: XP_011 GPPPAQGSPGDGGLQGLPGAIESVRVPLLPRNDQVGAWGLPGPTGPKGDAGSRGPMGMRG 160 170 180 190 200 210 230 240 250 260 270 280 pF1KB8 PPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTF 220 230 240 250 260 270 290 300 310 320 330 340 pF1KB8 TETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGER 280 290 300 310 320 330 350 360 370 380 390 400 pF1KB8 GLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLH---QLREALKILAERVLILETMIGL ::::::::::::::::::::::::::::::. .:. : . :..::.:: .::..: XP_011 GLRGEPGPQGSAGQRGEPGPKGDPGEKSHWAPSLQSFLQQQAQLELLARRVTLLEAII-W 340 350 360 370 380 390 410 420 430 440 pF1KB8 YEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSRDERG :::::::::::::::::::::::::::::::::::::::::: XP_011 PEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSRDERG 400 410 420 430 >>XP_011528170 (OMIM: 608926) PREDICTED: EMI domain-cont (462 aa) initn: 3062 init1: 1427 opt: 1738 Z-score: 662.3 bits: 131.8 E(85289): 3.8e-30 Smith-Waterman score: 3076; 91.8% identity (94.0% similar) in 463 aa overlap (1-443:1-462) 10 20 30 40 50 60 pF1KB8 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STMRRMALRPTAFSGCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLW 130 140 150 160 170 180 190 200 210 220 pF1KB8 GPPPAQGSPGDGGLQ-----------------DQVGAWGLPGPTGPKGDAGSRGPMGMRG ::::::::::::::: :::::::::::::::::::::::::::: XP_011 GPPPAQGSPGDGGLQGLPGAIESVRVPLLPRNDQVGAWGLPGPTGPKGDAGSRGPMGMRG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB8 PPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTF 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB8 TETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKGISGHPGEKGER 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB8 GLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLH---QLREALKILAERVLILETMIGL ::::::::::::::::::::::::::::::. .:. : . :..::.:: .::..: XP_011 GLRGEPGPQGSAGQRGEPGPKGDPGEKSHWAPSLQSFLQQQAQLELLARRVTLLEAII-W 370 380 390 400 410 410 420 430 440 pF1KB8 YEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSRDERG :::::::::::::::::::::::::::::::::::::::::: XP_011 PEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSRDERG 420 430 440 450 460 443 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:50:03 2016 done: Fri Nov 4 14:50:05 2016 Total Scan time: 11.060 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]