FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8716, 543 aa
  1>>>pF1KB8716 543 - 543 aa - 543 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.8032+/-0.000388; mu= -6.0273+/- 0.024
 mean_var=309.3684+/-63.241, 0's: 0 Z-trim(122.1): 14  B-trim: 0 in 0/57
 Lambda= 0.072918
 statistics sampled from 39570 (39584) to 39570 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.464), width:  16
 Scan time: 12.450

The best scores are:                                      opt bits E(85289)
NP_443071 (OMIM: 608421) pannexin-2 isoform 1 [Hom ( 677) 3642 396.8 1.1e-109
NP_001153772 (OMIM: 608421) pannexin-2 isoform 2 [ ( 643) 3339 364.9 4.3e-100
NP_443191 (OMIM: 608422) pannexin-3 [Homo sapiens] ( 392)  274 42.3  0.0033


>>NP_443071 (OMIM: 608421) pannexin-2 isoform 1 [Homo sa  (677 aa)
 initn: 3642 init1: 3642 opt: 3642  Z-score: 2090.0  bits: 396.8 E(85289): 1.1e-109
Smith-Waterman score: 3642; 100.0% identity (100.0% similar) in 543 aa overlap (1-543:135-677)

                                             10        20        30
pF1KB8                               MYVPALGWEFLASTRLTSELNFLLQEIDNC
                                     ::::::::::::::::::::::::::::::
NP_443 DALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNC
          110       120       130       140       150       160    

               40        50        60        70        80        90
pF1KB8 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
          170       180       190       200       210       220    

              100       110       120       130       140       150
pF1KB8 KLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 KLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSV
          230       240       250       260       270       280    

              160       170       180       190       200       210
pF1KB8 QLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 QLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDI
          290       300       310       320       330       340    

              220       230       240       250       260       270
pF1KB8 NILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 NILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQT
          350       360       370       380       390       400    

              280       290       300       310       320       330
pF1KB8 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
          410       420       430       440       450       460    

              340       350       360       370       380       390
pF1KB8 RKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGT
          470       480       490       500       510       520    

              400       410       420       430       440       450
pF1KB8 KKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 KKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLP
          530       540       550       560       570       580    

              460       470       480       490       500       510
pF1KB8 SGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRL
          590       600       610       620       630       640    

              520       530       540   
pF1KB8 PQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF
       :::::::::::::::::::::::::::::::::
NP_443 PQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF
          650       660       670       

>>NP_001153772 (OMIM: 608421) pannexin-2 isoform 2 [Homo  (643 aa)
 initn: 3339 init1: 3339 opt: 3339  Z-score: 1918.1  bits: 364.9 E(85289): 4.3e-100
Smith-Waterman score: 3339; 100.0% identity (100.0% similar) in 497 aa overlap (1-497:135-631)

                                             10        20        30
pF1KB8                               MYVPALGWEFLASTRLTSELNFLLQEIDNC
                                     ::::::::::::::::::::::::::::::
NP_001 DALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNC
          110       120       130       140       150       160    

               40        50        60        70        80        90
pF1KB8 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
          170       180       190       200       210       220    

              100       110       120       130       140       150
pF1KB8 KLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSV
          230       240       250       260       270       280    

              160       170       180       190       200       210
pF1KB8 QLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDI
          290       300       310       320       330       340    

              220       230       240       250       260       270
pF1KB8 NILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQT
          350       360       370       380       390       400    

              280       290       300       310       320       330
pF1KB8 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
          410       420       430       440       450       460    

              340       350       360       370       380       390
pF1KB8 RKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGT
          470       480       490       500       510       520    

              400       410       420       430       440       450
pF1KB8 KKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLP
          530       540       550       560       570       580    

              460       470       480       490       500       510
pF1KB8 SGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRL
       :::::::::::::::::::::::::::::::::::::::::::::::             
NP_001 SGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLSSSPPSTSRERS 
          590       600       610       620       630       640    

              520       530       540   
pF1KB8 PQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF

>>NP_443191 (OMIM: 608422) pannexin-3 [Homo sapiens]      (392 aa)
 initn: 102 init1: 102 opt: 274  Z-score: 178.5  bits: 42.3 E(85289): 0.0033
Smith-Waterman score: 274; 25.4% identity (58.7% similar) in 264 aa overlap (1-255:121-378)

                                             10        20        30
pF1KB8                               MYVPALGWEFLASTRLTSELNFLLQEIDNC
                                     ::.:.: :.. :   :.:.: :...:.:. 
NP_443 HKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKS
              100       110       120       130       140       150

               40        50        60        70        80        90
pF1KB8 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
       :.:. .     .. . .:. : .   :    .:.:.::.  :  :.:.::  . ::. :.
NP_443 YNRSIRLVQHMLKIRQKSSDPYVFWNE----LEKARKERYFEFPLLERYLACKQRSHSLV
              160       170           180       190       200      

              100       110        120       130       140         
pF1KB8 KLYLARHVLILLLSAVPISYLCTYYATQK-QNEFTCALGASPDGAAGAGPAVRVSCKLPS
         :: :. :.:.....   ::  ..     :.::.:.. ..  .     : . ..:.: :
NP_443 ATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNL-ITCRLTS
        210       220       230       240       250        260     

     150       160       170       180        190       200        
pF1KB8 VQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNF-IFDKLHKVGIKTRRQWRRSQFC
       ... .:..  ....  ..  .:. :: .:  . :  . ... :    . .:..     . 
NP_443 LSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLG-CPIN
         270       280       290       300       310       320     

      210       220       230       240              250       260 
pF1KB8 DINILAMFCNENRDHIKSLNRLDFITNESDLM-----YDNVVR--QLLAALAQSNHDATP
       :.:.. .:   : ... :.. :. .   .:        :.::    :::.:  :      
NP_443 DLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLT
          330       340       350       360       370       380    

             270       280       290       300       310       320 
pF1KB8 TVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENS
                                                                   
NP_443 NSACDEHP                                                    
          390                                                      




543 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 14:51:45 2016 done: Fri Nov  4 14:51:47 2016
 Total Scan time: 12.450 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]