FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8718, 605 aa 1>>>pF1KB8718 605 - 605 aa - 605 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0373+/-0.000971; mu= 14.9159+/- 0.058 mean_var=72.2728+/-14.753, 0's: 0 Z-trim(104.7): 42 B-trim: 0 in 0/52 Lambda= 0.150864 statistics sampled from 8023 (8049) to 8023 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.613), E-opt: 0.2 (0.247), width: 16 Scan time: 3.280 The best scores are: opt bits E(32554) CCDS13786.1 AIFM3 gene_id:150209|Hs108|chr22 ( 605) 4007 881.8 0 CCDS33605.1 AIFM3 gene_id:150209|Hs108|chr22 ( 598) 3939 867.0 0 CCDS54503.1 AIFM3 gene_id:150209|Hs108|chr22 ( 604) 3917 862.2 0 CCDS14619.1 AIFM1 gene_id:9131|Hs108|chrX ( 609) 285 71.7 3.1e-12 CCDS14618.1 AIFM1 gene_id:9131|Hs108|chrX ( 613) 285 71.7 3.1e-12 >>CCDS13786.1 AIFM3 gene_id:150209|Hs108|chr22 (605 aa) initn: 4007 init1: 4007 opt: 4007 Z-score: 4711.2 bits: 881.8 E(32554): 0 Smith-Waterman score: 4007; 100.0% identity (100.0% similar) in 605 aa overlap (1-605:1-605) 10 20 30 40 50 60 pF1KB8 MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 YPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 YPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 MAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 SLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 PKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 PKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 VELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 VELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 DVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 VNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 VNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 EELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKTGDMSWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 EELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKTGDMSWL 550 560 570 580 590 600 pF1KB8 TGKGS ::::: CCDS13 TGKGS >>CCDS33605.1 AIFM3 gene_id:150209|Hs108|chr22 (598 aa) initn: 3878 init1: 3878 opt: 3939 Z-score: 4631.3 bits: 867.0 E(32554): 0 Smith-Waterman score: 3939; 98.8% identity (98.8% similar) in 605 aa overlap (1-605:1-598) 10 20 30 40 50 60 pF1KB8 MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 YPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 YPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 MAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 SLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 PKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 PKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 VELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 VELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 DVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 VNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 VNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 EELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKTGDMSWL :::::::::::::::::::::::::::::::::::::::::::::: ::::::: CCDS33 EELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVE-------TGDMSWL 550 560 570 580 590 pF1KB8 TGKGS ::::: CCDS33 TGKGS >>CCDS54503.1 AIFM3 gene_id:150209|Hs108|chr22 (604 aa) initn: 3864 init1: 3797 opt: 3917 Z-score: 4605.4 bits: 862.2 E(32554): 0 Smith-Waterman score: 3917; 97.9% identity (97.9% similar) in 611 aa overlap (1-605:1-604) 10 20 30 40 50 pF1KB8 MGGCFSKPKP------VELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEER :::::::::: :::::::::::::::::::::::::::::::::::::::::::: CCDS54 MGGCFSKPKPGAALPTVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEER 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 LSTPHPYPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 LSTPHPYPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 PLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 PLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 QRRTKVMAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 QRRTKVMAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYD 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 RPKLSKSLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 RPKLSKSLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 LAPGSSPKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 LAPGSSPKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 AHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 AHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 SKVVRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 SKVVRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLA 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 WRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 WRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDV 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB8 IIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKT :::::::::::::::::::::::::::::::::::::::::::::::::::: : CCDS54 IIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVE-------T 550 560 570 580 590 600 pF1KB8 GDMSWLTGKGS ::::::::::: CCDS54 GDMSWLTGKGS 600 >>CCDS14619.1 AIFM1 gene_id:9131|Hs108|chrX (609 aa) initn: 234 init1: 127 opt: 285 Z-score: 333.1 bits: 71.7 E(32554): 3.1e-12 Smith-Waterman score: 398; 26.7% identity (56.6% similar) in 424 aa overlap (147-528:74-492) 120 130 140 150 160 170 pF1KB8 VKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYV-RASKQALQLQ : . ... : :: : : : .: . CCDS14 SPSRSLASTGASGKDGSNLVYFLIVGATVTGAGVYYAYKTMKEDEKRYNERISGLGLTPE 50 60 70 80 90 100 180 190 200 210 220 230 pF1KB8 RRTKVMAKCIS-----PSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRH .. : : : :. : . :..:.:.:... :...: . . :... . : . CCDS14 QKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPE 110 120 130 140 150 160 240 250 260 pF1KB8 LPYDRPKLSKSL-----------------DTQPEQLALRPKEFFRAY---------GIEV ::: :: ::: : . . ... ..: :. . :. : CCDS14 LPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAV 170 180 190 200 210 220 270 280 290 300 310 320 pF1KB8 LTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSC---KGKEVENVFTI-RTP :: .:: .::: . : ..:: .. : : :.: :..:..:: : ::.. :. : CCDS14 LTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKI 230 240 250 260 270 280 330 340 350 360 370 pF1KB8 EDANRVVRLARG-RNVVVVGAGFLGMEVAAYLTEKAHSVS--VVEL--EETPFRRFLGER : . ...: ......:.:::: :.: : .::.... :..: :. . ..: : CCDS14 GDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEY 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB8 VGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGF .. :. . . :: . .. :. . . ::: . ::... :..: :...: : . . CCDS14 LSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLL-IKLKDGRKVETDHIVAAVGLEPNVEL 350 360 370 380 390 400 440 450 460 470 480 490 pF1KB8 LRQSGIGLDSR-GFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGR . .:. .:: : . :: .:. ....::::. : . :.:. : . : ..:: CCDS14 AKTGGLEIDSDFGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRRRVE--HHDHAVVSGR 410 420 430 440 450 500 510 520 530 540 550 pF1KB8 VAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDE .:..:: . . ..:. . : .. : . : CCDS14 LAGENMTGAAKPYWHQSMFWSDL-GPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATE 460 470 480 490 500 510 560 570 580 590 600 pF1KB8 VIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKTGDMSWLTGKGS CCDS14 QSGTGIRSESETESEASEITIPPSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIF 520 530 540 550 560 570 >>CCDS14618.1 AIFM1 gene_id:9131|Hs108|chrX (613 aa) initn: 234 init1: 127 opt: 285 Z-score: 333.0 bits: 71.7 E(32554): 3.1e-12 Smith-Waterman score: 396; 26.7% identity (57.0% similar) in 419 aa overlap (152-528:83-496) 130 140 150 160 170 180 pF1KB8 SRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYV-RASKQALQLQRRTKV . ... : :: : : : .: ... : CCDS14 QMASSGASGGKIDNSVLVLIVGLSTVGAGAYAYKTMKEDEKRYNERISGLGLTPEQKQKK 60 70 80 90 100 110 190 200 210 220 230 pF1KB8 MAKCIS-----PSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDR : : :. : . :..:.:.:... :...: . . :... . : .::: : CCDS14 AALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMR 120 130 140 150 160 170 240 250 260 pF1KB8 PKLSKSL-----------------DTQPEQLALRPKEFFRAY---------GIEVLTEAQ : ::: : . . ... ..: :. . :. ::: . CCDS14 PPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKK 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB8 VVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSC---KGKEVENVFTI-RTPEDANR :: .::: . : ..:: .. : : :.: :..:..:: : ::.. :. : : CCDS14 VVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRS 240 250 260 270 280 290 330 340 350 360 370 380 pF1KB8 VVRLARG-RNVVVVGAGFLGMEVAAYLTEKAHSVS--VVEL--EETPFRRFLGERVGRAL . ...: ......:.:::: :.: : .::.... :..: :. . ..: : .. CCDS14 LEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEYLSNWT 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB8 MKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSG :. . . :: . .. :. . . ::: . ::... :..: :...: : . . . .: CCDS14 MEKVRREGVKVMPNAIVQSVGVSSGKLL-IKLKDGRKVETDHIVAAVGLEPNVELAKTGG 360 370 380 390 400 410 450 460 470 480 490 pF1KB8 IGLDSR-GFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQN . .:: : . :: .:. ....::::. : . :.:. : . : ..::.:..: CCDS14 LEIDSDFGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRRRVE--HHDHAVVSGRLAGEN 420 430 440 450 460 500 510 520 530 540 550 pF1KB8 MLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVA : . . ..:. . : .. : . : CCDS14 MTGAAKPYWHQSMFWSDL-GPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTG 470 480 490 500 510 520 605 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:52:52 2016 done: Fri Nov 4 14:52:52 2016 Total Scan time: 3.280 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]