FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8726, 358 aa 1>>>pF1KB8726 358 - 358 aa - 358 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5442+/-0.000666; mu= -3.7667+/- 0.039 mean_var=667.3320+/-158.026, 0's: 0 Z-trim(113.9): 1712 B-trim: 378 in 1/57 Lambda= 0.049648 statistics sampled from 21185 (23493) to 21185 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.275), width: 16 Scan time: 8.100 The best scores are: opt bits E(85289) NP_443732 (OMIM: 610710) testis-specific serine/th ( 358) 2393 187.3 4.5e-47 NP_114417 (OMIM: 610709) testis-specific serine/th ( 367) 1597 130.3 6.6e-30 NP_443073 (OMIM: 607660) testis-specific serine/th ( 268) 893 79.7 8.6e-15 NP_114426 (OMIM: 610712) testis-specific serine/th ( 273) 818 74.3 3.6e-13 XP_011527776 (OMIM: 605705,616341) PREDICTED: seri ( 734) 670 64.4 8.9e-10 NP_775490 (OMIM: 605705,616341) serine/threonine-p ( 783) 670 64.5 9.2e-10 NP_001094064 (OMIM: 612760) SNF-related serine/thr ( 765) 632 61.8 6e-09 NP_060189 (OMIM: 612760) SNF-related serine/threon ( 765) 632 61.8 6e-09 XP_005265302 (OMIM: 612760) PREDICTED: SNF-related ( 765) 632 61.8 6e-09 XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643) 630 61.5 6.1e-09 XP_016876782 (OMIM: 602678) PREDICTED: MAP/microtu ( 708) 630 61.6 6.4e-09 NP_001122392 (OMIM: 602678) MAP/microtubule affini ( 713) 630 61.6 6.4e-09 XP_016876781 (OMIM: 602678) PREDICTED: MAP/microtu ( 722) 630 61.6 6.4e-09 XP_016876780 (OMIM: 602678) PREDICTED: MAP/microtu ( 728) 630 61.6 6.5e-09 NP_002367 (OMIM: 602678) MAP/microtubule affinity- ( 729) 630 61.6 6.5e-09 XP_011541028 (OMIM: 614776) PREDICTED: serine/thre ( 660) 629 61.4 6.5e-09 XP_005267699 (OMIM: 602678) PREDICTED: MAP/microtu ( 737) 630 61.6 6.5e-09 XP_005267698 (OMIM: 602678) PREDICTED: MAP/microtu ( 738) 630 61.6 6.5e-09 XP_006720209 (OMIM: 602678) PREDICTED: MAP/microtu ( 739) 630 61.6 6.5e-09 NP_001122391 (OMIM: 602678) MAP/microtubule affini ( 744) 630 61.6 6.5e-09 NP_001122390 (OMIM: 602678) MAP/microtubule affini ( 753) 630 61.6 6.6e-09 NP_056006 (OMIM: 608973) serine/threonine-protein ( 926) 629 61.7 7.6e-09 NP_001156769 (OMIM: 600526) serine/threonine-prote ( 709) 624 61.1 8.6e-09 XP_016872913 (OMIM: 614776) PREDICTED: serine/thre (1213) 629 61.9 8.7e-09 NP_001156768 (OMIM: 600526) serine/threonine-prote ( 719) 624 61.1 8.7e-09 NP_004945 (OMIM: 600526) serine/threonine-protein ( 724) 624 61.1 8.7e-09 XP_011543100 (OMIM: 600526) PREDICTED: serine/thre ( 729) 624 61.1 8.7e-09 XP_016872800 (OMIM: 600526) PREDICTED: serine/thre ( 738) 624 61.2 8.8e-09 XP_011543099 (OMIM: 600526) PREDICTED: serine/thre ( 739) 624 61.2 8.8e-09 XP_011543098 (OMIM: 600526) PREDICTED: serine/thre ( 744) 624 61.2 8.8e-09 NP_059672 (OMIM: 600526) serine/threonine-protein ( 745) 624 61.2 8.8e-09 XP_011543097 (OMIM: 600526) PREDICTED: serine/thre ( 745) 624 61.2 8.8e-09 NP_001268678 (OMIM: 614776) serine/threonine-prote (1261) 629 61.9 8.8e-09 XP_005271541 (OMIM: 614776) PREDICTED: serine/thre (1261) 629 61.9 8.8e-09 XP_011543096 (OMIM: 600526) PREDICTED: serine/thre ( 753) 624 61.2 8.9e-09 XP_016872799 (OMIM: 600526) PREDICTED: serine/thre ( 763) 624 61.2 8.9e-09 XP_011541024 (OMIM: 614776) PREDICTED: serine/thre (1309) 629 61.9 9e-09 NP_001273055 (OMIM: 606511) serine/threonine-prote ( 780) 624 61.2 9e-09 XP_005273191 (OMIM: 606511) PREDICTED: serine/thre ( 781) 624 61.2 9e-09 NP_079440 (OMIM: 614776) serine/threonine-protein (1321) 629 62.0 9e-09 XP_005271539 (OMIM: 614776) PREDICTED: serine/thre (1321) 629 62.0 9e-09 XP_011543095 (OMIM: 600526) PREDICTED: serine/thre ( 784) 624 61.2 9e-09 XP_011507863 (OMIM: 606511) PREDICTED: serine/thre ( 788) 624 61.2 9.1e-09 NP_001034558 (OMIM: 600526) serine/threonine-prote ( 788) 624 61.2 9.1e-09 XP_011543094 (OMIM: 600526) PREDICTED: serine/thre ( 793) 624 61.2 9.1e-09 NP_061120 (OMIM: 606511) serine/threonine-protein ( 795) 624 61.2 9.1e-09 NP_001273053 (OMIM: 606511) serine/threonine-prote ( 796) 624 61.2 9.1e-09 XP_011543093 (OMIM: 600526) PREDICTED: serine/thre ( 798) 624 61.2 9.1e-09 XP_011543092 (OMIM: 600526) PREDICTED: serine/thre ( 799) 624 61.2 9.1e-09 XP_011543091 (OMIM: 600526) PREDICTED: serine/thre ( 808) 624 61.2 9.2e-09 >>NP_443732 (OMIM: 610710) testis-specific serine/threon (358 aa) initn: 2393 init1: 2393 opt: 2393 Z-score: 966.1 bits: 187.3 E(85289): 4.5e-47 Smith-Waterman score: 2393; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358) 10 20 30 40 50 60 pF1KB8 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST 310 320 330 340 350 >>NP_114417 (OMIM: 610709) testis-specific serine/threon (367 aa) initn: 1602 init1: 1566 opt: 1597 Z-score: 657.9 bits: 130.3 E(85289): 6.6e-30 Smith-Waterman score: 1597; 71.8% identity (89.4% similar) in 330 aa overlap (1-330:1-327) 10 20 30 40 50 60 pF1KB8 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE ::::.::...::..:::::.:::::::::::::::::::.:::::::.:.::.:.::::: NP_114 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL ..::: .:: :::::::::::: :..::.:::.:::::::.:: .:::::: ::: :.:: NP_114 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA : :.:::::::.:::::::.:::::::::::::::.::::::::..::. :::::::: : NP_114 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN ::::::::.::::::::::::::::::::::::::::::.:.:::::::::::.:::::. NP_114 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD :: :::::::.::::::..:::::::::: :.:: : ... :.....:::.. .: NP_114 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQP-KARGSPSVAINKEGESSRGTEPLWT 250 260 270 280 290 310 320 330 340 350 pF1KB8 TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST . : :.. :: . . . . ::.. NP_114 PEPG--SDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGP 300 310 320 330 340 350 >>NP_443073 (OMIM: 607660) testis-specific serine/threon (268 aa) initn: 843 init1: 458 opt: 893 Z-score: 386.5 bits: 79.7 E(85289): 8.6e-15 Smith-Waterman score: 893; 47.4% identity (77.9% similar) in 272 aa overlap (1-272:1-265) 10 20 30 40 50 60 pF1KB8 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE :.: : ..:: .: ..:.:.:.::: :.:.. . .::.:.::. : .:..:::::: NP_443 MED--FLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRE 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL ..:. :..: .::..::..:..::.: ..:::. ::... . : : :. :. .:::. NP_443 LQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQM 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA :..::: ..:::::::: :: . ::.::.::::.: : :. . ::.:::::.: NP_443 VEAIRYCHGCGVAHRDLKCENALL-QGFNLKLTDFGFAK-VLPKSHRE--LSQTFCGSTA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN ::::::::.::.. : :.::.::.::.:.:.:.:.::.:: ::: :... :.:: . NP_443 YAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLW-QQQKGVSFPTHLS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB8 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD .. .:.::. :.:.::. : :.:. : :: NP_443 ISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST 240 250 260 310 320 330 340 350 pF1KB8 TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST >>NP_114426 (OMIM: 610712) testis-specific serine/threon (273 aa) initn: 765 init1: 292 opt: 818 Z-score: 357.4 bits: 74.3 E(85289): 3.6e-13 Smith-Waterman score: 818; 46.4% identity (74.5% similar) in 274 aa overlap (1-273:1-268) 10 20 30 40 50 60 pF1KB8 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE :. .: . :: .: ..:.:::.::: : :.. : .::.:..::...: :::..::::: NP_114 MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL ..:: : : :....:..:. .:..::.:: .. :::. .. .: . :: .: :. NP_114 LSILRGVRHPHIVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQI 70 80 90 100 110 130 140 150 160 170 pF1KB8 SSAVKYCHDLDIVHRDLKCENLLLDKDFN-IKLSDFGFSKRCLRDSNGRIILSKTFCGSA ..::.: :: .:::::::::.::. : .::.::::. :...: :: :.:::: NP_114 AGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFG----RQAHGYPDLSTTYCGSA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 AYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSK :::.:::: .:::.:: ::.::.::.::.:: : ::.::::: . : ::. : .:.. NP_114 AYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRG-VLYPEGL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 NLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKL .:. .:: :: ..:: . : : .. . ::. NP_114 ELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG 240 250 260 270 300 310 320 330 340 350 pF1KB8 DTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST >>XP_011527776 (OMIM: 605705,616341) PREDICTED: serine/t (734 aa) initn: 621 init1: 267 opt: 670 Z-score: 296.5 bits: 64.4 E(85289): 8.9e-10 Smith-Waterman score: 670; 41.1% identity (68.4% similar) in 285 aa overlap (7-285:22-297) 10 20 30 40 pF1KB8 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDR :: : . .::::..: :: : . : .::.::::. XP_011 MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 KKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQ . .. .:.. ::.... .:: ::: :...::.: .::. :.. .:...... . XP_011 TRLDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSN 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 GALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDS : : :. ::: : :. :::.:::: ::::::: :::::: ...:::.::::.. . XP_011 GHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGN---FYK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 NGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKML .:. . .:.::: ::::::... :. :::::::.::..::::.:.: .. . XP_011 SGEPL--STWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLR 180 190 200 210 220 230 230 240 250 260 270 pF1KB8 RIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL--QP--PKPK--A . : : .: .. .:..:: ::: : ..:. : .: .: :. .: : : : XP_011 QRVLEGRFRIPFF--MSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 TSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAE :. :. XP_011 FSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVEVPQEGLSTDPFRPALLCPQPQTLVQSV 300 310 320 330 340 350 >>NP_775490 (OMIM: 605705,616341) serine/threonine-prote (783 aa) initn: 621 init1: 267 opt: 670 Z-score: 296.3 bits: 64.5 E(85289): 9.2e-10 Smith-Waterman score: 670; 41.1% identity (68.4% similar) in 285 aa overlap (7-285:22-297) 10 20 30 40 pF1KB8 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDR :: : . .::::..: :: : . : .::.::::. NP_775 MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 KKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQ . .. .:.. ::.... .:: ::: :...::.: .::. :.. .:...... . NP_775 TRLDSSNLEKIY-REVQLMKLLNHPHIIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSN 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 GALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDS : : :. ::: : :. :::.:::: ::::::: :::::: ...:::.::::.. . NP_775 GHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGN---FYK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 NGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKML .:. . .:.::: ::::::... :. :::::::.::..::::.:.: .. . NP_775 SGEPL--STWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLR 180 190 200 210 220 230 230 240 250 260 270 pF1KB8 RIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL--QP--PKPK--A . : : .: .. .:..:: ::: : ..:. : .: .: :. .: : : : NP_775 QRVLEGRFRIPFF--MSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 TSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAE :. :. NP_775 FSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNA 300 310 320 330 340 350 >>NP_001094064 (OMIM: 612760) SNF-related serine/threoni (765 aa) initn: 557 init1: 178 opt: 632 Z-score: 281.6 bits: 61.8 E(85289): 6e-09 Smith-Waterman score: 632; 39.9% identity (68.3% similar) in 281 aa overlap (9-277:5-276) 10 20 30 40 50 pF1KB8 MDDATVLRKKGY---IVGI-----NLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDF :.:: :.:. .::.: .: :: : .::::.::. : : . NP_001 MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-L 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFI-KCQGALHED . : .:. . :.: .:.. ::...:. ..:.:.::: ::....: : . .:.:: NP_001 ATGHLFQEVRCMKLVQHPNIVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNED 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 VARKMFRQLSSAVKYCHDLDIVHRDLKCENLLL-DKDFNIKLSDFGFSKRCLRDSNGRII .:.:.: :. :..::: : .:::::: ::... .:. .::.:::::.. . :. . NP_001 LAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF---QPGKKL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 LSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKE : ::: ::.:::.: . :. . :::::::::...:::. :..... . : . . NP_001 --TTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD 180 190 200 210 220 240 250 260 270 280 pF1KB8 HRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQ--PPKPKATSSASFKRE . : .... :::::: :::: : ..: ..:: .: ::: :.: NP_001 CKYTVP--SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSY 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB8 GEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHI NP_001 KNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQT 290 300 310 320 330 340 >>NP_060189 (OMIM: 612760) SNF-related serine/threonine- (765 aa) initn: 557 init1: 178 opt: 632 Z-score: 281.6 bits: 61.8 E(85289): 6e-09 Smith-Waterman score: 632; 39.9% identity (68.3% similar) in 281 aa overlap (9-277:5-276) 10 20 30 40 50 pF1KB8 MDDATVLRKKGY---IVGI-----NLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDF :.:: :.:. .::.: .: :: : .::::.::. : : . NP_060 MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-L 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFI-KCQGALHED . : .:. . :.: .:.. ::...:. ..:.:.::: ::....: : . .:.:: NP_060 ATGHLFQEVRCMKLVQHPNIVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNED 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 VARKMFRQLSSAVKYCHDLDIVHRDLKCENLLL-DKDFNIKLSDFGFSKRCLRDSNGRII .:.:.: :. :..::: : .:::::: ::... .:. .::.:::::.. . :. . NP_060 LAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF---QPGKKL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 LSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKE : ::: ::.:::.: . :. . :::::::::...:::. :..... . : . . NP_060 --TTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD 180 190 200 210 220 240 250 260 270 280 pF1KB8 HRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQ--PPKPKATSSASFKRE . : .... :::::: :::: : ..: ..:: .: ::: :.: NP_060 CKYTVP--SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSY 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB8 GEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHI NP_060 KNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQT 290 300 310 320 330 340 >>XP_005265302 (OMIM: 612760) PREDICTED: SNF-related ser (765 aa) initn: 557 init1: 178 opt: 632 Z-score: 281.6 bits: 61.8 E(85289): 6e-09 Smith-Waterman score: 632; 39.9% identity (68.3% similar) in 281 aa overlap (9-277:5-276) 10 20 30 40 50 pF1KB8 MDDATVLRKKGY---IVGI-----NLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDF :.:: :.:. .::.: .: :: : .::::.::. : : . XP_005 MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-L 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFI-KCQGALHED . : .:. . :.: .:.. ::...:. ..:.:.::: ::....: : . .:.:: XP_005 ATGHLFQEVRCMKLVQHPNIVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNED 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 VARKMFRQLSSAVKYCHDLDIVHRDLKCENLLL-DKDFNIKLSDFGFSKRCLRDSNGRII .:.:.: :. :..::: : .:::::: ::... .:. .::.:::::.. . :. . XP_005 LAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF---QPGKKL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 LSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKE : ::: ::.:::.: . :. . :::::::::...:::. :..... . : . . XP_005 --TTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD 180 190 200 210 220 240 250 260 270 280 pF1KB8 HRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQ--PPKPKATSSASFKRE . : .... :::::: :::: : ..: ..:: .: ::: :.: XP_005 CKYTVP--SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSY 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB8 GEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHI XP_005 KNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQT 290 300 310 320 330 340 >>XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtubule (643 aa) initn: 530 init1: 275 opt: 630 Z-score: 281.5 bits: 61.5 E(85289): 6.1e-09 Smith-Waterman score: 630; 40.3% identity (70.5% similar) in 258 aa overlap (18-272:62-307) 10 20 30 40 pF1KB8 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKK .:::..:::: : .::.::::. . XP_005 TSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQ 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB8 -TPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQG .::.. . : ::. :. .:: .:.: .:..:: . .:.::: . :...... .: XP_005 LNPTSLQKLF--REVRIMKILNHPNIVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHG 100 110 120 130 140 110 120 130 140 150 160 pF1KB8 ALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSN ..: ::. :::. :::.:::. ::::::: :::::: :.:::..:::::.. . XP_005 RMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFT--VG 150 160 170 180 190 200 170 180 190 200 210 220 pF1KB8 GRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKML- :.. ::::: :::::..:. :. :.:::::::: .: ::.:.: ...... XP_005 GKL---DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRE 210 220 230 240 250 260 230 240 250 260 270 280 pF1KB8 RIQK-EHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSAS :. . ..:. : .. .:..:. :.: . .: ...:.. :. XP_005 RVLRGKYRIPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPF 270 280 290 300 310 290 300 310 320 330 340 pF1KB8 FKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAK XP_005 VEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSS 320 330 340 350 360 370 358 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:58:29 2016 done: Fri Nov 4 14:58:30 2016 Total Scan time: 8.100 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]