FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8737, 143 aa 1>>>pF1KB8737 143 - 143 aa - 143 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2923+/-0.000313; mu= 11.7318+/- 0.020 mean_var=61.6752+/-12.331, 0's: 0 Z-trim(117.0): 44 B-trim: 564 in 2/51 Lambda= 0.163312 statistics sampled from 28581 (28627) to 28581 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.336), width: 16 Scan time: 5.310 The best scores are: opt bits E(85289) NP_002096 (OMIM: 601772) histone H2AX [Homo sapien ( 143) 905 221.0 5.2e-58 NP_778235 (OMIM: 615014) histone H2A type 2-B [Hom ( 130) 749 184.2 5.5e-47 NP_734466 (OMIM: 613499) histone H2A type 1-A [Hom ( 131) 740 182.1 2.4e-46 NP_003503 (OMIM: 602794) histone H2A type 1-C [Hom ( 130) 739 181.9 2.8e-46 NP_003508 (OMIM: 602797) histone H2A type 2-C [Hom ( 129) 738 181.6 3.3e-46 NP_003507 (OMIM: 142720) histone H2A type 2-A [Hom ( 130) 738 181.6 3.3e-46 NP_066544 (OMIM: 602791) histone cluster 1, H2aj [ ( 128) 737 181.4 3.9e-46 NP_542163 (OMIM: 615013) histone H2A type 1-H [Hom ( 128) 737 181.4 3.9e-46 NP_003505 (OMIM: 602796) histone H2A type 1 [Homo ( 130) 737 181.4 3.9e-46 NP_066408 (OMIM: 615012) histone H2A type 1 [Homo ( 130) 737 181.4 3.9e-46 NP_003501 (OMIM: 602788) histone H2A type 1 [Homo ( 130) 737 181.4 3.9e-46 NP_003500 (OMIM: 602787) histone H2A type 1 [Homo ( 130) 737 181.4 3.9e-46 NP_003502 (OMIM: 602793) histone H2A type 1 [Homo ( 130) 737 181.4 3.9e-46 NP_254280 (OMIM: 615015) histone H2A type 3 [Homo ( 130) 735 180.9 5.4e-46 NP_066409 (OMIM: 602792) histone H2A type 1-D [Hom ( 130) 733 180.5 7.5e-46 NP_066390 (OMIM: 602786) histone H2A type 1-B/E [H ( 130) 732 180.2 8.9e-46 NP_003504 (OMIM: 602795) histone H2A type 1-B/E [H ( 130) 732 180.2 8.9e-46 XP_011542037 (OMIM: 610054) PREDICTED: core histon ( 195) 524 131.3 7.1e-31 XP_011542036 (OMIM: 610054) PREDICTED: core histon ( 196) 524 131.3 7.2e-31 XP_005272192 (OMIM: 610054) PREDICTED: core histon ( 198) 524 131.3 7.2e-31 XP_005272191 (OMIM: 610054) PREDICTED: core histon ( 199) 524 131.3 7.2e-31 XP_016865558 (OMIM: 610054) PREDICTED: core histon ( 222) 524 131.3 8e-31 XP_016865557 (OMIM: 610054) PREDICTED: core histon ( 235) 524 131.3 8.4e-31 XP_016865556 (OMIM: 610054) PREDICTED: core histon ( 251) 524 131.3 8.9e-31 XP_011542035 (OMIM: 610054) PREDICTED: core histon ( 252) 524 131.3 8.9e-31 XP_011542034 (OMIM: 610054) PREDICTED: core histon ( 269) 524 131.4 9.4e-31 XP_011542033 (OMIM: 610054) PREDICTED: core histon ( 270) 524 131.4 9.4e-31 XP_005272189 (OMIM: 610054) PREDICTED: core histon ( 368) 524 131.4 1.2e-30 NP_613075 (OMIM: 610054) core histone macro-H2A.1 ( 369) 524 131.4 1.2e-30 NP_001035248 (OMIM: 610054) core histone macro-H2A ( 371) 524 131.4 1.2e-30 NP_004884 (OMIM: 610054) core histone macro-H2A.1 ( 371) 524 131.4 1.2e-30 XP_011542032 (OMIM: 610054) PREDICTED: core histon ( 371) 524 131.4 1.2e-30 NP_613258 (OMIM: 610054) core histone macro-H2A.1 ( 372) 524 131.4 1.2e-30 XP_011542031 (OMIM: 610054) PREDICTED: core histon ( 372) 524 131.4 1.2e-30 NP_061119 (OMIM: 616141) core histone macro-H2A.2 ( 372) 503 126.5 3.8e-29 NP_002097 (OMIM: 142763) histone H2A.Z [Homo sapie ( 128) 443 112.1 2.8e-25 NP_542451 (OMIM: 300445) histone H2A-Bbd type 2/3 ( 115) 312 81.2 4.9e-16 XP_011531366 (OMIM: 135300,182530,610733) PREDICTE (1276) 157 45.2 0.00039 XP_005264572 (OMIM: 135300,182530,610733) PREDICTE (1318) 157 45.2 0.0004 XP_011531364 (OMIM: 135300,182530,610733) PREDICTE (1326) 157 45.2 0.0004 NP_005624 (OMIM: 135300,182530,610733) son of seve (1333) 157 45.2 0.0004 >>NP_002096 (OMIM: 601772) histone H2AX [Homo sapiens] (143 aa) initn: 905 init1: 905 opt: 905 Z-score: 1162.5 bits: 221.0 E(85289): 5.2e-58 Smith-Waterman score: 905; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY ::::::::::::::::::::::: NP_002 TSATVGPKAPSGGKKATQASQEY 130 140 >>NP_778235 (OMIM: 615014) histone H2A type 2-B [Homo sa (130 aa) initn: 749 init1: 749 opt: 749 Z-score: 964.5 bits: 184.2 E(85289): 5.5e-47 Smith-Waterman score: 749; 97.5% identity (99.2% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::: :::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_778 MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: NP_778 AEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY : NP_778 TESHKPGKNK 130 >>NP_734466 (OMIM: 613499) histone H2A type 1-A [Homo sa (131 aa) initn: 740 init1: 740 opt: 740 Z-score: 953.0 bits: 182.1 E(85289): 2.4e-46 Smith-Waterman score: 740; 95.0% identity (99.2% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::: :::::::.:::::::::::::::.:::::::.::::.:::::::::::::::: NP_734 MSGRGKQGGKARAKSKSRSSRAGLQFPVGRIHRLLRKGNYAERIGAGAPVYLAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK ::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::: NP_734 AEILELAGNASRDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY : NP_734 TESHHHKAQSK 130 >>NP_003503 (OMIM: 602794) histone H2A type 1-C [Homo sa (130 aa) initn: 739 init1: 739 opt: 739 Z-score: 951.8 bits: 181.9 E(85289): 2.8e-46 Smith-Waterman score: 739; 97.5% identity (98.3% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::: :::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_003 MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_003 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY : NP_003 TESHHKAKGK 130 >>NP_003508 (OMIM: 602797) histone H2A type 2-C [Homo sa (129 aa) initn: 738 init1: 738 opt: 738 Z-score: 950.5 bits: 181.6 E(85289): 3.3e-46 Smith-Waterman score: 738; 96.7% identity (98.3% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::: :::::::::::::::::::::::::::::::.::::::::::::.:::::::: NP_003 MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_003 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY : NP_003 TESHKAKSK >>NP_003507 (OMIM: 142720) histone H2A type 2-A [Homo sa (130 aa) initn: 738 init1: 738 opt: 738 Z-score: 950.5 bits: 181.6 E(85289): 3.3e-46 Smith-Waterman score: 738; 96.7% identity (98.3% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::: :::::::::::::::::::::::::::::::.::::::::::::.:::::::: NP_003 MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_003 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY : NP_003 TESHHKAKGK 130 >>NP_066544 (OMIM: 602791) histone cluster 1, H2aj [Homo (128 aa) initn: 737 init1: 737 opt: 737 Z-score: 949.3 bits: 181.4 E(85289): 3.9e-46 Smith-Waterman score: 737; 96.7% identity (98.3% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::: :::::::::.:::::::::::::::::::::.::::::::::::::::::::: NP_066 MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_066 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY : NP_066 TESHHKTK >>NP_542163 (OMIM: 615013) histone H2A type 1-H [Homo sa (128 aa) initn: 737 init1: 737 opt: 737 Z-score: 949.3 bits: 181.4 E(85289): 3.9e-46 Smith-Waterman score: 737; 96.7% identity (98.3% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::: :::::::::.:::::::::::::::::::::.::::::::::::::::::::: NP_542 MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_542 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY : NP_542 TESHHKAK >>NP_003505 (OMIM: 602796) histone H2A type 1 [Homo sapi (130 aa) initn: 737 init1: 737 opt: 737 Z-score: 949.2 bits: 181.4 E(85289): 3.9e-46 Smith-Waterman score: 737; 96.7% identity (98.3% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::: :::::::::.:::::::::::::::::::::.::::::::::::::::::::: NP_003 MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_003 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY : NP_003 TESHHKAKGK 130 >>NP_066408 (OMIM: 615012) histone H2A type 1 [Homo sapi (130 aa) initn: 737 init1: 737 opt: 737 Z-score: 949.2 bits: 181.4 E(85289): 3.9e-46 Smith-Waterman score: 737; 96.7% identity (98.3% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB8 MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT :::::: :::::::::.:::::::::::::::::::::.::::::::::::::::::::: NP_066 MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_066 AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK 70 80 90 100 110 120 130 140 pF1KB8 TSATVGPKAPSGGKKATQASQEY : NP_066 TESHHKAKGK 130 143 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:05:37 2016 done: Fri Nov 4 15:05:38 2016 Total Scan time: 5.310 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]