FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8746, 177 aa 1>>>pF1KB8746 177 - 177 aa - 177 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2141+/-0.00028; mu= 13.9815+/- 0.017 mean_var=86.1702+/-18.317, 0's: 0 Z-trim(120.4): 180 B-trim: 1364 in 1/49 Lambda= 0.138164 statistics sampled from 35360 (35615) to 35360 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.792), E-opt: 0.2 (0.418), width: 16 Scan time: 5.900 The best scores are: opt bits E(85289) NP_000165 (OMIM: 173515,231200) platelet glycoprot ( 177) 1252 258.4 4.3e-69 XP_011511004 (OMIM: 173515,231200) PREDICTED: plat ( 177) 1252 258.4 4.3e-69 XP_011511003 (OMIM: 173515,231200) PREDICTED: plat ( 177) 1252 258.4 4.3e-69 XP_005247431 (OMIM: 173515,231200) PREDICTED: plat ( 177) 1252 258.4 4.3e-69 NP_000398 (OMIM: 138720,231200) platelet glycoprot ( 206) 333 75.3 6.7e-14 XP_011520834 (OMIM: 173900,601313) PREDICTED: poly (4287) 219 53.8 4.1e-06 NP_001073982 (OMIM: 603104) carboxypeptidase N sub ( 545) 199 49.0 1.5e-05 XP_005269337 (OMIM: 603104) PREDICTED: carboxypept ( 545) 199 49.0 1.5e-05 NP_001278917 (OMIM: 603104) carboxypeptidase N sub ( 545) 199 49.0 1.5e-05 XP_016877935 (OMIM: 614179) PREDICTED: immunoglobu ( 468) 186 46.3 8e-05 NP_001123609 (OMIM: 614179) immunoglobulin superfa ( 745) 186 46.5 0.00011 NP_065902 (OMIM: 614179) immunoglobulin superfamil ( 745) 186 46.5 0.00011 XP_011520142 (OMIM: 614179) PREDICTED: immunoglobu ( 745) 186 46.5 0.00011 NP_001123608 (OMIM: 614179) immunoglobulin superfa ( 745) 186 46.5 0.00011 XP_011520143 (OMIM: 614179) PREDICTED: immunoglobu ( 745) 186 46.5 0.00011 NP_001123610 (OMIM: 614179) immunoglobulin superfa ( 745) 186 46.5 0.00011 NP_001010847 (OMIM: 615212) leucine-rich repeat-co ( 294) 175 43.9 0.00026 NP_001013675 (OMIM: 613505) leucine-rich repeat-co ( 334) 172 43.4 0.00043 NP_001258 (OMIM: 602178) chondroadherin precursor ( 359) 170 43.0 0.0006 XP_011522516 (OMIM: 602178) PREDICTED: chondroadhe ( 440) 170 43.1 0.0007 NP_001333074 (OMIM: 604807) leucine-rich repeat tr ( 660) 171 43.5 0.00081 XP_016876621 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 171 43.5 0.00081 XP_016876618 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 171 43.5 0.00081 XP_005267547 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 171 43.5 0.00081 NP_001333075 (OMIM: 604807) leucine-rich repeat tr ( 660) 171 43.5 0.00081 XP_016876622 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 171 43.5 0.00081 XP_016876624 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 171 43.5 0.00081 XP_016876623 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 171 43.5 0.00081 XP_011534913 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 171 43.5 0.00081 NP_001333072 (OMIM: 604807) leucine-rich repeat tr ( 660) 171 43.5 0.00081 XP_016876620 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 171 43.5 0.00081 NP_001333073 (OMIM: 604807) leucine-rich repeat tr ( 660) 171 43.5 0.00081 NP_037363 (OMIM: 604807) leucine-rich repeat trans ( 660) 171 43.5 0.00081 XP_016876619 (OMIM: 604807) PREDICTED: leucine-ric ( 660) 171 43.5 0.00081 NP_003052 (OMIM: 603742) slit homolog 1 protein pr (1534) 175 44.6 0.00086 NP_848665 (OMIM: 610462) reticulon-4 receptor-like ( 420) 168 42.7 0.00089 NP_055632 (OMIM: 613356) TLR4 interactor with leuc ( 811) 171 43.6 0.00094 XP_011512212 (OMIM: 603746) PREDICTED: slit homolo (1159) 172 43.9 0.0011 NP_001005210 (OMIM: 615213) leucine-rich repeat-co ( 341) 165 42.0 0.0012 XP_005273528 (OMIM: 606823) PREDICTED: adhesion G ( 813) 169 43.2 0.0012 NP_037412 (OMIM: 604806) leucine-rich repeat trans ( 674) 168 42.9 0.0013 XP_005273918 (OMIM: 604806) PREDICTED: leucine-ric ( 674) 168 42.9 0.0013 XP_011543185 (OMIM: 604806) PREDICTED: leucine-ric ( 674) 168 42.9 0.0013 NP_958934 (OMIM: 602059) immunoglobulin superfamil ( 428) 165 42.1 0.0014 NP_005536 (OMIM: 602059) immunoglobulin superfamil ( 428) 165 42.1 0.0014 NP_001137480 (OMIM: 300561) SLIT and NTRK-like pro ( 845) 167 42.8 0.0017 NP_001137477 (OMIM: 300561) SLIT and NTRK-like pro ( 845) 167 42.8 0.0017 NP_001137475 (OMIM: 300561) SLIT and NTRK-like pro ( 845) 167 42.8 0.0017 XP_005262401 (OMIM: 300561) PREDICTED: SLIT and NT ( 845) 167 42.8 0.0017 NP_001137482 (OMIM: 300561) SLIT and NTRK-like pro ( 845) 167 42.8 0.0017 >>NP_000165 (OMIM: 173515,231200) platelet glycoprotein (177 aa) initn: 1252 init1: 1252 opt: 1252 Z-score: 1361.4 bits: 258.4 E(85289): 4.3e-69 Smith-Waterman score: 1252; 100.0% identity (100.0% similar) in 177 aa overlap (1-177:1-177) 10 20 30 40 50 60 pF1KB8 MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLAN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAA 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 HGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD 130 140 150 160 170 >>XP_011511004 (OMIM: 173515,231200) PREDICTED: platelet (177 aa) initn: 1252 init1: 1252 opt: 1252 Z-score: 1361.4 bits: 258.4 E(85289): 4.3e-69 Smith-Waterman score: 1252; 100.0% identity (100.0% similar) in 177 aa overlap (1-177:1-177) 10 20 30 40 50 60 pF1KB8 MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLAN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAA 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 HGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD 130 140 150 160 170 >>XP_011511003 (OMIM: 173515,231200) PREDICTED: platelet (177 aa) initn: 1252 init1: 1252 opt: 1252 Z-score: 1361.4 bits: 258.4 E(85289): 4.3e-69 Smith-Waterman score: 1252; 100.0% identity (100.0% similar) in 177 aa overlap (1-177:1-177) 10 20 30 40 50 60 pF1KB8 MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLAN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAA 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 HGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD 130 140 150 160 170 >>XP_005247431 (OMIM: 173515,231200) PREDICTED: platelet (177 aa) initn: 1252 init1: 1252 opt: 1252 Z-score: 1361.4 bits: 258.4 E(85289): 4.3e-69 Smith-Waterman score: 1252; 100.0% identity (100.0% similar) in 177 aa overlap (1-177:1-177) 10 20 30 40 50 60 pF1KB8 MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLAN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAA 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 HGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD 130 140 150 160 170 >>NP_000398 (OMIM: 138720,231200) platelet glycoprotein (206 aa) initn: 264 init1: 158 opt: 333 Z-score: 370.5 bits: 75.3 E(85289): 6.7e-14 Smith-Waterman score: 333; 39.3% identity (60.7% similar) in 168 aa overlap (7-169:13-167) 10 20 30 40 50 pF1KB8 MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLT--ALP-ALPA :.:: .. . ::.::.: : ::: .::: .:: :.:. NP_000 MGSGPRGALSLLLLLLAPPSRPAAGCPAPCSC-----AGTLVDCGRRGLTWASLPTAFPV 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 RTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQ- : .:.:..:.: ..::: .: :: :.: . :::.::: :. :: :: : .: . NP_000 DTTELVLTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWLAGRPERAPYRD 60 70 80 90 100 110 120 130 140 150 160 pF1KB8 VRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVL-WDVALVAVAALGLALLAGLL .::..: ::: : . .:.:. :: : : . . .: :::.:: .:: NP_000 LRCVAPPALR----GRLLPYLAED---ELRAA-CAPGPLCWGALAAQLALLGLGLLHALL 120 130 140 150 160 170 pF1KB8 CATTEALD NP_000 LVLLLCRLRRLRARARARAAARLSLTDPLVAERAGTDES 170 180 190 200 >>XP_011520834 (OMIM: 173900,601313) PREDICTED: polycyst (4287 aa) initn: 159 init1: 112 opt: 219 Z-score: 230.7 bits: 53.8 E(85289): 4.1e-06 Smith-Waterman score: 220; 32.1% identity (50.8% similar) in 187 aa overlap (2-171:6-187) 10 20 30 40 pF1KB8 MPAWGALFL---LWATAEA------TKDCPSPCTCRALETMGLWVDCRGHGLTAL- :: :: : :: : : : :: : . :.: :.:: .: XP_011 MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 PAL--PARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRT ::: :: . : ...: :... : . .: : :... ::..:::.:..: : :.. XP_011 PALRIPADATALDVSHNLLRALDVGLLANLSALAELNLSGNPFECDCGLAWLPRWAEEQQ 70 80 90 100 110 120 110 120 130 140 150 pF1KB8 -----PEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAA ::: . ::.:. : :: . . : :: . : . . :: :. .: XP_011 VRVVQPEA---ATCAGPGSLAGQPLLGIPLLDSG-CGEEYVAC-LPDNSSGTVAAVSFSA 130 140 150 160 170 160 170 pF1KB8 LGLALLAGLLCATTEALD .:: :. XP_011 AHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTC 180 190 200 210 220 230 >>NP_001073982 (OMIM: 603104) carboxypeptidase N subunit (545 aa) initn: 238 init1: 113 opt: 199 Z-score: 220.7 bits: 49.0 E(85289): 1.5e-05 Smith-Waterman score: 199; 34.8% identity (57.6% similar) in 132 aa overlap (41-159:347-477) 20 30 40 50 60 pF1KB8 WATAEATKDCPSPCTCRALETMGLWVDCRGHGLTAL-PALP---ARTRHLLLANNSLQSV ..:::: ::: .. . : :..:.: .. NP_001 SLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL 320 330 340 350 360 370 70 80 90 100 110 120 pF1KB8 PPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEAL-LQVRCASPSLAAHGPLG : : :: .: .: . :::.::: :.:: ::.. : . : .:. ::.:. . NP_001 PEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVP 380 390 400 410 420 430 130 140 150 160 170 pF1KB8 RLTGYQLGSCGWQ-----LQASW---VRPGVLWDVALVAVAALGLALLAGLLCATTEALD :. :: : .:..: . : ::.:. :: NP_001 ALNEKQL-VCPVTRDHLGFQVTWPDESKAGGSWDLAVQERAARSQCTYSNPEGTVVLACD 440 450 460 470 480 490 NP_001 QAQCRWLNVQLSPQQGSLGLQYNASQEWDLRSSCGSLRLTVSIEARAAGP 500 510 520 530 540 >>XP_005269337 (OMIM: 603104) PREDICTED: carboxypeptidas (545 aa) initn: 238 init1: 113 opt: 199 Z-score: 220.7 bits: 49.0 E(85289): 1.5e-05 Smith-Waterman score: 199; 34.8% identity (57.6% similar) in 132 aa overlap (41-159:347-477) 20 30 40 50 60 pF1KB8 WATAEATKDCPSPCTCRALETMGLWVDCRGHGLTAL-PALP---ARTRHLLLANNSLQSV ..:::: ::: .. . : :..:.: .. XP_005 SLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL 320 330 340 350 360 370 70 80 90 100 110 120 pF1KB8 PPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEAL-LQVRCASPSLAAHGPLG : : :: .: .: . :::.::: :.:: ::.. : . : .:. ::.:. . XP_005 PEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVP 380 390 400 410 420 430 130 140 150 160 170 pF1KB8 RLTGYQLGSCGWQ-----LQASW---VRPGVLWDVALVAVAALGLALLAGLLCATTEALD :. :: : .:..: . : ::.:. :: XP_005 ALNEKQL-VCPVTRDHLGFQVTWPDESKAGGSWDLAVQERAARSQCTYSNPEGTVVLACD 440 450 460 470 480 490 XP_005 QAQCRWLNVQLSPQQGSLGLQYNASQEWDLRSSCGSLRLTVSIEARAAGP 500 510 520 530 540 >>NP_001278917 (OMIM: 603104) carboxypeptidase N subunit (545 aa) initn: 238 init1: 113 opt: 199 Z-score: 220.7 bits: 49.0 E(85289): 1.5e-05 Smith-Waterman score: 199; 34.8% identity (57.6% similar) in 132 aa overlap (41-159:347-477) 20 30 40 50 60 pF1KB8 WATAEATKDCPSPCTCRALETMGLWVDCRGHGLTAL-PALP---ARTRHLLLANNSLQSV ..:::: ::: .. . : :..:.: .. NP_001 SLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL 320 330 340 350 360 370 70 80 90 100 110 120 pF1KB8 PPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEAL-LQVRCASPSLAAHGPLG : : :: .: .: . :::.::: :.:: ::.. : . : .:. ::.:. . NP_001 PEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVP 380 390 400 410 420 430 130 140 150 160 170 pF1KB8 RLTGYQLGSCGWQ-----LQASW---VRPGVLWDVALVAVAALGLALLAGLLCATTEALD :. :: : .:..: . : ::.:. :: NP_001 ALNEKQL-VCPVTRDHLGFQVTWPDESKAGGSWDLAVQERAARSQCTYSNPEGTVVLACD 440 450 460 470 480 490 NP_001 QAQCRWLNVQLSPQQGSLGLQYNASQEWDLRSSCGSLRLTVSIEARAAGP 500 510 520 530 540 >>XP_016877935 (OMIM: 614179) PREDICTED: immunoglobulin (468 aa) initn: 285 init1: 143 opt: 186 Z-score: 207.6 bits: 46.3 E(85289): 8e-05 Smith-Waterman score: 186; 39.5% identity (60.5% similar) in 86 aa overlap (45-127:142-225) 20 30 40 50 60 70 pF1KB8 EATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHL :: ::: : : . :: :... ::.:: : XP_016 SSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPD-LRSLRINNNRLRTLAPGTFDAL 120 130 140 150 160 170 80 90 100 110 120 130 pF1KB8 PQLQTLDVTQNPWHCDCSLTYLRLWLEDRT---PEALLQVRCASPSLAAHGPLGRLTGYQ :. :.. .::.:: :.:..:. : . :: .. :::: :. :: XP_016 SALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPD-SIACASPPALQGVPVYRLPALP 180 190 200 210 220 140 150 160 170 pF1KB8 LGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD XP_016 CAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLS 230 240 250 260 270 280 177 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:11:07 2016 done: Fri Nov 4 15:11:08 2016 Total Scan time: 5.900 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]