FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8748, 169 aa 1>>>pF1KB8748 169 - 169 aa - 169 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.5639+/-0.000386; mu= -10.8559+/- 0.024 mean_var=323.1766+/-64.088, 0's: 0 Z-trim(122.7): 56 B-trim: 0 in 0/55 Lambda= 0.071343 statistics sampled from 41305 (41370) to 41305 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.772), E-opt: 0.2 (0.485), width: 16 Scan time: 5.580 The best scores are: opt bits E(85289) NP_001091058 (OMIM: 182271) small proline-rich pro ( 169) 1240 139.8 1.9e-33 NP_005407 (OMIM: 182271) small proline-rich protei ( 169) 1240 139.8 1.9e-33 NP_003116 (OMIM: 182266) cornifin-B [Homo sapiens] ( 89) 387 51.8 3.2e-07 NP_001186757 (OMIM: 182265) cornifin-A [Homo sapie ( 89) 373 50.4 8.7e-07 NP_005978 (OMIM: 182265) cornifin-A [Homo sapiens] ( 89) 373 50.4 8.7e-07 XP_016855492 (OMIM: 208250,604283) PREDICTED: prot (1270) 282 42.0 0.0043 NP_001121182 (OMIM: 208250,604283) proteoglycan 4 (1270) 282 42.0 0.0043 XP_016855491 (OMIM: 208250,604283) PREDICTED: prot (1311) 282 42.0 0.0044 NP_001121181 (OMIM: 208250,604283) proteoglycan 4 (1311) 282 42.0 0.0044 NP_001290161 (OMIM: 208250,604283) proteoglycan 4 (1361) 282 42.0 0.0045 NP_001121180 (OMIM: 208250,604283) proteoglycan 4 (1363) 282 42.0 0.0045 NP_005798 (OMIM: 208250,604283) proteoglycan 4 iso (1404) 282 42.0 0.0046 >>NP_001091058 (OMIM: 182271) small proline-rich protein (169 aa) initn: 1240 init1: 1240 opt: 1240 Z-score: 721.3 bits: 139.8 E(85289): 1.9e-33 Smith-Waterman score: 1240; 99.4% identity (100.0% similar) in 169 aa overlap (1-169:1-169) 10 20 30 40 50 60 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVPDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVPDQ 70 80 90 100 110 120 130 140 150 160 pF1KB8 GFIKFPEPGAIKVPEQGYTKVPVPGYTKVPEPCPSTVTPGPAQQKTKQK ::::::::::::::::::::::::::::.:::::::::::::::::::: NP_001 GFIKFPEPGAIKVPEQGYTKVPVPGYTKLPEPCPSTVTPGPAQQKTKQK 130 140 150 160 >>NP_005407 (OMIM: 182271) small proline-rich protein 3 (169 aa) initn: 1240 init1: 1240 opt: 1240 Z-score: 721.3 bits: 139.8 E(85289): 1.9e-33 Smith-Waterman score: 1240; 99.4% identity (100.0% similar) in 169 aa overlap (1-169:1-169) 10 20 30 40 50 60 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVPDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVPDQ 70 80 90 100 110 120 130 140 150 160 pF1KB8 GFIKFPEPGAIKVPEQGYTKVPVPGYTKVPEPCPSTVTPGPAQQKTKQK ::::::::::::::::::::::::::::.:::::::::::::::::::: NP_005 GFIKFPEPGAIKVPEQGYTKVPVPGYTKLPEPCPSTVTPGPAQQKTKQK 130 140 150 160 >>NP_003116 (OMIM: 182266) cornifin-B [Homo sapiens] (89 aa) initn: 375 init1: 375 opt: 387 Z-score: 250.6 bits: 51.8 E(85289): 3.2e-07 Smith-Waterman score: 387; 62.9% identity (73.0% similar) in 89 aa overlap (1-87:1-88) 10 20 30 40 50 60 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTK ::: :::: :::::::::::::: :::::: .: :::::: :::.: . :.::: : NP_003 MSSQQQKQPCTPPPQLQQQQVKQPCQPPPQEPCIPKTKEPCHPKVPEPCHPKVPEPCQPK 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VPEPGCTKVPEPGCTKV--PEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVP :::: ::::: : .. : :. :. . NP_003 VPEPCHPKVPEP-CPSIVTPAPAQQKTKQK 70 80 >>NP_001186757 (OMIM: 182265) cornifin-A [Homo sapiens] (89 aa) initn: 362 init1: 362 opt: 373 Z-score: 242.8 bits: 50.4 E(85289): 8.7e-07 Smith-Waterman score: 373; 61.8% identity (71.9% similar) in 89 aa overlap (1-87:1-88) 10 20 30 40 50 60 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTK :.: :::: ::::: :::::::: :::::: .: :::::: :::.: . :.::: : NP_001 MNSQQQKQPCTPPPQPQQQQVKQPCQPPPQEPCIPKTKEPCHPKVPEPCHPKVPEPCQPK 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VPEPGCTKVPEPGC--TKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVP :::: ::::: : : .: :. :. . NP_001 VPEPCQPKVPEP-CPSTVTPAPAQQKTKQK 70 80 >>NP_005978 (OMIM: 182265) cornifin-A [Homo sapiens] (89 aa) initn: 362 init1: 362 opt: 373 Z-score: 242.8 bits: 50.4 E(85289): 8.7e-07 Smith-Waterman score: 373; 61.8% identity (71.9% similar) in 89 aa overlap (1-87:1-88) 10 20 30 40 50 60 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTK :.: :::: ::::: :::::::: :::::: .: :::::: :::.: . :.::: : NP_005 MNSQQQKQPCTPPPQPQQQQVKQPCQPPPQEPCIPKTKEPCHPKVPEPCHPKVPEPCQPK 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VPEPGCTKVPEPGC--TKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVP :::: ::::: : : .: :. :. . NP_005 VPEPCQPKVPEP-CPSTVTPAPAQQKTKQK 70 80 >>XP_016855492 (OMIM: 208250,604283) PREDICTED: proteogl (1270 aa) initn: 284 init1: 109 opt: 282 Z-score: 176.5 bits: 42.0 E(85289): 0.0043 Smith-Waterman score: 282; 36.1% identity (45.6% similar) in 169 aa overlap (6-165:307-472) 10 20 30 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVP .: . : : . :.:. :.: .: XP_016 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP-AP 280 290 300 310 320 330 40 50 60 70 80 90 pF1KB8 TTKEPCHS--KVPQPGNTKIPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKV ::::: . : : : : : : : : : : : : :: : : : : : :: XP_016 TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK- 340 350 360 370 380 390 100 110 120 130 140 150 pF1KB8 PEPGCTKVPEPGYTKVPEPGSIKVPDQGFIKFPEPGAIKVPEQGYTKVPVPGYTKVP--- : :: : : :: : . : :. : : : . : : : :.: : : XP_016 SAPTTTKEPAPTTTK-SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 400 410 420 430 440 450 160 pF1KB8 ---EPCPSTVT-PGPAQQKTKQK :: :.:. :.:. : XP_016 TPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 460 470 480 490 500 510 >>NP_001121182 (OMIM: 208250,604283) proteoglycan 4 isof (1270 aa) initn: 284 init1: 109 opt: 282 Z-score: 176.5 bits: 42.0 E(85289): 0.0043 Smith-Waterman score: 282; 36.1% identity (45.6% similar) in 169 aa overlap (6-165:307-472) 10 20 30 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVP .: . : : . :.:. :.: .: NP_001 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP-AP 280 290 300 310 320 330 40 50 60 70 80 90 pF1KB8 TTKEPCHS--KVPQPGNTKIPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKV ::::: . : : : : : : : : : : : : :: : : : : : :: NP_001 TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK- 340 350 360 370 380 390 100 110 120 130 140 150 pF1KB8 PEPGCTKVPEPGYTKVPEPGSIKVPDQGFIKFPEPGAIKVPEQGYTKVPVPGYTKVP--- : :: : : :: : . : :. : : : . : : : :.: : : NP_001 SAPTTTKEPAPTTTK-SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 400 410 420 430 440 450 160 pF1KB8 ---EPCPSTVT-PGPAQQKTKQK :: :.:. :.:. : NP_001 TPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 460 470 480 490 500 510 >>XP_016855491 (OMIM: 208250,604283) PREDICTED: proteogl (1311 aa) initn: 203 init1: 109 opt: 282 Z-score: 176.4 bits: 42.0 E(85289): 0.0044 Smith-Waterman score: 282; 36.1% identity (45.6% similar) in 169 aa overlap (6-165:348-513) 10 20 30 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVP .: . : : . :.:. :.: .: XP_016 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP-AP 320 330 340 350 360 370 40 50 60 70 80 90 pF1KB8 TTKEPCHS--KVPQPGNTKIPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKV ::::: . : : : : : : : : : : : : :: : : : : : :: XP_016 TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK- 380 390 400 410 420 430 100 110 120 130 140 150 pF1KB8 PEPGCTKVPEPGYTKVPEPGSIKVPDQGFIKFPEPGAIKVPEQGYTKVPVPGYTKVP--- : :: : : :: : . : :. : : : . : : : :.: : : XP_016 SAPTTTKEPAPTTTK-SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 440 450 460 470 480 490 160 pF1KB8 ---EPCPSTVT-PGPAQQKTKQK :: :.:. :.:. : XP_016 TPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 500 510 520 530 540 550 >>NP_001121181 (OMIM: 208250,604283) proteoglycan 4 isof (1311 aa) initn: 203 init1: 109 opt: 282 Z-score: 176.4 bits: 42.0 E(85289): 0.0044 Smith-Waterman score: 282; 36.1% identity (45.6% similar) in 169 aa overlap (6-165:348-513) 10 20 30 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVP .: . : : . :.:. :.: .: NP_001 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP-AP 320 330 340 350 360 370 40 50 60 70 80 90 pF1KB8 TTKEPCHS--KVPQPGNTKIPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKV ::::: . : : : : : : : : : : : : :: : : : : : :: NP_001 TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK- 380 390 400 410 420 430 100 110 120 130 140 150 pF1KB8 PEPGCTKVPEPGYTKVPEPGSIKVPDQGFIKFPEPGAIKVPEQGYTKVPVPGYTKVP--- : :: : : :: : . : :. : : : . : : : :.: : : NP_001 SAPTTTKEPAPTTTK-SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 440 450 460 470 480 490 160 pF1KB8 ---EPCPSTVT-PGPAQQKTKQK :: :.:. :.:. : NP_001 TPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 500 510 520 530 540 550 >>NP_001290161 (OMIM: 208250,604283) proteoglycan 4 isof (1361 aa) initn: 284 init1: 109 opt: 282 Z-score: 176.1 bits: 42.0 E(85289): 0.0045 Smith-Waterman score: 282; 36.1% identity (45.6% similar) in 169 aa overlap (6-165:398-563) 10 20 30 pF1KB8 MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVP .: . : : . :.:. :.: .: NP_001 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP-AP 370 380 390 400 410 420 40 50 60 70 80 90 pF1KB8 TTKEPCHS--KVPQPGNTKIPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKV ::::: . : : : : : : : : : : : : :: : : : : : :: NP_001 TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK- 430 440 450 460 470 480 100 110 120 130 140 150 pF1KB8 PEPGCTKVPEPGYTKVPEPGSIKVPDQGFIKFPEPGAIKVPEQGYTKVPVPGYTKVP--- : :: : : :: : . : :. : : : . : : : :.: : : NP_001 SAPTTTKEPAPTTTK-SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 490 500 510 520 530 540 160 pF1KB8 ---EPCPSTVT-PGPAQQKTKQK :: :.:. :.:. : NP_001 TPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 550 560 570 580 590 600 169 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:02:36 2016 done: Sat Nov 5 21:02:37 2016 Total Scan time: 5.580 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]