FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8753, 196 aa 1>>>pF1KB8753 196 - 196 aa - 196 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8617+/-0.000385; mu= 16.1411+/- 0.024 mean_var=83.4025+/-16.955, 0's: 0 Z-trim(115.2): 204 B-trim: 802 in 1/53 Lambda= 0.140438 statistics sampled from 25334 (25582) to 25334 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.681), E-opt: 0.2 (0.3), width: 16 Scan time: 4.900 The best scores are: opt bits E(85289) XP_005266310 (OMIM: 609351) PREDICTED: ADP-ribosyl ( 196) 1288 270.3 1.4e-72 NP_612459 (OMIM: 609351) ADP-ribosylation factor-l ( 196) 1288 270.3 1.4e-72 NP_079323 (OMIM: 614439) ADP-ribosylation factor-l ( 192) 514 113.5 2.2e-25 NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 ( 175) 472 104.9 7.7e-23 NP_004302 (OMIM: 604695) ADP-ribosylation factor-l ( 182) 466 103.7 1.8e-22 XP_016871749 (OMIM: 604695) PREDICTED: ADP-ribosyl ( 182) 466 103.7 1.8e-22 NP_001658 (OMIM: 601175) ADP-ribosylation factor-l ( 184) 455 101.5 8.6e-22 NP_001269360 (OMIM: 604787) ADP-ribosylation facto ( 201) 454 101.3 1.1e-21 NP_001653 (OMIM: 103188) ADP-ribosylation factor 5 ( 180) 450 100.5 1.7e-21 NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 ( 181) 449 100.3 2e-21 XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 181) 449 100.3 2e-21 NP_005728 (OMIM: 604787) ADP-ribosylation factor-l ( 192) 449 100.3 2.1e-21 NP_001019397 (OMIM: 103180) ADP-ribosylation facto ( 181) 443 99.0 4.6e-21 NP_001019398 (OMIM: 103180) ADP-ribosylation facto ( 181) 443 99.0 4.6e-21 NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 ( 181) 443 99.0 4.6e-21 NP_001019399 (OMIM: 103180) ADP-ribosylation facto ( 181) 443 99.0 4.6e-21 NP_001652 (OMIM: 600732) ADP-ribosylation factor-l ( 201) 440 98.5 7.6e-21 XP_011523084 (OMIM: 600732) PREDICTED: ADP-ribosyl ( 201) 440 98.5 7.6e-21 NP_036229 (OMIM: 608960) ADP-ribosylation factor-l ( 179) 432 96.8 2.1e-20 NP_001651 (OMIM: 601177) ADP-ribosylation factor 4 ( 180) 427 95.8 4.3e-20 NP_001168 (OMIM: 603425) ADP-ribosylation factor-l ( 181) 418 94.0 1.5e-19 NP_001032241 (OMIM: 604786) ADP-ribosylation facto ( 200) 413 93.0 3.3e-19 NP_005729 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 413 93.0 3.3e-19 NP_001182325 (OMIM: 604786) ADP-ribosylation facto ( 200) 413 93.0 3.3e-19 NP_997625 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 413 93.0 3.3e-19 XP_005248554 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 398) 415 93.7 4e-19 NP_001647 (OMIM: 601747) E3 ubiquitin-protein liga ( 574) 415 93.9 5.2e-19 NP_848930 (OMIM: 608909) ADP-ribosylation factor-l ( 179) 405 91.3 9.5e-19 NP_150230 (OMIM: 601747) E3 ubiquitin-protein liga ( 569) 388 88.4 2.3e-17 XP_016864933 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 569) 388 88.4 2.3e-17 XP_006719454 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 137) 354 80.9 1e-15 NP_150231 (OMIM: 601747) E3 ubiquitin-protein liga ( 546) 360 82.7 1.1e-15 NP_816931 (OMIM: 209900,268000,600151,608845,61357 ( 186) 354 81.0 1.3e-15 XP_016862800 (OMIM: 209900,268000,600151,608845,61 ( 186) 354 81.0 1.3e-15 NP_001265222 (OMIM: 209900,268000,600151,608845,61 ( 186) 354 81.0 1.3e-15 NP_115522 (OMIM: 209900,268000,600151,608845,61357 ( 186) 354 81.0 1.3e-15 XP_016856722 (OMIM: 103180) PREDICTED: ADP-ribosyl ( 212) 353 80.9 1.6e-15 NP_001310442 (OMIM: 209900,268000,600151,608845,61 ( 193) 351 80.4 2e-15 NP_001032251 (OMIM: 608960) ADP-ribosylation facto ( 142) 348 79.7 2.4e-15 NP_817114 (OMIM: 608960) ADP-ribosylation factor-l ( 142) 348 79.7 2.4e-15 NP_060654 (OMIM: 616596) ADP-ribosylation factor-l ( 186) 348 79.8 2.9e-15 NP_620150 (OMIM: 616597) ADP-ribosylation factor-l ( 186) 347 79.6 3.4e-15 NP_001254476 (OMIM: 604699) ADP-ribosylation facto ( 201) 332 76.6 2.9e-14 NP_001254477 (OMIM: 604699) ADP-ribosylation facto ( 201) 332 76.6 2.9e-14 XP_016883065 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 332 76.6 2.9e-14 XP_011526785 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 332 76.6 2.9e-14 XP_011526784 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 332 76.6 2.9e-14 NP_003215 (OMIM: 604699) ADP-ribosylation factor-r ( 201) 332 76.6 2.9e-14 XP_005252458 (OMIM: 608909) PREDICTED: ADP-ribosyl ( 142) 324 74.8 7.1e-14 NP_878899 (OMIM: 608922,612291) ADP-ribosylation f ( 428) 325 75.5 1.3e-13 >>XP_005266310 (OMIM: 609351) PREDICTED: ADP-ribosylatio (196 aa) initn: 1288 init1: 1288 opt: 1288 Z-score: 1424.0 bits: 270.3 E(85289): 1.4e-72 Smith-Waterman score: 1288; 99.5% identity (99.5% similar) in 196 aa overlap (1-196:1-196) 10 20 30 40 50 60 pF1KB8 MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ANKQEAPDALPLLKIRNRLSLERFQDHRWELRGCSALTGEGLPEALQSLWSLLKSRSCMC ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_005 ANKQEAPDALPLLKIRNRLSLERFQDHCWELRGCSALTGEGLPEALQSLWSLLKSRSCMC 130 140 150 160 170 180 190 pF1KB8 LQARAHGAERGDSKRS :::::::::::::::: XP_005 LQARAHGAERGDSKRS 190 >>NP_612459 (OMIM: 609351) ADP-ribosylation factor-like (196 aa) initn: 1288 init1: 1288 opt: 1288 Z-score: 1424.0 bits: 270.3 E(85289): 1.4e-72 Smith-Waterman score: 1288; 99.5% identity (99.5% similar) in 196 aa overlap (1-196:1-196) 10 20 30 40 50 60 pF1KB8 MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 LWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ANKQEAPDALPLLKIRNRLSLERFQDHRWELRGCSALTGEGLPEALQSLWSLLKSRSCMC ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_612 ANKQEAPDALPLLKIRNRLSLERFQDHCWELRGCSALTGEGLPEALQSLWSLLKSRSCMC 130 140 150 160 170 180 190 pF1KB8 LQARAHGAERGDSKRS :::::::::::::::: NP_612 LQARAHGAERGDSKRS 190 >>NP_079323 (OMIM: 614439) ADP-ribosylation factor-like (192 aa) initn: 530 init1: 416 opt: 514 Z-score: 576.6 bits: 113.5 E(85289): 2.2e-25 Smith-Waterman score: 514; 45.8% identity (76.8% similar) in 177 aa overlap (1-175:1-177) 10 20 30 40 50 pF1KB8 MGSVNSRGHKA-EAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSL :::..:.. .. .:::...:::::::.::::::: . . :.::.::::: .. ..:: NP_079 MGSLGSKNPQTKQAQVLLLGLDSAGKSTLLYKLKLAKDITTIPTIGFNVEMIELERNLSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 TLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLV :.:::::: .:. : : :.:: ::::.::::. :: :: .. ..:.. .. .:: .. NP_079 TVWDVGGQEKMRTVWGCYCENTDGLVYVVDSTDKQRLEESQRQFEHILKNEHIKNVPVVL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 LANKQEAPDALPLLKIRNRLSLERF-QDHRWELRGCSALTGEGLPEALQSLWSLLKSRSC :::::. : :: : ...... .:. : .. : ::::::: .....: ...:: NP_079 LANKQDMPGALTAEDITRMFKVKKLCSDRNWYVQPCCALTGEGLAQGFRKLTGFVKSHMK 130 140 150 160 170 180 180 190 pF1KB8 MCLQARAHGAERGDSKRS NP_079 SRGDTLAFFKQN 190 >>NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 [Ho (175 aa) initn: 461 init1: 308 opt: 472 Z-score: 531.1 bits: 104.9 E(85289): 7.7e-23 Smith-Waterman score: 472; 44.6% identity (72.3% similar) in 177 aa overlap (1-175:1-175) 10 20 30 40 50 pF1KB8 MGSVNSR--GHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVS ::.: :. :.: : ...:.:::.:::::.::::: : : :.:::::::: . .:. NP_001 MGKVLSKIFGNK-EMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYK-NVK 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 LTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFL ...:::::: .: :. : ::. :..:.: .:. :. :. :: ...:: .: . .: NP_001 FNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIIL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 VLANKQEAPDALPLLKIRNRLSLERFQDHRWELRGCSALTGEGLPEALQSLWSLLKSRSC ..::::. :::. .:...:.: :..:. : .. : .:.:: :.: : : :: NP_001 IFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS 120 130 140 150 160 170 180 190 pF1KB8 MCLQARAHGAERGDSKRS >>NP_004302 (OMIM: 604695) ADP-ribosylation factor-like (182 aa) initn: 440 init1: 341 opt: 466 Z-score: 524.3 bits: 103.7 E(85289): 1.8e-22 Smith-Waterman score: 466; 42.1% identity (79.2% similar) in 159 aa overlap (12-170:17-172) 10 20 30 40 50 pF1KB8 MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPG :......:::.::::::: .: .... . :: :::.. ... : NP_004 MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 HVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGV .:..::.::: .: ::.:.:.::::.::.::.:. :. :.. ::.:.:.. ... : NP_004 F-KLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCV 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PFLVLANKQEAPDALPLLKIRNRLSLERFQDHRWELRGCSALTGEGLPEALQSLWSLLKS : :..::::. : : .: . :.:. ..:. :....::::::::. .... : NP_004 PVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMN--WVCKNV 120 130 140 150 160 170 180 190 pF1KB8 RSCMCLQARAHGAERGDSKRS NP_004 NAKKK 180 >>XP_016871749 (OMIM: 604695) PREDICTED: ADP-ribosylatio (182 aa) initn: 440 init1: 341 opt: 466 Z-score: 524.3 bits: 103.7 E(85289): 1.8e-22 Smith-Waterman score: 466; 42.1% identity (79.2% similar) in 159 aa overlap (12-170:17-172) 10 20 30 40 50 pF1KB8 MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPG :......:::.::::::: .: .... . :: :::.. ... : XP_016 MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 HVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGV .:..::.::: .: ::.:.:.::::.::.::.:. :. :.. ::.:.:.. ... : XP_016 F-KLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCV 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PFLVLANKQEAPDALPLLKIRNRLSLERFQDHRWELRGCSALTGEGLPEALQSLWSLLKS : :..::::. : : .: . :.:. ..:. :....::::::::. .... : XP_016 PVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMN--WVCKNV 120 130 140 150 160 170 180 190 pF1KB8 RSCMCLQARAHGAERGDSKRS XP_016 NAKKK 180 >>NP_001658 (OMIM: 601175) ADP-ribosylation factor-like (184 aa) initn: 454 init1: 335 opt: 455 Z-score: 512.2 bits: 101.5 E(85289): 8.6e-22 Smith-Waterman score: 455; 42.4% identity (75.2% similar) in 165 aa overlap (12-176:16-179) 10 20 30 40 50 pF1KB8 MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGH : ...:.:::.:::::.: :..:... ::.:::.. :. : NP_001 MGLLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNGEDIDTISPTLGFNIKTLEHRGF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 VSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVP .:..:::::: ::. :..:.:.:: :..:.::.:. :. . :: .: . .::. NP_001 -KLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGAT 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 FLVLANKQEAPDALPLLKIRNRLSLERFQDHRWELRGCSALTGEGLPEALQSLWSLLKSR .:..::::. : :: ::. : :. ...:.: ..::::.:::.: ... : . ..:: NP_001 LLIFANKQDLPGALSSNAIREVLELDSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISSR 120 130 140 150 160 170 180 190 pF1KB8 SCMCLQARAHGAERGDSKRS NP_001 IFTAD 180 >>NP_001269360 (OMIM: 604787) ADP-ribosylation factor-li (201 aa) initn: 458 init1: 246 opt: 454 Z-score: 510.6 bits: 101.3 E(85289): 1.1e-21 Smith-Waterman score: 454; 40.9% identity (70.2% similar) in 198 aa overlap (1-190:1-197) 10 20 30 40 50 pF1KB8 MGSVNSRGHKAEA-QVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLK-----AP ::...: .. ..::.:::::::::.::.:: ...:.:.::.:::.: .: : NP_001 MGNISSNISAFQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPTIGFNTEKIKLSNGTAK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 GHVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAG : .: .:::::: :: ::.: . :: ..::.::.: :: :. .:: .: . . : NP_001 G-ISCHFWDVGGQEKLRPLWKSYSRCTDGIIYVVDSVDVDRLEEAKTELHKVTKFAENQG 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 VPFLVLANKQEAPDALPLLKIRNRLSL-ERFQDHRWELRGCSALTGEGLPEALQSLWSL- .:.::.::::. : .::. .:...:.: : . .... :. :::: :....:. . NP_001 TPLLVIANKQDLPKSLPVAEIEKQLALHELIPATTYHVQPACAIIGEGLTEGMDKLYEMI 120 130 140 150 160 170 180 190 pF1KB8 LKSRSCMCLQARAHGAERGDSKRS :: :. . . . : : NP_001 LKRRKSLKQKKKRTGDLRSCEV 180 190 200 >>NP_001653 (OMIM: 103188) ADP-ribosylation factor 5 [Ho (180 aa) initn: 416 init1: 284 opt: 450 Z-score: 506.8 bits: 100.5 E(85289): 1.7e-21 Smith-Waterman score: 450; 40.1% identity (76.6% similar) in 167 aa overlap (10-176:15-180) 10 20 30 40 50 pF1KB8 MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPG : . ...:.:::.:::::.::::: ..: :.::.::::: .. NP_001 MGLTVSALFSRIFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYK- 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 HVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGV .. .:.:::::: .: :. :...:. :..:.::.:. :. ::: :: ..:.. .. . NP_001 NICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVQESADELQKMLQEDELRDA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PFLVLANKQEAPDALPLLKIRNRLSLERFQDHRWELRGCSALTGEGLPEALQSLWSLLKS .::.::::. :.:.:. .. ..:.:...... : ... : : :: ..:. : :.. NP_001 VLLVFANKQDMPNAMPVSELTDKLGLQHLRSRTWYVQATCATQGTGLYDGLDWLSHELSK 120 130 140 150 160 170 180 190 pF1KB8 RSCMCLQARAHGAERGDSKRS : NP_001 R 180 >>NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 [Ho (181 aa) initn: 423 init1: 277 opt: 449 Z-score: 505.7 bits: 100.3 E(85289): 2e-21 Smith-Waterman score: 449; 40.7% identity (75.4% similar) in 167 aa overlap (10-176:15-180) 10 20 30 40 50 pF1KB8 MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPG : : ...:.:::.:::::.::::: ..: :.::.::::: .. NP_001 MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYK- 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 HVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGV ..:.:.:::::: .: :. :...:. :..:.::.:. :. :. :: ..: . .. . NP_001 NISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PFLVLANKQEAPDALPLLKIRNRLSLERFQDHRWELRGCSALTGEGLPEALQSLWSLLKS .::.::::. :.:. .: ..:.:. .. . : ... : .:.:: :.:. : . ::. NP_001 VLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKN 120 130 140 150 160 170 180 190 pF1KB8 RSCMCLQARAHGAERGDSKRS . NP_001 KK 180 196 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:16:05 2016 done: Fri Nov 4 15:16:06 2016 Total Scan time: 4.900 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]