FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8760, 203 aa 1>>>pF1KB8760 203 - 203 aa - 203 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6842+/-0.00029; mu= 13.5845+/- 0.018 mean_var=117.4036+/-24.794, 0's: 0 Z-trim(121.1): 78 B-trim: 1194 in 1/57 Lambda= 0.118368 statistics sampled from 37086 (37178) to 37086 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.793), E-opt: 0.2 (0.436), width: 16 Scan time: 5.330 The best scores are: opt bits E(85289) XP_005266707 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 1416 251.7 6e-67 XP_005266709 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 1416 251.7 6e-67 XP_011524180 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 1416 251.7 6e-67 XP_016881102 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 1416 251.7 6e-67 NP_775828 (OMIM: 616512) E3 ubiquitin-protein liga ( 203) 1416 251.7 6e-67 XP_016881101 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 1416 251.7 6e-67 XP_011524181 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 1416 251.7 6e-67 NP_061935 (OMIM: 617163) RING finger protein 186 [ ( 227) 202 44.4 0.00017 XP_016869975 (OMIM: 254110,602290,615988) PREDICTE ( 653) 207 45.8 0.00019 XP_005251870 (OMIM: 254110,602290,615988) PREDICTE ( 653) 207 45.8 0.00019 NP_001093149 (OMIM: 254110,602290,615988) E3 ubiqu ( 653) 207 45.8 0.00019 XP_011516700 (OMIM: 254110,602290,615988) PREDICTE ( 653) 207 45.8 0.00019 NP_036342 (OMIM: 254110,602290,615988) E3 ubiquiti ( 653) 207 45.8 0.00019 >>XP_005266707 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 1416 init1: 1416 opt: 1416 Z-score: 1322.9 bits: 251.7 E(85289): 6e-67 Smith-Waterman score: 1416; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KB8 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV 130 140 150 160 170 180 190 200 pF1KB8 FLLGIVLHNMSCISKRFTVISCG ::::::::::::::::::::::: XP_005 FLLGIVLHNMSCISKRFTVISCG 190 200 >>XP_005266709 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 1416 init1: 1416 opt: 1416 Z-score: 1322.9 bits: 251.7 E(85289): 6e-67 Smith-Waterman score: 1416; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KB8 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV 130 140 150 160 170 180 190 200 pF1KB8 FLLGIVLHNMSCISKRFTVISCG ::::::::::::::::::::::: XP_005 FLLGIVLHNMSCISKRFTVISCG 190 200 >>XP_011524180 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 1416 init1: 1416 opt: 1416 Z-score: 1322.9 bits: 251.7 E(85289): 6e-67 Smith-Waterman score: 1416; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KB8 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV 130 140 150 160 170 180 190 200 pF1KB8 FLLGIVLHNMSCISKRFTVISCG ::::::::::::::::::::::: XP_011 FLLGIVLHNMSCISKRFTVISCG 190 200 >>XP_016881102 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 1416 init1: 1416 opt: 1416 Z-score: 1322.9 bits: 251.7 E(85289): 6e-67 Smith-Waterman score: 1416; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KB8 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV 130 140 150 160 170 180 190 200 pF1KB8 FLLGIVLHNMSCISKRFTVISCG ::::::::::::::::::::::: XP_016 FLLGIVLHNMSCISKRFTVISCG 190 200 >>NP_775828 (OMIM: 616512) E3 ubiquitin-protein ligase R (203 aa) initn: 1416 init1: 1416 opt: 1416 Z-score: 1322.9 bits: 251.7 E(85289): 6e-67 Smith-Waterman score: 1416; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KB8 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV 130 140 150 160 170 180 190 200 pF1KB8 FLLGIVLHNMSCISKRFTVISCG ::::::::::::::::::::::: NP_775 FLLGIVLHNMSCISKRFTVISCG 190 200 >>XP_016881101 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 1416 init1: 1416 opt: 1416 Z-score: 1322.9 bits: 251.7 E(85289): 6e-67 Smith-Waterman score: 1416; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KB8 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV 130 140 150 160 170 180 190 200 pF1KB8 FLLGIVLHNMSCISKRFTVISCG ::::::::::::::::::::::: XP_016 FLLGIVLHNMSCISKRFTVISCG 190 200 >>XP_011524181 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 1416 init1: 1416 opt: 1416 Z-score: 1322.9 bits: 251.7 E(85289): 6e-67 Smith-Waterman score: 1416; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KB8 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLV 130 140 150 160 170 180 190 200 pF1KB8 FLLGIVLHNMSCISKRFTVISCG ::::::::::::::::::::::: XP_011 FLLGIVLHNMSCISKRFTVISCG 190 200 >>NP_061935 (OMIM: 617163) RING finger protein 186 [Homo (227 aa) initn: 182 init1: 129 opt: 202 Z-score: 201.9 bits: 44.4 E(85289): 0.00017 Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (5-84:33-114) 10 20 30 pF1KB8 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC : . ::: .: . :: : :::: :.:. NP_061 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF :..::. . : . . :: :: :: .: :. . .: : :.. .: : : NP_061 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV NP_061 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV 130 140 150 160 170 180 >>XP_016869975 (OMIM: 254110,602290,615988) PREDICTED: E (653 aa) initn: 201 init1: 92 opt: 207 Z-score: 201.0 bits: 45.8 E(85289): 0.00019 Smith-Waterman score: 207; 35.5% identity (61.7% similar) in 107 aa overlap (4-99:9-112) 10 20 30 40 50 pF1KB8 METLSQDSL---LECQICFNYYSPRR-RPKLLDCKHTCCSVCLQQMRTSQKD-VR :. :.: ::: ::.. .. .. ::::: : :: : ::... .:. . :: XP_016 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR 10 20 30 40 50 60 60 70 80 90 100 pF1KB8 CPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFI------KLPSNGCYMLPL ::.: .:.. :..:: :. :: .: :: . ... .:: . : XP_016 CPFCSKITRIT---SLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGL 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 PISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSS XP_016 VLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDL 120 130 140 150 160 170 >>XP_005251870 (OMIM: 254110,602290,615988) PREDICTED: E (653 aa) initn: 201 init1: 92 opt: 207 Z-score: 201.0 bits: 45.8 E(85289): 0.00019 Smith-Waterman score: 207; 35.5% identity (61.7% similar) in 107 aa overlap (4-99:9-112) 10 20 30 40 50 pF1KB8 METLSQDSL---LECQICFNYYSPRR-RPKLLDCKHTCCSVCLQQMRTSQKD-VR :. :.: ::: ::.. .. .. ::::: : :: : ::... .:. . :: XP_005 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR 10 20 30 40 50 60 60 70 80 90 100 pF1KB8 CPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFI------KLPSNGCYMLPL ::.: .:.. :..:: :. :: .: :: . ... .:: . : XP_005 CPFCSKITRIT---SLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGL 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 PISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSS XP_005 VLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDL 120 130 140 150 160 170 203 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:21:18 2016 done: Fri Nov 4 15:21:19 2016 Total Scan time: 5.330 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]