Result of FASTA (omim) for
pF1KB8767
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8767, 225 aa
1>>>pF1KB8767 225 - 225 aa - 225 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.6284+/-0.000303; mu= -3.8376+/- 0.019
mean_var=231.3802+/-47.160, 0's: 0 Z-trim(124.5): 31 B-trim: 0 in 0/61
Lambda= 0.084316
statistics sampled from 46155 (46187) to 46155 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.829), E-opt: 0.2 (0.542), width: 16
Scan time: 7.480
The best scores are: opt bits E(85289)
NP_003946 (OMIM: 604176) suppressor of cytokine si ( 225) 1521 196.5 3.1e-50
NP_659508 (OMIM: 602441,607948,611162,614383) cyto ( 258) 349 54.0 2.8e-07
XP_011531631 (OMIM: 602441,607948,611162,614383) P ( 264) 349 54.0 2.9e-07
NP_037456 (OMIM: 602441,607948,611162,614383) cyto ( 275) 349 54.0 3e-07
NP_003736 (OMIM: 603597) suppressor of cytokine si ( 211) 284 46.0 5.8e-05
NP_001257396 (OMIM: 605117) suppressor of cytokine ( 198) 244 41.1 0.0016
NP_001257398 (OMIM: 605117) suppressor of cytokine ( 198) 244 41.1 0.0016
NP_001257397 (OMIM: 605117) suppressor of cytokine ( 198) 244 41.1 0.0016
NP_001257400 (OMIM: 605117) suppressor of cytokine ( 198) 244 41.1 0.0016
XP_016875645 (OMIM: 605117) PREDICTED: suppressor ( 198) 244 41.1 0.0016
NP_001257399 (OMIM: 605117) suppressor of cytokine ( 198) 244 41.1 0.0016
NP_003868 (OMIM: 605117) suppressor of cytokine si ( 198) 244 41.1 0.0016
XP_011537238 (OMIM: 605117) PREDICTED: suppressor ( 204) 244 41.1 0.0016
XP_011537237 (OMIM: 605117) PREDICTED: suppressor ( 212) 244 41.1 0.0017
XP_011537231 (OMIM: 605117) PREDICTED: suppressor ( 220) 244 41.1 0.0017
XP_016875644 (OMIM: 605117) PREDICTED: suppressor ( 222) 244 41.1 0.0018
XP_016875640 (OMIM: 605117) PREDICTED: suppressor ( 243) 244 41.2 0.0019
XP_016875639 (OMIM: 605117) PREDICTED: suppressor ( 243) 244 41.2 0.0019
XP_016875636 (OMIM: 605117) PREDICTED: suppressor ( 243) 244 41.2 0.0019
XP_016875638 (OMIM: 605117) PREDICTED: suppressor ( 243) 244 41.2 0.0019
XP_016875637 (OMIM: 605117) PREDICTED: suppressor ( 243) 244 41.2 0.0019
XP_016875641 (OMIM: 605117) PREDICTED: suppressor ( 243) 244 41.2 0.0019
XP_016875642 (OMIM: 605117) PREDICTED: suppressor ( 243) 244 41.2 0.0019
XP_016875643 (OMIM: 605117) PREDICTED: suppressor ( 243) 244 41.2 0.0019
>>NP_003946 (OMIM: 604176) suppressor of cytokine signal (225 aa)
initn: 1521 init1: 1521 opt: 1521 Z-score: 1022.9 bits: 196.5 E(85289): 3.1e-50
Smith-Waterman score: 1521; 100.0% identity (100.0% similar) in 225 aa overlap (1-225:1-225)
10 20 30 40 50 60
pF1KB8 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR
130 140 150 160 170 180
190 200 210 220
pF1KB8 PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
:::::::::::::::::::::::::::::::::::::::::::::
NP_003 PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
190 200 210 220
>>NP_659508 (OMIM: 602441,607948,611162,614383) cytokine (258 aa)
initn: 331 init1: 235 opt: 349 Z-score: 251.6 bits: 54.0 E(85289): 2.8e-07
Smith-Waterman score: 349; 33.6% identity (58.4% similar) in 214 aa overlap (15-221:51-254)
10 20 30 40
pF1KB8 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQES
: .: . :... . . .... :.::
NP_659 PLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRES
30 40 50 60 70 80
50 60 70 80 90 100
pF1KB8 GFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSL
:.::...:..:: :. : ::::.:::. ..::::::: : :.::. .:: :
NP_659 GWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRL
90 100 110 120 130 140
110 120 130 140 150
pF1KB8 QSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSF---PSPPTEPSSEVPEQ--PSAQPLPGS
.:. : . : :..::.::. : . :.: :. .:.. :: ::.
NP_659 DSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAP
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB8 PPRRAYYIYSGGEKIPLVLSRPL--SSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREF
:: : . : : .:. :.. .:::::: ..: .: . :: . ..
NP_659 PPATA---------VHLKLVQPFVRRSSARSLQHLCRLVIN-RLVADVDCLPLPRRMADY
210 220 230 240 250
220
pF1KB8 LDQYDAPL
: ::
NP_659 LRQYPFQL
>>XP_011531631 (OMIM: 602441,607948,611162,614383) PREDI (264 aa)
initn: 331 init1: 235 opt: 349 Z-score: 251.4 bits: 54.0 E(85289): 2.9e-07
Smith-Waterman score: 349; 33.6% identity (58.4% similar) in 214 aa overlap (15-221:57-260)
10 20 30 40
pF1KB8 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQES
: .: . :... . . .... :.::
XP_011 PLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRES
30 40 50 60 70 80
50 60 70 80 90 100
pF1KB8 GFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSL
:.::...:..:: :. : ::::.:::. ..::::::: : :.::. .:: :
XP_011 GWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRL
90 100 110 120 130 140
110 120 130 140 150
pF1KB8 QSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSF---PSPPTEPSSEVPEQ--PSAQPLPGS
.:. : . : :..::.::. : . :.: :. .:.. :: ::.
XP_011 DSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAP
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB8 PPRRAYYIYSGGEKIPLVLSRPL--SSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREF
:: : . : : .:. :.. .:::::: ..: .: . :: . ..
XP_011 PPATA---------VHLKLVQPFVRRSSARSLQHLCRLVIN-RLVADVDCLPLPRRMADY
210 220 230 240 250
220
pF1KB8 LDQYDAPL
: ::
XP_011 LRQYPFQL
260
>>NP_037456 (OMIM: 602441,607948,611162,614383) cytokine (275 aa)
initn: 331 init1: 235 opt: 349 Z-score: 251.2 bits: 54.0 E(85289): 3e-07
Smith-Waterman score: 349; 33.6% identity (58.4% similar) in 214 aa overlap (15-221:68-271)
10 20 30 40
pF1KB8 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQES
: .: . :... . . .... :.::
NP_037 PLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRES
40 50 60 70 80 90
50 60 70 80 90 100
pF1KB8 GFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSL
:.::...:..:: :. : ::::.:::. ..::::::: : :.::. .:: :
NP_037 GWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRL
100 110 120 130 140 150
110 120 130 140 150
pF1KB8 QSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSF---PSPPTEPSSEVPEQ--PSAQPLPGS
.:. : . : :..::.::. : . :.: :. .:.. :: ::.
NP_037 DSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAP
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB8 PPRRAYYIYSGGEKIPLVLSRPL--SSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREF
:: : . : : .:. :.. .:::::: ..: .: . :: . ..
NP_037 PPATA---------VHLKLVQPFVRRSSARSLQHLCRLVIN-RLVADVDCLPLPRRMADY
220 230 240 250 260
220
pF1KB8 LDQYDAPL
: ::
NP_037 LRQYPFQL
270
>>NP_003736 (OMIM: 603597) suppressor of cytokine signal (211 aa)
initn: 294 init1: 215 opt: 284 Z-score: 210.1 bits: 46.0 E(85289): 5.8e-05
Smith-Waterman score: 284; 38.9% identity (64.9% similar) in 131 aa overlap (8-134:43-165)
10 20 30
pF1KB8 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNA
::. : :: .: :: :...:. .. :
NP_003 VSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFR--TFRSHADYRRITRA
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB8 VRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQC
:. ::::. .. :. : :::.::::.::: .. ::.:::: :: ..:..
NP_003 SALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHF
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB8 EGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPP----GAPSFPSPPTEPSSEVPEQPSA
..: : :... .: :::...:..::. : :::
NP_003 QAGRFHLDGSRES------FDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVA
140 150 160 170 180
160 170 180 190 200 210
pF1KB8 QPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGP
NP_003 TVGRENLARIPLNPVLRDYLSSFPFQI
190 200 210
>>NP_001257396 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 300 init1: 210 opt: 244 Z-score: 184.2 bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)
10 20 30 40 50 60
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
...:.:.: ..:.::...: .::. :.
NP_001 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
: ::::::::: . ...:.::::..: ::::. . :.: :.: . . .:: :..:
NP_001 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
. .:. . . :: : :. . : :..::
NP_001 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
130 140 150
190 200 210 220
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
... .:::::: :.: . . :: ....:..:
NP_001 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
160 170 180 190
>>NP_001257398 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 300 init1: 210 opt: 244 Z-score: 184.2 bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)
10 20 30 40 50 60
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
...:.:.: ..:.::...: .::. :.
NP_001 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
: ::::::::: . ...:.::::..: ::::. . :.: :.: . . .:: :..:
NP_001 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
. .:. . . :: : :. . : :..::
NP_001 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
130 140 150
190 200 210 220
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
... .:::::: :.: . . :: ....:..:
NP_001 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
160 170 180 190
>>NP_001257397 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 300 init1: 210 opt: 244 Z-score: 184.2 bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)
10 20 30 40 50 60
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
...:.:.: ..:.::...: .::. :.
NP_001 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
: ::::::::: . ...:.::::..: ::::. . :.: :.: . . .:: :..:
NP_001 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
. .:. . . :: : :. . : :..::
NP_001 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
130 140 150
190 200 210 220
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
... .:::::: :.: . . :: ....:..:
NP_001 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
160 170 180 190
>>NP_001257400 (OMIM: 605117) suppressor of cytokine sig (198 aa)
initn: 300 init1: 210 opt: 244 Z-score: 184.2 bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)
10 20 30 40 50 60
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
...:.:.: ..:.::...: .::. :.
NP_001 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
: ::::::::: . ...:.::::..: ::::. . :.: :.: . . .:: :..:
NP_001 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
. .:. . . :: : :. . : :..::
NP_001 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
130 140 150
190 200 210 220
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
... .:::::: :.: . . :: ....:..:
NP_001 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
160 170 180 190
>>XP_016875645 (OMIM: 605117) PREDICTED: suppressor of c (198 aa)
initn: 300 init1: 210 opt: 244 Z-score: 184.2 bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)
10 20 30 40 50 60
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
...:.:.: ..:.::...: .::. :.
XP_016 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
: ::::::::: . ...:.::::..: ::::. . :.: :.: . . .:: :..:
XP_016 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
. .:. . . :: : :. . : :..::
XP_016 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
130 140 150
190 200 210 220
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
... .:::::: :.: . . :: ....:..:
XP_016 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
160 170 180 190
225 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 15:24:56 2016 done: Fri Nov 4 15:24:57 2016
Total Scan time: 7.480 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]