Result of FASTA (omim) for
pF1KB8786
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8786, 297 aa
1>>>pF1KB8786 297 - 297 aa - 297 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8357+/-0.000578; mu= 19.1868+/- 0.036
mean_var=167.6648+/-50.315, 0's: 0 Z-trim(107.3): 362 B-trim: 1007 in 1/50
Lambda= 0.099050
statistics sampled from 14863 (15396) to 14863 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.507), E-opt: 0.2 (0.181), width: 16
Scan time: 5.800
The best scores are: opt bits E(85289)
XP_016881270 (OMIM: 202200,607397) PREDICTED: adre ( 297) 1960 293.1 4.3e-79
NP_000520 (OMIM: 202200,607397) adrenocorticotropi ( 297) 1960 293.1 4.3e-79
NP_001278840 (OMIM: 202200,607397) adrenocorticotr ( 297) 1960 293.1 4.3e-79
NP_005904 (OMIM: 600042) melanocortin receptor 5 [ ( 325) 942 147.7 2.8e-35
NP_005903 (OMIM: 155541,601665) melanocortin recep ( 332) 934 146.6 6.2e-35
NP_002377 (OMIM: 155555,203200,266300,613098,61309 ( 317) 750 120.3 5e-27
NP_063941 (OMIM: 155540,602025,607948) melanocorti ( 323) 583 96.4 7.7e-20
NP_004221 (OMIM: 605111,610419,610419) sphingosine ( 353) 310 57.5 4.4e-08
NP_005217 (OMIM: 601965) sphingosine 1-phosphate r ( 378) 306 57.0 6.8e-08
NP_001391 (OMIM: 601974) sphingosine 1-phosphate r ( 382) 252 49.3 1.4e-05
NP_001307659 (OMIM: 601974) sphingosine 1-phosphat ( 382) 252 49.3 1.4e-05
XP_011535972 (OMIM: 605108) PREDICTED: neuromedin- ( 321) 232 46.3 9.6e-05
NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [ ( 415) 232 46.5 0.00011
XP_016869885 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_005251838 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869889 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_005251839 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869878 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869887 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869886 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869876 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869884 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869880 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869894 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
NP_476500 (OMIM: 602282) lysophosphatidic acid rec ( 364) 223 45.1 0.00025
XP_016869881 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869877 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869892 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869879 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869895 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
NP_001392 (OMIM: 602282) lysophosphatidic acid rec ( 364) 223 45.1 0.00025
XP_016869882 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869875 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869883 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869888 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869896 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869874 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869872 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869873 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869890 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869893 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
XP_016869891 (OMIM: 602282) PREDICTED: lysophospha ( 364) 223 45.1 0.00025
NP_004215 (OMIM: 300207) melatonin-related recepto ( 617) 219 44.9 0.00048
NP_005949 (OMIM: 600665) melatonin receptor type 1 ( 350) 212 43.5 0.00073
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 207 42.7 0.0012
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 207 42.7 0.0012
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 207 42.8 0.0012
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 207 42.8 0.0013
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 207 42.9 0.0013
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 207 43.1 0.0014
>>XP_016881270 (OMIM: 202200,607397) PREDICTED: adrenoco (297 aa)
initn: 1960 init1: 1960 opt: 1960 Z-score: 1541.0 bits: 293.1 E(85289): 4.3e-79
Smith-Waterman score: 1960; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297)
10 20 30 40 50 60
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
190 200 210 220 230 240
250 260 270 280 290
pF1KB8 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
250 260 270 280 290
>>NP_000520 (OMIM: 202200,607397) adrenocorticotropic ho (297 aa)
initn: 1960 init1: 1960 opt: 1960 Z-score: 1541.0 bits: 293.1 E(85289): 4.3e-79
Smith-Waterman score: 1960; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297)
10 20 30 40 50 60
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
190 200 210 220 230 240
250 260 270 280 290
pF1KB8 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
250 260 270 280 290
>>NP_001278840 (OMIM: 202200,607397) adrenocorticotropic (297 aa)
initn: 1960 init1: 1960 opt: 1960 Z-score: 1541.0 bits: 293.1 E(85289): 4.3e-79
Smith-Waterman score: 1960; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297)
10 20 30 40 50 60
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
190 200 210 220 230 240
250 260 270 280 290
pF1KB8 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
250 260 270 280 290
>>NP_005904 (OMIM: 600042) melanocortin receptor 5 [Homo (325 aa)
initn: 930 init1: 559 opt: 942 Z-score: 754.4 bits: 147.7 E(85289): 2.8e-35
Smith-Waterman score: 942; 46.5% identity (77.8% similar) in 288 aa overlap (13-293:25-312)
10 20 30 40
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLA
:. ..: : . . :.:.:......:::..:. :
NP_005 MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB8 VFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDS
. :::::..:::::.::::..::: :. . :.: : : : .: .: :...::
NP_005 IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB8 LFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIF
.. .:...:. :: .::.:::.:::.::::: :.: ::. .... ::.:::: ::.....
NP_005 MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB8 SHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLP-------RANMKGAITL
:. . ... . :.: :: ... ::.:::::::.:...:..:: :..:.::.:.
NP_005 SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB8 TILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSP
:.::::: ::::: ::. :: ::.: ::. .:: :.. .:::::.:.::.::::::
NP_005 TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
250 260 270 280 290 300
290
pF1KB8 ELRDAFKKMIFCSRYW
:.: .::..: :
NP_005 EMRKTFKEIICCRGFRIACSFPRRD
310 320
>>NP_005903 (OMIM: 155541,601665) melanocortin receptor (332 aa)
initn: 950 init1: 397 opt: 934 Z-score: 748.2 bits: 146.6 E(85289): 6.2e-35
Smith-Waterman score: 934; 47.3% identity (77.7% similar) in 296 aa overlap (6-293:26-319)
10 20 30
pF1KB8 MKHIINSYENINNTARNNSDC-PRVVLPEEIFFTISIVGV
:. :.... . ... : .. . :.: :......
NP_005 MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGK-GYSDGGCYEQLFVSPEVFVTLGVISL
10 20 30 40 50
40 50 60 70 80 90
pF1KB8 LENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFE
:::..:..:. :::::..::::::::::..::: :. . :.:.: : : . ::
NP_005 LENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQ-SFT
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB8 TTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCT
.. :..:::.. :::.:: :: ::.:::.:::.::.::.:.:..:. .... ::. ::
NP_005 VNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACT
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB8 GTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPR-------
.:: ..:.: ..: . ..: ::... :::::::.:: : ..:..::
NP_005 VSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQG
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB8 ANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVID
::::::::::::.:::. ::::: ::.... ::.::::.:.:: :.. .:::::..::
NP_005 ANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIID
240 250 260 270 280 290
280 290
pF1KB8 PFIYAFRSPELRDAFKKMIFCSRYW
:.:::.:: ::: .::..: :
NP_005 PLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
300 310 320 330
>>NP_002377 (OMIM: 155555,203200,266300,613098,613099) m (317 aa)
initn: 773 init1: 390 opt: 750 Z-score: 606.2 bits: 120.3 E(85289): 5e-27
Smith-Waterman score: 750; 40.7% identity (73.0% similar) in 285 aa overlap (21-297:35-317)
10 20 30 40 50
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF
: .: . . .:.....:...:: .:. ..
NP_002 GSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF
::.::..::: ::: ::.::.: : ..::. .:.: . : : :.. :..:: .
NP_002 KNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVIT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH
:.:.:. :..::.::::.::.:::::::::. :. ....::. . . .. .
NP_002 CSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD
130 140 150 160 170 180
180 190 200 210 220
pF1KB8 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN--------MKGAITLT
:: ... .. .: :::.. :::::. : .:.. :. : . . .:::.:::
NP_002 HVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB8 ILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE
::::.:..::.:: ::. :...:: .: :.: .. :.. ::.:::.:::.::::.: :
NP_002 ILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQE
250 260 270 280 290 300
290
pF1KB8 LRDAFKKMIFCSRYW
:: ..:... :: :
NP_002 LRRTLKEVLTCS--W
310
>>NP_063941 (OMIM: 155540,602025,607948) melanocortin re (323 aa)
initn: 951 init1: 583 opt: 583 Z-score: 477.2 bits: 96.4 E(85289): 7.7e-20
Smith-Waterman score: 940; 47.9% identity (79.8% similar) in 282 aa overlap (21-293:35-315)
10 20 30 40 50
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF
: .: . :.:....::..:::..:.:::
NP_063 CCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF
.: ::..:::::.::::..::: :. . ::.:.: . . :: . .: :.:.::..
NP_063 RNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMI
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH
.::..:: .: .::.:::.:::.:::::::.:.:........::. : :......:.
NP_063 CISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSE
130 140 150 160 170 180
180 190 200 210 220
pF1KB8 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN---------MKGAITL
... . ..: :.... :::::::.:: :...:..:: :. ::::.:.
NP_063 SKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTI
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB8 TILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSP
:::::::::::::: ::..:. ::.:::: :: . :.. .:::::.::::.::::::
NP_063 TILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSL
250 260 270 280 290 300
290
pF1KB8 ELRDAFKKMIFCSRYW
:::..:.. :.:
NP_063 ELRNTFRE-ILCGCNGMNLG
310 320
>>NP_004221 (OMIM: 605111,610419,610419) sphingosine 1-p (353 aa)
initn: 322 init1: 115 opt: 310 Z-score: 266.0 bits: 57.5 E(85289): 4.4e-08
Smith-Waterman score: 315; 30.4% identity (59.4% similar) in 283 aa overlap (39-295:48-307)
10 20 30 40 50 60
pF1KB8 ENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAI
:.:::.::.:: .:..... ::.:. .::
NP_004 YNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAA
20 30 40 50 60 70
70 80 90 100 110 120
pF1KB8 SDMLGSLYKILENIL---IILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIA
::.:... . ...: . :: : : : . : :. .: .:.::: .::
NP_004 SDLLAGVAFVANTLLSGSVTLR----LTPVQWFAREG-----SAFI-TLSASVFSLLAIA
80 90 100 110 120
130 140 150 160
pF1KB8 ADRYITIFHALRYHSIVTMRRTVVV------------LTVI-WTFCTG----TGITMVIF
.:...: .. : : . : ... : .. :. : : . .. ..
NP_004 IERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWN-CLGHLEACSTVLPLY
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB8 SHHVPTVITFTSLFPLMLVFILCLYVHMFLLARS-HTRKISTLPRANMKGAITLTILLGV
..: :. ...: ..:. :. :::... ..:: :. . : .: :.::.:::
NP_004 AKHY--VLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLK---TVTIVLGV
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB8 FIFCWAPFVLHVLLMTF-CP--SNP--YCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE
:: :: : .. .::. . :: : : : : : .: :. . :....: ::..:: .
NP_004 FIVCWLP-AFSILLLDYACPVHSCPILYKAHY--FFAVSTL----NSLLNPVIYTWRSRD
250 260 270 280 290
290
pF1KB8 LRDAFKKMIFCSRYW
:: . . : :
NP_004 LRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
300 310 320 330 340 350
>>NP_005217 (OMIM: 601965) sphingosine 1-phosphate recep (378 aa)
initn: 221 init1: 126 opt: 306 Z-score: 262.7 bits: 57.0 E(85289): 6.8e-08
Smith-Waterman score: 355; 30.2% identity (63.2% similar) in 285 aa overlap (30-294:45-315)
10 20 30 40 50
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPM
.:..: :::::.::.:..::.... :
NP_005 NETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRM
20 30 40 50 60 70
60 70 80 90 100 110
pF1KB8 YFFICSLAISDML-GSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSI
:::: .::. :.: : ::. :::. .. :.: : . :.:: .: .:
NP_005 YFFIGNLALCDLLAGIAYKV--NILMSGKKTFSLSPTVWFLREG-----SMFV-ALGAST
80 90 100 110 120
120 130 140 150 160 170
pF1KB8 FSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVI---FSHHVP--
:: .:: .:..:... .: .. .:. ... . : . : .. :..:
NP_005 CSLLAIAIERHLTMIK-MRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDC
130 140 150 160 170 180
180 190 200 210 220
pF1KB8 -TV--------ITFT-SLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAI--TL
:. :.: :.: .:: :. ::.....:..: .::... .. . :. :.
NP_005 STILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTV
190 200 210 220 230 240
230 240 250 260 270
pF1KB8 TILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMC--NAVIDPFIYAFR
.:...::: ::.:. . :. . : . :: . ::... .... :....: ::..
NP_005 VIVVSVFIACWSPLFILFLIDVACRVQ---ACPI-LFKAQWFIVLAVLNSAMNPVIYTLA
250 260 270 280 290 300
280 290
pF1KB8 SPELRDAFKKMIFCSRYW
: :.: :: ... :.
NP_005 SKEMRRAFFRLV-CNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
310 320 330 340 350 360
>>NP_001391 (OMIM: 601974) sphingosine 1-phosphate recep (382 aa)
initn: 253 init1: 130 opt: 252 Z-score: 220.9 bits: 49.3 E(85289): 1.4e-05
Smith-Waterman score: 373; 28.9% identity (60.7% similar) in 298 aa overlap (24-295:45-330)
10 20 30 40 50
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNK
. : .:. : .:::..:::...:.:
NP_001 SVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTK
20 30 40 50 60 70
60 70 80 90 100 110
pF1KB8 NLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLS
... :::.:: .::.::.:... :.:. . : : : . :.:: .
NP_001 KFHRPMYYFIGNLALSDLLAGV-AYTANLLLSGATTYKLTPAQWFLREG-----SMFV-A
80 90 100 110 120
120 130 140 150 160
pF1KB8 LLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTF-------------CTG
: .:.::: .:: .::::... .. :. . : ..... :.. : .
NP_001 LSASVFSLLAIAIERYITMLK-MKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCIS
130 140 150 160 170 180
170 180 190 200 210
pF1KB8 --TGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRK------ISTLPR
.. . :. .: .. :..: :.:. :. :: ... :.:...:. :: :
NP_001 ALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASR
190 200 210 220 230 240
220 230 240 250 260
pF1KB8 ANMKGAI---TLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMC--
.. :. :. :.:.::: ::::. . .:: . : . .: . ::... .:..
NP_001 SSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK---TCDI-LFRAEYFLVLAVL
250 260 270 280 290 300
270 280 290
pF1KB8 NAVIDPFIYAFRSPELRDAFKKMIFCSRYW
:. .:.::.. . :.: :: ... : .
NP_001 NSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQ
310 320 330 340 350 360
297 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 15:36:44 2016 done: Fri Nov 4 15:36:45 2016
Total Scan time: 5.800 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]