FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8794, 330 aa 1>>>pF1KB8794 330 - 330 aa - 330 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8478+/-0.000331; mu= 20.9143+/- 0.021 mean_var=127.5948+/-32.216, 0's: 0 Z-trim(116.8): 347 B-trim: 1537 in 1/50 Lambda= 0.113542 statistics sampled from 27709 (28250) to 27709 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.682), E-opt: 0.2 (0.331), width: 16 Scan time: 6.200 The best scores are: opt bits E(85289) NP_005272 (OMIM: 600241) G-protein coupled recepto ( 330) 2199 371.3 1.5e-102 NP_005275 (OMIM: 600553) G-protein coupled recepto ( 362) 1294 223.2 6.8e-58 NP_001273028 (OMIM: 600553) G-protein coupled rece ( 377) 1294 223.2 6.9e-58 NP_005279 (OMIM: 600752) G-protein coupled recepto ( 334) 1276 220.2 5e-57 XP_005266417 (OMIM: 600752) PREDICTED: G-protein c ( 175) 786 139.5 5.1e-33 XP_011526723 (OMIM: 605110) PREDICTED: lysophospha ( 351) 478 89.5 1.2e-17 XP_016882958 (OMIM: 605110) PREDICTED: lysophospha ( 351) 478 89.5 1.2e-17 NP_004711 (OMIM: 605110) lysophosphatidic acid rec ( 351) 478 89.5 1.2e-17 XP_016882957 (OMIM: 605110) PREDICTED: lysophospha ( 351) 478 89.5 1.2e-17 NP_036284 (OMIM: 605106) lysophosphatidic acid rec ( 353) 466 87.5 4.5e-17 NP_001307659 (OMIM: 601974) sphingosine 1-phosphat ( 382) 444 84.0 5.7e-16 NP_001391 (OMIM: 601974) sphingosine 1-phosphate r ( 382) 444 84.0 5.7e-16 XP_016869872 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869886 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869873 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869890 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869889 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869884 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869881 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869880 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_005251839 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869875 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869893 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869879 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869874 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_005251838 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869877 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869878 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869876 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869892 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869891 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869888 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869887 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 NP_476500 (OMIM: 602282) lysophosphatidic acid rec ( 364) 442 83.6 7e-16 XP_016869882 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 NP_001392 (OMIM: 602282) lysophosphatidic acid rec ( 364) 442 83.6 7e-16 XP_016869895 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869885 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869896 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869883 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 XP_016869894 (OMIM: 602282) PREDICTED: lysophospha ( 364) 442 83.6 7e-16 NP_005217 (OMIM: 601965) sphingosine 1-phosphate r ( 378) 398 76.4 1.1e-13 NP_004221 (OMIM: 605111,610419,610419) sphingosine ( 353) 394 75.7 1.6e-13 NP_001159687 (OMIM: 605146) sphingosine 1-phosphat ( 398) 389 75.0 3e-13 NP_110387 (OMIM: 605146) sphingosine 1-phosphate r ( 398) 389 75.0 3e-13 NP_003766 (OMIM: 603751) sphingosine 1-phosphate r ( 384) 384 74.1 5.2e-13 XP_011538931 (OMIM: 605051) PREDICTED: cannabinoid ( 360) 381 73.6 7.1e-13 XP_016855750 (OMIM: 605051) PREDICTED: cannabinoid ( 360) 381 73.6 7.1e-13 NP_001832 (OMIM: 605051) cannabinoid receptor 2 [H ( 360) 381 73.6 7.1e-13 NP_149421 (OMIM: 114610) cannabinoid receptor 1 is ( 439) 307 61.6 3.5e-09 >>NP_005272 (OMIM: 600241) G-protein coupled receptor 3 (330 aa) initn: 2199 init1: 2199 opt: 2199 Z-score: 1962.0 bits: 371.3 E(85289): 1.5e-102 Smith-Waterman score: 2199; 100.0% identity (100.0% similar) in 330 aa overlap (1-330:1-330) 10 20 30 40 50 60 pF1KB8 MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFR 250 260 270 280 290 300 310 320 330 pF1KB8 NQDVQKVLWAVCCCCSSSKIPFRSRSPSDV :::::::::::::::::::::::::::::: NP_005 NQDVQKVLWAVCCCCSSSKIPFRSRSPSDV 310 320 330 >>NP_005275 (OMIM: 600553) G-protein coupled receptor 6 (362 aa) initn: 1369 init1: 1272 opt: 1294 Z-score: 1160.4 bits: 223.2 E(85289): 6.8e-58 Smith-Waterman score: 1294; 59.5% identity (83.7% similar) in 331 aa overlap (3-330:36-362) 10 20 pF1KB8 MMWGAGSPLAWLSAG---SGNVNVSSVGPAEG :: . : :.:: .:....:: : : NP_005 ASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAA-LGAGGGANGSLELSSQLSA-G 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB8 PTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLA : :. ::. . :::.::.:::... :::::::.:..:::.:.:::.::::::.::::: NP_005 P--PGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLA 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB8 GLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETT : ::.:::. . . : .::. :: :. .:.::..:::::::::::::::::::::. : NP_005 GCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRT 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB8 VTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIM . ....:: .: .:::::::::.:::: ..:.:: ::...:...:. ::::::::: NP_005 LLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIM 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB8 LQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLL :.::..::..: :::.:::::.: : : .:::::..:::::::.:.: ::::..::.. NP_005 LHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVV 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB8 GDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSD :. ..: .::: :::::::::::::::::::::..:..:: . : : .::.::::::::. NP_005 GSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSE 310 320 330 340 350 360 330 pF1KB8 V : NP_005 V >>NP_001273028 (OMIM: 600553) G-protein coupled receptor (377 aa) initn: 1369 init1: 1272 opt: 1294 Z-score: 1160.2 bits: 223.2 E(85289): 6.9e-58 Smith-Waterman score: 1294; 59.5% identity (83.7% similar) in 331 aa overlap (3-330:51-377) 10 20 pF1KB8 MMWGAGSPLAWLSAG---SGNVNVSSVGPAEG :: . : :.:: .:....:: : : NP_001 ASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAA-LGAGGGANGSLELSSQLSA-G 30 40 50 60 70 30 40 50 60 70 80 pF1KB8 PTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLA : :. ::. . :::.::.:::... :::::::.:..:::.:.:::.::::::.::::: NP_001 P--PGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLA 80 90 100 110 120 130 90 100 110 120 130 140 pF1KB8 GLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETT : ::.:::. . . : .::. :: :. .:.::..:::::::::::::::::::::. : NP_001 GCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRT 140 150 160 170 180 190 150 160 170 180 190 200 pF1KB8 VTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIM . ....:: .: .:::::::::.:::: ..:.:: ::...:...:. ::::::::: NP_001 LLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIM 200 210 220 230 240 250 210 220 230 240 250 260 pF1KB8 LQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLL :.::..::..: :::.:::::.: : : .:::::..:::::::.:.: ::::..::.. NP_001 LHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVV 260 270 280 290 300 310 270 280 290 300 310 320 pF1KB8 GDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSD :. ..: .::: :::::::::::::::::::::..:..:: . : : .::.::::::::. NP_001 GSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSE 320 330 340 350 360 370 330 pF1KB8 V : NP_001 V >>NP_005279 (OMIM: 600752) G-protein coupled receptor 12 (334 aa) initn: 1255 init1: 1255 opt: 1276 Z-score: 1144.8 bits: 220.2 E(85289): 5e-57 Smith-Waterman score: 1276; 57.1% identity (82.8% similar) in 326 aa overlap (5-330:10-334) 10 20 30 40 50 pF1KB8 MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVS .: : .:.:.... :.:.. .. :. : . ::.::: ::::.: NP_005 MNEDLKVNLSGLPRDYLDAAAAE-NISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLIS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 CENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGV ::::.:: :: .:..:::::::.::::.::::::.::. .:. .. . : .:: .:. NP_005 CENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 LAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAW .. .:.::. :::::::::::::: ::::.:: ::: :::::...:: .. ::::::..: NP_005 IVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGW 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 NCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLP ::: .::.:: ::.::. ..:...:...:..::::: :::.:: :::.:::::.:.: NP_005 NCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 ASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPI .::::.::::..:::..::.:::::.:::.: :..: : .::: :::::::::.:::. NP_005 TSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPV 240 250 260 270 280 290 300 310 320 330 pF1KB8 IYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSDV :::::::..::.: .:: : :.. :.:::::: NP_005 IYAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV 300 310 320 330 >>XP_005266417 (OMIM: 600752) PREDICTED: G-protein coupl (175 aa) initn: 786 init1: 786 opt: 786 Z-score: 713.8 bits: 139.5 E(85289): 5.1e-33 Smith-Waterman score: 786; 60.6% identity (86.9% similar) in 175 aa overlap (156-330:1-175) 130 140 150 160 170 180 pF1KB8 SLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCG ::...:: .. ::::::..:::: .::. XP_005 MLVMLWGTSICLGLLPVMGWNCLRDESTCS 10 20 30 190 200 210 220 230 240 pF1KB8 VVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKG :: ::.::. ..:...:...:..::::: :::.:: :::.:::::.:.: .::::.:::: XP_005 VVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG 40 50 60 70 80 90 250 260 270 280 290 300 pF1KB8 IATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQ ..:::..::.:::::.:::.: :..: : .::: :::::::::.:::.:::::::..: XP_005 VSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQ 100 110 120 130 140 150 310 320 330 pF1KB8 KVLWAVCCCCSSSKIPFRSRSPSDV :.: .:: : :.. :.:::::: XP_005 KALCLICCGCIPSSLAQRARSPSDV 160 170 >>XP_011526723 (OMIM: 605110) PREDICTED: lysophosphatidi (351 aa) initn: 380 init1: 175 opt: 478 Z-score: 438.1 bits: 89.5 E(85289): 1.2e-17 Smith-Waterman score: 478; 33.8% identity (64.5% similar) in 290 aa overlap (40-315:30-314) 10 20 30 40 50 60 pF1KB8 AWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSC----ENALVVAII :: :::. : :: : ::.: : XP_011 MVIMGQCYYNETIGFFYNNSGKELSSHWRPK--DVVVVALGLTVSVLVLLTNLLVIAAI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 VGTPAFRAPMFLLVGSLAVADLLAGLG---LVLHFAAVFCIGSAEMSLVLVGVLAMAFTA ... :. :.. :.:.::.:::.::.. :..: . : : .. :.: ..:: XP_011 ASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 SIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLT :...::::.:.:. :.. :. .:. :. .... :: .::::::::. .:.:: .: XP_011 SVATLLAIAVERHRSVM-AVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 TCGVVYPL-SKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVA :. . :: :...:.: :.. ..:: .:. .:..: : :..:..: . : . . XP_011 RCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHP-RYRET 180 190 200 210 220 230 250 260 270 280 290 pF1KB8 TRKGIATLAVVLGAFAACWLPFTVYCLLG-----DAHSPPLYTYLTLLPATYNSMINPII : . . :....::::..:: : : :: . . . :. :: : ::..: . XP_011 TLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLL-AEANSLVNAAV 240 250 260 270 280 290 300 310 320 330 pF1KB8 YAFRNQDVQKVLWAV-CCCCSSSKIPFRSRSPSDV :. :. ...... . :: : XP_011 YSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL 300 310 320 330 340 350 >>XP_016882958 (OMIM: 605110) PREDICTED: lysophosphatidi (351 aa) initn: 380 init1: 175 opt: 478 Z-score: 438.1 bits: 89.5 E(85289): 1.2e-17 Smith-Waterman score: 478; 33.8% identity (64.5% similar) in 290 aa overlap (40-315:30-314) 10 20 30 40 50 60 pF1KB8 AWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSC----ENALVVAII :: :::. : :: : ::.: : XP_016 MVIMGQCYYNETIGFFYNNSGKELSSHWRPK--DVVVVALGLTVSVLVLLTNLLVIAAI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 VGTPAFRAPMFLLVGSLAVADLLAGLG---LVLHFAAVFCIGSAEMSLVLVGVLAMAFTA ... :. :.. :.:.::.:::.::.. :..: . : : .. :.: ..:: XP_016 ASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 SIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLT :...::::.:.:. :.. :. .:. :. .... :: .::::::::. .:.:: .: XP_016 SVATLLAIAVERHRSVM-AVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 TCGVVYPL-SKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVA :. . :: :...:.: :.. ..:: .:. .:..: : :..:..: . : . . XP_016 RCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHP-RYRET 180 190 200 210 220 230 250 260 270 280 290 pF1KB8 TRKGIATLAVVLGAFAACWLPFTVYCLLG-----DAHSPPLYTYLTLLPATYNSMINPII : . . :....::::..:: : : :: . . . :. :: : ::..: . XP_016 TLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLL-AEANSLVNAAV 240 250 260 270 280 290 300 310 320 330 pF1KB8 YAFRNQDVQKVLWAV-CCCCSSSKIPFRSRSPSDV :. :. ...... . :: : XP_016 YSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL 300 310 320 330 340 350 >>NP_004711 (OMIM: 605110) lysophosphatidic acid recepto (351 aa) initn: 380 init1: 175 opt: 478 Z-score: 438.1 bits: 89.5 E(85289): 1.2e-17 Smith-Waterman score: 478; 33.8% identity (64.5% similar) in 290 aa overlap (40-315:30-314) 10 20 30 40 50 60 pF1KB8 AWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSC----ENALVVAII :: :::. : :: : ::.: : NP_004 MVIMGQCYYNETIGFFYNNSGKELSSHWRPK--DVVVVALGLTVSVLVLLTNLLVIAAI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 VGTPAFRAPMFLLVGSLAVADLLAGLG---LVLHFAAVFCIGSAEMSLVLVGVLAMAFTA ... :. :.. :.:.::.:::.::.. :..: . : : .. :.: ..:: NP_004 ASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 SIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLT :...::::.:.:. :.. :. .:. :. .... :: .::::::::. .:.:: .: NP_004 SVATLLAIAVERHRSVM-AVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 TCGVVYPL-SKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVA :. . :: :...:.: :.. ..:: .:. .:..: : :..:..: . : . . NP_004 RCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHP-RYRET 180 190 200 210 220 230 250 260 270 280 290 pF1KB8 TRKGIATLAVVLGAFAACWLPFTVYCLLG-----DAHSPPLYTYLTLLPATYNSMINPII : . . :....::::..:: : : :: . . . :. :: : ::..: . NP_004 TLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLL-AEANSLVNAAV 240 250 260 270 280 290 300 310 320 330 pF1KB8 YAFRNQDVQKVLWAV-CCCCSSSKIPFRSRSPSDV :. :. ...... . :: : NP_004 YSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL 300 310 320 330 340 350 >>XP_016882957 (OMIM: 605110) PREDICTED: lysophosphatidi (351 aa) initn: 380 init1: 175 opt: 478 Z-score: 438.1 bits: 89.5 E(85289): 1.2e-17 Smith-Waterman score: 478; 33.8% identity (64.5% similar) in 290 aa overlap (40-315:30-314) 10 20 30 40 50 60 pF1KB8 AWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSC----ENALVVAII :: :::. : :: : ::.: : XP_016 MVIMGQCYYNETIGFFYNNSGKELSSHWRPK--DVVVVALGLTVSVLVLLTNLLVIAAI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 VGTPAFRAPMFLLVGSLAVADLLAGLG---LVLHFAAVFCIGSAEMSLVLVGVLAMAFTA ... :. :.. :.:.::.:::.::.. :..: . : : .. :.: ..:: XP_016 ASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 SIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLT :...::::.:.:. :.. :. .:. :. .... :: .::::::::. .:.:: .: XP_016 SVATLLAIAVERHRSVM-AVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 TCGVVYPL-SKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVA :. . :: :...:.: :.. ..:: .:. .:..: : :..:..: . : . . XP_016 RCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHP-RYRET 180 190 200 210 220 230 250 260 270 280 290 pF1KB8 TRKGIATLAVVLGAFAACWLPFTVYCLLG-----DAHSPPLYTYLTLLPATYNSMINPII : . . :....::::..:: : : :: . . . :. :: : ::..: . XP_016 TLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLL-AEANSLVNAAV 240 250 260 270 280 290 300 310 320 330 pF1KB8 YAFRNQDVQKVLWAV-CCCCSSSKIPFRSRSPSDV :. :. ...... . :: : XP_016 YSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL 300 310 320 330 340 350 >>NP_036284 (OMIM: 605106) lysophosphatidic acid recepto (353 aa) initn: 406 init1: 180 opt: 466 Z-score: 427.5 bits: 87.5 E(85289): 4.5e-17 Smith-Waterman score: 466; 32.1% identity (63.6% similar) in 308 aa overlap (45-330:32-327) 20 30 40 50 60 70 pF1KB8 GSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTL----VSCENALVVAIIVGTPA .:::. ::. . :.::.: .. . NP_036 NECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCV-GTFFCLFIFFSNSLVIAAVIKNRK 10 20 30 40 50 60 80 90 100 110 120 pF1KB8 FRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLV------GVLAMAFTASI :. :.. :...::.::..::.. :. .: : . .:.. :.: ..:::. NP_036 FHFPFYYLLANLAAADFFAGIAYVF---LMFNTGPVSKTLTVNRWFLRQGLLDSSLTASL 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 GSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTC .::.:.:.:..:.. . .:. : :. ... :::. :. .: .:.:.:::: ....: NP_036 TNLLVIAVERHMSIMR-MRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISAC 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 GVVYPL-SKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPA-SHYVAT . . :. :...:: ... .:.: ::. .: .: : :... .:. : . :. . NP_036 SSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTN--VLSPHTSGSISRRRTP 180 190 200 210 220 230 250 260 270 280 290 pF1KB8 RKGIATLAVVLGAFAACWLPFTVYCLL--------GDAHSPPLYTYLTLLPATYNSMINP : . :. .:::::..:: : : :: : : . :.:: ::..:: NP_036 MKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALL----NSVVNP 240 250 260 270 280 290 300 310 320 330 pF1KB8 IIYAFRNQDVQKVLWAVCCCCSSSKIPFR--SRSPSDV :::.....:. .. . :: :. . : : :: :: : NP_036 IIYSYKDEDMYGTMKKMICCFSQEN-PERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCN 300 310 320 330 340 NP_036 KSTS 350 330 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:39:45 2016 done: Fri Nov 4 15:39:46 2016 Total Scan time: 6.200 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]