FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8808, 355 aa 1>>>pF1KB8808 355 - 355 aa - 355 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8610+/-0.000515; mu= 19.4109+/- 0.032 mean_var=107.8083+/-24.742, 0's: 0 Z-trim(109.2): 689 B-trim: 1767 in 2/47 Lambda= 0.123523 statistics sampled from 16541 (17327) to 16541 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.536), E-opt: 0.2 (0.203), width: 16 Scan time: 6.730 The best scores are: opt bits E(85289) NP_005192 (OMIM: 601834) C-C chemokine receptor ty ( 355) 2339 428.4 1.2e-119 NP_005499 (OMIM: 604836) C-C chemokine receptor ty ( 360) 1095 206.7 6.6e-53 XP_016861176 (OMIM: 604836) PREDICTED: C-C chemoki ( 360) 1095 206.7 6.6e-53 NP_000570 (OMIM: 601373,609532,610379,612522) C-C ( 352) 999 189.6 9.3e-48 NP_001093638 (OMIM: 601373,609532,610379,612522) C ( 352) 999 189.6 9.3e-48 NP_001116868 (OMIM: 601267) C-C chemokine receptor ( 360) 995 188.9 1.5e-47 XP_011532371 (OMIM: 601267) PREDICTED: C-C chemoki ( 360) 995 188.9 1.5e-47 NP_001286 (OMIM: 601159) C-C chemokine receptor ty ( 355) 975 185.3 1.8e-46 NP_001116513 (OMIM: 601267) C-C chemokine receptor ( 374) 957 182.1 1.7e-45 NP_001164645 (OMIM: 601470,607339,609423,613784) C ( 387) 927 176.8 7.1e-44 NP_847899 (OMIM: 601268) C-C chemokine receptor ty ( 355) 925 176.4 8.7e-44 XP_006713023 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 925 176.4 8.7e-44 XP_011531637 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 925 176.4 8.7e-44 NP_001828 (OMIM: 601268) C-C chemokine receptor ty ( 355) 925 176.4 8.7e-44 NP_001158152 (OMIM: 601268) C-C chemokine receptor ( 373) 925 176.4 8.9e-44 NP_847898 (OMIM: 601268) C-C chemokine receptor ty ( 376) 925 176.4 9e-44 XP_016861175 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 925 176.5 9.5e-44 XP_016861174 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 925 176.5 9.5e-44 NP_001164643 (OMIM: 601470,607339,609423,613784) C ( 355) 918 175.1 2.1e-43 NP_001328 (OMIM: 601470,607339,609423,613784) CX3C ( 355) 918 175.1 2.1e-43 NP_001164642 (OMIM: 601470,607339,609423,613784) C ( 355) 918 175.1 2.1e-43 NP_001287 (OMIM: 602648) atypical chemokine recept ( 384) 781 150.8 4.8e-36 XP_005246587 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 738 143.1 9.4e-34 XP_016859480 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 738 143.1 9.4e-34 NP_001548 (OMIM: 146928) C-X-C chemokine receptor ( 360) 738 143.1 9.4e-34 NP_001161770 (OMIM: 146928) C-X-C chemokine recept ( 360) 738 143.1 9.4e-34 XP_016859479 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 738 143.1 9.4e-34 XP_016859481 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 738 143.1 9.4e-34 NP_113597 (OMIM: 601835) C-C chemokine receptor ty ( 374) 721 140.0 7.9e-33 NP_004358 (OMIM: 601835) C-C chemokine receptor ty ( 374) 721 140.0 7.9e-33 NP_000625 (OMIM: 146929,609423) C-X-C chemokine re ( 350) 715 138.9 1.6e-32 NP_003458 (OMIM: 162643,193670) C-X-C chemokine re ( 352) 699 136.1 1.1e-31 NP_001008540 (OMIM: 162643,193670) C-X-C chemokine ( 356) 699 136.1 1.2e-31 NP_006632 (OMIM: 604738) C-C chemokine receptor ty ( 357) 696 135.6 1.7e-31 NP_001243298 (OMIM: 604738) C-C chemokine receptor ( 357) 696 135.6 1.7e-31 NP_112477 (OMIM: 604738) C-C chemokine receptor ty ( 369) 696 135.6 1.7e-31 XP_011531614 (OMIM: 604738) PREDICTED: C-C chemoki ( 369) 696 135.6 1.7e-31 NP_001288645 (OMIM: 600242) C-C chemokine receptor ( 372) 688 134.2 4.6e-31 NP_001288646 (OMIM: 600242) C-C chemokine receptor ( 372) 688 134.2 4.6e-31 NP_001288647 (OMIM: 600242) C-C chemokine receptor ( 372) 688 134.2 4.6e-31 NP_001829 (OMIM: 600242) C-C chemokine receptor ty ( 378) 688 134.2 4.7e-31 NP_001288643 (OMIM: 600242) C-C chemokine receptor ( 315) 658 128.7 1.7e-29 NP_001707 (OMIM: 601613) C-X-C chemokine receptor ( 372) 652 127.7 3.9e-29 NP_116743 (OMIM: 601613) C-X-C chemokine receptor ( 327) 642 125.9 1.3e-28 XP_011532511 (OMIM: 608379) PREDICTED: C-C chemoki ( 344) 636 124.9 2.7e-28 XP_011532510 (OMIM: 608379) PREDICTED: C-C chemoki ( 344) 636 124.9 2.7e-28 XP_016862925 (OMIM: 608379) PREDICTED: C-C chemoki ( 344) 636 124.9 2.7e-28 NP_003956 (OMIM: 608379) C-C chemokine receptor-li ( 344) 636 124.9 2.7e-28 NP_001124382 (OMIM: 608379) C-C chemokine receptor ( 356) 636 124.9 2.8e-28 NP_057641 (OMIM: 606065) atypical chemokine recept ( 350) 628 123.4 7.4e-28 >>NP_005192 (OMIM: 601834) C-C chemokine receptor type 8 (355 aa) initn: 2339 init1: 2339 opt: 2339 Z-score: 2268.9 bits: 428.4 E(85289): 1.2e-119 Smith-Waterman score: 2339; 99.7% identity (100.0% similar) in 355 aa overlap (1-355:1-355) 10 20 30 40 50 60 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCDGELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVL ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_005 MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 MFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIY 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 AFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL 310 320 330 340 350 >>NP_005499 (OMIM: 604836) C-C chemokine receptor type 4 (360 aa) initn: 1087 init1: 1060 opt: 1095 Z-score: 1070.8 bits: 206.7 E(85289): 6.6e-53 Smith-Waterman score: 1095; 45.5% identity (75.8% similar) in 347 aa overlap (2-345:8-351) 10 20 30 40 50 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCDGELIQTNGKLLLAVFYCLLFVFSLLGNS : ::: :. ..:: . . .:: : :.. :.:.: .: :.:::.::::: NP_005 MNPTDIADTTLDESI--YSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 LVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYY .:.::: :.:::.:::::::::.::::::::.:: :: :::::: .::..: .: NP_005 VVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 IGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQV .::::..::. :::.:::::.::::..:..::. .:. ::.: .:..:..: ..: NP_005 VGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 ASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKT .: . : . :. .. ::.......:::::.::. :..::: :.. :..:.:..:. NP_005 YTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKN 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 KAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCC ::..... ::. : ::.:.:.:::: .: ...:. :.. . : :: ..:: ..:.::: NP_005 KAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 VNPVIYAFVGEKFKKHLSEIFQKSCSQIF---NYLGRQMPRESCEKSSSCQQHSSRSSSV .::.:: :.::::.:.. ..: :.: .: .: : . . ::: : . NP_005 LNPIIYFFLGEKFRKYILQLF-KTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLH 300 310 320 330 340 350 pF1KB8 DYIL NP_005 DAL 360 >>XP_016861176 (OMIM: 604836) PREDICTED: C-C chemokine r (360 aa) initn: 1087 init1: 1060 opt: 1095 Z-score: 1070.8 bits: 206.7 E(85289): 6.6e-53 Smith-Waterman score: 1095; 45.5% identity (75.8% similar) in 347 aa overlap (2-345:8-351) 10 20 30 40 50 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCDGELIQTNGKLLLAVFYCLLFVFSLLGNS : ::: :. ..:: . . .:: : :.. :.:.: .: :.:::.::::: XP_016 MNPTDIADTTLDESI--YSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 LVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYY .:.::: :.:::.:::::::::.::::::::.:: :: :::::: .::..: .: XP_016 VVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 IGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQV .::::..::. :::.:::::.::::..:..::. .:. ::.: .:..:..: ..: XP_016 VGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 ASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKT .: . : . :. .. ::.......:::::.::. :..::: :.. :..:.:..:. XP_016 YTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKN 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 KAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCC ::..... ::. : ::.:.:.:::: .: ...:. :.. . : :: ..:: ..:.::: XP_016 KAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 VNPVIYAFVGEKFKKHLSEIFQKSCSQIF---NYLGRQMPRESCEKSSSCQQHSSRSSSV .::.:: :.::::.:.. ..: :.: .: .: : . . ::: : . XP_016 LNPIIYFFLGEKFRKYILQLF-KTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLH 300 310 320 330 340 350 pF1KB8 DYIL XP_016 DAL 360 >>NP_000570 (OMIM: 601373,609532,610379,612522) C-C chem (352 aa) initn: 1015 init1: 557 opt: 999 Z-score: 978.4 bits: 189.6 E(85289): 9.3e-48 Smith-Waterman score: 999; 42.0% identity (75.0% similar) in 348 aa overlap (1-346:1-343) 10 20 30 40 50 60 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCDGELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVL ::: .. . . .:: : ::. .. . :: .: :.:.:...:: ::::.: NP_000 MDYQVSSPIYDI-NYYT----SEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILIL 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 VVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSS . ::.:.:.::.::::::.:::.:... :: ..: :: ::..::....:.:.:::.:. NP_000 INCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 MFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGV .::: :...::::::::::.:::.::. .:.. . .:..:..:..: ..: . .: NP_000 IFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLH 120 130 140 150 160 170 190 200 210 220 230 pF1KB8 LQCYS-FYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKT-KAIR : : : .: :: : ..:. ::::..:. ....:: ::. : ::.:..: .:.: NP_000 YTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 LVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPV :.. ..:. .:::.:.:.::.:.... . :..:: :..: : .::: ...::::.::. NP_000 LIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 IYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL :::::::::...: .::: .. : . .:. :..:: .:. NP_000 IYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL 300 310 320 330 340 350 >>NP_001093638 (OMIM: 601373,609532,610379,612522) C-C c (352 aa) initn: 1015 init1: 557 opt: 999 Z-score: 978.4 bits: 189.6 E(85289): 9.3e-48 Smith-Waterman score: 999; 42.0% identity (75.0% similar) in 348 aa overlap (1-346:1-343) 10 20 30 40 50 60 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCDGELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVL ::: .. . . .:: : ::. .. . :: .: :.:.:...:: ::::.: NP_001 MDYQVSSPIYDI-NYYT----SEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILIL 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 VVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSS . ::.:.:.::.::::::.:::.:... :: ..: :: ::..::....:.:.:::.:. NP_001 INCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 MFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGV .::: :...::::::::::.:::.::. .:.. . .:..:..:..: ..: . .: NP_001 IFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLH 120 130 140 150 160 170 190 200 210 220 230 pF1KB8 LQCYS-FYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKT-KAIR : : : .: :: : ..:. ::::..:. ....:: ::. : ::.:..: .:.: NP_001 YTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 LVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPV :.. ..:. .:::.:.:.::.:.... . :..:: :..: : .::: ...::::.::. NP_001 LIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 IYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL :::::::::...: .::: .. : . .:. :..:: .:. NP_001 IYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL 300 310 320 330 340 350 >>NP_001116868 (OMIM: 601267) C-C chemokine receptor typ (360 aa) initn: 964 init1: 570 opt: 995 Z-score: 974.5 bits: 188.9 E(85289): 1.5e-47 Smith-Waterman score: 995; 41.5% identity (75.7% similar) in 342 aa overlap (9-346:20-351) 10 20 30 40 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCDGELIQTNGKLLLAVFYCLLFVFS ::: :: : ..:: .. : :: .: :.:.:. NP_001 MLSTSRSRFIRNTNESGEEVTTFFDYDY----GAPCHKFDVKQIGAQLLPPLYSLVFIFG 10 20 30 40 50 50 60 70 80 90 100 pF1KB8 LLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVV ..:: ::.:.:. ::::. .::.::::::.:::::....:. .. ..::::..:::. NP_001 FVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLF 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 SGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLL .:.:.::.....::: :...:::::.::::.:::.::. .:.. . .::.:..:..: . NP_001 TGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 VFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQ .: . .::.: : .. . :. : .. :::::..:. :...:: ::. : ::. NP_001 IFTKCQKEDSVYVCGPYFPR---GWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCR 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB8 NHNKT-KAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEII :..: .:.:... ..:. .:::.:.:.:..:.... . :..: ..:: ::.::: . NP_001 NEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB8 SFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMP---RESCEKSSSCQQHS ..::::.::.:::::::::...:: .:.: .. : .: : ::. . .: . : NP_001 GMTHCCINPIIYAFVGEKFRRYLSVFFRKHITKRFC---KQCPVFYRETVDGVTSTNTPS 300 310 320 330 340 350 350 pF1KB8 SRSSSVDYIL . NP_001 TGEQEVSAGL 360 >>XP_011532371 (OMIM: 601267) PREDICTED: C-C chemokine r (360 aa) initn: 964 init1: 570 opt: 995 Z-score: 974.5 bits: 188.9 E(85289): 1.5e-47 Smith-Waterman score: 995; 41.5% identity (75.7% similar) in 342 aa overlap (9-346:20-351) 10 20 30 40 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCDGELIQTNGKLLLAVFYCLLFVFS ::: :: : ..:: .. : :: .: :.:.:. XP_011 MLSTSRSRFIRNTNESGEEVTTFFDYDY----GAPCHKFDVKQIGAQLLPPLYSLVFIFG 10 20 30 40 50 50 60 70 80 90 100 pF1KB8 LLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVV ..:: ::.:.:. ::::. .::.::::::.:::::....:. .. ..::::..:::. XP_011 FVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLF 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 SGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLL .:.:.::.....::: :...:::::.::::.:::.::. .:.. . .::.:..:..: . XP_011 TGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 VFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQ .: . .::.: : .. . :. : .. :::::..:. :...:: ::. : ::. XP_011 IFTKCQKEDSVYVCGPYFPR---GWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCR 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB8 NHNKT-KAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEII :..: .:.:... ..:. .:::.:.:.:..:.... . :..: ..:: ::.::: . XP_011 NEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB8 SFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMP---RESCEKSSSCQQHS ..::::.::.:::::::::...:: .:.: .. : .: : ::. . .: . : XP_011 GMTHCCINPIIYAFVGEKFRRYLSVFFRKHITKRFC---KQCPVFYRETVDGVTSTNTPS 300 310 320 330 340 350 350 pF1KB8 SRSSSVDYIL . XP_011 TGEQEVSAGL 360 >>NP_001286 (OMIM: 601159) C-C chemokine receptor type 1 (355 aa) initn: 942 init1: 429 opt: 975 Z-score: 955.3 bits: 185.3 E(85289): 1.8e-46 Smith-Waterman score: 975; 42.6% identity (76.0% similar) in 329 aa overlap (11-337:12-335) 10 20 30 40 50 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCDGELIQTNGKLLLAVFYCLLFVFSLLGNSLVILV :.:.. : : ..::. .. : :: .: :.::..:.:: ::.:: NP_001 METPNTTEDYDTTTEFDYGD--ATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLV 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 LVVCKKLRSITDVYLLNLALSDLLFVFSFPFQT-YYLLDQWVFGTVMCKVVSGFYYIGFY :: :.:...:..::::::.:::::.:..:: : : :.:::: .:::..::::: :.: NP_001 LVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 SSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASED : .::: :...:::::.::::.::..::. .:. . .: ::.:..: : : .. : NP_001 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 GVLQCYSFYNQQTLK-WKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAI : . ...:. ::.: .:.:..::..:. ....:: :.. : : :..:.::. NP_001 THHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 RLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNP ::.....: .:::.:.:...... .... . : :..: :..:::.:..::::::: NP_001 RLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 VIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL ::::::::.:.:.: ..:.. .. .: . .: : .. NP_001 VIYAFVGERFRKYLRQLFHR---RVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF 300 310 320 330 340 350 >>NP_001116513 (OMIM: 601267) C-C chemokine receptor typ (374 aa) initn: 898 init1: 570 opt: 957 Z-score: 937.7 bits: 182.1 E(85289): 1.7e-45 Smith-Waterman score: 957; 43.5% identity (78.4% similar) in 301 aa overlap (9-308:20-313) 10 20 30 40 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCDGELIQTNGKLLLAVFYCLLFVFS ::: :: : ..:: .. : :: .: :.:.:. NP_001 MLSTSRSRFIRNTNESGEEVTTFFDYDY----GAPCHKFDVKQIGAQLLPPLYSLVFIFG 10 20 30 40 50 50 60 70 80 90 100 pF1KB8 LLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVV ..:: ::.:.:. ::::. .::.::::::.:::::....:. .. ..::::..:::. NP_001 FVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLF 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 SGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLL .:.:.::.....::: :...:::::.::::.:::.::. .:.. . .::.:..:..: . NP_001 TGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 VFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQ .: . .::.: : .. . :. : .. :::::..:. :...:: ::. : ::. NP_001 IFTKCQKEDSVYVCGPYFPRG---WNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCR 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB8 NHNKT-KAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEII :..: .:.:... ..:. .:::.:.:.:..:.... . :..: ..:: ::.::: . NP_001 NEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB8 SFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRS ..::::.::.:::::::::. NP_001 GMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDG 300 310 320 330 340 350 >>NP_001164645 (OMIM: 601470,607339,609423,613784) CX3C (387 aa) initn: 861 init1: 466 opt: 927 Z-score: 908.6 bits: 176.8 E(85289): 7.1e-44 Smith-Waterman score: 927; 39.8% identity (75.6% similar) in 349 aa overlap (3-350:31-372) 10 20 30 pF1KB8 MDYTLDLSVTTVTDYYYPDIFSSPCD-GELIQ .:.: .::. . : .. : :... NP_001 MREPLEAFKLADLDFRKSSLASGWRMASGAFTMDQFPESVTENFEYDDLAEACYIGDIV- 10 20 30 40 50 40 50 60 70 80 90 pF1KB8 TNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQ . : ..:..:: ..:...:.:: ::...:. :: .:.::.::::::::::::: ..:: NP_001 VFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFW 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB8 TYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGT :.::... . ..::: ...:..:::..:.::::..:.:::::.: :. ... ::.. :. NP_001 THYLINEKGLHNAMCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAANSMNNRTVQHGV 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB8 TLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPF :. :.:: .::... : ..: . .:. : : :. : .. : . :.::.:.:. NP_001 TISLGVWAAAILVAAPQFMFTK-QKENECLGDYPEVLQEI--WPVLRNVETNFLGFLLPL 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB8 TIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDG :. .::..:.. : :.::.:.:::.:.:.:::. .:::.:.::..:: .:. . .. . NP_001 LIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPS 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 CSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMP :.. ..: : ::: ..:.:::.::.::::.::::...: ... : : .. ::.. NP_001 CDMRKDLRLALSVTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGK-CLAVL--CGRSVH 300 310 320 330 340 350 340 350 pF1KB8 RESCEKSSSCQQHSSRSSSVDYIL . . :. ..:.: :: NP_001 VDFSSSESQRSRHGSVLSSNFTYHTSDGDALLLL 360 370 380 355 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:45:37 2016 done: Fri Nov 4 15:45:38 2016 Total Scan time: 6.730 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]