FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8809, 360 aa 1>>>pF1KB8809 360 - 360 aa - 360 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.3363+/-0.000509; mu= 22.1559+/- 0.032 mean_var=123.2576+/-32.314, 0's: 0 Z-trim(109.0): 625 B-trim: 912 in 1/48 Lambda= 0.115523 statistics sampled from 16352 (17126) to 16352 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.536), E-opt: 0.2 (0.201), width: 16 Scan time: 7.350 The best scores are: opt bits E(85289) XP_016861176 (OMIM: 604836) PREDICTED: C-C chemoki ( 360) 2398 411.8 1.2e-114 NP_005499 (OMIM: 604836) C-C chemokine receptor ty ( 360) 2398 411.8 1.2e-114 NP_000570 (OMIM: 601373,609532,610379,612522) C-C ( 352) 1206 213.2 7.3e-55 NP_001093638 (OMIM: 601373,609532,610379,612522) C ( 352) 1206 213.2 7.3e-55 NP_001286 (OMIM: 601159) C-C chemokine receptor ty ( 355) 1145 203.0 8.4e-52 NP_001116868 (OMIM: 601267) C-C chemokine receptor ( 360) 1134 201.2 3e-51 XP_011532371 (OMIM: 601267) PREDICTED: C-C chemoki ( 360) 1134 201.2 3e-51 NP_001116513 (OMIM: 601267) C-C chemokine receptor ( 374) 1099 195.4 1.8e-49 NP_005192 (OMIM: 601834) C-C chemokine receptor ty ( 355) 1096 194.8 2.4e-49 XP_006713023 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 1069 190.3 5.5e-48 XP_011531637 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 1069 190.3 5.5e-48 NP_847899 (OMIM: 601268) C-C chemokine receptor ty ( 355) 1069 190.3 5.5e-48 NP_001828 (OMIM: 601268) C-C chemokine receptor ty ( 355) 1069 190.3 5.5e-48 NP_001158152 (OMIM: 601268) C-C chemokine receptor ( 373) 1069 190.4 5.6e-48 NP_847898 (OMIM: 601268) C-C chemokine receptor ty ( 376) 1069 190.4 5.6e-48 XP_016861174 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 1069 190.4 5.9e-48 XP_016861175 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 1069 190.4 5.9e-48 NP_001164643 (OMIM: 601470,607339,609423,613784) C ( 355) 946 169.8 8.1e-42 NP_001164642 (OMIM: 601470,607339,609423,613784) C ( 355) 946 169.8 8.1e-42 NP_001328 (OMIM: 601470,607339,609423,613784) CX3C ( 355) 946 169.8 8.1e-42 NP_001164645 (OMIM: 601470,607339,609423,613784) C ( 387) 946 169.9 8.5e-42 NP_001287 (OMIM: 602648) atypical chemokine recept ( 384) 888 160.2 6.9e-39 NP_004358 (OMIM: 601835) C-C chemokine receptor ty ( 374) 880 158.9 1.7e-38 NP_113597 (OMIM: 601835) C-C chemokine receptor ty ( 374) 880 158.9 1.7e-38 NP_001288646 (OMIM: 600242) C-C chemokine receptor ( 372) 836 151.5 2.8e-36 NP_001288647 (OMIM: 600242) C-C chemokine receptor ( 372) 836 151.5 2.8e-36 NP_001288645 (OMIM: 600242) C-C chemokine receptor ( 372) 836 151.5 2.8e-36 NP_001829 (OMIM: 600242) C-C chemokine receptor ty ( 378) 836 151.6 2.8e-36 XP_005246587 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 811 147.4 4.9e-35 NP_001161770 (OMIM: 146928) C-X-C chemokine recept ( 360) 811 147.4 4.9e-35 XP_016859479 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 811 147.4 4.9e-35 NP_001548 (OMIM: 146928) C-X-C chemokine receptor ( 360) 811 147.4 4.9e-35 XP_016859480 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 811 147.4 4.9e-35 XP_016859481 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 811 147.4 4.9e-35 NP_003458 (OMIM: 162643,193670) C-X-C chemokine re ( 352) 807 146.7 7.6e-35 NP_001008540 (OMIM: 162643,193670) C-X-C chemokine ( 356) 807 146.7 7.7e-35 NP_000625 (OMIM: 146929,609423) C-X-C chemokine re ( 350) 775 141.3 3.1e-33 NP_112477 (OMIM: 604738) C-C chemokine receptor ty ( 369) 773 141.0 4e-33 XP_011531614 (OMIM: 604738) PREDICTED: C-C chemoki ( 369) 773 141.0 4e-33 NP_001243298 (OMIM: 604738) C-C chemokine receptor ( 357) 771 140.7 4.9e-33 NP_006632 (OMIM: 604738) C-C chemokine receptor ty ( 357) 771 140.7 4.9e-33 NP_001288643 (OMIM: 600242) C-C chemokine receptor ( 315) 762 139.1 1.3e-32 NP_001495 (OMIM: 300574) C-X-C chemokine receptor ( 368) 734 134.5 3.6e-31 XP_005262313 (OMIM: 300574) PREDICTED: C-X-C chemo ( 378) 734 134.6 3.6e-31 XP_016884924 (OMIM: 300574) PREDICTED: C-X-C chemo ( 415) 734 134.6 3.8e-31 NP_001136269 (OMIM: 300574) C-X-C chemokine recept ( 415) 734 134.6 3.8e-31 NP_057641 (OMIM: 606065) atypical chemokine recept ( 350) 718 131.8 2.2e-30 NP_848540 (OMIM: 606065) atypical chemokine recept ( 350) 718 131.8 2.2e-30 NP_003956 (OMIM: 608379) C-C chemokine receptor-li ( 344) 696 128.2 2.8e-29 XP_011532510 (OMIM: 608379) PREDICTED: C-C chemoki ( 344) 696 128.2 2.8e-29 >>XP_016861176 (OMIM: 604836) PREDICTED: C-C chemokine r (360 aa) initn: 2398 init1: 2398 opt: 2398 Z-score: 2179.5 bits: 411.8 E(85289): 1.2e-114 Smith-Waterman score: 2398; 100.0% identity (100.0% similar) in 360 aa overlap (1-360:1-360) 10 20 30 40 50 60 pF1KB8 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL 310 320 330 340 350 360 >>NP_005499 (OMIM: 604836) C-C chemokine receptor type 4 (360 aa) initn: 2398 init1: 2398 opt: 2398 Z-score: 2179.5 bits: 411.8 E(85289): 1.2e-114 Smith-Waterman score: 2398; 100.0% identity (100.0% similar) in 360 aa overlap (1-360:1-360) 10 20 30 40 50 60 pF1KB8 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL 310 320 330 340 350 360 >>NP_000570 (OMIM: 601373,609532,610379,612522) C-C chem (352 aa) initn: 1149 init1: 701 opt: 1206 Z-score: 1105.9 bits: 213.2 E(85289): 7.3e-55 Smith-Waterman score: 1206; 49.4% identity (80.4% similar) in 352 aa overlap (8-356:2-348) 10 20 30 40 50 pF1KB8 MNPTDIADTTLDESIYS-NYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSV : .. ::. ::: : :: : ..: .. .:::::::::.::..:: . NP_000 MDYQVSSPIYDINYYTSE----PCQKINVKQIAARLLPPLYSLVFIFGFVGNML 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLV :.:.:.. :::.::::.::::::::::.:....:::..::: :: :: .:.... .:.. NP_000 VILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 GFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCY ::.:::::..:..::::::.:::::.:.:::.:.::.::. :: :::::::::..:. NP_000 GFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 TERNHTYCKTKYSLNSTT-WKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKK- : : :.... .. :: ...:.: :::::.:: .:..::: :..:: .:.:::: NP_000 KEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 NKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHC ..::..::....... ::.::::::.:.:. :. :..:. :: :.:.::::...:: NP_000 HRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 CLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLH :.::::: :.:::::.:.: .:. . .:. :...: . . :: ::.:: .... NP_000 CINPIIYAFVGEKFRNYLLVFFQK-HIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEIS 300 310 320 330 340 360 pF1KB8 DAL NP_000 VGL 350 >>NP_001093638 (OMIM: 601373,609532,610379,612522) C-C c (352 aa) initn: 1149 init1: 701 opt: 1206 Z-score: 1105.9 bits: 213.2 E(85289): 7.3e-55 Smith-Waterman score: 1206; 49.4% identity (80.4% similar) in 352 aa overlap (8-356:2-348) 10 20 30 40 50 pF1KB8 MNPTDIADTTLDESIYS-NYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSV : .. ::. ::: : :: : ..: .. .:::::::::.::..:: . NP_001 MDYQVSSPIYDINYYTSE----PCQKINVKQIAARLLPPLYSLVFIFGFVGNML 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLV :.:.:.. :::.::::.::::::::::.:....:::..::: :: :: .:.... .:.. NP_001 VILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 GFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCY ::.:::::..:..::::::.:::::.:.:::.:.::.::. :: :::::::::..:. NP_001 GFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 TERNHTYCKTKYSLNSTT-WKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKK- : : :.... .. :: ...:.: :::::.:: .:..::: :..:: .:.:::: NP_001 KEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 NKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHC ..::..::....... ::.::::::.:.:. :. :..:. :: :.:.::::...:: NP_001 HRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 CLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLH :.::::: :.:::::.:.: .:. . .:. :...: . . :: ::.:: .... NP_001 CINPIIYAFVGEKFRNYLLVFFQK-HIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEIS 300 310 320 330 340 360 pF1KB8 DAL NP_001 VGL 350 >>NP_001286 (OMIM: 601159) C-C chemokine receptor type 1 (355 aa) initn: 1126 init1: 459 opt: 1145 Z-score: 1051.0 bits: 203.0 E(85289): 8.4e-52 Smith-Waterman score: 1145; 50.2% identity (79.8% similar) in 331 aa overlap (28-356:23-351) 10 20 30 40 50 60 pF1KB8 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV :: : . .::: .::::::::::.::.:: .: NP_001 METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILV 10 20 30 40 50 70 80 90 100 110 pF1KB8 VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFW-GYYAADQWVFGLGLCKMISWMYLV :::: .::::..::..::::::::::::.:.:::: : :.:::: ..::..: .: . NP_001 VLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 GFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCY :.:: :::..:..::::::::::::.:::::.:.:::::. :..:..::.::. :: NP_001 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 TERNHTYCKTKYSLNSTT-WKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKN : .: :. .. .: ::....:..:..:::.:: .:..::. ::. : . ::::. NP_001 WEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 KAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCC :::..::.....:. ::::::..... .. .. ..: :.:: :.:.::..:..::: NP_001 KAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 LNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHD .::.:: :.::.::::. :::. : : .. .:.. . ::. . :: .:.: NP_001 VNPVIYAFVGERFRKYLRQLFHR-RVAVHLVKWLPFLSVDRLERVSST-SPSTGEHELSA 300 310 320 330 340 350 360 pF1KB8 AL NP_001 GF >>NP_001116868 (OMIM: 601267) C-C chemokine receptor typ (360 aa) initn: 1087 init1: 676 opt: 1134 Z-score: 1041.0 bits: 201.2 E(85289): 3e-51 Smith-Waterman score: 1134; 48.7% identity (78.6% similar) in 337 aa overlap (28-360:31-360) 10 20 30 40 50 pF1KB8 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGN :: : .: .: .:::::::::.::..:: NP_001 MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 SVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMY .:::.:.. :.:. .::.::::::::::::...::.:.. ::..:::: ..::... .: NP_001 MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 LVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFST .:...::::..:..::::::::::::.:.:::.:.::.::. :: ::::::.::..:. NP_001 HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 CYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKK : : . : . . :. . .. ::::::.:: ::..::: :..:: .:.:::: NP_001 CQKEDSVYVCGPYFPRG---WNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKK 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 -NKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVH ..::..::....... ::::::::..:.:. :. :..: :: : :.::::...: NP_001 RHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTH 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 CCLNPIIYFFLGEKFRKYILQLFK---TCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMD ::.::::: :.:::::.:. .:. : : .:. : .. ..: .:. : :: . NP_001 CCINPIIYAFVGEKFRRYLSVFFRKHITKR----FCKQCPVFYRETVDGVTSTNTPSTGE 300 310 320 330 340 350 360 pF1KB8 HDLHDAL ... .: NP_001 QEVSAGL 360 >>XP_011532371 (OMIM: 601267) PREDICTED: C-C chemokine r (360 aa) initn: 1087 init1: 676 opt: 1134 Z-score: 1041.0 bits: 201.2 E(85289): 3e-51 Smith-Waterman score: 1134; 48.7% identity (78.6% similar) in 337 aa overlap (28-360:31-360) 10 20 30 40 50 pF1KB8 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGN :: : .: .: .:::::::::.::..:: XP_011 MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 SVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMY .:::.:.. :.:. .::.::::::::::::...::.:.. ::..:::: ..::... .: XP_011 MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 LVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFST .:...::::..:..::::::::::::.:.:::.:.::.::. :: ::::::.::..:. XP_011 HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 CYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKK : : . : . . :. . .. ::::::.:: ::..::: :..:: .:.:::: XP_011 CQKEDSVYVCGPYFPRG---WNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKK 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 -NKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVH ..::..::....... ::::::::..:.:. :. :..: :: : :.::::...: XP_011 RHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTH 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 CCLNPIIYFFLGEKFRKYILQLFK---TCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMD ::.::::: :.:::::.:. .:. : : .:. : .. ..: .:. : :: . XP_011 CCINPIIYAFVGEKFRRYLSVFFRKHITKR----FCKQCPVFYRETVDGVTSTNTPSTGE 300 310 320 330 340 350 360 pF1KB8 HDLHDAL ... .: XP_011 QEVSAGL 360 >>NP_001116513 (OMIM: 601267) C-C chemokine receptor typ (374 aa) initn: 959 init1: 676 opt: 1099 Z-score: 1009.3 bits: 195.4 E(85289): 1.8e-49 Smith-Waterman score: 1099; 50.8% identity (80.1% similar) in 307 aa overlap (28-333:31-333) 10 20 30 40 50 pF1KB8 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGN :: : .: .: .:::::::::.::..:: NP_001 MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 SVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMY .:::.:.. :.:. .::.::::::::::::...::.:.. ::..:::: ..::... .: NP_001 MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 LVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFST .:...::::..:..::::::::::::.:.:::.:.::.::. :: ::::::.::..:. NP_001 HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 CYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKK : : . : . . :. . .. ::::::.:: ::..::: :..:: .:.:::: NP_001 CQKEDSVYVCGPYFPRG---WNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKK 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 -NKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVH ..::..::....... ::::::::..:.:. :. :..: :: : :.::::...: NP_001 RHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTH 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 CCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDL ::.::::: :.:::::. .... :: . :: NP_001 CCINPIIYAFVGEKFRS-LFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGK 300 310 320 330 340 350 360 pF1KB8 HDAL NP_001 GKSIGRAPEASLQDKEGA 360 370 >>NP_005192 (OMIM: 601834) C-C chemokine receptor type 8 (355 aa) initn: 1088 init1: 1061 opt: 1096 Z-score: 1006.8 bits: 194.8 E(85289): 2.4e-49 Smith-Waterman score: 1096; 45.5% identity (75.8% similar) in 347 aa overlap (8-351:2-345) 10 20 30 40 50 pF1KB8 MNPTDIADTTLDESI--YSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNS : ::: :. ..:: . . .:: : :.. :.:.: .: :.:::.::::: NP_005 MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYL .:.::: :.:::.:::::::::.::::::::.:: :: :::::: .::..: .: NP_005 LVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 VGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTC .::::..::. :::.:::::.::::..:..::. .:. ::.: .:..:..: ..: NP_005 IGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 YTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKN .: . : . :. .. ::.......:::::.::. :..::: :.. :..:.:..:. NP_005 ASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 KAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCC ::..... ::. : ::.:.:.:::: .: ...:. :.. . : :: ..:: ..:.::: NP_005 KAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 LNPIIYFFLGEKFRKYILQLF-KTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLH .::.:: :.::::.:.. ..: :.: .: .: : . . ::: : . NP_005 VNPVIYAFVGEKFKKHLSEIFQKSCSQIF---NYLGRQMPRESCEKSSSCQQHSSRSSSV 300 310 320 330 340 350 360 pF1KB8 DAL NP_005 DYIL >>XP_006713023 (OMIM: 601268) PREDICTED: C-C chemokine r (355 aa) initn: 728 init1: 384 opt: 1069 Z-score: 982.5 bits: 190.3 E(85289): 5.5e-48 Smith-Waterman score: 1069; 46.2% identity (77.1% similar) in 353 aa overlap (9-356:3-351) 10 20 30 40 50 pF1KB8 MNPTDIADTTLD--ESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNS :.:: :.. .. : :... : : .:. :.::::::::. ::::: XP_006 MTTSLDTVETFGTTSY-YDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNV 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYA-ADQWVFGLGLCKMISWMY :::..:.::.::: ::..::::::::::::. .:::: .:. . .:::: :.::..: .: XP_006 VVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 LVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFST .:.:: :::..:..::::::::::::.:::::.:.:::::..::..::.:.:: :.: XP_006 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 CYTERNHTYCKTKYSLNST-TWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEK ..: :.. : ... .:. . .:...:. ::.:: .: .::. ::.:: .: ..: XP_006 TEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 KNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVH : ::...::.....:. ::::::....: . . .:: ..:: .. .::..:. : XP_006 KYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSH 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 CCLNPIIYFFLGEKFRKYILQLFKTCRGLFV-LCQYCGLLQIYSADTPSSSYTQSTMDHD ::.::.:: :.::.::::. ..:. : :.. : .: .: . . .:: . :: . . XP_006 CCMNPVIYAFVGERFRKYLRHFFH--RHLLMHLGRYIPFLPSEKLER-TSSVSPSTAEPE 300 310 320 330 340 350 360 pF1KB8 LHDAL : XP_006 LSIVF 360 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:46:50 2016 done: Fri Nov 4 15:46:52 2016 Total Scan time: 7.350 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]