FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8825, 415 aa 1>>>pF1KB8825 415 - 415 aa - 415 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0364+/-0.000346; mu= 19.3092+/- 0.022 mean_var=89.2046+/-20.183, 0's: 0 Z-trim(116.3): 570 B-trim: 2822 in 2/49 Lambda= 0.135794 statistics sampled from 26632 (27338) to 26632 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.321), width: 16 Scan time: 9.490 The best scores are: opt bits E(85289) NP_001136269 (OMIM: 300574) C-X-C chemokine recept ( 415) 2769 552.6 6.5e-157 XP_016884924 (OMIM: 300574) PREDICTED: C-X-C chemo ( 415) 2769 552.6 6.5e-157 XP_005262313 (OMIM: 300574) PREDICTED: C-X-C chemo ( 378) 2465 493.0 5.2e-139 NP_001495 (OMIM: 300574) C-X-C chemokine receptor ( 368) 2435 487.1 3e-137 XP_005262314 (OMIM: 300574) PREDICTED: C-X-C chemo ( 278) 1409 286.0 8e-77 XP_016884925 (OMIM: 300574) PREDICTED: C-X-C chemo ( 268) 1379 280.1 4.6e-75 NP_001707 (OMIM: 601613) C-X-C chemokine receptor ( 372) 845 175.6 1.8e-43 NP_116743 (OMIM: 601613) C-X-C chemokine receptor ( 327) 835 173.6 6.3e-43 NP_001548 (OMIM: 146928) C-X-C chemokine receptor ( 360) 827 172.1 2e-42 XP_016859481 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 827 172.1 2e-42 XP_005246587 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 827 172.1 2e-42 NP_001161770 (OMIM: 146928) C-X-C chemokine recept ( 360) 827 172.1 2e-42 XP_016859479 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 827 172.1 2e-42 XP_016859480 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 827 172.1 2e-42 NP_000625 (OMIM: 146929,609423) C-X-C chemokine re ( 350) 791 165.0 2.6e-40 NP_001288647 (OMIM: 600242) C-C chemokine receptor ( 372) 786 164.1 5.4e-40 NP_001288646 (OMIM: 600242) C-C chemokine receptor ( 372) 786 164.1 5.4e-40 NP_001288645 (OMIM: 600242) C-C chemokine receptor ( 372) 786 164.1 5.4e-40 NP_001829 (OMIM: 600242) C-C chemokine receptor ty ( 378) 786 164.1 5.4e-40 NP_001008540 (OMIM: 162643,193670) C-X-C chemokine ( 356) 758 158.6 2.3e-38 NP_003458 (OMIM: 162643,193670) C-X-C chemokine re ( 352) 754 157.8 4e-38 NP_113597 (OMIM: 601835) C-C chemokine receptor ty ( 374) 750 157.0 7.1e-38 NP_004358 (OMIM: 601835) C-C chemokine receptor ty ( 374) 750 157.0 7.1e-38 NP_001288643 (OMIM: 600242) C-C chemokine receptor ( 315) 747 156.4 9.5e-38 NP_057686 (OMIM: 600240) C-C chemokine receptor ty ( 362) 735 154.1 5.4e-37 NP_005499 (OMIM: 604836) C-C chemokine receptor ty ( 360) 734 153.9 6.1e-37 XP_016861176 (OMIM: 604836) PREDICTED: C-C chemoki ( 360) 734 153.9 6.1e-37 NP_001287 (OMIM: 602648) atypical chemokine recept ( 384) 731 153.3 9.6e-37 NP_001116513 (OMIM: 601267) C-C chemokine receptor ( 374) 694 146.1 1.4e-34 XP_011532371 (OMIM: 601267) PREDICTED: C-C chemoki ( 360) 685 144.3 4.7e-34 NP_001116868 (OMIM: 601267) C-C chemokine receptor ( 360) 685 144.3 4.7e-34 NP_001093638 (OMIM: 601373,609532,610379,612522) C ( 352) 683 143.9 6.1e-34 NP_000570 (OMIM: 601373,609532,610379,612522) C-C ( 352) 683 143.9 6.1e-34 NP_006632 (OMIM: 604738) C-C chemokine receptor ty ( 357) 677 142.7 1.4e-33 NP_001243298 (OMIM: 604738) C-C chemokine receptor ( 357) 677 142.7 1.4e-33 NP_112477 (OMIM: 604738) C-C chemokine receptor ty ( 369) 677 142.7 1.4e-33 XP_011531614 (OMIM: 604738) PREDICTED: C-C chemoki ( 369) 677 142.7 1.4e-33 NP_001286 (OMIM: 601159) C-C chemokine receptor ty ( 355) 670 141.3 3.6e-33 NP_848540 (OMIM: 606065) atypical chemokine recept ( 350) 655 138.4 2.7e-32 NP_057641 (OMIM: 606065) atypical chemokine recept ( 350) 655 138.4 2.7e-32 XP_011531637 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 643 136.0 1.4e-31 NP_001828 (OMIM: 601268) C-C chemokine receptor ty ( 355) 643 136.0 1.4e-31 XP_006713023 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 643 136.0 1.4e-31 NP_847899 (OMIM: 601268) C-C chemokine receptor ty ( 355) 643 136.0 1.4e-31 NP_001158152 (OMIM: 601268) C-C chemokine receptor ( 373) 643 136.1 1.5e-31 NP_847898 (OMIM: 601268) C-C chemokine receptor ty ( 376) 643 136.1 1.5e-31 XP_016861174 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 643 136.1 1.6e-31 XP_016861175 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 643 136.1 1.6e-31 XP_011531593 (OMIM: 605163) PREDICTED: C-X-C chemo ( 342) 639 135.2 2.4e-31 XP_005264866 (OMIM: 605163) PREDICTED: C-X-C chemo ( 342) 639 135.2 2.4e-31 >>NP_001136269 (OMIM: 300574) C-X-C chemokine receptor t (415 aa) initn: 2769 init1: 2769 opt: 2769 Z-score: 2938.0 bits: 552.6 E(85289): 6.5e-157 Smith-Waterman score: 2769; 100.0% identity (100.0% similar) in 415 aa overlap (1-415:1-415) 10 20 30 40 50 60 pF1KB8 MELRKYGPGRLAGTVIGGAAQSKSQTKSDSITKEFLPGLYTAPSSPFPPSQVSDHQVLND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELRKYGPGRLAGTVIGGAAQSKSQTKSDSITKEFLPGLYTAPSSPFPPSQVSDHQVLND 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 HDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 MRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCL 310 320 330 340 350 360 370 380 390 400 410 pF1KB8 NPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 370 380 390 400 410 >>XP_016884924 (OMIM: 300574) PREDICTED: C-X-C chemokine (415 aa) initn: 2769 init1: 2769 opt: 2769 Z-score: 2938.0 bits: 552.6 E(85289): 6.5e-157 Smith-Waterman score: 2769; 100.0% identity (100.0% similar) in 415 aa overlap (1-415:1-415) 10 20 30 40 50 60 pF1KB8 MELRKYGPGRLAGTVIGGAAQSKSQTKSDSITKEFLPGLYTAPSSPFPPSQVSDHQVLND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MELRKYGPGRLAGTVIGGAAQSKSQTKSDSITKEFLPGLYTAPSSPFPPSQVSDHQVLND 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 HDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 MRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCL 310 320 330 340 350 360 370 380 390 400 410 pF1KB8 NPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 370 380 390 400 410 >>XP_005262313 (OMIM: 300574) PREDICTED: C-X-C chemokine (378 aa) initn: 2441 init1: 2441 opt: 2465 Z-score: 2616.7 bits: 493.0 E(85289): 5.2e-139 Smith-Waterman score: 2465; 97.4% identity (98.4% similar) in 380 aa overlap (36-415:1-378) 10 20 30 40 50 60 pF1KB8 YGPGRLAGTVIGGAAQSKSQTKSDSITKEFLPGLYTAPSSPFPPSQVSDHQVLNDAEVAA .::: .:.:: . :::::::::::::: XP_005 MPGLAHSPGSP--QGWVSDHQVLNDAEVAA 10 20 70 80 90 100 110 120 pF1KB8 LLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVL 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB8 LSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAG 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB8 ALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB8 NATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVV 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB8 VVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLY 270 280 290 300 310 320 370 380 390 400 410 pF1KB8 AFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 330 340 350 360 370 >>NP_001495 (OMIM: 300574) C-X-C chemokine receptor type (368 aa) initn: 2435 init1: 2435 opt: 2435 Z-score: 2585.1 bits: 487.1 E(85289): 3e-137 Smith-Waterman score: 2435; 99.7% identity (100.0% similar) in 365 aa overlap (51-415:4-368) 30 40 50 60 70 80 pF1KB8 QSKSQTKSDSITKEFLPGLYTAPSSPFPPSQVSDHQVLNDAEVAALLENFSSSYDYGENE .::::::::::::::::::::::::::::: NP_001 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENE 10 20 30 90 100 110 120 130 140 pF1KB8 SDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLL 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 HLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRT 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 ALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHL 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 VVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLL 280 290 300 310 320 330 390 400 410 pF1KB8 LRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL ::::::::::::::::::::::::::::::::::: NP_001 LRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 340 350 360 >>XP_005262314 (OMIM: 300574) PREDICTED: C-X-C chemokine (278 aa) initn: 1405 init1: 1385 opt: 1409 Z-score: 1500.2 bits: 286.0 E(85289): 8e-77 Smith-Waterman score: 1409; 95.5% identity (97.3% similar) in 221 aa overlap (36-256:1-219) 10 20 30 40 50 60 pF1KB8 YGPGRLAGTVIGGAAQSKSQTKSDSITKEFLPGLYTAPSSPFPPSQVSDHQVLNDAEVAA .::: .:.:: . :::::::::::::: XP_005 MPGLAHSPGSP--QGWVSDHQVLNDAEVAA 10 20 70 80 90 100 110 120 pF1KB8 LLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVL 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB8 LSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAG 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB8 ALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB8 NATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVV ::::::::::: XP_005 NATHCQYNFPQGSSSGSGCGCCSCAWAAPTREGSRGSHRLPAGIHPGLRPQRPPTRACEA 210 220 230 240 250 260 >>XP_016884925 (OMIM: 300574) PREDICTED: C-X-C chemokine (268 aa) initn: 1399 init1: 1379 opt: 1379 Z-score: 1468.7 bits: 280.1 E(85289): 4.6e-75 Smith-Waterman score: 1379; 99.5% identity (100.0% similar) in 206 aa overlap (51-256:4-209) 30 40 50 60 70 80 pF1KB8 QSKSQTKSDSITKEFLPGLYTAPSSPFPPSQVSDHQVLNDAEVAALLENFSSSYDYGENE .::::::::::::::::::::::::::::: XP_016 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENE 10 20 30 90 100 110 120 130 140 pF1KB8 SDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLL 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 HLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQGSSS 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 ALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHL XP_016 GSGCGCCSCAWAAPTREGSRGSHRLPAGIHPGLRPQRPPTRACEAGIRAPLSPTV 220 230 240 250 260 >>NP_001707 (OMIM: 601613) C-X-C chemokine receptor type (372 aa) initn: 788 init1: 444 opt: 845 Z-score: 901.5 bits: 175.6 E(85289): 1.8e-43 Smith-Waterman score: 845; 40.9% identity (68.3% similar) in 357 aa overlap (67-411:14-367) 40 50 60 70 80 90 pF1KB8 PGLYTAPSSPFPPSQVSDHQVLNDAEVAALLENFSSSYDYGENESD-SCCTSPPCPQD-- ::.. : .: .: : . :: NP_001 MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEG 10 20 30 40 100 110 120 130 140 150 pF1KB8 -FSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLT . .: .:.:. :::.::::..:: : ..: .: . :::.:::.:::::: :::. NP_001 PLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFI 50 60 70 80 90 100 160 170 180 190 200 210 pF1KB8 LPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP ::. .....: ::.:. :::.. :: ..::: ..::::::. :::: ::::.. ::. NP_001 LPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRL 110 120 130 140 150 160 220 230 240 250 260 pF1KB8 ARVTLTCLAVWGLCLLFALPDFIFLSA---HHDERLNATHCQYNFPQVGRT----ALRVL . .:: ..: . .:.:::...: .. ::.. : .: .. . ..: . : : NP_001 LSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSL--PRCTFSQENQAETHAWFTSRFL 170 180 190 200 210 220 270 280 290 300 310 320 pF1KB8 QLVAGFLLPLLVMAYCYAHILAVL-LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLV :::::::.:::..::. .. : ..: .: .:.:....:. : :::.:::.:... NP_001 YHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFL 230 240 250 260 270 280 330 340 350 360 370 380 pF1KB8 DILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLG : : : :. .: .. . :: .. :: ::::::.::.:.::::: . :: .:: NP_001 DTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLG 290 300 310 320 330 340 390 400 410 pF1KB8 CPNQRGLQRQPSSSRRDSSWSETSEASYSGL : . .: . : :: :: ::. .:. NP_001 CTGPASLCQLFPSWRR-SSLSESENATSLTTF 350 360 370 >>NP_116743 (OMIM: 601613) C-X-C chemokine receptor type (327 aa) initn: 788 init1: 444 opt: 835 Z-score: 891.6 bits: 173.6 E(85289): 6.3e-43 Smith-Waterman score: 835; 42.7% identity (71.2% similar) in 323 aa overlap (97-411:3-322) 70 80 90 100 110 120 pF1KB8 LENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLL .: .:.:. :::.::::..:: : ..: NP_116 MASFKAVFVPVAYSLIFLLGVIGNVLVLVILE 10 20 30 130 140 150 160 170 180 pF1KB8 SRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGA .: . :::.:::.:::::: :::. ::. .....: ::.:. :::.. :: ..::: .. NP_116 RHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSS 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB8 LLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSA---HHDE ::::::. :::: ::::.. ::. . .:: ..: . .:.:::...: .. ::.. NP_116 LLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNN 100 110 120 130 140 150 250 260 270 280 290 pF1KB8 RLNATHCQYNFPQVGRT----ALRVLQLVAGFLLPLLVMAYCYAHILAVL-LVSRGQRRL : .: .. . ..: . : : :::::::.:::..::. .. : ..: .: NP_116 SL--PRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQ 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB8 RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHC .:.:....:. : :::.:::.:...: : : :. .: .. . :: .. :: :: NP_116 KAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHC 220 230 240 250 260 270 360 370 380 390 400 410 pF1KB8 CLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL ::::.::.:.::::: . :: .::: . .: . : :: :: ::. .:. NP_116 CLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRR-SSLSESENATSLTTF 280 290 300 310 320 >>NP_001548 (OMIM: 146928) C-X-C chemokine receptor type (360 aa) initn: 829 init1: 388 opt: 827 Z-score: 882.7 bits: 172.1 E(85289): 2e-42 Smith-Waterman score: 827; 40.6% identity (68.5% similar) in 340 aa overlap (72-408:21-357) 50 60 70 80 90 100 pF1KB8 APSSPFPPSQVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRA :.:.:. . . :: . ::.... NP_001 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPE-SLEINKY 10 20 30 40 110 120 130 140 150 160 pF1KB8 FLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAA :. .:.:.:::.::::. : :.: :.. : ::..::.::.:: :..::::.::.. . NP_001 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB8 VQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLA :.::. ::::.. : ..:::.: ::::::: :::: :::::. . : . ::. NP_001 NGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQ-KRYLVKFICLS 110 120 130 140 150 160 230 240 250 260 270 pF1KB8 VWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVG---RTALRVLQLVAGFLLPLLVM .::: ::.::: ..: . .. .. . : .. . : ::.: ::..:::.: NP_001 IWGLSLLLALPVLLFRRTVYSSNVSPA-CYEDMGNNTANWRMLLRILPQSFGFIVPLLIM 170 180 190 200 210 220 280 290 300 310 320 330 pF1KB8 AYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCG .::. : .:. .. .. ::::.. .::. : ::: ::.::.:.: :: .. ..: NP_001 LFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCE 230 240 250 260 270 280 340 350 360 370 380 390 pF1KB8 RESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSS :....: : ..: :: .: :::::.:::.: :::. . .: : .. .: .. : NP_001 RRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPS 290 300 310 320 330 340 400 410 pF1KB8 RRDSSWSETSEASYSGL :: ..:: NP_001 FVGSSSGHTSTTL 350 360 >>XP_016859481 (OMIM: 146928) PREDICTED: C-X-C chemokine (360 aa) initn: 829 init1: 388 opt: 827 Z-score: 882.7 bits: 172.1 E(85289): 2e-42 Smith-Waterman score: 827; 40.6% identity (68.5% similar) in 340 aa overlap (72-408:21-357) 50 60 70 80 90 100 pF1KB8 APSSPFPPSQVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRA :.:.:. . . :: . ::.... XP_016 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPE-SLEINKY 10 20 30 40 110 120 130 140 150 160 pF1KB8 FLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAA :. .:.:.:::.::::. : :.: :.. : ::..::.::.:: :..::::.::.. . XP_016 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB8 VQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLA :.::. ::::.. : ..:::.: ::::::: :::: :::::. . : . ::. XP_016 NGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQ-KRYLVKFICLS 110 120 130 140 150 160 230 240 250 260 270 pF1KB8 VWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVG---RTALRVLQLVAGFLLPLLVM .::: ::.::: ..: . .. .. . : .. . : ::.: ::..:::.: XP_016 IWGLSLLLALPVLLFRRTVYSSNVSPA-CYEDMGNNTANWRMLLRILPQSFGFIVPLLIM 170 180 190 200 210 220 280 290 300 310 320 330 pF1KB8 AYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCG .::. : .:. .. .. ::::.. .::. : ::: ::.::.:.: :: .. ..: XP_016 LFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCE 230 240 250 260 270 280 340 350 360 370 380 390 pF1KB8 RESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSS :....: : ..: :: .: :::::.:::.: :::. . .: : .. .: .. : XP_016 RRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPS 290 300 310 320 330 340 400 410 pF1KB8 RRDSSWSETSEASYSGL :: ..:: XP_016 FVGSSSGHTSTTL 350 360 415 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:53:55 2016 done: Fri Nov 4 15:53:56 2016 Total Scan time: 9.490 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]