FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8857, 92 aa 1>>>pF1KB8857 92 - 92 aa - 92 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8956+/-0.000326; mu= 11.8326+/- 0.021 mean_var=75.7848+/-14.885, 0's: 0 Z-trim(117.0): 66 B-trim: 713 in 2/52 Lambda= 0.147327 statistics sampled from 28476 (28582) to 28476 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.737), E-opt: 0.2 (0.335), width: 16 Scan time: 4.110 The best scores are: opt bits E(85289) XP_016883913 (OMIM: 176990) PREDICTED: protein S10 ( 92) 606 137.0 4e-33 NP_006263 (OMIM: 176990) protein S100-B [Homo sapi ( 92) 606 137.0 4e-33 NP_006262 (OMIM: 176940) protein S100-A1 [Homo sap ( 94) 351 82.9 8.5e-17 NP_005971 (OMIM: 600614) protein S100-P [Homo sapi ( 95) 315 75.2 1.7e-14 NP_002952 (OMIM: 114210) protein S100-A4 [Homo sap ( 101) 289 69.7 8.3e-13 NP_062427 (OMIM: 114210) protein S100-A4 [Homo sap ( 101) 289 69.7 8.3e-13 NP_005969 (OMIM: 176993) protein S100-A2 [Homo sap ( 97) 284 68.6 1.7e-12 XP_011541546 (OMIM: 610103) PREDICTED: protein S10 ( 99) 277 67.1 4.8e-12 XP_011541541 (OMIM: 610103) PREDICTED: protein S10 ( 99) 277 67.1 4.8e-12 XP_011541543 (OMIM: 610103) PREDICTED: protein S10 ( 99) 277 67.1 4.8e-12 NP_570128 (OMIM: 610103) protein S100-Z [Homo sapi ( 99) 277 67.1 4.8e-12 XP_011541547 (OMIM: 610103) PREDICTED: protein S10 ( 99) 277 67.1 4.8e-12 XP_016864662 (OMIM: 610103) PREDICTED: protein S10 ( 99) 277 67.1 4.8e-12 XP_011541542 (OMIM: 610103) PREDICTED: protein S10 ( 99) 277 67.1 4.8e-12 XP_016864660 (OMIM: 610103) PREDICTED: protein S10 ( 99) 277 67.1 4.8e-12 XP_016864661 (OMIM: 610103) PREDICTED: protein S10 ( 99) 277 67.1 4.8e-12 XP_016857520 (OMIM: 176991) PREDICTED: protein S10 ( 92) 251 61.6 2.1e-10 XP_016857521 (OMIM: 176991) PREDICTED: protein S10 ( 92) 251 61.6 2.1e-10 NP_002953 (OMIM: 176991) protein S100-A5 [Homo sap ( 92) 251 61.6 2.1e-10 XP_011508162 (OMIM: 176991) PREDICTED: protein S10 ( 104) 251 61.6 2.3e-10 XP_016857519 (OMIM: 176991) PREDICTED: protein S10 ( 110) 251 61.7 2.4e-10 XP_016857518 (OMIM: 176991) PREDICTED: protein S10 ( 133) 251 61.7 2.7e-10 NP_005612 (OMIM: 603112) protein S100-A12 [Homo sa ( 92) 246 60.5 4.4e-10 NP_005611 (OMIM: 603114) protein S100-A11 [Homo sa ( 105) 237 58.7 1.8e-09 NP_002956 (OMIM: 123886) protein S100-A9 [Homo sap ( 114) 230 57.2 5.4e-09 XP_016857522 (OMIM: 114110) PREDICTED: protein S10 ( 90) 228 56.7 6.1e-09 NP_055439 (OMIM: 114110) protein S100-A6 [Homo sap ( 90) 228 56.7 6.1e-09 NP_002951 (OMIM: 176992) protein S100-A3 [Homo sap ( 101) 219 54.8 2.5e-08 NP_002957 (OMIM: 114085) protein S100-A10 [Homo sa ( 97) 218 54.6 2.8e-08 XP_011507833 (OMIM: 616284) PREDICTED: filaggrin-2 (2239) 222 56.7 1.5e-07 NP_001014364 (OMIM: 616284) filaggrin-2 [Homo sapi (2391) 222 56.7 1.6e-07 NP_001116437 (OMIM: 613259) repetin [Homo sapiens] ( 784) 209 53.5 4.8e-07 NP_001306130 (OMIM: 123885) protein S100-A8 isofor ( 93) 181 46.7 6.3e-06 NP_002955 (OMIM: 123885) protein S100-A8 isoform d ( 93) 181 46.7 6.3e-06 NP_001306127 (OMIM: 123885) protein S100-A8 isofor ( 101) 181 46.7 6.7e-06 NP_001009931 (OMIM: 616293) hornerin [Homo sapiens (2850) 197 51.5 7.1e-06 NP_001306126 (OMIM: 123885) protein S100-A8 isofor ( 116) 181 46.8 7.4e-06 NP_001306125 (OMIM: 123885) protein S100-A8 isofor ( 117) 181 46.8 7.5e-06 NP_009044 (OMIM: 190370) trichohyalin [Homo sapien (1943) 194 50.7 8.3e-06 XP_016885330 (OMIM: 302020) PREDICTED: protein S10 ( 79) 167 43.7 4.4e-05 NP_004048 (OMIM: 302020) protein S100-G [Homo sapi ( 79) 167 43.7 4.4e-05 NP_057274 (OMIM: 611312) cornulin [Homo sapiens] ( 495) 174 45.9 5.9e-05 NP_002007 (OMIM: 135940,146700,605803) filaggrin [ (4061) 183 48.7 7.2e-05 XP_016857523 (OMIM: 601989) PREDICTED: protein S10 ( 98) 152 40.6 0.00047 XP_011508164 (OMIM: 601989) PREDICTED: protein S10 ( 98) 152 40.6 0.00047 XP_011508166 (OMIM: 601989) PREDICTED: protein S10 ( 98) 152 40.6 0.00047 XP_005245491 (OMIM: 601989) PREDICTED: protein S10 ( 98) 152 40.6 0.00047 NP_001019384 (OMIM: 601989) protein S100-A13 [Homo ( 98) 152 40.6 0.00047 XP_011508165 (OMIM: 601989) PREDICTED: protein S10 ( 98) 152 40.6 0.00047 NP_001019381 (OMIM: 601989) protein S100-A13 [Homo ( 98) 152 40.6 0.00047 >>XP_016883913 (OMIM: 176990) PREDICTED: protein S100-B (92 aa) initn: 606 init1: 606 opt: 606 Z-score: 715.6 bits: 137.0 E(85289): 4e-33 Smith-Waterman score: 606; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:1-92) 10 20 30 40 50 60 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMET 10 20 30 40 50 60 70 80 90 pF1KB8 LDNDGDGECDFQEFMAFVAMVTTACHEFFEHE :::::::::::::::::::::::::::::::: XP_016 LDNDGDGECDFQEFMAFVAMVTTACHEFFEHE 70 80 90 >>NP_006263 (OMIM: 176990) protein S100-B [Homo sapiens] (92 aa) initn: 606 init1: 606 opt: 606 Z-score: 715.6 bits: 137.0 E(85289): 4e-33 Smith-Waterman score: 606; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:1-92) 10 20 30 40 50 60 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMET 10 20 30 40 50 60 70 80 90 pF1KB8 LDNDGDGECDFQEFMAFVAMVTTACHEFFEHE :::::::::::::::::::::::::::::::: NP_006 LDNDGDGECDFQEFMAFVAMVTTACHEFFEHE 70 80 90 >>NP_006262 (OMIM: 176940) protein S100-A1 [Homo sapiens (94 aa) initn: 351 init1: 351 opt: 351 Z-score: 422.6 bits: 82.9 E(85289): 8.5e-17 Smith-Waterman score: 351; 60.2% identity (88.6% similar) in 88 aa overlap (2-89:3-90) 10 20 30 40 50 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVME :::: :: .::.::: .::.::::.::.:.:::::...::: ::. :. ..:::::. NP_006 MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMK 10 20 30 40 50 60 60 70 80 90 pF1KB8 TLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE ::..:::: ::::....:: .:.::..:: NP_006 ELDENGDGEVDFQEYVVLVAALTVACNNFFWENS 70 80 90 >>NP_005971 (OMIM: 600614) protein S100-P [Homo sapiens] (95 aa) initn: 315 init1: 315 opt: 315 Z-score: 381.2 bits: 75.2 E(85289): 1.7e-14 Smith-Waterman score: 315; 51.1% identity (81.1% similar) in 90 aa overlap (1-90:1-90) 10 20 30 40 50 60 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMET :.::: :: .:::: .::: ::. . : :.::: :...:: ::. :....:::... NP_005 MTELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKELPGFLQSGKDKDAVDKLLKD 10 20 30 40 50 60 70 80 90 pF1KB8 LDNDGDGECDFQEFMAFVAMVTTACHEFFEHE :: .::.. ::.::..::: .:.:::..:: NP_005 LDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK 70 80 90 >>NP_002952 (OMIM: 114210) protein S100-A4 [Homo sapiens (101 aa) initn: 289 init1: 289 opt: 289 Z-score: 351.0 bits: 69.7 E(85289): 8.3e-13 Smith-Waterman score: 289; 48.3% identity (80.5% similar) in 87 aa overlap (4-90:5-91) 10 20 30 40 50 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVME ::::. .....::.:::.:::: ::.:::::::.. :: :: . .. . .:.: NP_002 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS 10 20 30 40 50 60 60 70 80 90 pF1KB8 TLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE .::.. :.: ::::. .:.. .. :.:::: NP_002 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK 70 80 90 100 >>NP_062427 (OMIM: 114210) protein S100-A4 [Homo sapiens (101 aa) initn: 289 init1: 289 opt: 289 Z-score: 351.0 bits: 69.7 E(85289): 8.3e-13 Smith-Waterman score: 289; 48.3% identity (80.5% similar) in 87 aa overlap (4-90:5-91) 10 20 30 40 50 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVME ::::. .....::.:::.:::: ::.:::::::.. :: :: . .. . .:.: NP_062 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS 10 20 30 40 50 60 60 70 80 90 pF1KB8 TLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE .::.. :.: ::::. .:.. .. :.:::: NP_062 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK 70 80 90 100 >>NP_005969 (OMIM: 176993) protein S100-A2 [Homo sapiens (97 aa) initn: 297 init1: 280 opt: 284 Z-score: 345.4 bits: 68.6 E(85289): 1.7e-12 Smith-Waterman score: 284; 44.9% identity (82.0% similar) in 89 aa overlap (2-90:3-91) 10 20 30 40 50 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVME : ::.:...:. .::.:: .:::: ::.:.:.:::...:: :. : ..: . :.: NP_005 MCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMG 10 20 30 40 50 60 60 70 80 90 pF1KB8 TLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE .::...: . ::::. .:.:..:. :..::. NP_005 SLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP 70 80 90 >>XP_011541546 (OMIM: 610103) PREDICTED: protein S100-Z (99 aa) initn: 300 init1: 273 opt: 277 Z-score: 337.3 bits: 67.1 E(85289): 4.8e-12 Smith-Waterman score: 277; 46.6% identity (80.7% similar) in 88 aa overlap (2-89:3-90) 10 20 30 40 50 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVME ..:: :: ..: .::.:::.: . ::.:.::: :.. ::..:: :: ..:::... XP_011 MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTEFLSCQKETQLVDKIVQ 10 20 30 40 50 60 60 70 80 90 pF1KB8 TLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE :: . :.: ::.::...:: .:.::...: XP_011 DLDANKDNEVDFNEFVVMVAALTVACNDYFVEQLKKKGK 70 80 90 >>XP_011541541 (OMIM: 610103) PREDICTED: protein S100-Z (99 aa) initn: 300 init1: 273 opt: 277 Z-score: 337.3 bits: 67.1 E(85289): 4.8e-12 Smith-Waterman score: 277; 46.6% identity (80.7% similar) in 88 aa overlap (2-89:3-90) 10 20 30 40 50 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVME ..:: :: ..: .::.:::.: . ::.:.::: :.. ::..:: :: ..:::... XP_011 MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTEFLSCQKETQLVDKIVQ 10 20 30 40 50 60 60 70 80 90 pF1KB8 TLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE :: . :.: ::.::...:: .:.::...: XP_011 DLDANKDNEVDFNEFVVMVAALTVACNDYFVEQLKKKGK 70 80 90 >>XP_011541543 (OMIM: 610103) PREDICTED: protein S100-Z (99 aa) initn: 300 init1: 273 opt: 277 Z-score: 337.3 bits: 67.1 E(85289): 4.8e-12 Smith-Waterman score: 277; 46.6% identity (80.7% similar) in 88 aa overlap (2-89:3-90) 10 20 30 40 50 pF1KB8 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVME ..:: :: ..: .::.:::.: . ::.:.::: :.. ::..:: :: ..:::... XP_011 MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTEFLSCQKETQLVDKIVQ 10 20 30 40 50 60 60 70 80 90 pF1KB8 TLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE :: . :.: ::.::...:: .:.::...: XP_011 DLDANKDNEVDFNEFVVMVAALTVACNDYFVEQLKKKGK 70 80 90 92 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:08:15 2016 done: Fri Nov 4 16:08:16 2016 Total Scan time: 4.110 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]