FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8858, 92 aa 1>>>pF1KB8858 92 - 92 aa - 92 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5522+/-0.000384; mu= 13.3913+/- 0.024 mean_var=65.5941+/-12.942, 0's: 0 Z-trim(113.2): 73 B-trim: 1035 in 3/51 Lambda= 0.158359 statistics sampled from 22371 (22457) to 22371 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.263), width: 16 Scan time: 4.140 The best scores are: opt bits E(85289) NP_005612 (OMIM: 603112) protein S100-A12 [Homo sa ( 92) 584 141.5 1.9e-34 NP_002956 (OMIM: 123886) protein S100-A9 [Homo sap ( 114) 274 70.7 4.6e-13 NP_005971 (OMIM: 600614) protein S100-P [Homo sapi ( 95) 253 65.9 1.1e-11 XP_016883913 (OMIM: 176990) PREDICTED: protein S10 ( 92) 246 64.2 3.3e-11 NP_006263 (OMIM: 176990) protein S100-B [Homo sapi ( 92) 246 64.2 3.3e-11 XP_011541542 (OMIM: 610103) PREDICTED: protein S10 ( 99) 223 59.0 1.3e-09 XP_016864660 (OMIM: 610103) PREDICTED: protein S10 ( 99) 223 59.0 1.3e-09 XP_016864661 (OMIM: 610103) PREDICTED: protein S10 ( 99) 223 59.0 1.3e-09 XP_011541546 (OMIM: 610103) PREDICTED: protein S10 ( 99) 223 59.0 1.3e-09 XP_016864662 (OMIM: 610103) PREDICTED: protein S10 ( 99) 223 59.0 1.3e-09 XP_011541543 (OMIM: 610103) PREDICTED: protein S10 ( 99) 223 59.0 1.3e-09 NP_570128 (OMIM: 610103) protein S100-Z [Homo sapi ( 99) 223 59.0 1.3e-09 XP_011541541 (OMIM: 610103) PREDICTED: protein S10 ( 99) 223 59.0 1.3e-09 XP_011541547 (OMIM: 610103) PREDICTED: protein S10 ( 99) 223 59.0 1.3e-09 NP_006262 (OMIM: 176940) protein S100-A1 [Homo sap ( 94) 212 56.5 7.3e-09 NP_002955 (OMIM: 123885) protein S100-A8 isoform d ( 93) 203 54.4 3e-08 NP_001306130 (OMIM: 123885) protein S100-A8 isofor ( 93) 203 54.4 3e-08 NP_001306127 (OMIM: 123885) protein S100-A8 isofor ( 101) 203 54.5 3.2e-08 NP_005611 (OMIM: 603114) protein S100-A11 [Homo sa ( 105) 203 54.5 3.3e-08 NP_001306126 (OMIM: 123885) protein S100-A8 isofor ( 116) 203 54.5 3.5e-08 NP_001306125 (OMIM: 123885) protein S100-A8 isofor ( 117) 203 54.5 3.6e-08 NP_002007 (OMIM: 135940,146700,605803) filaggrin [ (4061) 218 59.4 4.3e-08 NP_001009931 (OMIM: 616293) hornerin [Homo sapiens (2850) 212 57.9 8.6e-08 NP_005969 (OMIM: 176993) protein S100-A2 [Homo sap ( 97) 196 52.8 9.4e-08 NP_002952 (OMIM: 114210) protein S100-A4 [Homo sap ( 101) 194 52.4 1.3e-07 NP_062427 (OMIM: 114210) protein S100-A4 [Homo sap ( 101) 194 52.4 1.3e-07 XP_011507833 (OMIM: 616284) PREDICTED: filaggrin-2 (2239) 203 55.7 3e-07 NP_001014364 (OMIM: 616284) filaggrin-2 [Homo sapi (2391) 203 55.7 3.1e-07 NP_057274 (OMIM: 611312) cornulin [Homo sapiens] ( 495) 195 53.3 3.6e-07 XP_016857522 (OMIM: 114110) PREDICTED: protein S10 ( 90) 186 50.5 4.3e-07 NP_055439 (OMIM: 114110) protein S100-A6 [Homo sap ( 90) 186 50.5 4.3e-07 NP_002953 (OMIM: 176991) protein S100-A5 [Homo sap ( 92) 184 50.1 6.1e-07 XP_016857521 (OMIM: 176991) PREDICTED: protein S10 ( 92) 184 50.1 6.1e-07 XP_016857520 (OMIM: 176991) PREDICTED: protein S10 ( 92) 184 50.1 6.1e-07 XP_011508162 (OMIM: 176991) PREDICTED: protein S10 ( 104) 184 50.1 6.6e-07 XP_016857519 (OMIM: 176991) PREDICTED: protein S10 ( 110) 184 50.2 6.9e-07 XP_016857518 (OMIM: 176991) PREDICTED: protein S10 ( 133) 184 50.2 7.9e-07 XP_005245491 (OMIM: 601989) PREDICTED: protein S10 ( 98) 174 47.8 3.1e-06 XP_016857523 (OMIM: 601989) PREDICTED: protein S10 ( 98) 174 47.8 3.1e-06 XP_016857525 (OMIM: 601989) PREDICTED: protein S10 ( 98) 174 47.8 3.1e-06 XP_011508166 (OMIM: 601989) PREDICTED: protein S10 ( 98) 174 47.8 3.1e-06 NP_001019382 (OMIM: 601989) protein S100-A13 [Homo ( 98) 174 47.8 3.1e-06 XP_011508164 (OMIM: 601989) PREDICTED: protein S10 ( 98) 174 47.8 3.1e-06 NP_001019384 (OMIM: 601989) protein S100-A13 [Homo ( 98) 174 47.8 3.1e-06 NP_005970 (OMIM: 601989) protein S100-A13 [Homo sa ( 98) 174 47.8 3.1e-06 XP_016857524 (OMIM: 601989) PREDICTED: protein S10 ( 98) 174 47.8 3.1e-06 NP_001019383 (OMIM: 601989) protein S100-A13 [Homo ( 98) 174 47.8 3.1e-06 NP_001019381 (OMIM: 601989) protein S100-A13 [Homo ( 98) 174 47.8 3.1e-06 XP_011508165 (OMIM: 601989) PREDICTED: protein S10 ( 98) 174 47.8 3.1e-06 NP_002957 (OMIM: 114085) protein S100-A10 [Homo sa ( 97) 169 46.7 6.8e-06 >>NP_005612 (OMIM: 603112) protein S100-A12 [Homo sapien (92 aa) initn: 584 init1: 584 opt: 584 Z-score: 739.5 bits: 141.5 E(85289): 1.9e-34 Smith-Waterman score: 584; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:1-92) 10 20 30 40 50 60 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQG 10 20 30 40 50 60 70 80 90 pF1KB8 LDANQDEQVDFQEFISLVAIALKAAHYHTHKE :::::::::::::::::::::::::::::::: NP_005 LDANQDEQVDFQEFISLVAIALKAAHYHTHKE 70 80 90 >>NP_002956 (OMIM: 123886) protein S100-A9 [Homo sapiens (114 aa) initn: 252 init1: 164 opt: 274 Z-score: 355.6 bits: 70.7 E(85289): 4.6e-13 Smith-Waterman score: 274; 46.7% identity (79.3% similar) in 92 aa overlap (1-91:5-96) 10 20 30 40 50 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKN-IKDKAVID :..::...: :.: ::::::. :: :::..::.:.:. :.: : .:. :.. ::. NP_002 MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEKVIE 10 20 30 40 50 60 60 70 80 90 pF1KB8 EIFQGLDANQDEQVDFQEFISLVAIALKAAHYHTHKE .:.. ::.: :.:..:.::: :.: :.: . :. NP_002 HIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP 70 80 90 100 110 >>NP_005971 (OMIM: 600614) protein S100-P [Homo sapiens] (95 aa) initn: 269 init1: 253 opt: 253 Z-score: 330.7 bits: 65.9 E(85289): 1.1e-11 Smith-Waterman score: 253; 45.1% identity (72.5% similar) in 91 aa overlap (1-91:1-91) 10 20 30 40 50 60 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQG ::.:: . :...: .:: .: .::.::::: :. ::: . ... ::: ..:.... NP_005 MTELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKELPGFLQSGKDKDAVDKLLKD 10 20 30 40 50 60 70 80 90 pF1KB8 LDANQDEQVDFQEFISLVAIALKAAHYHTHKE :::: : ::::.::: .:: .: : . .: NP_005 LDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK 70 80 90 >>XP_016883913 (OMIM: 176990) PREDICTED: protein S100-B (92 aa) initn: 250 init1: 235 opt: 246 Z-score: 322.2 bits: 64.2 E(85289): 3.3e-11 Smith-Waterman score: 246; 38.0% identity (78.3% similar) in 92 aa overlap (1-91:1-92) 10 20 30 40 50 60 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQG :..::. . .....::::: :.: :.:.:::.:...::.. ...::.. :.:.... XP_016 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMET 10 20 30 40 50 60 70 80 90 pF1KB8 LDANQDEQVDFQEFISLVAIALKAAH-YHTHKE :: . : . :::::...::.. : : . :. XP_016 LDNDGDGECDFQEFMAFVAMVTTACHEFFEHE 70 80 90 >>NP_006263 (OMIM: 176990) protein S100-B [Homo sapiens] (92 aa) initn: 250 init1: 235 opt: 246 Z-score: 322.2 bits: 64.2 E(85289): 3.3e-11 Smith-Waterman score: 246; 38.0% identity (78.3% similar) in 92 aa overlap (1-91:1-92) 10 20 30 40 50 60 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQG :..::. . .....::::: :.: :.:.:::.:...::.. ...::.. :.:.... NP_006 MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMET 10 20 30 40 50 60 70 80 90 pF1KB8 LDANQDEQVDFQEFISLVAIALKAAH-YHTHKE :: . : . :::::...::.. : : . :. NP_006 LDNDGDGECDFQEFMAFVAMVTTACHEFFEHE 70 80 90 >>XP_011541542 (OMIM: 610103) PREDICTED: protein S100-Z (99 aa) initn: 221 init1: 221 opt: 223 Z-score: 293.4 bits: 59.0 E(85289): 1.3e-09 Smith-Waterman score: 223; 45.2% identity (75.0% similar) in 84 aa overlap (2-85:3-85) 10 20 30 40 50 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQ :.:: .. .. :::.:: .. . ::::::: :: .::.. .. :. ..:.: : XP_011 MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTEFLSCQKETQLVDKIVQ 10 20 30 40 50 60 60 70 80 90 pF1KB8 GLDANQDEQVDFQEFISLVAIALKAAHYHTHKE ::::.:..:::.::. .:: :: .: XP_011 DLDANKDNEVDFNEFVVMVA-ALTVACNDYFVEQLKKKGK 70 80 90 >>XP_016864660 (OMIM: 610103) PREDICTED: protein S100-Z (99 aa) initn: 221 init1: 221 opt: 223 Z-score: 293.4 bits: 59.0 E(85289): 1.3e-09 Smith-Waterman score: 223; 45.2% identity (75.0% similar) in 84 aa overlap (2-85:3-85) 10 20 30 40 50 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQ :.:: .. .. :::.:: .. . ::::::: :: .::.. .. :. ..:.: : XP_016 MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTEFLSCQKETQLVDKIVQ 10 20 30 40 50 60 60 70 80 90 pF1KB8 GLDANQDEQVDFQEFISLVAIALKAAHYHTHKE ::::.:..:::.::. .:: :: .: XP_016 DLDANKDNEVDFNEFVVMVA-ALTVACNDYFVEQLKKKGK 70 80 90 >>XP_016864661 (OMIM: 610103) PREDICTED: protein S100-Z (99 aa) initn: 221 init1: 221 opt: 223 Z-score: 293.4 bits: 59.0 E(85289): 1.3e-09 Smith-Waterman score: 223; 45.2% identity (75.0% similar) in 84 aa overlap (2-85:3-85) 10 20 30 40 50 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQ :.:: .. .. :::.:: .. . ::::::: :: .::.. .. :. ..:.: : XP_016 MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTEFLSCQKETQLVDKIVQ 10 20 30 40 50 60 60 70 80 90 pF1KB8 GLDANQDEQVDFQEFISLVAIALKAAHYHTHKE ::::.:..:::.::. .:: :: .: XP_016 DLDANKDNEVDFNEFVVMVA-ALTVACNDYFVEQLKKKGK 70 80 90 >>XP_011541546 (OMIM: 610103) PREDICTED: protein S100-Z (99 aa) initn: 221 init1: 221 opt: 223 Z-score: 293.4 bits: 59.0 E(85289): 1.3e-09 Smith-Waterman score: 223; 45.2% identity (75.0% similar) in 84 aa overlap (2-85:3-85) 10 20 30 40 50 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQ :.:: .. .. :::.:: .. . ::::::: :: .::.. .. :. ..:.: : XP_011 MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTEFLSCQKETQLVDKIVQ 10 20 30 40 50 60 60 70 80 90 pF1KB8 GLDANQDEQVDFQEFISLVAIALKAAHYHTHKE ::::.:..:::.::. .:: :: .: XP_011 DLDANKDNEVDFNEFVVMVA-ALTVACNDYFVEQLKKKGK 70 80 90 >>XP_016864662 (OMIM: 610103) PREDICTED: protein S100-Z (99 aa) initn: 221 init1: 221 opt: 223 Z-score: 293.4 bits: 59.0 E(85289): 1.3e-09 Smith-Waterman score: 223; 45.2% identity (75.0% similar) in 84 aa overlap (2-85:3-85) 10 20 30 40 50 pF1KB8 MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQ :.:: .. .. :::.:: .. . ::::::: :: .::.. .. :. ..:.: : XP_016 MPTQLEMAMDTMIRIFHRYSGKERKRFKLSKGELKLLLQRELTEFLSCQKETQLVDKIVQ 10 20 30 40 50 60 60 70 80 90 pF1KB8 GLDANQDEQVDFQEFISLVAIALKAAHYHTHKE ::::.:..:::.::. .:: :: .: XP_016 DLDANKDNEVDFNEFVVMVA-ALTVACNDYFVEQLKKKGK 70 80 90 92 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:09:34 2016 done: Fri Nov 4 16:09:35 2016 Total Scan time: 4.140 Total Display time: -0.040 Function used was FASTA [36.3.4 Apr, 2011]