FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8863, 101 aa 1>>>pF1KB8863 101 - 101 aa - 101 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8490+/-0.000303; mu= 11.7463+/- 0.019 mean_var=66.8393+/-13.220, 0's: 0 Z-trim(117.3): 60 B-trim: 145 in 1/50 Lambda= 0.156877 statistics sampled from 29086 (29151) to 29086 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.746), E-opt: 0.2 (0.342), width: 16 Scan time: 3.150 The best scores are: opt bits E(85289) NP_062427 (OMIM: 114210) protein S100-A4 [Homo sap ( 101) 684 162.8 8.7e-41 NP_002952 (OMIM: 114210) protein S100-A4 [Homo sap ( 101) 684 162.8 8.7e-41 NP_005969 (OMIM: 176993) protein S100-A2 [Homo sap ( 97) 415 101.9 1.8e-22 XP_016857522 (OMIM: 114110) PREDICTED: protein S10 ( 90) 318 79.9 6.8e-16 NP_055439 (OMIM: 114110) protein S100-A6 [Homo sap ( 90) 318 79.9 6.8e-16 NP_006262 (OMIM: 176940) protein S100-A1 [Homo sap ( 94) 310 78.1 2.5e-15 NP_002951 (OMIM: 176992) protein S100-A3 [Homo sap ( 101) 309 77.9 3.1e-15 XP_016857520 (OMIM: 176991) PREDICTED: protein S10 ( 92) 299 75.6 1.4e-14 XP_016857521 (OMIM: 176991) PREDICTED: protein S10 ( 92) 299 75.6 1.4e-14 NP_002953 (OMIM: 176991) protein S100-A5 [Homo sap ( 92) 299 75.6 1.4e-14 XP_011508162 (OMIM: 176991) PREDICTED: protein S10 ( 104) 299 75.7 1.5e-14 XP_016857519 (OMIM: 176991) PREDICTED: protein S10 ( 110) 299 75.7 1.6e-14 XP_016857518 (OMIM: 176991) PREDICTED: protein S10 ( 133) 299 75.7 1.8e-14 XP_016864661 (OMIM: 610103) PREDICTED: protein S10 ( 99) 291 73.8 5.1e-14 XP_011541542 (OMIM: 610103) PREDICTED: protein S10 ( 99) 291 73.8 5.1e-14 XP_016864662 (OMIM: 610103) PREDICTED: protein S10 ( 99) 291 73.8 5.1e-14 XP_011541547 (OMIM: 610103) PREDICTED: protein S10 ( 99) 291 73.8 5.1e-14 XP_011541543 (OMIM: 610103) PREDICTED: protein S10 ( 99) 291 73.8 5.1e-14 XP_016864660 (OMIM: 610103) PREDICTED: protein S10 ( 99) 291 73.8 5.1e-14 NP_570128 (OMIM: 610103) protein S100-Z [Homo sapi ( 99) 291 73.8 5.1e-14 XP_011541541 (OMIM: 610103) PREDICTED: protein S10 ( 99) 291 73.8 5.1e-14 XP_011541546 (OMIM: 610103) PREDICTED: protein S10 ( 99) 291 73.8 5.1e-14 XP_016883913 (OMIM: 176990) PREDICTED: protein S10 ( 92) 289 73.4 6.6e-14 NP_006263 (OMIM: 176990) protein S100-B [Homo sapi ( 92) 289 73.4 6.6e-14 NP_005971 (OMIM: 600614) protein S100-P [Homo sapi ( 95) 258 66.3 8.7e-12 NP_002957 (OMIM: 114085) protein S100-A10 [Homo sa ( 97) 225 58.9 1.6e-09 NP_005611 (OMIM: 603114) protein S100-A11 [Homo sa ( 105) 216 56.9 6.8e-09 NP_002956 (OMIM: 123886) protein S100-A9 [Homo sap ( 114) 197 52.6 1.4e-07 NP_005612 (OMIM: 603112) protein S100-A12 [Homo sa ( 92) 194 51.8 2e-07 NP_002955 (OMIM: 123885) protein S100-A8 isoform d ( 93) 164 45.1 2.2e-05 NP_001306130 (OMIM: 123885) protein S100-A8 isofor ( 93) 164 45.1 2.2e-05 NP_001306127 (OMIM: 123885) protein S100-A8 isofor ( 101) 164 45.1 2.3e-05 NP_001306126 (OMIM: 123885) protein S100-A8 isofor ( 116) 164 45.1 2.6e-05 NP_001306125 (OMIM: 123885) protein S100-A8 isofor ( 117) 164 45.1 2.6e-05 NP_001019384 (OMIM: 601989) protein S100-A13 [Homo ( 98) 162 44.6 3.1e-05 NP_005970 (OMIM: 601989) protein S100-A13 [Homo sa ( 98) 162 44.6 3.1e-05 XP_011508166 (OMIM: 601989) PREDICTED: protein S10 ( 98) 162 44.6 3.1e-05 XP_005245491 (OMIM: 601989) PREDICTED: protein S10 ( 98) 162 44.6 3.1e-05 XP_011508164 (OMIM: 601989) PREDICTED: protein S10 ( 98) 162 44.6 3.1e-05 NP_001019383 (OMIM: 601989) protein S100-A13 [Homo ( 98) 162 44.6 3.1e-05 XP_011508165 (OMIM: 601989) PREDICTED: protein S10 ( 98) 162 44.6 3.1e-05 XP_016857525 (OMIM: 601989) PREDICTED: protein S10 ( 98) 162 44.6 3.1e-05 NP_001019382 (OMIM: 601989) protein S100-A13 [Homo ( 98) 162 44.6 3.1e-05 XP_016857523 (OMIM: 601989) PREDICTED: protein S10 ( 98) 162 44.6 3.1e-05 XP_016857524 (OMIM: 601989) PREDICTED: protein S10 ( 98) 162 44.6 3.1e-05 NP_001019381 (OMIM: 601989) protein S100-A13 [Homo ( 98) 162 44.6 3.1e-05 NP_004048 (OMIM: 302020) protein S100-G [Homo sapi ( 79) 160 44.1 3.6e-05 XP_016885330 (OMIM: 302020) PREDICTED: protein S10 ( 79) 160 44.1 3.6e-05 NP_001116437 (OMIM: 613259) repetin [Homo sapiens] ( 784) 171 47.4 3.7e-05 XP_011507833 (OMIM: 616284) PREDICTED: filaggrin-2 (2239) 169 47.3 0.00011 >>NP_062427 (OMIM: 114210) protein S100-A4 [Homo sapiens (101 aa) initn: 684 init1: 684 opt: 684 Z-score: 853.3 bits: 162.8 E(85289): 8.7e-41 Smith-Waterman score: 684; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS 10 20 30 40 50 60 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK ::::::::::::::::::::::::::::::::::::::::: NP_062 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK 70 80 90 100 >>NP_002952 (OMIM: 114210) protein S100-A4 [Homo sapiens (101 aa) initn: 684 init1: 684 opt: 684 Z-score: 853.3 bits: 162.8 E(85289): 8.7e-41 Smith-Waterman score: 684; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS 10 20 30 40 50 60 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK ::::::::::::::::::::::::::::::::::::::::: NP_002 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK 70 80 90 100 >>NP_005969 (OMIM: 176993) protein S100-A2 [Homo sapiens (97 aa) initn: 420 init1: 411 opt: 415 Z-score: 524.5 bits: 101.9 E(85289): 1.8e-22 Smith-Waterman score: 415; 61.5% identity (87.5% similar) in 96 aa overlap (1-96:1-96) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS : ::.:: :.:.:::::: .:::::::.:.:.:::: .:::::.:...:: ...:::. NP_005 MCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMG 10 20 30 40 50 60 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK .:: : :..:::::: :::. :..:::.::.: ::. NP_005 SLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP 70 80 90 >>XP_016857522 (OMIM: 114110) PREDICTED: protein S100-A6 (90 aa) initn: 299 init1: 188 opt: 318 Z-score: 406.3 bits: 79.9 E(85289): 6.8e-16 Smith-Waterman score: 318; 50.0% identity (81.5% similar) in 92 aa overlap (1-92:1-90) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS :::::..:. ..:. ::::::.:::: :.:.:::::. .:: .:.. ..: . .:: XP_016 MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELT--IGSKLQDAEIARLME 10 20 30 40 50 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK .:: :.:.::.:::: .::. .:.. :: ..: XP_016 DLDRNKDQEVNFQEYVTFLGALALIYNEALKG 60 70 80 90 >>NP_055439 (OMIM: 114110) protein S100-A6 [Homo sapiens (90 aa) initn: 299 init1: 188 opt: 318 Z-score: 406.3 bits: 79.9 E(85289): 6.8e-16 Smith-Waterman score: 318; 50.0% identity (81.5% similar) in 92 aa overlap (1-92:1-90) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS :::::..:. ..:. ::::::.:::: :.:.:::::. .:: .:.. ..: . .:: NP_055 MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELT--IGSKLQDAEIARLME 10 20 30 40 50 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK .:: :.:.::.:::: .::. .:.. :: ..: NP_055 DLDRNKDQEVNFQEYVTFLGALALIYNEALKG 60 70 80 90 >>NP_006262 (OMIM: 176940) protein S100-A1 [Homo sapiens (94 aa) initn: 310 init1: 310 opt: 310 Z-score: 396.2 bits: 78.1 E(85289): 2.5e-15 Smith-Waterman score: 310; 51.1% identity (80.0% similar) in 90 aa overlap (1-90:1-90) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS :. :: :.......:: .:::::::.::.:.:::::: :: .:: . : : .:.:. NP_006 MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMK 10 20 30 40 50 60 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK .:: : :.::::::: :... ... ::.:: NP_006 ELDENGDGEVDFQEYVVLVAALTVACNNFFWENS 70 80 90 >>NP_002951 (OMIM: 176992) protein S100-A3 [Homo sapiens (101 aa) initn: 243 init1: 243 opt: 309 Z-score: 394.6 bits: 77.9 E(85289): 3.1e-15 Smith-Waterman score: 309; 45.9% identity (75.5% similar) in 98 aa overlap (1-98:1-98) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS :: :::.:. ..: ::..:.:. :::.:: ..:::::: .:: .. . : ..:.:: NP_002 MARPLEQAVAAIVCTFQEYAGRCGDKYKLCQAELKELLQKELATWTPTEFRECDYNKFMS 10 20 30 40 50 60 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK ::.:.: :::: :: :.:. ..:.:.:. :.. : NP_002 VLDTNKDCEVDFVEYVRSLACLCLYCHEYFKDCPSEPPCSQ 70 80 90 100 >>XP_016857520 (OMIM: 176991) PREDICTED: protein S100-A5 (92 aa) initn: 301 init1: 180 opt: 299 Z-score: 382.9 bits: 75.6 E(85289): 1.4e-14 Smith-Waterman score: 299; 53.3% identity (80.0% similar) in 90 aa overlap (1-90:1-87) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS : :::::: .::.:::::::.::.:. :...:::::. .:: ::. :.... ::. XP_016 METPLEKALTTMVTTFHKYSGREGSKLTLSRKELKELIKKEL--CLGE-MKESSIDDLMK 10 20 30 40 50 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK .::.: :.:.::.:: :::. . : :.:: XP_016 SLDKNSDQEIDFKEYSVFLTMLCMAYNDFFLEDNK 60 70 80 90 >>XP_016857521 (OMIM: 176991) PREDICTED: protein S100-A5 (92 aa) initn: 301 init1: 180 opt: 299 Z-score: 382.9 bits: 75.6 E(85289): 1.4e-14 Smith-Waterman score: 299; 53.3% identity (80.0% similar) in 90 aa overlap (1-90:1-87) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS : :::::: .::.:::::::.::.:. :...:::::. .:: ::. :.... ::. XP_016 METPLEKALTTMVTTFHKYSGREGSKLTLSRKELKELIKKEL--CLGE-MKESSIDDLMK 10 20 30 40 50 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK .::.: :.:.::.:: :::. . : :.:: XP_016 SLDKNSDQEIDFKEYSVFLTMLCMAYNDFFLEDNK 60 70 80 90 >>NP_002953 (OMIM: 176991) protein S100-A5 [Homo sapiens (92 aa) initn: 301 init1: 180 opt: 299 Z-score: 382.9 bits: 75.6 E(85289): 1.4e-14 Smith-Waterman score: 299; 53.3% identity (80.0% similar) in 90 aa overlap (1-90:1-87) 10 20 30 40 50 60 pF1KB8 MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS : :::::: .::.:::::::.::.:. :...:::::. .:: ::. :.... ::. NP_002 METPLEKALTTMVTTFHKYSGREGSKLTLSRKELKELIKKEL--CLGE-MKESSIDDLMK 10 20 30 40 50 70 80 90 100 pF1KB8 NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK .::.: :.:.::.:: :::. . : :.:: NP_002 SLDKNSDQEIDFKEYSVFLTMLCMAYNDFFLEDNK 60 70 80 90 101 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:12:54 2016 done: Fri Nov 4 16:12:55 2016 Total Scan time: 3.150 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]