FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8864, 110 aa 1>>>pF1KB8864 110 - 110 aa - 110 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6977+/-0.000254; mu= 13.3688+/- 0.016 mean_var=55.0771+/-11.039, 0's: 0 Z-trim(122.1): 28 B-trim: 662 in 1/51 Lambda= 0.172818 statistics sampled from 39738 (39768) to 39738 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.827), E-opt: 0.2 (0.466), width: 16 Scan time: 4.980 The best scores are: opt bits E(85289) NP_001278826 (OMIM: 125852,176730,606176,613370,61 ( 110) 765 197.4 3.9e-51 NP_000198 (OMIM: 125852,176730,606176,613370,61621 ( 110) 765 197.4 3.9e-51 NP_001172026 (OMIM: 125852,176730,606176,613370,61 ( 110) 765 197.4 3.9e-51 NP_001172027 (OMIM: 125852,176730,606176,613370,61 ( 110) 765 197.4 3.9e-51 NP_001007140 (OMIM: 130650,147470,180860,194070,61 ( 180) 126 38.2 0.0053 NP_000603 (OMIM: 130650,147470,180860,194070,61648 ( 180) 126 38.2 0.0053 NP_001278791 (OMIM: 130650,147470,180860,194070,61 ( 180) 126 38.2 0.0053 NP_001278790 (OMIM: 130650,147470,180860,194070,61 ( 180) 126 38.2 0.0053 NP_001121070 (OMIM: 130650,147470,180860,194070,61 ( 236) 126 38.3 0.0066 NP_001252516 (OMIM: 146738,219050) insulin-like 3 ( 157) 122 37.2 0.0095 >>NP_001278826 (OMIM: 125852,176730,606176,613370,616214 (110 aa) initn: 765 init1: 765 opt: 765 Z-score: 1039.0 bits: 197.4 E(85289): 3.9e-51 Smith-Waterman score: 765; 100.0% identity (100.0% similar) in 110 aa overlap (1-110:1-110) 10 20 30 40 50 60 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN 70 80 90 100 110 >>NP_000198 (OMIM: 125852,176730,606176,613370,616214) i (110 aa) initn: 765 init1: 765 opt: 765 Z-score: 1039.0 bits: 197.4 E(85289): 3.9e-51 Smith-Waterman score: 765; 100.0% identity (100.0% similar) in 110 aa overlap (1-110:1-110) 10 20 30 40 50 60 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN :::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN 70 80 90 100 110 >>NP_001172026 (OMIM: 125852,176730,606176,613370,616214 (110 aa) initn: 765 init1: 765 opt: 765 Z-score: 1039.0 bits: 197.4 E(85289): 3.9e-51 Smith-Waterman score: 765; 100.0% identity (100.0% similar) in 110 aa overlap (1-110:1-110) 10 20 30 40 50 60 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN 70 80 90 100 110 >>NP_001172027 (OMIM: 125852,176730,606176,613370,616214 (110 aa) initn: 765 init1: 765 opt: 765 Z-score: 1039.0 bits: 197.4 E(85289): 3.9e-51 Smith-Waterman score: 765; 100.0% identity (100.0% similar) in 110 aa overlap (1-110:1-110) 10 20 30 40 50 60 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN 70 80 90 100 110 >>NP_001007140 (OMIM: 130650,147470,180860,194070,616489 (180 aa) initn: 217 init1: 115 opt: 126 Z-score: 174.8 bits: 38.2 E(85289): 0.0053 Smith-Waterman score: 159; 33.7% identity (54.8% similar) in 104 aa overlap (7-109:9-84) 10 20 30 40 50 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYT-PKTRRE .: ::..::. . :: .. :::..::..: .:::.:::... : .: NP_001 MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRV- 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 AEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN : ..:::::.:: :.: ::.:: NP_001 ---------------------------SRRSRGIVEECCFRSCDLALLETYCATPAKSER 60 70 80 90 NP_001 DVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFREA 100 110 120 130 140 150 >>NP_000603 (OMIM: 130650,147470,180860,194070,616489) i (180 aa) initn: 217 init1: 115 opt: 126 Z-score: 174.8 bits: 38.2 E(85289): 0.0053 Smith-Waterman score: 159; 33.7% identity (54.8% similar) in 104 aa overlap (7-109:9-84) 10 20 30 40 50 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYT-PKTRRE .: ::..::. . :: .. :::..::..: .:::.:::... : .: NP_000 MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRV- 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 AEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN : ..:::::.:: :.: ::.:: NP_000 ---------------------------SRRSRGIVEECCFRSCDLALLETYCATPAKSER 60 70 80 90 NP_000 DVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFREA 100 110 120 130 140 150 >>NP_001278791 (OMIM: 130650,147470,180860,194070,616489 (180 aa) initn: 217 init1: 115 opt: 126 Z-score: 174.8 bits: 38.2 E(85289): 0.0053 Smith-Waterman score: 159; 33.7% identity (54.8% similar) in 104 aa overlap (7-109:9-84) 10 20 30 40 50 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYT-PKTRRE .: ::..::. . :: .. :::..::..: .:::.:::... : .: NP_001 MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRV- 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 AEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN : ..:::::.:: :.: ::.:: NP_001 ---------------------------SRRSRGIVEECCFRSCDLALLETYCATPAKSER 60 70 80 90 NP_001 DVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFREA 100 110 120 130 140 150 >>NP_001278790 (OMIM: 130650,147470,180860,194070,616489 (180 aa) initn: 217 init1: 115 opt: 126 Z-score: 174.8 bits: 38.2 E(85289): 0.0053 Smith-Waterman score: 159; 33.7% identity (54.8% similar) in 104 aa overlap (7-109:9-84) 10 20 30 40 50 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYT-PKTRRE .: ::..::. . :: .. :::..::..: .:::.:::... : .: NP_001 MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRV- 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 AEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN : ..:::::.:: :.: ::.:: NP_001 ---------------------------SRRSRGIVEECCFRSCDLALLETYCATPAKSER 60 70 80 90 NP_001 DVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFREA 100 110 120 130 140 150 >>NP_001121070 (OMIM: 130650,147470,180860,194070,616489 (236 aa) initn: 218 init1: 115 opt: 126 Z-score: 173.1 bits: 38.3 E(85289): 0.0066 Smith-Waterman score: 159; 33.7% identity (54.8% similar) in 104 aa overlap (7-109:65-140) 10 20 30 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLV .: ::..::. . :: .. :::..:: NP_001 FWVGRKGELLRRTPVSSAMQTPMGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELV 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB8 EALYLVCGERGFFYT-PKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQC ..: .:::.:::... : .: : ..:::::.: NP_001 DTLQFVCGDRGFYFSRPASRV----------------------------SRRSRGIVEEC 100 110 120 100 110 pF1KB8 CTSICSLYQLENYCN : :.: ::.:: NP_001 CFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGL 130 140 150 160 170 180 >>NP_001252516 (OMIM: 146738,219050) insulin-like 3 isof (157 aa) initn: 103 init1: 75 opt: 122 Z-score: 170.3 bits: 37.2 E(85289): 0.0095 Smith-Waterman score: 122; 31.8% identity (55.1% similar) in 107 aa overlap (4-102:8-109) 10 20 30 40 50 pF1KB8 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRR : .: ::. :: :. . ..::: :.:.:: ::: : .. ..:: NP_001 MDPRLPAWALVLLGPALVFALGPAPTPE-MREKLCGHHFVRALVRVCG--GPRWSTEARR 10 20 30 40 50 60 70 80 90 100 pF1KB8 EA---EDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTS-----ICSLYQLENY : .. . .: .: .: .: .: ..:. :: . : : :::. NP_001 PATGGDQRESHSVSQAGLKLLSSSNPPTL--TFQSVGISDVSCYSGWRDDICSMGWWPTV 60 70 80 90 100 110 110 pF1KB8 CN NP_001 ISRWDLACSPCPRPLTITATTVQLPPTLHATAASVAVPNKTC 120 130 140 150 110 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:56:52 2016 done: Sat Nov 5 19:56:53 2016 Total Scan time: 4.980 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]